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11.发明授权Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same 有权含聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法公开(公告)号：US08808723B2
公开(公告)日：2014-08-19
申请号：US12504542
申请日：2009-07-16
申请人： Stephen D. Pacetti , Charles Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F. A. Hossainy
发明人： Stephen D. Pacetti , Charles Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F. A. Hossainy
摘要： Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.
摘要翻译： 公开了含有聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含包含多元醇，多元羧酸，氨基酸和试剂的反应的聚合产物的聚合物。
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12.发明授权Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating 有权包含弹性蛋白五肽嵌段和亲水嵌段的共聚物，以及医疗装置和治疗方法公开(公告)号：US08778376B2
公开(公告)日：2014-07-15
申请号：US11449896
申请日：2006-06-09
IPC分类号： A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06 , A61K9/00 , A61K38/43 , A61K38/44 , A61K38/00 , A61K38/08 , C12N5/07 , C12N11/02 , C12N11/08
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.
摘要翻译： 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。
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13.发明授权Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof 有权具有水化梯度的药物递送装置的涂层及其制造方法公开(公告)号：US07329413B1
公开(公告)日：2008-02-12
申请号：US10703334
申请日：2003-11-06
IPC分类号： A61F2/00
CPC分类号： A61L31/10 , A61F2250/0067 , A61L2420/08 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要： Coatings for implantable medical devices, and methods for fabricating thereof, are provided. The coatings include a first polymer layer and a second polymer layer, where the second polymer has a higher degree of hydration than the first polymer.
摘要翻译： 提供了用于可植入医疗装置的涂层及其制造方法。 涂层包括第一聚合物层和第二聚合物层，其中第二聚合物具有比第一聚合物更高的水合度。
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14.发明授权公开(公告)号：US09089627B2
公开(公告)日：2015-07-28
申请号：US11827180
申请日：2007-07-10
CPC分类号： A61F2/86 , A61F2210/0076 , A61F2230/0069 , A61L31/10 , A61L31/129
摘要： Stents fabricated from polymer composites toughened by a dispersed phase are disclosed.
摘要翻译： 公开了由分散相增韧的聚合物复合材料制成的支架。
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公开(公告)号：US09056155B1
公开(公告)日：2015-06-16
申请号：US11807833
申请日：2007-05-29
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L2300/00 , A61L2300/416 , C08G63/6856 , C08L67/02 , C09D167/02 , C08L67/04
摘要： Provided herein is a coating an elastic primer layer and the method of making and using the same.
摘要翻译： 本文提供了一种弹性底漆层的涂层及其制造和使用方法。
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公开(公告)号：US08685430B1
公开(公告)日：2014-04-01
申请号：US11827783
申请日：2007-07-13
CPC分类号： A61L31/10 , A61L27/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2400/18 , A61L2420/08 , C08L67/04
摘要： A aliphatic polyester polymer for stent coating is described.
摘要翻译： 描述了用于支架涂层的脂族聚酯聚合物。
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17.发明授权公开(公告)号：US08661630B2
公开(公告)日：2014-03-04
申请号：US12124991
申请日：2008-05-21
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译： 本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。
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公开(公告)号：US08632845B2
公开(公告)日：2014-01-21
申请号：US12766758
申请日：2010-04-23
CPC分类号： B29C65/76 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61F2310/00389 , A61L31/14 , A61L31/148 , A61L2420/02 , B05D1/38 , B05D3/0254 , B05D3/0473 , B29C65/10 , B29K2067/046 , B29K2105/258 , B29L2031/7534
摘要： Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
摘要翻译： 本文描述了用于涂覆支架的方法的各种实施例。 公开了将包含聚合物组分和溶剂的组合物施用到支架基底，然后将聚合物组分暴露于等于或大于聚合物组分的Tg的温度。 重复施加和暴露一次或多次以形成涂层，结果是在最终曝光步骤之后涂层的溶剂含量处于适合成品支架的水平。
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19.发明授权公开(公告)号：US08435550B2
公开(公告)日：2013-05-07
申请号：US12191209
申请日：2008-08-13
申请人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F. A. Hossainy
发明人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F. A. Hossainy
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61K31/4745 , A61K31/56 , A61K31/573 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
摘要翻译： 提供了一种药物递送系统，其包括至少100杯依维莫司和氯倍他索，使得依维莫司与氯倍他索的比例至少为10：1（w / w），依维莫司的重量比为至少10倍 氯倍他索 该系统可以是支架。 还提供了治疗血管的再狭窄或易损斑块的方法，所述方法包括向患者局部施用选自雷帕霉素（西罗莫司），Biolimus A9，deforolimus，AP23572，他克莫司，替西罗莫司，吡美莫司， 40-（2-羟基）乙基雷帕霉素（依维莫司），40-O-（3-羟基）丙基雷帕霉素，40-O- [2-（2-羟基）乙氧基]乙基雷帕霉素，40- O-四唑基雷帕霉素和40-表 - （N1-四唑基）雷帕霉素，并且对患者局部施用由氯倍他索组成的第二药物，其中局部施用的第一药物的最小量为100杯，其中 第二种药物的第一种药物例如为10：1〜100：1（w / w）。
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公开(公告)号：US08383142B2
公开(公告)日：2013-02-26
申请号：US12723556
申请日：2010-03-12
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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