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公开(公告)号：US20050271700A1
公开(公告)日：2005-12-08
申请号：US10750139
申请日：2004-06-03
申请人： Jessica DesNoyer , Syed Hossainy , Stephen Pacetti , Yiwen Tang
发明人： Jessica DesNoyer , Syed Hossainy , Stephen Pacetti , Yiwen Tang
IPC分类号： A61F2/00 , A61L2/00 , A61L31/10 , A61L31/16 , C09D177/12 , C09D187/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/602 , C08L77/12
摘要： A poly(ester amide) (PEA) coating with enhanced mechanical and/or release rate for coating an implantable device, such as a drug-eluting stent, is disclosed. A method of forming the PEA coating onto a device and a method of treating a disorder, such as restenosis, are also disclosed.
摘要翻译： 公开了用于涂覆可植入装置（例如药物洗脱支架）的具有增强的机械和/或释放速率的聚（酯酰胺）（PEA）涂层。 还公开了将PEA涂层形成在器件上的方法和治疗诸如再狭窄的病症的方法。
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公开(公告)号：US20050143808A1
公开(公告)日：2005-06-30
申请号：US11067375
申请日：2005-02-25
申请人： Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
发明人： Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
CPC分类号： A61F2/06 , A61F2/0077 , A61F2250/0067 , Y10T428/13 , Y10T428/24942 , Y10T428/3154 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935
摘要： An implantable medical device, such as a stent, is disclosed having a coating. The coating includes a poly(butylene terephthalate-co-ethylene glycol) polymer. The coating can also include a drug.
摘要翻译： 公开了一种具有涂层的可植入医疗装置，例如支架。 涂层包括聚（对苯二甲酸丁二醇酯 - 共 - 乙二醇）聚合物。 涂层还可以包括药物。
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13.发明申请Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 审中-公开用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号：US20050112170A1
公开(公告)日：2005-05-26
申请号：US10718976
申请日：2003-11-20
申请人： Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
发明人： Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
IPC分类号： A61F2/00 , A61F2/86 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/06 , A61M29/02
CPC分类号： A61L31/10 , A61F2/86 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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14.发明申请METHODS, COMPOSITIONS AND DEVICES FOR TREATING LESIONED SITES USING BIOABSORBABLE CARRIERS 审中-公开方法，组合物和使用生物可降解载体处理裂解位点的装置公开(公告)号：US20080051335A1
公开(公告)日：2008-02-28
申请号：US11614047
申请日：2006-12-20
申请人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
发明人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
摘要翻译： 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。 另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。
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15.发明申请Design of poly(ester amides) for the control of agent-release from polymeric compositions 审中-公开聚（酯酰胺）的设计，用于控制聚合物组合物释放的药剂公开(公告)号：US20050288481A1
公开(公告)日：2005-12-29
申请号：US11187467
申请日：2005-07-22
申请人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。
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16.发明申请Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers 审中-公开用生物可吸收载体处理损伤部位的方法，组合物和装置公开(公告)号：US20070258903A1
公开(公告)日：2007-11-08
申请号：US11416860
申请日：2006-05-02
申请人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
发明人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
CPC分类号： A61K9/0019 , A61K9/143 , A61K9/1611 , A61L31/148 , A61L31/16 , A61L2300/602
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device.
摘要翻译： 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。
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公开(公告)号：US20070243256A1
公开(公告)日：2007-10-18
申请号：US11405976
申请日：2006-04-17
IPC分类号： A61K31/4745 , A61K31/337 , C08G69/48 , C08G63/91 , A61K9/14
CPC分类号： A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
摘要： A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
摘要翻译： 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 也描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。
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18.发明申请Poly(ester amide)-based drug delivery systems with controlled release rate and morphology 有权具有控制释放速率和形态的基于聚（酯酰胺）的药物递送系统公开(公告)号：US20070202147A1
公开(公告)日：2007-08-30
申请号：US11365549
申请日：2006-02-28
IPC分类号： A61F2/02 , A61K38/44 , A61K31/56 , A61K31/4745 , A61K31/337
CPC分类号： A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
摘要： A method of forming a coating on a medical device having a controlled morphology is described.
摘要翻译： 描述了在具有受控形态的医疗装置上形成涂层的方法。
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19.发明申请Method of fabricating a bioactive agent-releasing implantable medical device 审中-公开制造生物活性剂释放植入式医疗装置的方法公开(公告)号：US20070020312A1
公开(公告)日：2007-01-25
申请号：US11186030
申请日：2005-07-20
IPC分类号： A61L33/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/146 , A61L2300/41 , A61L2300/604 , C08L77/12
摘要： The present invention relates to methods of controlling the loading of a bioactive agent into a polymeric carrier to be coated on an implantable medical device to achieve controlled release of the bioactive agent.
摘要翻译： 本发明涉及控制将生物活性剂负载到待涂覆在可植入医疗装置上的聚合物载体中以实现生物活性剂的受控释放的方法。
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20.发明申请公开(公告)号：US20050287184A1
公开(公告)日：2005-12-29
申请号：US10881540
申请日：2004-06-29
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61K31/4745 , A61K31/56 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译： 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。
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