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公开(公告)号：US20230416457A1
公开(公告)日：2023-12-28
申请号：US18159084
申请日：2023-01-24
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Baran D. SUMER , Xiankai SUN
CPC classification number: C08G65/007 , A61K49/0054 , G01N33/582 , G01N21/643 , G01N21/6456 , G01N33/84 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20220071903A1
公开(公告)日：2022-03-10
申请号：US17469111
申请日：2021-09-08
Inventor： Jinming GAO , Suxin LI
IPC: A61K9/107 , A61P35/00 , A61K31/5377 , A61K31/4184 , A61K31/7076 , A61K47/32
Abstract: Described herein are therapeutic pH responsive compositions useful for the treatment of cancer. The compositions involve combining a STING activating polymer micelle, such as PC7A, with a non-peptide STING agonist, such as cGAMP. Methods of administering these compositions in the treatment of cancer are also disclosed. These methods include administration of the pharmaceutical compositions by intratumoral injection in the treatment of solid tumors.
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公开(公告)号：US20200333357A1
公开(公告)日：2020-10-22
申请号：US16763518
申请日：2018-11-13
Inventor： Jinming GAO , Michael A. WHITE , Chensu WANG , Yang LI , Bruce POSNER , Gang HUANG
IPC: G01N33/68 , C08F293/00 , A61K49/00
Abstract: The present disclosure is directed to a nanotechnology-enabled screening strategy to identify small molecule TFEB agonists that shift maturation of autophagosomes to degradative autolysosomes.
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公开(公告)号：US20230085899A1
公开(公告)日：2023-03-23
申请号：US17810591
申请日：2022-07-01
Inventor： Jinming GAO , David BOOTHMAN , Kejin ZHOU , Xiaonan HUANG , Yiguang WANG
IPC: C08F293/00 , C07D311/92 , A61K47/58 , A61K47/62 , A61K9/127 , A61K49/00 , A61K31/352 , A61P35/00 , C08F299/02 , A61K47/69 , C08G81/02 , G01N33/58 , A61K9/50 , A61K31/337 , A61K31/704 , A61K9/107 , A61K47/68
Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
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公开(公告)号：US20210333263A1
公开(公告)日：2021-10-28
申请号：US16333164
申请日：2017-09-12
Inventor： Jinming GAO , Zhaohui WANG , Min LUO , Qi WEI , Gang HUANG
IPC: G01N33/50 , G01N33/542 , C09K11/07 , G01N21/64
Abstract: Provided herein are compounds of the formula: (I) wherein the variables are defined herein, which may be used as redox-activatable sensors. In some aspects, the compounds are fluorescence sensors which are activated by the redox state of the cell. Also provided herein are methods of using these compounds to image the cellular environment or the delivery of macromolecules to a cell.
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Patent Agency Ranking
公开(公告)号：US20200325265A1
公开(公告)日：2020-10-15
申请号：US16814803
申请日：2020-03-10
Inventor： Jinming GAO , David BOOTHMAN , Kejin ZHOU , Xiaonan HUANG , Yiguang WANG
IPC: C08F299/02 , A61K9/107 , A61P35/00
Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
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公开(公告)号：US20190071380A1
公开(公告)日：2019-03-07
申请号：US16063347
申请日：2016-12-16
Inventor： Jinming GAO , Yuliang LIU , Qi WEI , Xinpeng MA , Gang HUANG
IPC: C07C50/32 , C07C311/21 , C07C233/33 , C07C225/30 , C07D295/116 , C07C233/42 , C07C233/91 , C07C311/08 , A61P35/00
CPC classification number: C07C50/32 , A61K9/0019 , A61K9/5123 , A61K9/5146 , A61P35/00 , C07C205/46 , C07C225/30 , C07C233/18 , C07C233/31 , C07C233/33 , C07C233/42 , C07C233/91 , C07C271/30 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/51 , C07C2601/14 , C07C2602/10 , C07D295/116 , C07D317/70
Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.
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公开(公告)号：US20160030457A1
公开(公告)日：2016-02-04
申请号：US14783344
申请日：2014-04-08
Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventor： Paul J. HERGENROTHER , David A. BOOTHMAN , Joseph S. BAIR , Lifen CAO , Jinming GAO , Xiumei HUANG , Xiuquan LUO , Xinpeng MA , Zachary R. MOORE , Elizabeth I. PARKINSON
IPC: A61K31/706 , A61K31/4745 , A61K45/06 , A61K31/353 , A61K31/131
CPC classification number: A61K31/706 , A61K31/131 , A61K31/353 , A61K31/4738 , A61K31/4745 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.
Abstract translation: 本文所述的疗法可以选择性地对受试者中各种不同的癌细胞类型和癌症状况致命。 本文所述的联合治疗可用于治疗，治疗，控制或辅助治疗疾病，其中选择性致死性在化学治疗中是有益的，特别是在疾病伴随着NQO1水平升高的情况下。
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公开(公告)号：US20220380534A1
公开(公告)日：2022-12-01
申请号：US17620570
申请日：2020-06-22
Inventor： Jinming GAO , Xu WANG , Houliang TANG , Wei LI , Jonathan WILHELM , Baran SUMER
IPC: C08G65/333 , A61P35/00 , A61K9/107 , C08G65/334
Abstract: The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo. In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.
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公开(公告)号：US20220226511A1
公开(公告)日：2022-07-21
申请号：US17614638
申请日：2020-05-28
Inventor： Jinming GAO , Baran SUMER , Tian ZHAO , Zachary T. BENNETT
Abstract: Described herein are pH responsive compounds, micelles, and compositions useful for the detection of primary and metastatic tumor tissues. Compounds described herein are imaging agents useful for the detection of primary and metastatic tumor tissue (including lymph nodes). Real-time fluorescence imaging during surgery aids surgeon in the detection of metastatic lymph nodes or delineate tumor tissue versus normal tissue, with the goal of achieving negative margins and complete tumor resection.
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