公开(公告)号：US11224577B2

公开(公告)日：2022-01-18

申请号：US15737594

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Soracha Kun Thamphiwatana

IPC: A61K9/51 ,  A61K31/337 ,  A61K31/7042 ,  A61K47/69 ,  A61P31/04 ,  A61K9/50 ,  A61K45/06 ,  B82Y5/00

Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.

公开(公告)号：US20180169027A1

公开(公告)日：2018-06-21

申请号：US15737594

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Soracha Kun Thamphiwatana

IPC: A61K9/51 ,  A61K31/337 ,  A61K47/69 ,  A61K31/7042 ,  A61K9/50 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K9/51 ,  A61K9/5068 ,  A61K9/5084 ,  A61K9/5094 ,  A61K31/337 ,  A61K31/7042 ,  A61K45/06 ,  A61K47/6901 ,  A61K2300/00 ,  A61P31/04 ,  B82Y5/00

Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.

公开(公告)号：US20170274059A1

公开(公告)日：2017-09-28

申请号：US15505148

申请日：2015-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Jonathan Copp ,  Ronnie H. Fang ,  Brian T. Luk

IPC: A61K39/00 ,  A61K45/06 ,  A61K47/34

CPC classification number: A61K39/0008 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/5146 ,  A61K9/5184 ,  A61K35/12 ,  A61K39/385 ,  A61K45/06 ,  A61K47/34 ,  A61K2039/55555 ,  A61K2039/6006

Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.

公开(公告)号：US20180153821A1

公开(公告)日：2018-06-07

申请号：US15737566

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337

CPC classification number: A61K9/5176 ,  A61K9/5153 ,  A61K9/5169 ,  A61K31/337 ,  A61K47/6901 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  B82Y5/00 ,  B82Y30/00

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US20180140558A1

公开(公告)日：2018-05-24

申请号：US15568316

申请日：2016-04-13

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Zhiqing Pang ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  A61K9/50 ,  A61K45/06

CPC classification number: A61K9/5176 ,  A61K9/5068 ,  A61K45/06

Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.

公开(公告)号：US20170079909A1

公开(公告)日：2017-03-23

申请号：US15126342

申请日：2015-03-20

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Copp

IPC: A61K9/06 ,  A61L27/54 ,  A61K9/00 ,  A61L27/52

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K9/1629 ,  A61K9/5068 ,  A61K9/5115 ,  A61K9/5153 ,  A61K9/5176 ,  A61K31/49 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K35/58 ,  A61K35/63 ,  A61K38/1709 ,  A61K45/06 ,  A61L26/008 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/404 ,  A61L2400/12 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

公开(公告)号：US20160136106A1

公开(公告)日：2016-05-19

申请号：US15000110

申请日：2016-01-19

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  G01N33/58 ,  G01N33/569 ,  A61K31/4709 ,  A61K49/00

CPC classification number: A61K9/5176 ,  A61K9/5094 ,  A61K9/51 ,  A61K9/5153 ,  A61K31/4709 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K49/00 ,  G01N33/56905 ,  G01N33/587 ,  G01N2333/445 ,  Y02A50/411 ,  Y02A50/473

Abstract: Provided are methods, combinations and pharmaceutical compositions for treating or preventing an infection in a subject using a nanoparticle comprising a) an inner core comprising a non-cellular material, and b) an outer surface comprising a cellular membrane configured for adhesion of a pathogen that causes said infection. Exemplary infection includes infection caused by a virus, bacterium, fungus, or protozoan.

Abstract translation: 提供了使用纳米颗粒治疗或预防受试者感染的方法，组合和药物组合物，所述纳米颗粒包含a）包含非细胞材料的内核，和b）包含被配置用于粘附病原体的细胞膜的外表面， 导致感染。 示例性感染包括由病毒，细菌，真菌或原生动物引起的感染。

公开(公告)号：US20200276122A1

公开(公告)日：2020-09-03

申请号：US16811515

申请日：2020-03-06

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Copp

IPC: A61K9/06 ,  A61K9/16 ,  A61K9/51 ,  A61K38/17 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K35/58 ,  A61K35/63 ,  A61K45/06 ,  A61K31/49 ,  A61L26/00 ,  A61K9/00 ,  A61L27/52 ,  A61L27/54

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

公开(公告)号：US10588867B2

公开(公告)日：2020-03-17

申请号：US16515906

申请日：2019-07-18

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Weiwei Gao ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K39/00 ,  A61K9/51 ,  A61K39/02 ,  A61K9/50 ,  A61K31/427 ,  A61K31/43 ,  A61K31/49 ,  A61K31/545 ,  A61K45/06 ,  B82Y5/00

Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.

公开(公告)号：US20190142746A1

公开(公告)日：2019-05-16

申请号：US16139612

申请日：2018-09-24

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Coop

IPC: A61K9/06 ,  A61L27/54 ,  A61L27/52 ,  A61K9/16 ,  A61K38/17 ,  A61K35/17 ,  A61K9/00 ,  A61K9/51 ,  A61L26/00 ,  A61K31/49 ,  A61K45/06 ,  A61K35/63 ,  A61K35/58 ,  A61K35/19 ,  A61K35/18

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.