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公开(公告)号：US20120015868A1
公开(公告)日：2012-01-19
申请号：US13135230
申请日：2011-06-29
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/08 , A61P3/10 , A61P25/28 , A61P15/00 , A61P35/00 , A61P25/00 , A61P3/04 , A61P13/00 , C07K7/06 , A61P9/10
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译： 本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转移衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。
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公开(公告)号：US20060155109A1
公开(公告)日：2006-07-13
申请号：US11376694
申请日：2006-03-15
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof. An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。
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公开(公告)号：US5925731A
公开(公告)日：1999-07-20
申请号：US732289
申请日：1996-10-28
申请人： Chieko Kitada , Taiji Asami , Tetsuya Ohtaki , Toshifumi Watanabe
发明人： Chieko Kitada , Taiji Asami , Tetsuya Ohtaki , Toshifumi Watanabe
IPC分类号： A61K38/00 , C07K5/02 , C07K5/103 , C07K14/575 , A61K38/07
CPC分类号： C07K14/57536 , C07K5/0202 , C07K5/101 , A61K38/00
摘要： The peptide derivatives having endothelin receptor-antagonistic action or a salt thereof and medicinal compositions containing them are provided.Since peptide derivatives or a salt thereof of this invention exhibit remarkable endothelin receptor-antagonistic action with low toxicity, they are effective as medicines for prophylaxis and therapy of, for example, cardio- or cerebro-circulatory diseases hepatic diseases and/or renal diseases.
摘要翻译： PCT No.PCT / JP96 / 02778 371日期1996年10月28日第 102（e）1996年10月28日PCT PCT 1996年9月26日PCT公布。 公开号WO97 / 11961 日期1997年3月3日提供具有内皮素受体拮抗作用的肽衍生物或其盐和含有它们的药物组合物。 由于本发明的肽衍生物或其盐表现出显着的低毒性的内皮素受体拮抗作用，因此它们作为预防和治疗例如心脏或脑循环疾病肝脏疾病和/或肾脏疾病的药物是有效的。
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14.发明授权Methods of inhibiting secretion of follicle-stimulating hormone and testosterone 有权抑制促卵泡激素和睾丸激素分泌的方法公开(公告)号：US07754220B2
公开(公告)日：2010-07-13
申请号：US10547974
申请日：2004-03-11
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。
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公开(公告)号：US20060241051A1
公开(公告)日：2006-10-26
申请号：US10540494
申请日：2003-12-26
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
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公开(公告)号：US07374910B2
公开(公告)日：2008-05-20
申请号：US11376694
申请日：2006-03-15
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/72
摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。
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17.发明授权PACAP receptor protein, method for preparing said protein, and use thereof 失效PACAP受体蛋白质，所述蛋白质的制备方法及其用途公开(公告)号：US06399316B1
公开(公告)日：2002-06-04
申请号：US09201474
申请日：1998-11-30
申请人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
发明人： Haruo Onda , Tetsuya Ohtaki , Yasushi Masuda , Chieko Kitada , Yoshihiro Ishibashi , Masaki Hosoya , Kazuhiro Ogi , Yasunori Miyamoto , Yugo Habata , Norio Shimamoto
IPC分类号： G01N3353
摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein, and use of the protein, DNA, and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. Further, amino acid sequences deduced from the nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.
摘要翻译： 本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体以及该蛋白质，DNA及抗体的用途。 从牛大脑中纯化PACAP受体蛋白。 从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。 此外，确定从核苷酸序列推导的氨基酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用 表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较来执行药物设计，（5）基因诊断中探针和PCR引物的制备等 。
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公开(公告)号：US08361968B2
公开(公告)日：2013-01-29
申请号：US13135230
申请日：2011-06-29
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译： 本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转移衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。
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公开(公告)号：US20110052563A1
公开(公告)日：2011-03-03
申请号：US12710864
申请日：2010-02-23
IPC分类号： A61K39/395 , A61K38/16 , A61K31/7088 , A61K31/711 , A61P15/08 , A61P15/00 , A61P5/00
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。
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公开(公告)号：US07691979B2
公开(公告)日：2010-04-06
申请号：US11498439
申请日：2006-08-02
IPC分类号： C07K16/00
CPC分类号： G01N33/689 , C07K16/18 , G01N33/6857 , G01N2800/368
摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same. Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.
摘要翻译： 本发明的目的在于提供抗体，通过该抗体可以以高灵敏度特异性地定量分析蛋白或其衍生物，使用抗体检测/定量分析蛋白或其衍生物的方法，以及诊断剂（例如，怀孕诊断） 一样。 具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/定量分析的方法 衍生物以及使用该抗体的诊断剂。
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