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    Expandable fluoropolymer device for delivery of therapeutic agents and method of making
    11.
    发明申请
    Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
    用于递送治疗剂的可扩展含氟聚合物装置和制备方法

    公开(公告)号：US20050154416A1

    公开(公告)日：2005-07-14

    申请号：US11068680

    申请日：2005-02-28

    申请人： Steve Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61F2/958 ,  A61L29/04 ,  B29C47/00 ,  B29C55/24 ,  A61M29/00

    CPC分类号： A61M25/1029 ,  A61L29/041 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1075 ,  B29C47/00 ,  B29C47/0023 ,  B29C55/24 ,  B29C2049/465 ,  B29K2027/18 ,  B29L2022/022 ,  B29L2031/753 ,  B32B2305/026 ,  C08L27/18

    摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.

    摘要翻译： 一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸， 径向膨胀力。 该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。

    Gastric Constriction Device
    12.
    发明申请
    Gastric Constriction Device 审中-公开
    胃收缩装置

    公开(公告)号：US20110004054A1

    公开(公告)日：2011-01-06

    申请号：US12839250

    申请日：2010-07-19

    申请人： Peter Gingras

    发明人： Peter Gingras

    IPC分类号： A61F2/04 ,  A61N1/36

    CPC分类号： A61F5/0063 ,  A61F5/0003 ,  A61F5/0026 ,  A61F5/0086

    摘要： A gastric constriction device (160) comprises a sheet (131) extending over part of the wall of the stomach (24). Five bands (151) extend around the stomach (24) to fix the sheet (131) in position relative to the stomach (24). The lower two bands (151) extend from the first side (152) of the sheet (131) around the stomach (24) only partially towards the second side (153). These lower two bands (151) are not fixed to the second side (153). This arrangement results in an unconstricted portion of the stomach (161). In this manner, the device (160) restricts expansion of the majority of the stomach wall while facilitating expansion of this unconstricted portion (161). The unconstricted portion (161) is therefore free to expand or bulge outwardly upon ingestion. This expansion may trigger the feeling of satiation due to the presence of the vagal nerves in this portion (161) of the stomach (24).

    摘要翻译： 胃收缩装置（160）包括在胃（24）的壁的一部分上延伸的片（131）。 五个带（151）围绕胃（24）延伸以将片（131）相对于胃（24）固定在适当位置。 下两个带（151）从片（131）的第一侧（152）围绕胃（24）仅部分地朝向第二侧（153）延伸。 这些较低的两个带（151）不固定到第二侧（153）。 这种布置导致胃的无约束部分（161）。 以这种方式，装置（160）限制胃壁的大部分的膨胀，同时有助于该无约束部分（161）的膨胀。 因此，非限制部分（161）在摄入时可以自由地向外膨胀或膨胀。 由于在胃部（24）的该部分（161）存在迷走神经，所以这种扩张可能引起饱腹感。

    Tissue Repair Implant
    15.
    发明申请
    Tissue Repair Implant 有权
    组织修复植入

    公开(公告)号：US20140207249A1

    公开(公告)日：2014-07-24

    申请号：US14224569

    申请日：2014-03-25

    申请人： Peter Gingras ,  Gabriela Voskerician ,  Michael F. White

    发明人： Peter Gingras ,  Gabriela Voskerician ,  Michael F. White

    IPC分类号： A61L31/00 ,  A61F2/02

    CPC分类号： A61L27/3604 ,  A61F2/0063 ,  A61F2/02 ,  A61L31/005 ,  A61L2430/34

    摘要： Described herein are tissue repair implants comprising at least a first layer of peritoneal membrane. The first layer of peritoneal membrane can be located adjacent to a second layer of peritoneal membrane and can be in direct contact with the second layer of peritoneal membrane. Additional layers (e.g., a third or fourth layer) can be included. Where more than one layer is present, the layers can be affixed to one another. For example, a first layer of peritoneal membrane can be attached to the second layer of peritoneal membrane by an adhesive bond, suture, or staple. One or more of the peritoneal membranes can be non-crosslinked, partially crosslinked, or substantially fully crosslinked. Any of the layers of peritoneal membrane may be attached to a wall (e.g., an interior or exterior wall) of an abdominal tissue by an adhesive, suture, and/or staples.

    摘要翻译： 本文描述的是包括至少第一层腹膜的组织修复植入物。 第一层腹膜可以位于第二层腹膜附近，并且可以与第二层腹膜直接接触。 可以包括附加层（例如，第三层或第四层）。 在存在多于一层的情况下，层可以彼此固定。 例如，第一层腹膜可以通过粘合剂粘合剂，缝合线或缝钉连接到第二层腹膜。 一个或多个腹膜可以是非交联的，部分交联的或基本完全交联的。 腹膜的任何一层可以通过粘合剂，缝合线和/或钉钉连接到腹部组织的壁（例如，内壁或外壁）上。

    Tissue repair implant
    16.
    发明授权
    Tissue repair implant 有权
    组织修复植入物

    公开(公告)号：US08709096B2

    公开(公告)日：2014-04-29

    申请号：US12432314

    申请日：2009-04-29

    申请人： Peter Gingras ,  Gabriela Voskerician ,  Michael F. White

    发明人： Peter Gingras ,  Gabriela Voskerician ,  Michael F. White

    IPC分类号： A61F2/02

    CPC分类号： A61L27/3604 ,  A61F2/0063 ,  A61F2/02 ,  A61L31/005 ,  A61L2430/34

    摘要： Described herein are tissue repair implants comprising at least a first layer of peritoneal membrane. The first layer of peritoneal membrane can be located adjacent to a second layer of peritoneal membrane and can be in direct contact with the second layer of peritoneal membrane. Additional layers (e.g., a third or fourth layer) can be included. Where more than one layer is present, the layers can be affixed to one another. For example, a first layer of peritoneal membrane can be attached to the second layer of peritoneal membrane by an adhesive bond, suture, or staple. One or more of the peritoneal membranes can be non-crosslinked, partially crosslinked, or substantially fully crosslinked. Any of the layers of peritoneal membrane may be attached to a wall (e.g., an interior or exterior wall) of an abdominal tissue by an adhesive, suture, and/or staples.

    摘要翻译： 本文描述的是包括至少第一层腹膜的组织修复植入物。 第一层腹膜可以位于第二层腹膜附近，并且可以与第二层腹膜直接接触。 可以包括附加层（例如，第三层或第四层）。 在存在多于一层的情况下，层可以彼此固定。 例如，第一层腹膜可以通过粘合剂粘合剂，缝合线或缝钉连接到第二层腹膜。 一个或多个腹膜可以是非交联的，部分交联的或基本完全交联的。 腹膜的任何一层可以通过粘合剂，缝合线和/或钉钉连接到腹部组织的壁（例如，内壁或外壁）上。

    SOFT TISSUE IMPLANTS AND METHODS FOR MAKING SAME
    17.
    发明申请
    SOFT TISSUE IMPLANTS AND METHODS FOR MAKING SAME 审中-公开
    软组织植入物及其制备方法

    公开(公告)号：US20090216338A1

    公开(公告)日：2009-08-27

    申请号：US12066628

    申请日：2006-09-12

    申请人： Peter Gingras ,  Dean King

    发明人： Peter Gingras ,  Dean King

    IPC分类号： A61F2/02 ,  A61B17/08

    CPC分类号： A61F2/0063 ,  A61F2/0077

    摘要： The present invention features soft tissue implants comprising major (34) and minor struts (36) and methods for making same. The implants can include biocompatible film (30) that is rendered porous due to the inclusion of uniformly or non-uniformly patterned cells (32), and the film has a thickness of less than about (0.015 inches) in the event the starting material is non-porous and less than about (0.035 inches) in the event the starting material is a microporous film. Multi-film implants can also be made.

    摘要翻译： 本发明的特征在于包括主要（34）和次要支柱（36）的软组织植入物及其制造方法。 植入物可以包括由于包含均匀或不均匀图案化的细胞（32）而变成多孔的生物相容性膜（30），并且在起始材料是的情况下，膜的厚度小于约（0.015英寸） 在起始材料是微孔膜的情况下，其为非多孔的且小于约（0.035英寸）。 也可以制作多层植入物。

    Medical device
    18.
    发明申请
    Medical device 审中-公开
    医疗装置

    公开(公告)号：US20050222591A1

    公开(公告)日：2005-10-06

    申请号：US11093983

    申请日：2005-03-30

    申请人： Peter Gingras ,  Dean King

    发明人： Peter Gingras ,  Dean King

    IPC分类号： A61F2/00 ,  A61L27/00 ,  A61L27/50 ,  A61L27/56 ,  A61F2/02

    CPC分类号： A61L27/56 ,  A61F2/0045 ,  A61F2/0063 ,  A61F2002/0068 ,  A61L27/50 ,  D04B21/12 ,  D10B2509/08 ,  Y10T442/30 ,  Y10T442/40

    摘要： A soft tissue implant comprises a condensed surgical mesh having a plurality of monofilament biocompatible fibres 12. Condensing of the fibres reduces the void space between adjacent fibres 12 in the mesh and reduces the surface area of the fibres 12 available for contact with tissue 18. Condensation of the fibres 12 may be achieved by applying mechanical pressure, and/or vacuum, and/or heat to the mesh.

    摘要翻译： 软组织植入物包括具有多根单丝生物相容性纤维12的冷凝手术网。 纤维的冷凝减小了网中相邻纤维12之间的空隙，并减少了可用于与组织18接触的纤维12的表面积。 纤维12的冷凝可以通过向网状物施加机械压力和/或真空和/或加热来实现。

    Covered stent and method of covering a stent
    19.
    发明申请
    Covered stent and method of covering a stent 有权
    覆盖支架和覆盖支架的方法

    公开(公告)号：US20050055081A1

    公开(公告)日：2005-03-10

    申请号：US10972197

    申请日：2004-10-22

    申请人： Jonathan Goodwin ,  Gary Jordan ,  Peter Gingras

    发明人： Jonathan Goodwin ,  Gary Jordan ,  Peter Gingras

    IPC分类号： A61F2/86 ,  A61L31/10 ,  A61L31/14 ,  A61F2/06

    CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2002/072 ,  A61F2210/0076 ,  A61F2220/005 ,  A61L31/10 ,  A61L31/146 ,  C08L27/18

    摘要： A radially deployable covered stent that predictably and dependably expands to an increased diameter state at relatively low deployment pressures while concomitantly minimizing the risk of tearing of the stent covering during expansion. The stent covering includes an inner cover and an outer cover that are bonded together through and around the stent structure to cover the stent. The stent cover is constructed from expanded polytetrafluoroethylene (ePTFE) having a structure of nodes interconnected by fibrils. The stent covering has a radial thickness of at least about 0.008″ and an average internodal distance (IND) of at least about 100 microns when the stent is in the reduced diameter, unexpanded state. The covered stent deploys at an average deployment pressure of less than or equal to about 10 atm. A method for covering a stent structure according to the present invention includes placing a compression member in the form of a tubular sleeve over the outer cover and heating the compressed covered stent to bond the inner cover to the outer cover. An adhesive in the form of an aqueous dispersion of PTFE can be applied to either the inner cover or the outer cover to facilitate bonding of the inner cover to the outer cover.

    摘要翻译： 可径向展开的覆盖支架可预测地且可靠地在相对较低的部署压力下扩张到增加的直径状态，同时最小化扩张期间支架覆盖物撕裂的风险。 支架覆盖物包括通过支架结构并且围绕支架结构粘合在一起以覆盖支架的内盖和外盖。 支架盖由膨胀的聚四氟乙烯（ePTFE）构成，其具有通过纤维互连的节点结构。 当支架处于减小直径，未膨胀状态时，支架覆盖物具有至少约0.008“的径向厚度和至少约100微米的平均间隔距离（IND）。 覆盖的支架以小于或等于约10atm的平均部署压力部署。 根据本发明的覆盖支架结构的方法包括将管状套筒形式的压缩构件放置在外盖上并加热压缩的被覆盖的支架以将内盖结合到外盖。 可以将PTFE的水性分散体形式的粘合剂施加到内盖或外盖上，以便于内盖与外盖接合。