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公开(公告)号：US10465234B2
公开(公告)日：2019-11-05
申请号：US16169801
申请日：2018-10-24
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/26 , C12Q1/6827 , G01N33/50 , C12N9/02 , G01N33/53 , C12N5/00 , C12Q1/6806 , C12N5/074 , G01N33/574 , C12N5/0783 , C12N15/873 , C12Q1/6869 , C12Q1/6886
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20190233885A1
公开(公告)日：2019-08-01
申请号：US16380846
申请日：2019-04-10
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Serviv
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , G01N33/50 , G01N33/574 , C12N5/00 , C12N9/02 , G01N33/53 , C12Q1/6806 , C12N5/0783 , C12Q1/6869 , C12N15/873 , C12N5/074 , C12Q1/6886 , C12Q1/26
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20190048405A1
公开(公告)日：2019-02-14
申请号：US16169801
申请日：2018-10-24
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Servic
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , G01N33/574 , C12Q1/26 , C12Q1/6886 , C12Q1/6869 , C12N5/0783 , C12N15/873 , C12N5/074 , C12Q1/6806 , G01N33/53 , C12N9/02 , C12N5/00 , G01N33/50
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US10031131B2
公开(公告)日：2018-07-24
申请号：US15440284
申请日：2017-02-23
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： G01N33/574 , G01N33/53 , C12N5/074
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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15.发明申请公开(公告)号：US20180120304A1
公开(公告)日：2018-05-03
申请号：US15440826
申请日：2017-02-23
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Servic
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： G01N33/53 , G01N33/574 , C12N9/02
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00 , C12Q2537/164 , C12Q2522/10 , C12Q2521/531
摘要： Provided herein are methods and kits for measuring a level of a 5-hydroxymethylcytosine in a nucleotide sequence from a subject, wherein the subject is a subject having a cancer or suspected of having cancer.
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公开(公告)号：US20240191284A1
公开(公告)日：2024-06-13
申请号：US18588956
申请日：2024-02-27
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US11208683B2
公开(公告)日：2021-12-28
申请号：US17231671
申请日：2021-04-15
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/26 , C12N9/10 , G01N33/53 , C12Q1/6806 , C12Q1/6869
摘要： The present invention provides for methods of epigenetic analysis. In some cases, the methods may include obtaining a sample comprising a nucleic acid sequence. In some cases, the nucleic acid sequence may comprise one or more epigenetic marks. The methods may include performing a sequencing. The methods may include distinguishing a hydroxymethylated base from a methylated base.
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公开(公告)号：US10767216B2
公开(公告)日：2020-09-08
申请号：US16180450
申请日：2018-11-05
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6827 , G01N33/53
摘要： Provided herein are methods and kits for distinguishing 5-hydroxymethylcytosine from 5-methylcytosine.
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公开(公告)号：US10323269B2
公开(公告)日：2019-06-18
申请号：US15440815
申请日：2017-02-23
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12N9/02 , C12Q1/6827 , C12Q1/26 , G01N33/50 , G01N33/53 , C12N5/00 , C12Q1/6806 , C12N5/074 , G01N33/574 , C12N5/0783 , C12N15/873 , C12Q1/6869 , C12Q1/6886
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20190062817A1
公开(公告)日：2019-02-28
申请号：US16180450
申请日：2018-11-05
申请人： The Children's Medical Center Corporation , The United States of America,As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/26 , G01N33/574 , G01N33/50 , C12N5/00 , C12N9/02 , G01N33/53 , C12Q1/6806 , C12N5/074 , C12N15/873 , C12N5/0783 , C12Q1/6869 , C12Q1/6886
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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