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    METHODS AND COMPOSITIONS FOR UPREGULATION OF PEROXIREDOXIN ACTIVITY
    16.
    发明申请
    METHODS AND COMPOSITIONS FOR UPREGULATION OF PEROXIREDOXIN ACTIVITY 审中-公开
    过氧化物酶活性升高的方法和组合物

    公开(公告)号：US20100297673A1

    公开(公告)日：2010-11-25

    申请号：US12441924

    申请日：2007-09-20

    申请人： Ish Khanna ,  Ram Pillarisetti ,  Uday Saxena

    发明人： Ish Khanna ,  Ram Pillarisetti ,  Uday Saxena

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/28 ,  G01N33/92 ,  G01N2500/10 ,  G01N2800/044

    摘要： A novel method of identifying compounds capable of upregulating Peroxiredoxin activity is disclosed. The method includes providing a sample of cells that express Peroxiredoxin, providing a sample of a candidate compound, contacting the cell sample and the compound sample, and measuring a quantitative indicator of Peroxiredoxin activity within the cell sample after the contacting step. Peroxiredoxin inducers identified by the method and uses therefore to upregulate Peroxiredoxin activity in subjects and to reduce LDL and/or VLDL levels and to prevent or treat atherosclerosis and inflammatory disorders such as arthritis in subjects are also described. The invention also provides a method of treatment of inflammatory and cardiovascular diseases which comprises providing a patient in need of treatment with an effective amount of a composition that increases Peroxiredoxin protein or activity.

    摘要翻译： 公开了鉴定能够上调过氧化还原毒素活性的化合物的新方法。 该方法包括提供表达过氧化还原毒素的细胞样品，提供候选化合物的样品，接触细胞样品和化合物样品，以及在接触步骤之后测量细胞样品内过氧化还原毒素活性的定量指标。 本文还描述了通过该方法和用途鉴定的过氧化还原毒素诱导剂，以上调受试者中的过氧化还原毒素活性并降低LDL和/或VLDL水平并预防或治疗动脉粥样硬化和炎症性疾病如受试者中的关节炎。 本发明还提供了一种治疗炎性和心血管疾病的方法，其包括提供需要治疗的患者，所述治疗有效量的增加过氧化还原蛋白或活性的组合物。

    Methods and compositions to lower plasma cholesterol levels
    20.
    发明申请
    Methods and compositions to lower plasma cholesterol levels 审中-公开
    降低血浆胆固醇水平的方法和组合物

    公开(公告)号：US20050196819A1

    公开(公告)日：2005-09-08

    申请号：US11121157

    申请日：2005-05-03

    申请人： Russell Medford ,  Uday Saxena

    发明人： Russell Medford ,  Uday Saxena

    IPC分类号： A61K31/00 ,  G01N33/92 ,  G01N33/53 ,  C12Q1/60 ,  G01N33/537 ,  G01N33/543

    CPC分类号： A61K31/00 ,  G01N33/92 ,  G01N2800/044 ,  Y10S436/805 ,  Y10S436/815 ,  Y10T436/12

    摘要： A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol is provided that includes assessing the ability of the compound to form a complex with the lipoprotein, e.g., LDL or VLDL, and then determining whether the newly formed complex causes a change in the structure of apoB-100 that results in increased binding affinity to the LDL receptor. Also disclosed is a method for lowering cholesterol in a host in need thereof, including a human, is provided that includes the administration of an effective amount of a compound which binds to cholesterol-carrying lipoprotein (e.g. LDL or VLDL) in a manner that alters the three dimensional configuration of the lipoprotein and increases the binding affinity of the apoB-100 protein to the LDL receptor, including those on the surface of a hepatic cell.

    摘要翻译： 公开了一种用于确定化合物是否以降低血浆胆固醇的方式与脂蛋白如LDL或VLDL结合的方法，其包括评估化合物与脂蛋白（例如LDL或VLDL）形成复合物的能力， 然后确定新形成的复合物是否导致apoB-100的结构改变，导致对LDL受体的结合亲和力增加。 还公开了一种降低有需要的宿主（包括人）中胆固醇的方法，其包括施用有效量的与携带胆固醇的脂蛋白（例如LDL或VLDL）结合的化合物，其改变方式 脂蛋白的三维构型，并增加apoB-100蛋白与LDL受体的结合亲和力，包括肝细胞表面的结合亲和力。