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83 条记录 (耗时 0.044 秒)

    Chemokine &bgr;-4 polypeptides
    11.
    发明授权
    Chemokine &bgr;-4 polypeptides 有权
    趋化因子β-4多肽

    公开(公告)号：US06458349B1

    公开(公告)日：2002-10-01

    申请号：US09261201

    申请日：1999-03-03

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： A61K3819

    CPC分类号： C07K14/521 ,  A61K38/00 ,  G01N33/564 ,  G01N2500/04 ,  G01N2800/26

    摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

    摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

    Polynucleotide encoding chemokine .beta.-4
    12.
    发明授权
    Polynucleotide encoding chemokine .beta.-4 失效
    多核苷酸编码趋化因子β-4

    公开(公告)号：US5981230A

    公开(公告)日：1999-11-09

    申请号：US458355

    申请日：1995-06-02

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： C07K14/52 ,  C12N15/19 ,  C12N15/63

    CPC分类号： C07K14/52 ,  C12N15/63

    摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

    摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

    Antibodies to chemokine β-4
    15.
    发明授权
    Antibodies to chemokine β-4 失效
    趋化因子β-4的抗体

    公开(公告)号：US06921645B2

    公开(公告)日：2005-07-26

    申请号：US10164621

    申请日：2002-06-10

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： A01N37/18 ,  A61K38/00 ,  A61K38/19 ,  C07H21/04 ,  C07K5/00 ,  C07K7/00 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K17/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/06 ,  C12N15/00 ,  C12N15/09 ,  C12N15/19 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C07K14/521 ,  A61K38/00 ,  G01N33/564 ,  G01N2500/04 ,  G01N2800/26

    摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

    摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

    Human chemokine &bgr;-9
    18.
    发明授权
    Human chemokine &bgr;-9 失效
    人趋化因子β-9

    公开(公告)号：US06518046B1

    公开(公告)日：2003-02-11

    申请号：US08793381

    申请日：1997-05-19

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： C12N1500

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： The present invention relates to Human Ck&bgr;-9 polypeptides and DNA (RNA) encoding such chemolcine polypeptides. Moreover, a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ck&bgr;-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune diseases, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic agent to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective disease, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ck&bgr;-9 coding sequence and over-expression of the Ck&bgr;-9 protein.

    摘要翻译： 本发明涉及人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）。 此外，公开了通过重组技术生产这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。

    Human chemokine β-9 viral vectors
    20.
    发明授权
    Human chemokine β-9 viral vectors 失效
    人趋化因子β-9病毒载体

    公开(公告)号：US07198944B2

    公开(公告)日：2007-04-03

    申请号：US11260166

    申请日：2005-10-28

    申请人： Haodong Li ,  Mark D. Adams

    发明人： Haodong Li ,  Mark D. Adams

    IPC分类号： C12N15/63

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/523 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6863 ,  G01N2333/52

    摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.

    摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。