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公开(公告)号:US20240148766A1
公开(公告)日:2024-05-09
申请号:US18253155
申请日:2021-11-15
Applicant: Hayashibara Co., Ltd. , Tsubota Laboratory, Inc.
Inventor: Yosuke NAKAZAWA , Naoki MORISHITA , Shin ENDO , Masaki MIYAKE , Hitoshi MITSUZUMI , Motoshi HAYANO , Kazuo TSUBOTA
IPC: A61K31/7048 , A23C9/13 , A23G3/36 , A23G4/12 , A23L2/52 , A23L27/30 , A23L33/00 , A23L33/125 , A23L33/15 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/68 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/46 , A61P27/10
CPC classification number: A61K31/7048 , A23C9/1307 , A23C9/1322 , A23G3/368 , A23G4/126 , A23L2/52 , A23L27/30 , A23L33/125 , A23L33/15 , A23L33/40 , A61K9/0053 , A61K9/0056 , A61K9/0058 , A61K9/0095 , A61K9/1623 , A61K9/2013 , A61K9/2018 , A61K9/2068 , A61K9/4825 , A61K9/4858 , A61K9/4875 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/46 , A61P27/10
Abstract: An object of the present invention is to provide a novel agent for adjusting hardness of a lens of an eye which can be taken easily, conveniently, and safely for a long-term, can effectively adjust the hardness of the lens, and is capable of preventing, alleviating and improving poor focus and decreased near visual acuity, such as presbyopia, caused by aging and various diseases. The present invention solves the above object by providing an agent for adjusting hardness of a lens of an eye comprising a glycosyl hesperetin as an active ingredient.
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公开(公告)号:US20230364441A1
公开(公告)日:2023-11-16
申请号:US18026232
申请日:2021-09-16
Applicant: TSUBOTA LABORATORY, INC.
Inventor: Xiaoyan JIANG , Kiwako MORI , Toshihide KURIHARA , Kazuo TSUBOTA
IPC: A61N5/06
CPC classification number: A61N5/0613 , A61N2005/0663
Abstract: A device and a method for inhibiting thinning of a choroid. A choroidal thinning inhibiting device including a light source that emits violet light having a wavelength within a range from 360 nm to 400 nm, the choroidal thinning inhibiting device inhibiting thinning of a choroid by irradiation with the violet light. This device may further include a control mechanism that controls an irradiance and an irradiation time of the violet light, can be applied to ocular diseases selected from age-related macular degeneration, glaucoma, diabetic retinopathy, macular edema, eye strain, retinal vascular occlusion, triangle syndrome, central serous chorioretinopathy, retinitis pigmentosa, presbyopia, cataracts, and the like that are based on inadequate blood flow or reduced blood flow, and can be expected to prevent and treat such ocular diseases.
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13.
公开(公告)号:US20210228901A1
公开(公告)日:2021-07-29
申请号:US17301859
申请日:2021-04-16
Applicant: TOSHIBA MATERIALS CO., LTD. , TSUBOTA LABORATORY, INC.
Inventor: Masahiko YAMAKAWA , Hidemasa TORII , Toshihide KURIHARA , Kazuo TSUBOTA
Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.
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公开(公告)号:US20190121165A1
公开(公告)日:2019-04-25
申请号:US16090986
申请日:2017-04-07
Applicant: TSUBOTA LABORATORY, INC.
Inventor: Kazuo TSUBOTA , Masahiko AYAKI
IPC: G02C7/10
Abstract: To provide a translucent member that has the effect of lowering triglycerides, increasing IRS-2, and the like. The above-described problem is solved by a translucent member (1) that blocks or suppresses transmission of at least light that is received by an eye and has a wavelength of 460 nm. The translucent member (1) may be an eyeglass lens or eyeglasses as a whole. The eyeglasses (1) preferably comprise a lens (2) that blocks or suppresses transmission of at least light having a wavelength of 460 nm, and a rim (3) that blocks or suppresses transmission of at least light having a wavelength of 460 nm. The rim (3) preferably comprise a projecting portion (3a) for decreasing a gap between the rim (3) and a face of an eyeglass wearer or eliminating the gap by coming into contact with the face.
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公开(公告)号:US20180280718A1
公开(公告)日:2018-10-04
申请号:US15996842
申请日:2018-06-04
Applicant: TSUBOTA LABORATORY, INC.
Inventor: Kazuo TSUBOTA , Kazuno Negishi , Hidemasa Torii , Toshihide Kurihara
IPC: A61N5/06
Abstract: To provide an irradiation device capable of preventing myopia or slowing the progression of myopia by the action of light irradiated toward the eyeball. An irradiation device (10) comprises a light source (1) and an instrument (2) on which the light source (1) is mounted. The light source (1) emits at least light having a wavelength within a range of 350 to 400 nm, inclusive, and is disposed in a position that allows irradiation in an eyeball direction when the instrument (2) is mounted. Further, the light source (1) is disposed in a position 0 to 100 mm, inclusive, from a surface of the eyeball. At this time, an irradiance of the light having a wavelength within the range of 350 to 400 nm, inclusive, is 0.02 to 1.0 W/m2, inclusive, on the eyeball surface when the instrument (2) is worn.
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16.
公开(公告)号:US20250135221A1
公开(公告)日:2025-05-01
申请号:US18835615
申请日:2023-02-09
Applicant: Tsubota Laboratory, Inc.
Inventor: Motoshi HAYANO , Kazuo TSUBOTA
IPC: A61N5/06
Abstract: The present disclosure is related to a method for improving physiological state by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency, and an apparatus used for the same. More specifically, improvement of physiological state such as, improvement or suppression of dermatitis, improvement or suppression of alopecia, improvement of hair condition, improvement or suppression of graying of hair, improvement or suppression of hearing loss, improvement or suppression of vision loss, improvement or enhancement of muscle strength, improvement or suppression of kyphosis, improvement or suppression of pain and/or feeling of discomfort, improvement of autonomic nerve abnormalities, improvement of healthy life expectancy, and obesity control is carried out by irradiating light of a specific wavelength such as violet light to a living body.
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公开(公告)号:US20240366959A1
公开(公告)日:2024-11-07
申请号:US18741929
申请日:2024-06-13
Applicant: TSUBOTA LABORATORY, INC. , SUMITOMO PHARMA CO., LTD.
Inventor: Motoshi HAYANO , Kazuo TSUBOTA , Yoshihiro NODA
IPC: A61N5/06
Abstract: To provide a device and a method for preventing, improving, or preventing a worsening of depression by irradiating light having specific wavelengths, such as violet light, as well as a method for operating the device.
The above-described problem is solved by a device and a method used for the purpose of preventing, improving, or preventing a worsening of depression by irradiating a subject with violet light having a wavelength within a range of 360 to 400 nm. An operating method of a device is a method for operating a device including irradiation means for irradiating a subject with violet light having a wavelength within a range of 360 to 400 nm and used for the purpose of preventing, improving, or preventing a worsening of depression. The operating method comprises operating the irradiation means of the device by changing, by transmission and reception with an isolation controller such as a mobile terminal, one or two or more irradiation conditions selected from an irradiation state (including continuous light or blinking frequency), an irradiance, an irradiation time, an irradiation start time, an irradiation end time, and continuous light or a blinking frequency.-
18.
公开(公告)号:US20240210736A1
公开(公告)日:2024-06-27
申请号:US18600985
申请日:2024-03-11
Applicant: TSUBOTA LABORATORY, INC.
Inventor: Shinichi IKEDA , Xiaoyan JIANG , Kazuo TSUBOTA , Toshihide KURIHARA
IPC: G02C7/06 , A01K67/02 , A61K9/00 , A61K31/575
CPC classification number: G02C7/06 , A01K67/02 , A61K9/0048 , A61K31/575 , A01K2227/105 , A01K2267/03
Abstract: A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.
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19.
公开(公告)号:US20240165422A1
公开(公告)日:2024-05-23
申请号:US18551167
申请日:2022-03-18
Applicant: Tsubota Laboratory, Inc.
Inventor: Motoshi HAYANO , Kazuo TSUBOTA , Yasue MITSUKURA
IPC: A61N5/06
CPC classification number: A61N5/0622 , A61N2005/0632 , A61N2005/0645 , A61N2005/0661
Abstract: The present disclosure relates to an apparatus and method for controlling biological function by stimulation by light of a specific wavelength, such as violet light, which is irradiated at a specific blinking frequency, and an apparatus and method for improving light environment. An illustrative apparatus for controlling biological function includes at least one light source 10 which irradiates light of a specific wavelength, and a controller 20 which is configured to control irradiation conditions including a blinking frequency of the light source 10.
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公开(公告)号:US20200229973A1
公开(公告)日:2020-07-23
申请号:US16697283
申请日:2019-11-27
Applicant: TSUBOTA LABORATORY, INC.
Inventor: Kazuo TSUBOTA
Abstract: To provide a spraying device and a spraying method for moisture mist that supply at least a micro liquid to the eye, and can be used for dry eye symptom relief, drug delivery, allergy prevention, relaxation, and the like. The above-described problem is solved by a spraying device (1, 31) that supplies at least a micro liquid, and includes a spraying element (16) that sprays a mist-like substance containing the micro liquid onto a local region (50). The raw material is a liquid raw material or a solid raw material that may include a medicinal additive. The medicinal additive is preferably selected from among menthol, analgesics, antibiotics, antiallergic agents, steroids, intraocular pressure-lowering agents, and the like. The spraying device (1, 31) may be an eyeglasses-type spraying device (1) in which the local region (50) is configured by a rim (3) and a temple (6) of eyeglasses, or a cup-type spraying device (31) in which the local region (50) includes an opening (32).
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