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    Antibiotics aclacinomycins A and B
    11.
    发明授权
    Antibiotics aclacinomycins A and B 失效
    抗生素阿卡霉素A和B

    公开(公告)号：US3988315A

    公开(公告)日：1976-10-26

    申请号：US596682

    申请日：1975-07-16

    申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Akira Takamatsu ,  Toshikazu Oki

    发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Akira Takamatsu ,  Toshikazu Oki

    IPC分类号： C07H15/252 ,  C12P1/06 ,  C12P19/56 ,  C07H17/08

    CPC分类号： C07H15/252 ,  Y10S435/886

    摘要： New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as leukemia L1210 and P388 and lymphoma 6C3HED in mice and hepatomas in rats are produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces galilaeus (MA144-M1 and A.T.C.C. 31133); they are recovered from the broth by conventional methods for recovering antibiotics.

    摘要翻译： 新型抗肿瘤剂名为阿沙利霉素A和B，它们是蒽环类苷并抑制各种微生物的生长，例如金黄色葡萄球菌，黄曲霉，牛磺酸棒状杆菌，并抑制小鼠和肝癌中白血病L1210和P388和淋巴瘤6C3HED等动物肿瘤的生长 在大鼠中通过发酵属于链霉菌属（Streptomyces）的微生物来产生，其被命名为马链霉菌（Streptomyces galilaeus）（MA144-M1和ATCC 31133）; 它们通过用于回收抗生素的常规方法从肉汤中回收。

    Antiviral antibiotic BU-3889V
    14.
    发明授权
    Antiviral antibiotic BU-3889V 失效
    抗病毒抗生素BU-3889V

    公开(公告)号：US5098708A

    公开(公告)日：1992-03-24

    申请号：US546463

    申请日：1990-07-06

    申请人： Masataka Konishi ,  Mitsuaki Tsunakawa ,  Osamu Tenmyo ,  Takeo Miyaki ,  Toshikazu Oki

    发明人： Masataka Konishi ,  Mitsuaki Tsunakawa ,  Osamu Tenmyo ,  Takeo Miyaki ,  Toshikazu Oki

    IPC分类号： C12P1/06

    CPC分类号： C12P1/06 ,  Y10S435/822 ,  Y10S435/826

    摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.

    摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。

    Method of producing anthracycline antibiotics
    20.
    发明授权
    Method of producing anthracycline antibiotics 失效
    生产蒽环类抗生素的方法

    公开(公告)号：US4245045A

    公开(公告)日：1981-01-13

    申请号：US37804

    申请日：1979-05-10

    申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Toshikazu Oki ,  Taiji Inui

    发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Toshikazu Oki ,  Taiji Inui

    IPC分类号： C07H15/252 ,  C12P19/56

    CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C12R1/48 ,  Y10S435/886 ,  Y10S435/888

    摘要： New anthracycline glycosides designated MA 144-G1, -G2, -L, -S1, -N1, -U1 and -Y which inhibit the growth of gram-positive bacteria and mammalian tumors are produced by fermentation of certain species of Streptomyces and by the chemical or enzymatic conversion of certain anthracycline glycosides. New microbiological and chemical processes are also provided for preparation of the anthracycline glycosides MA 144-S2 and -U2 which have been found to be identical with the previously reported anthracyclines, marcellomycin and musettamycin.

    摘要翻译： 名称为MA 144-G1，-G2，-L，-S1，-N1，-U1和-Y的新型蒽环类苷，其抑制革兰氏阳性细菌和哺乳动物肿瘤的生长是通过某些种类的链霉菌的发酵和 某些蒽环类苷的化学或酶转化。 还提供了新的微生物和化学方法用于制备蒽环类甙MA 144-S2和-U 2，其已被发现与先前报道的蒽环霉素，马塞罗霉素和musettamycin相同。