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279 条记录 (耗时 0.043 秒)

    Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
    17.
    发明授权
    Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands 有权
    咪唑并 - 嘧啶和三唑并嘧啶：苯并二氮杂受体配体

    公开(公告)号：US07271170B2

    公开(公告)日：2007-09-18

    申请号：US10898690

    申请日：2004-07-23

    申请人： Linghong Xie ,  Bingsong Han ,  Yuelian Xu ,  George Maynard ,  Bertrand L. Chenard ,  Kenneth Shaw ,  Yang Gao

    发明人： Linghong Xie ,  Bingsong Han ,  Yuelian Xu ,  George Maynard ,  Bertrand L. Chenard ,  Kenneth Shaw ,  Yang Gao

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/24 ,  A61P25/22 ,  A61P25/20

    CPC分类号： C07D487/04

    摘要： Compounds of Formula I are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

    摘要翻译： 提供了式I化合物，以及其制备方法。 变量Z 1，Z 2，Z 3，R 4，R 5，/或 >，R 6，R 7，R 8和Ar如上所定义。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合，并且特别可用于治疗人类中的各种中枢神经系统（CNS）紊乱，驯养伴侣动物 和牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用，以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这种配体检测GABA A受体的方法（例如，受体定位研究）。

    IMIDAZO-PYRIMIDINES AND TRIAZOLO-PYRIMIDINES: BENZODIAZEPINE RECEPTOR LIGANDS
    18.
    发明申请
    IMIDAZO-PYRIMIDINES AND TRIAZOLO-PYRIMIDINES: BENZODIAZEPINE RECEPTOR LIGANDS 审中-公开
    咪唑并吡啶和三唑并嘧啶：苯并咪唑受体配体

    公开(公告)号：US20080139580A1

    公开(公告)日：2008-06-12

    申请号：US11855386

    申请日：2007-09-14

    申请人： Linghong Xie ,  Bingsong Han ,  Yuelian Xu ,  George Maynard ,  Bertrand L. Chenard ,  Kenneth Shaw ,  Yang Gao

    发明人： Linghong Xie ,  Bingsong Han ,  Yuelian Xu ,  George Maynard ,  Bertrand L. Chenard ,  Kenneth Shaw ,  Yang Gao

    IPC分类号： A61K31/437 ,  C12N5/06 ,  C07K14/705 ,  A61P25/00 ,  A61P25/24

    CPC分类号： C07D487/04

    摘要： Compounds of Formula I are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

    摘要翻译： 提供了式I化合物，以及其制备方法。 变量Z 1，Z 2，Z 3，R 4，R 5，/或 >，R 6，R 7，R 8和Ar如上所定义。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合，并且特别可用于治疗人类中的各种中枢神经系统（CNS）紊乱，驯养伴侣动物 和牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用，以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这种配体检测GABA A受体的方法（例如，受体定位研究）。

    Kit, a device and a method for detecting copy number of fetal chromosomes or tumor cell chromosomes
    20.
    发明授权
    Kit, a device and a method for detecting copy number of fetal chromosomes or tumor cell chromosomes 有权

    公开(公告)号：US09885080B2

    公开(公告)日：2018-02-06

    申请号：US13811634

    申请日：2011-05-31

    申请人： Yang Gao ,  Daixing Zhou ,  Jianguang Zhang ,  Feng Tian

    发明人： Yang Gao ,  Daixing Zhou ,  Jianguang Zhang ,  Feng Tian

    IPC分类号： C12Q1/68 ,  G06F19/20

    CPC分类号： C12Q1/6874 ,  C12Q1/6809 ,  C12Q1/6869 ,  G06F19/20 ,  C12Q2535/122 ,  C12Q2537/16 ,  C12Q2537/165 ,  C12Q2563/159

    摘要： The invention relates to a kit, a device and a method for detecting the copy number of fetal chromosomes and tumor cell chromosomes. The method for detecting the copy number of fetal chromosomes or tumor cell chromosomes of the invention includes the following steps: collecting maternal plasma or plasma of tumor patient; separating the plasma from blood cells in blood; preparing Deoxyribonucleic Acids (DNA) in the plasma into a sequencing library; sequencing the DNA sequencing library; comparing a sequencing result with a genomic sequence map to determine which chromosome the DNA sequence comes from and the length of each DNA sequence; and calculating the ratio of the DNA segments from the chromosomes to be detected to all DNA segments in the same sample by a sequencing and comparison result of DNA, correcting the ratio according to a GC content of the DNA segments from the chromosomes to be detected, and calculating the variation of the corrected ratio of the DNA segments from the chromosomes to be detected in a sample to be detected, and determining the copy number of the chromosomes to be detected according to degree of variation.