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公开(公告)号：US20140228409A1
公开(公告)日：2014-08-14
申请号：US14346071
申请日：2012-09-21
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Kazuko Yonemori , Hideyuki Nakagawa
IPC分类号： C07D401/12 , C07D209/08 , C07D209/88
CPC分类号： C07D401/12 , A61K31/403 , A61K31/404 , C07D209/08 , C07D209/88
摘要： The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的稠合杂环化合物。 本发明涉及由式（I'）表示的化合物：其中每个符号如说明书中所定义，条件是2-（2 - （（2-氰基苯基）氨基）-2-氧代乙氧基）-N-（ 9-乙基-9H-咔唑-3-基）乙酰胺和N-（4-氰基苯基）-N' - （9-乙基-9H-咔唑-3-基）-3-甲基戊二酰胺或其盐。
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公开(公告)号：US11851449B2
公开(公告)日：2023-12-26
申请号：US17316185
申请日：2021-05-10
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07D239/36 , C07D213/64 , C07D309/06 , C07D333/38 , C07F7/10 , C07D403/06 , C07D271/10 , C07C237/22 , C07D295/14 , C07D207/26 , C07D413/12 , C07F7/30 , C07D233/72 , C07D309/08 , C07D231/56 , C07D261/08 , C07D209/18 , C07D405/12 , C07D261/12 , C07D239/54 , C07D211/62 , C07D237/14 , C07D231/12 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
CPC分类号： C07F7/0812 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P43/00 , C07C237/22 , C07D205/04 , C07D207/12 , C07D207/26 , C07D209/18 , C07D211/62 , C07D213/64 , C07D231/12 , C07D231/56 , C07D233/72 , C07D237/14 , C07D239/36 , C07D239/54 , C07D261/08 , C07D261/12 , C07D271/10 , C07D295/14 , C07D309/06 , C07D309/08 , C07D333/38 , C07D403/06 , C07D405/12 , C07D413/12 , C07D487/04 , C07F7/081 , C07F7/10 , C07F7/30 , C07K5/06078 , C07K5/0812
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US11495331B2
公开(公告)日：2022-11-08
申请号：US16766559
申请日：2018-09-10
发明人： Hiroshi Nara , Junya Shirai , Tatsuki Koike , Kenjiro Sato , Takaharu Hirayama , Hiromi Fukuda , Tsutomu Morita , Hiromasa Ishihara , Kazue Suzuki , Hiroki Sakamoto , Fumiaki Kikuchi , Kenta Tamaki , Toru Tanoue , Yuichi Horita , Takeshi Ueda
摘要： An objective of the present invention is to provide a document creation assistance server and document creation assistance method which are capable of efficiently acquiring information necessary to write a specification or other such documents, and of generating a document from the acquired information. According to an embodiment, this document creation assistance server for assisting with the creation of a document comprises: a final product identification part for accepting identification information for identifying a final product generated by synthesizing a plurality of chemical compounds; a chemical equation acquisition part for referring to electronic experiment note data which provides an electronic record of the details of an experiment relating to the synthesis of the chemical compounds, and acquiring a chemical equation for generating the final product associated with the accepted identification information; and a document generation part for generating a document including the acquired chemical equation.
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公开(公告)号：US11053262B2
公开(公告)日：2021-07-06
申请号：US16576293
申请日：2019-09-19
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D309/06 , C07D405/12 , C07D239/36 , C07D413/12 , C07D205/04 , C07C237/22 , C07D207/12 , C07D271/10 , C07F7/10 , C07F7/30 , C07K5/065 , C07D309/08 , C07D231/12 , C07D231/56 , C07D333/38 , C07D233/72 , C07D403/06 , C07D237/14 , C07D239/54 , C07D213/64 , C07D295/14 , C07D207/26 , C07D261/08 , C07D209/18 , C07D261/12 , C07D211/62 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20170050974A1
公开(公告)日：2017-02-23
申请号：US14902309
申请日：2014-07-02
发明人： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC分类号： C07D491/056 , C07D471/04
CPC分类号： C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
摘要翻译： 其中每个符号如说明书中所定义。
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公开(公告)号：US09120776B2
公开(公告)日：2015-09-01
申请号：US14346071
申请日：2012-09-21
发明人： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Kazuko Yonemori , Hideyuki Nakagawa
IPC分类号： A61K31/403 , A61K31/404 , C07D401/12 , C07D209/88 , C07D209/08
CPC分类号： C07D401/12 , A61K31/403 , A61K31/404 , C07D209/08 , C07D209/88
摘要： The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a thereof.
摘要翻译： 本发明提供具有RORγt抑制作用的稠合杂环化合物。 本发明涉及由式（I'）表示的化合物：其中每个符号如说明书中所定义，条件是2-（2 - （（2-氰基苯基）氨基）-2-氧代乙氧基）-N-（ 9-乙基-9H-咔唑-3-基）乙酰胺和N-（4-氰基苯基）-N' - （9-乙基-9H-咔唑-3-基）-3-甲基戊二酰胺或其中的一种。
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公开(公告)号：USRE48334E1
公开(公告)日：2020-12-01
申请号：US15445251
申请日：2017-02-28
发明人： Junya Shirai , Hideyuki Sugiyama , Taku Kamei , Hironobu Maezaki
IPC分类号： C07D401/04 , C07D207/14 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/14 , C07D417/08
摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain; R1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.
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公开(公告)号：US20190000981A1
公开(公告)日：2019-01-03
申请号：US16064061
申请日：2016-12-21
申请人： Nigel W. Bunnett , Christopher J.H. Porter , Derek Cole , Gareth Hicks , Junya Shirai , Gavin Hirst , Takeda Pharmaceutical Company Limited
发明人： Nigel W. Bunnett , Christopher J.H. Porter , Derek Cole , Gareth Hicks , Junya Shirai , Gavin Hirst
IPC分类号： A61K47/54 , A61K47/60 , A61K31/575 , A61K31/44 , A61P43/00
摘要： The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.
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19.发明授权公开(公告)号：US10093629B2
公开(公告)日：2018-10-09
申请号：US15321609
申请日：2015-06-30
发明人： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC分类号： C07D217/26 , C07D491/056 , C07D491/048 , C07F7/08 , C07D471/04 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
摘要： Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US10053468B2
公开(公告)日：2018-08-21
申请号：US14902309
申请日：2014-07-02
发明人： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC分类号： C07D491/056 , C07D217/26 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D491/048 , C07D401/12 , C07D413/12 , C07D491/04 , C07D413/14 , C07D401/04 , C07D405/12 , C07F7/08
CPC分类号： C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
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