公开(公告)号：US08025638B2

公开(公告)日：2011-09-27

申请号：US10851547

申请日：2004-05-21

申请人： Tsunenori Arai ,  Atsushi Utsumi ,  Takashi Kawabata

发明人： Tsunenori Arai ,  Atsushi Utsumi ,  Takashi Kawabata

IPC分类号： A61F7/12 ,  A61F7/00 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61B18/04 ,  A61B18/22 ,  A61B18/28 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/00791 ,  A61M2025/1093

摘要： A balloon catheter including a connecting member, a catheter shaft, a balloon and a heat-generating member. The heat-generating member is in contact with a fluid in a distal portion of the catheter shaft. A method for treating a patient including introducing a low temperature fluid which flows through the balloon, introducing energy into a catheter shaft, and converting the energy into heat by a heat-generating member to heat the fluid, whereby an organ of the patient is heated and cooled. In the method, a portion of a diseased tissue of the organ is (i) heated from 35 to 40° C. to 60 to 80° C. within 30 seconds, (ii) expanded by applying a pressure of 500 kPa or smaller to the balloon, and (iii) cooled to 45° C. or lower within 40 seconds.

摘要翻译： 包括连接构件，导管轴，球囊和发热构件的气囊导管。 发热构件与导管轴的远端部分中的流体接触。 一种用于治疗患者的方法，包括引入流过气囊的低温流体，将能量引入导管轴，并且通过发热构件将能量转换成热量以加热流体，从而使患者的器官被加热 并冷却。 在该方法中，器官的病变组织的一部分（i）在30秒内从35至40℃加热至60至80℃，（ii）通过施加500kPa或更小的压力至 气球，和（iii）在40秒内冷却至45℃或更低。

公开(公告)号：US20050261626A1

公开(公告)日：2005-11-24

申请号：US10851547

申请日：2004-05-21

申请人： Tsunenori Arai ,  Atsushi Utsumi ,  Takashi Kawabata

发明人： Tsunenori Arai ,  Atsushi Utsumi ,  Takashi Kawabata

IPC分类号： A61B17/22 ,  A61B18/04 ,  A61B18/22 ,  A61M29/00 ,  A61M29/02

CPC分类号： A61M25/104 ,  A61B18/04 ,  A61B18/22 ,  A61B18/28 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/00791 ,  A61M2025/1093

摘要： A balloon catheter comprises a connecting member, a catheter shaft, a balloon and a heat-generating member contacting a fluid in the balloon or in a distal portion of the catheter shaft. A medical apparatus have the balloon catheter. In a method for treating a living organ, a low temperature fluid is introduced and flows through the balloon, energy is introduced into the catheter shaft, is converted into heat by the heat-generating member and heats the fluid, and a living organ is heated and cooled for a medical treatment. A portion of disease is heated from 35˜40° C. to 60˜80° C. within 30 seconds, expanded by applying a pressure of 500 kPa or smaller to the balloon, and cooled to 45° C. or lower within 40 seconds. A living organ can be heated and cooled within a very short time to cure a diseased tissue. A blood vessel can be expanded without damages.

摘要翻译： 球囊导管包括连接构件，导管轴，球囊和与气囊中的流体或导管轴的远侧部分接触的发热构件。 医疗器具具有气囊导管。 在用于处理活体器官的方法中，引入低温流体并流过球囊，将能量引入导管轴，由发热部件转化为热量并加热流体，并且活体器官被加热 并冷却治疗。 30秒内将疾病的一部分从35〜40℃加热至60〜80℃，通过对球囊施加500kPa以下的压力进行膨胀，并在40秒内冷却至45℃以下 。 生物器官可以在很短的时间内加热和冷却，以治愈患病组织。 血管可以扩张而不受损害。

公开(公告)号：US08961580B2

公开(公告)日：2015-02-24

申请号：US12516765

申请日：2007-11-30

申请人： Tsunenori Arai ,  Shuntaro Hosokawa

发明人： Tsunenori Arai ,  Shuntaro Hosokawa

IPC分类号： A61N5/06 ,  A61B19/00 ,  A61B18/24

CPC分类号： A61N5/062 ,  A61B18/24 ,  A61K31/409 ,  A61N5/0601 ,  A61N5/0603 ,  A61N2005/0626 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0663 ,  A61N2005/067

摘要： There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.

摘要翻译： 提供了使用光动力疗法或用于治疗心律失常来阻断心肌异常传导的装置和方法。 提供了一种用于使用光动力疗法治疗心律失常的导管消融装置，其包括将导管单元引导到测试对象的心肌中的异常电传导部位或发生心肌中的过度兴奋性发生部位的导管，其中通过以下方式存在光敏剂： 预先施用光敏剂并引起心律不齐的手段，用于产生异常导电部位或过度兴奋发生部位的照射用的光线的手段，以及将光线透射到异常导电部位或发生兴奋发生部位的装置，其中， 使用的光敏剂是水溶性氯系光敏剂，所使用的光线是具有与光敏剂相同的激发波长的光线。

公开(公告)号：US20130123642A1

公开(公告)日：2013-05-16

申请号：US13583531

申请日：2011-03-07

申请人： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

发明人： Takashi Yamaguchi ,  Shiho Hakomori ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito ,  Jun Uchiyama

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/6869 ,  A61B18/24 ,  A61B2018/00351 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0626

摘要： A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser the catheter, including a connector, a light source, and a light detection unit. The laser the catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser the catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser the catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser the catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

摘要翻译： 作为估计装置的光动力治疗装置是一种用于从吸收了光敏药物的组织照射吸光激发光并发射荧光的光敏药物与从激光器的尖端部分发射的激发光的导管的装置， 包括连接器，光源和光检测单元。 激光器能够将导管与连接器连接/分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光通过连接器从激光导入导管，以估计组织是否因激光的尖端部分发射的激发光之间的反应而发生变化 和吸收在组织中的感光药物。

公开(公告)号：US20120330293A1

公开(公告)日：2012-12-27

申请号：US13581105

申请日：2011-02-25

申请人： Tsunenori Arai ,  Arisa Ito

发明人： Tsunenori Arai ,  Arisa Ito

IPC分类号： A61B18/24

CPC分类号： A61B18/24 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/062

摘要： This invention provides a catheter used for blocking abnormal conduction in the cardiac muscle using photodynamic therapy or treating arrhythmia and a method for evaluating the therapeutic effects of the catheter. The catheter has a structure that freely bends at its end, which is used for performing photodynamic ablation of cardiac muscle tissue via photochemical reactions in the blood vessel or cardiac lumen. The catheter comprises a light-emitting window for applying a light beam transmitted through an optical fiber to a target site of cardiac muscle tissue and at least two electrodes for potential measurement in the periphery of the light-emitting window.

摘要翻译： 本发明提供一种用于使用光动力学治疗或治疗心律失常来阻断心肌异常传导的导管和用于评估导管的治疗效果的方法。 导管具有在其端部自由弯曲的结构，其用于通过血管或心脏腔中的光化学反应进行心肌组织的光动力消融。 导管包括用于将通过光纤传输的光束施加到心脏肌肉组织的靶位点的发光窗口和用于在发光窗口的周边进行电位测量的至少两个电极。

公开(公告)号：US08145286B2

公开(公告)日：2012-03-27

申请号：US11606155

申请日：2006-11-30

申请人： Tsunenori Arai ,  Yuki Kawase ,  Yasunobu Oka ,  Narushi Ito

发明人： Tsunenori Arai ,  Yuki Kawase ,  Yasunobu Oka ,  Narushi Ito

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2018/00452

摘要： A device and method for optically measuring a substance in blood using the nail as an optical window are provided. A device for optically measuring a test substance in blood by using the nail as an optical window and correcting or eliminating fluctuation of a measurement value based on optical characteristics of the nail plate, comprising irradiation means applying light within a wavelength range for measuring absorption by the test substance to the nail of a subject, detection means detecting light diffused/reflected from or transmitted through the body of the subject, and processing means processing a signal obtained by the detection means to convert the signal into a concentration of the test substance.

摘要翻译： 提供了使用钉子作为光学窗口来光学测量血液中的物质的装置和方法。 一种用于通过使用指甲作为光学窗口来对血液中的测试物质进行光学测量的装置，并且基于所述指甲板的光学特性来校正或消除测量值的波动，所述装置包括：在波长范围内施加用于测量吸收的光的照射装置 检测物体到受试者的指甲，检测装置，其检测从被检体的身体扩散/反射或透过的物体，以及处理装置，对由检测装置获得的信号进行处理，将该信号转换成检测物质的浓度。

公开(公告)号：US20100022998A1

公开(公告)日：2010-01-28

申请号：US12516765

申请日：2007-11-30

申请人： Tsunenori Arai ,  Shuntaro Hosokawa

发明人： Tsunenori Arai ,  Shuntaro Hosokawa

IPC分类号： A61B18/18

CPC分类号： A61N5/062 ,  A61B18/24 ,  A61K31/409 ,  A61N5/0601 ,  A61N5/0603 ,  A61N2005/0626 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0663 ,  A61N2005/067

摘要： There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.

摘要翻译： 提供了使用光动力疗法或用于治疗心律失常来阻断心肌异常传导的装置和方法。 提供了一种用于使用光动力疗法治疗心律失常的导管消融装置，其包括将导管单元引导到测试对象的心肌中的异常电传导部位或发生心肌中的过度兴奋性发生部位的导管，其中通过以下方式存在光敏剂： 预先施用光敏剂并引起心律不齐的手段，用于产生异常导电部位或过度兴奋发生部位的照射用的光线的手段，以及将光线透射到异常导电部位或发生兴奋发生部位的装置，其中， 使用的光敏剂是水溶性氯系光敏剂，所使用的光线是具有与光敏剂相同的激发波长的光线。

公开(公告)号：US20130172863A1

公开(公告)日：2013-07-04

申请号：US13583140

申请日：2011-03-07

申请人： Shiho Hakomori ,  Takashi Yamaguchi ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito

发明人： Shiho Hakomori ,  Takashi Yamaguchi ,  Koshi Tamamura ,  Tsunenori Arai ,  Arisa Ito

IPC分类号： A61B18/24

CPC分类号： A61B18/24 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0402 ,  A61B5/1459 ,  A61B5/6885 ,  A61B5/7285 ,  A61N5/062

摘要： A photodynamic therapy apparatus as a determining apparatus is the photodynamic therapy apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, or a tissue absorbing the excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to determine whether the tip portion of the laser catheter contacts the tissue or not.

摘要翻译： 作为决定装置的光动力治疗装置是用于对具有吸收光敏药物的组织，吸收激发光并发出荧光的感光药物或吸收激发光并发出荧光的组织进行照射的光动力治疗装置， 从包括连接器，光源和光检测单元的激光导管的尖端部分发射的激发光。 激光导管能够连接到/从连接器分离。 光源通过连接器将激发光输出到激光导管。 光检测单元检测荧光的强度或光谱，荧光从激光导管经由连接器进入，以确定激光导管的尖端部分是否与组织接触。

公开(公告)号：US20130046293A1

公开(公告)日：2013-02-21

申请号：US13583566

申请日：2011-03-01

申请人： Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

发明人： Tsunenori Arai ,  Arisa Ito ,  Mei Takahashi

IPC分类号： A61B18/18

CPC分类号： A61B18/24 ,  A61B18/245 ,  A61B2018/00785

摘要： This invention provides a method and a system for preventing charring at a laser beam emitting site during treatment or diagnosis using a laser catheter for applying a laser beam. The method is intended to control laser beam irradiation of an apparatus equipped with a laser catheter comprising a laser beam transmission means and a laser beam emitting site used for diagnosis or treatment with the irradiation of the inside of a blood vessel or heart cavity with a laser beam. The method for controlling laser beam irradiation is intended to prevent blood charring at a laser emission site of an apparatus equipped with a laser catheter, and the method comprises a step of controlling a laser beam output in accordance with temporal changes in the intensity of the diffuse reflected light beam by erythrocytes applied to the inside of a blood vessel or heart cavity.

摘要翻译： 本发明提供一种用于在使用激光导管施加激光束的治疗或诊断期间防止激光束发射部位的炭化的方法和系统。 该方法旨在控制配备有激光导管的装置的激光束照射，该激光导管包括激光束传输装置和用于诊断或治疗的激光束发射部位，用激光照射血管或心腔内 光束。 用于控制激光束照射的方法旨在防止装备有激光导管的装置的激光发射部位处的血液烧焦，并且该方法包括根据扩散的强度的时间变化来控制激光束输出的步骤 反射光束被红细胞施加到血管或心脏腔内。

公开(公告)号：US20120164210A1

公开(公告)日：2012-06-28

申请号：US12998931

申请日：2009-12-17

申请人： Masakazu Ueda ,  Kayoko Ueda ,  Tsunenori Arai ,  Sachiko Matsuda ,  Kazuhiko Ishihara

发明人： Masakazu Ueda ,  Kayoko Ueda ,  Tsunenori Arai ,  Sachiko Matsuda ,  Kazuhiko Ishihara

IPC分类号： A61K31/80 ,  A61P35/00 ,  A61K9/127

CPC分类号： A61K41/0071 ,  A61K9/127 ,  A61K31/409 ,  A61K31/78 ,  A61K47/6849 ,  A61K47/6933 ,  C08F20/34 ,  C08F30/02

摘要： The present invention relates to a cancer-cell-specific polymer compound containing a photosensitizer for photodynamic therapy and having a surface to which an antibody against a cancer-cell-specific antigen binds. An object of the present invention is to provide a photodynamic therapeutic agent that can reach the cancer tissue at a low concentration via active targeting and makes complications (e.g., sunlight hypersensitivity) associated with photodynamic therapy unlikely to occur.

摘要翻译： 本发明涉及含有用于光动力学治疗的光敏剂并具有针对癌细胞特异性抗原的抗体结合的表面的癌细胞特异性聚合物化合物。 本发明的目的是提供一种能够通过活性靶向以低浓度达到癌组织的光动力治疗剂，并且与光动力学治疗相关的并发症（例如，阳光超敏反应）不太可能发生。