公开(公告)号：US08481758B2

公开(公告)日：2013-07-09

申请号：US12500669

申请日：2009-07-10

申请人： Martin Albert ,  Andreas Berger ,  Dominic De Souza ,  Kerstin Knepper ,  Hubert Sturm

发明人： Martin Albert ,  Andreas Berger ,  Dominic De Souza ,  Kerstin Knepper ,  Hubert Sturm

IPC分类号： C07D307/93 ,  C07C69/76

CPC分类号： C07C405/00 ,  C07D307/935

摘要： The present invention relates to an improved process for the production of prostaglandins and prostaglandin analogs. In particular, this invention relates to the production of prostaglandins of the PGF2α-series, including latanoprost, travoprost, and bimatoprost, which are active pharmaceutical ingredients used for the reduction of elevated intra-ocular pressure in patients with glaucoma and ocular hypertension.

摘要翻译： 本发明涉及前列腺素和前列腺素类似物的生产改进方法。 特别地，本发明涉及PGF2α系列前列腺素的生产，包括拉坦前列素，曲伏前列素和比马前列素，它们是用于降低青光眼和高眼压患者眼内压升高的活性药物成分。

公开(公告)号：US20110118995A1

公开(公告)日：2011-05-19

申请号：US12950085

申请日：2010-11-19

申请人： Andreas Berger ,  Frank Wandeler ,  Achim Wiest

发明人： Andreas Berger ,  Frank Wandeler ,  Achim Wiest

IPC分类号： G01F1/66

CPC分类号： B06B3/00 ,  G01F1/662

摘要： A coupling element of a sensor of an ultrasonic, flow measuring device, which includes at least three rods having, in each case, a first rod end and a second rod end. The rods, in each case, have, on their respective first ends, first end faces, which, in each case, can be acoustically coupled with the sound-emitting and/or sound-receiving area of an ultrasonic transducer element. The respective first end faces of the rods together form a first coupling surface of the coupling element, and the rods, in each case, have, on their respective second ends, second end faces, which form a second coupling surface of the coupling element, wherein the rods, in each case, have a first rod cross section, which is different in shape and/or size from a respective second rod cross section.

摘要翻译： 超声波测量装置的传感器的耦合元件，其包括至少三个杆，每个杆在每种情况下具有第一杆端和第二杆端。 在每种情况下，杆在它们各自的第一端具有在每种情况下可以与超声换能器元件的发声和/或声音接收区域声学耦合的第一端面。 杆的相应的第一端面一起形成联接元件的第一联接表面，并且在每种情况下，杆在它们各自的第二端具有形成联接元件的第二联接表面的第二端面， 其中，在每种情况下，所述杆具有与相应的第二杆横截面不同的形状和/或尺寸的第一杆横截面。

公开(公告)号：US20090095088A1

公开(公告)日：2009-04-16

申请号：US11795894

申请日：2005-12-16

申请人： Andreas Berger ,  Achim Wiest ,  Patrick Oudoire

发明人： Andreas Berger ,  Achim Wiest ,  Patrick Oudoire

IPC分类号： G01F1/00

CPC分类号： G01F1/662

摘要： An apparatus for ascertaining and/or monitoring volume- and/or mass-flow of a measured medium flowing in a flow direction through a measuring tube of predetermined inner diameter. The apparatus includes a plurality of ultrasonic sensors, which transmit and/or receive ultrasonic measuring signals along different, defined measuring paths, and a control/evaluation unit, which ascertains volume- and/or mass-flow of the measured medium in a pipeline/in the measuring tube on the basis of the ultrasonic measuring signals according to a sound entrainment method or the echo principle. At least two ultrasonic sensors, which transmit and/or receive the ultrasonic measuring signals on different measuring paths, are positioned in an opening located in the wall of the measuring tube.

摘要翻译： 用于确定和/或监测沿流动方向流过预定内径的测量管的测量介质的体积和/或质量流量的装置。 该设备包括多个超声波传感器，其传送和/或接收沿着不同的定义的测量路径的超声波测量信号，以及控制/评估单元，其确定测量的介质在管道中的体积和/或质量流量， 在测量管中基于超声波测量信号，根据声音夹带方法或回波原理。 在不同测量路径上传输和/或接收超声波测量信号的至少两个超声波传感器位于测量管壁中的开口中。

公开(公告)号：US20090080110A1

公开(公告)日：2009-03-26

申请号：US11860441

申请日：2007-09-24

申请人： Andreas Berger ,  Yoshihiro Ikeda ,  Kentaro Takano

发明人： Andreas Berger ,  Yoshihiro Ikeda ,  Kentaro Takano

IPC分类号： G11B5/127

CPC分类号： G11B5/02 ,  G11B5/66

摘要： A perpendicular magnetic recording media is provided having an imbalanced magnetic moment multilayer cap. The perpendicular magnetic recording media comprises a granular layer, and a multilayer cap structure exchange coupled to the granular layer. The multilayer cap structure includes upper and lower magnetic layers separated by a non-magnetic layer, where the upper magnetic layer has a magnetic moment greater than the lower magnetic layer. When an external field is applied to the recording media, a larger moment torque is triggered at the surface, and more efficient switching is facilitated. The upper magnetic layer may have a higher magnetic moment than the lower magnetic layer if the upper magnetic layer comprises a larger magnetic moment material than the lower magnetic layer. The upper magnetic layer may also have a higher magnetic moment than the lower magnetic layer if the upper magnetic layer has a greater thickness than the lower magnetic layer.

摘要翻译： 提供具有不平衡磁矩多层盖的垂直磁记录介质。 垂直磁记录介质包括粒状层，以及与颗粒层耦合的多层帽结构交换。 多层盖结构包括由非磁性层分离的上磁层和下磁层，其中上磁层的磁矩大于下磁层。 当向记录介质施加外部场时，在表面触发更大的力矩，并且更有效地切换。 如果上部磁性层包含比下部磁性层更大的磁矩材料，则上磁性层的磁矩可能比下部磁性层高。 如果上部磁性层的厚度大于下部磁性层的厚度，则上部磁性层也可以具有比下部磁性层更高的磁矩。

公开(公告)号：US20070020486A1

公开(公告)日：2007-01-25

申请号：US11185659

申请日：2005-07-19

申请人： Andreas Berger ,  Eric Fullerton

发明人： Andreas Berger ,  Eric Fullerton

IPC分类号： G11B5/66

CPC分类号： G11B5/66 ,  G11B5/656 ,  G11B5/667 ,  G11B5/732 ,  G11B5/7325

摘要： A perpendicular magnetic recording medium includes a metamagnetic antiferromagnetically-coupled (AFC) layer between the recording layer (RL) and the soft magnetically permeable underlayer (SUL). The metamagnetic AFC layer has essentially no net magnetic moment in the absence of a magnetic field, but is highly ferromagnetic in the presence of a magnetic field above a threshold field. Thus the metamagnetic AFC layer does not contribute to the readback signal during reading, but channels the write field to the SUL during writing because the threshold field is selected to be below the write field. An exchange-break layer EBL is located between the metamagnetic AFC layer and the RL. The metamagnetic AFC layer contains films with a crystalline structure suitable as a growth template for the EBL and RL, so the metamagnetic AFC layer also functions as part of an “effective EBL”, thereby allowing the actual EBL to be made as thin as possible.

摘要翻译： 垂直磁记录介质包括在记录层（RL）和软磁性可渗透底层（SUL）之间的超磁性反铁磁耦合（AFC）层。 在没有磁场的情况下，超磁性AFC层基本上没有净磁矩，但是在存在超过阈值场的磁场的情况下是高铁磁性的。 因此，偏磁AFC层在读取期间不对回读信号有贡献，而是在写入期间将写入场指向SUL，因为阈值域被选择为低于写入场。 交换断层EBL位于超磁性AFC层和RL之间。 超磁性AFC层含有具有适合于EBL和RL的生​​长模板的晶体结构的膜，因此，反磁性AFC层也起到“有效EBL”的一部分的作用，从而使实际的EBL尽可能薄。

公开(公告)号：US20060177704A1

公开(公告)日：2006-08-10

申请号：US11231516

申请日：2005-09-21

申请人： Andreas Berger ,  Eric Fullerton ,  Hoa Do ,  Natacha Supper

发明人： Andreas Berger ,  Eric Fullerton ,  Hoa Do ,  Natacha Supper

IPC分类号： G11B5/66

CPC分类号： G11B5/66 ,  G11B5/656

摘要： A recording medium providing improved writeability in perpendicular recording applications includes a magnetic recording layer having an axis of magnetic anisotropy substantially perpendicular to the surface thereof, an exchange-spring layer ferromagnetically exchange coupled to the magnetic recording layer and having a coercivity less than the magnetic recording layer coercivity, and a coupling layer between the magnetic recording layer and the exchange-spring layer. The coupling layer regulates the ferromagnetic exchange coupling between the magnetic recording layer and the exchange-spring layer.

摘要翻译： 在垂直记录应用中提供改善的写入能力的记录介质包括具有基本上垂直于其表面的磁各向异性轴的磁记录层，耦合到磁记录层并具有小于磁记录的矫顽磁力的磁性交换弹簧层 层矫顽力和磁记录层与交换弹簧层之间的耦合层。 耦合层调节磁记录层与交换弹簧层之间的铁磁交换耦合。

公开(公告)号：US06931944B2

公开(公告)日：2005-08-23

申请号：US10481880

申请日：2002-07-11

申请人： Achim Wiest ,  Andreas Berger

发明人： Achim Wiest ,  Andreas Berger

IPC分类号： G01F1/00 ,  G01F1/66 ,  G10K11/00

CPC分类号： G10K11/004 ,  G01F1/662 ,  G01F1/667 ,  G10K11/006

摘要： A measuring head for an ultrasonic flowmeter, in which an ultrasonic coupling element and a measuring head housing are cast together and form, along with casting material, a contact surface E. The surface E allows an effective transfer of heat to the measuring head. In order to compensate manufacturing tolerances, the distance a between the measuring head housing and the ultrasonic coupling element is at least 1 mm in the area of the contact surface E.

摘要翻译： 一种用于超声波流量计的测量头，其中超声波耦合元件和测量头壳体一起铸造并与铸造材料一起形成接触表面E.表面E允许有效地传递热量到测量头。 为了补偿制造公差，测量头壳体和超声波耦合元件之间的距离a在接触表面E的面积上至少为1mm。

公开(公告)号：US06515724B1

公开(公告)日：2003-02-04

申请号：US09622619

申请日：2000-09-25

申请人： Wolf-Gernot Drost ,  Klaus Berndt ,  Andreas Berger

发明人： Wolf-Gernot Drost ,  Klaus Berndt ,  Andreas Berger

IPC分类号： G02F11325

CPC分类号： G02F1/133533 ,  G02F1/133516 ,  G02F2001/133302

摘要： The invention generally relates to an optical switch which in particular, is able to present a high-resolution color display. The aim of the invention is to produce an optical switch which has a simpler design than known constructive solutions and has a high degree of luminous efficiency and low parallax. The optical switch should also be guaranteed to function at approx. 550° C. The inventive e.g., LCD-type optical switch is characterized in that at least one of the support plates consists of color-structured dichroic polarization glass which is impressed with dichroic color filters, in that the dichroic color filters are situated within an orthogonal matrix in color filter layers and in that the color filter layers of the support plate, starting form the surface of the support plate, extend into the same to a depth of a few &mgr;m. Once the glass support plates have been structured, the color patterns remain stable to approx. 550° C. As a result of using the color-structured dichroic polarization filter, the invention requires at least one less polarization filter than conventional LCD's and therefore has a simpler construction.

摘要翻译： 本发明一般涉及一种特别是能够呈现高分辨率彩色显示的光开关。 本发明的目的是生产一种光学开关，其具有比已知的结构化解决方案更简单的设计，并且具有高度的发光效率和低视差。 光开关也应保证在大约 本发明例如LCD型光开关的特征在于，至少一个支撑板由彩色结构的分色偏光玻璃构成，二色性偏光玻璃被二色性滤色器印迹，因为二向色滤色器位于 彩色滤光层中的正交矩阵，并且从支撑板的表面开始的支撑板的滤色器层延伸到相同的几个微米的深度。 一旦玻璃支撑板已经结构化，颜色图案保持稳定到大约。 作为使用彩色结构的二向色偏振滤光器的结果，本发明需要比常规LCD至少少一个偏振滤光器，因此具有更简单的结构。

公开(公告)号：US08546112B2

公开(公告)日：2013-10-01

申请号：US12993132

申请日：2009-05-19

申请人： Martin Albert ,  Ferdinand Zepeck ,  Andreas Berger ,  Waander Riethorst ,  Helmut Schwab ,  Daniel Luschnig ,  Peter Remler ,  Joerg Salchenegger ,  Doris Osl ,  Dominic De Souza

发明人： Martin Albert ,  Ferdinand Zepeck ,  Andreas Berger ,  Waander Riethorst ,  Helmut Schwab ,  Daniel Luschnig ,  Peter Remler ,  Joerg Salchenegger ,  Doris Osl ,  Dominic De Souza

IPC分类号： C12P13/04

CPC分类号： C12P41/005 ,  C07B2200/07 ,  C07C67/343 ,  C07C201/12 ,  C07C205/51 ,  C07C227/04 ,  C07C229/08 ,  C07D207/46 ,  C12P13/008 ,  C07C69/533

摘要： The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.

摘要翻译： 本发明涉及5-甲基-3-硝基甲基 - 己酸酯及其盐的制备方法。 还公开了制备5-甲基-3-硝基甲基 - 己酸盐的方法和制备3-（氨基甲基）-5-甲基己酸的方法。 （S）-5-甲基-3-硝基甲基 - 己酸或（R）-5-甲基-3-硝基甲基 - 己酸，其具有对映体形式或对映体形式及其盐，（S）-5-甲基-3- - 硝基甲基 - 己酸酯或具有对映体形式或对映体形式的（R）-5-甲基-3-硝基甲基 - 己酸酯和式（XIII）化合物，外消旋形式，对映体形式或对映体形式也被公开 。

公开(公告)号：US20120227496A1

公开(公告)日：2012-09-13

申请号：US13510660

申请日：2010-10-14

申请人： Andreas Berger ,  Michal Bezdek ,  Arno Lang

发明人： Andreas Berger ,  Michal Bezdek ,  Arno Lang

IPC分类号： G01H17/00 ,  B21D7/00 ,  B23P17/00 ,  G01D7/00

CPC分类号： G01F1/667 ,  G01F1/662 ,  Y10T29/49826

摘要： A method for the manufacture of a measuring device, and a measuring device for registering at least one measured value of at least one process variable, wherein the measuring device includes a measuring tube, which has at least one necked out portion, on which at least one measuring transducer is arranged, wherein the measuring tube together with the necked out portion is monolithic, and wherein the necked out portion is manufacturable from the measuring tube at least partially by a deformation method.

摘要翻译： 一种用于制造测量装置的方法和用于记录至少一个测量值的至少一个过程变量的测量装置，其中所述测量装置包括具有至少一个颈缩部分的测量管，至少一个颈缩部 布置了一个测量传感器，其中测量管与颈缩部分一体是整体的，并且其中缩颈部分至少部分地通过变形方法从测量管制造。