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公开(公告)号：US5843688A
公开(公告)日：1998-12-01
申请号：US583238
申请日：1996-01-05
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , G01N33/53 , A61K38/04 , A61K39/385
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5744316A
公开(公告)日：1998-04-28
申请号：US587391
申请日：1996-01-17
IPC分类号： C12N15/09 , A61K31/00 , A61K35/14 , A61K35/76 , A61K38/00 , A61K38/46 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07K7/06 , C07K14/47 , C07K14/74 , C12N9/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/569 , A61K38/04 , A61K39/385
CPC分类号： C12Y114/18001 , C07K14/4748 , C07K14/70539 , C12N9/0071 , G01N33/505 , G01N33/5091 , G01N33/56972 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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公开(公告)号：US5843687A
公开(公告)日：1998-12-01
申请号：US545212
申请日：1995-10-19
IPC分类号： C12N15/09 , A61K35/14 , A61K35/17 , A61K38/00 , A61K38/46 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07K7/06 , C07K14/47 , C07K14/74 , C12N5/08 , C12N9/02 , C12P21/02 , C12Q1/04 , C12R1/91 , G01N33/50 , G01N33/569 , G01N33/53 , A61K39/385 , A61K38/04
CPC分类号： G01N33/56972 , A61K35/17 , C07K14/4748 , C07K14/70539 , C12N9/0071 , C12Y114/18001 , G01N33/505 , G01N33/5091 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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公开(公告)号：US5530096A
公开(公告)日：1996-06-25
申请号：US203054
申请日：1994-02-28
申请人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
发明人： Thomas Wolfel , Aline Van Pel , Vincent Brichard , Thierry Boon-Falleur , Etienne DePlaen , Pierre Coulie , Jean-Christophe Renauld , Bernard Lethe
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61K49/00 , A61P43/00 , C07K7/06 , C07K14/47 , C12N5/06 , C12N5/10 , C12N9/02 , C12Q1/02 , G01N33/50 , G01N33/569 , A61K38/08
CPC分类号： G01N33/56972 , C07K14/4748 , C12N9/0071 , C12Y114/18001 , G01N33/505 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定人白细胞抗原分子和酪氨酸酶衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US6096520A
公开(公告)日：2000-08-01
申请号：US215966
申请日：1998-12-18
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61P37/04 , C07K14/47 , C12N9/10 , C12N15/54 , C12Q1/48 , C12Q1/68 , C07K7/00 , C07K14/435 , C12N15/63
CPC分类号： C12N9/1051 , C07K14/4748 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention describes brain glycogen phosphorylase tumor rejection antigen precursors, including nucleic acids encoding such tumor rejection antigen precursors, tumor rejection antigen peptides or precursors thereof and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a brain glycogen phosphorylase tumor rejection antigen or precursor thereof.
摘要翻译： 本发明描述了脑糖原磷酸化酶肿瘤排斥抗原前体，包括编码这种肿瘤排斥抗原前体的核酸，肿瘤排斥抗原肽或其前体以及与之相关的抗体。 还提供了用于诊断和治疗特征在于表达脑糖原磷酸化酶肿瘤排斥抗原或其前体的病症的方法和产品。
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公开(公告)号：US5519117A
公开(公告)日：1996-05-21
申请号：US233305
申请日：1994-04-26
IPC分类号： C12N15/09 , A61K35/14 , A61K35/17 , A61K38/00 , A61K38/46 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07K7/06 , C07K14/47 , C07K14/74 , C12N5/08 , C12N9/02 , C12P21/02 , C12Q1/04 , C12R1/91 , G01N33/50 , G01N33/569 , C07K7/00
CPC分类号： G01N33/56972 , A61K35/17 , C07K14/4748 , C07K14/70539 , C12N9/0071 , C12Y114/18001 , G01N33/505 , G01N33/5091 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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17.发明授权Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof 失效分离的核酸分子，与MHC分子HLA-A2形成复合物的肽及其用途
公开(公告)号：US5886145A
公开(公告)日：1999-03-23
申请号：US915972
申请日：1997-08-21
IPC分类号： G01N33/50 , A61K35/26 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K14/74 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/53 , C07H21/04 , C07K7/06 , C07K14/705
CPC分类号： C07K14/4748 , A61K38/00
摘要： New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了新的肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为NAG肿瘤排斥抗原前体，编码它们的核酸分子被称为NAG编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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18.发明授权
公开(公告)号：US5958711A
公开(公告)日：1999-09-28
申请号：US177909
申请日：1998-10-23
IPC分类号： G01N33/50 , A61K35/26 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K14/74 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/53
CPC分类号： C07K14/4748 , A61K38/00
摘要： New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了新的肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为NAG肿瘤排斥抗原前体，编码它们的核酸分子被称为NAG编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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19.发明授权
公开(公告)号：US5821122A
公开(公告)日：1998-10-13
申请号：US487135
申请日：1995-06-07
IPC分类号： G01N33/50 , A61K35/26 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K14/74 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/53 , C07H21/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
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公开(公告)号：US20110070268A1
公开(公告)日：2011-03-24
申请号：US12884407
申请日：2010-09-17
申请人： Vincent Brichard , Benjamin Georges Elie Lea Ghislain Dizier , Olivier Gruselle , Jamila Louahed , Fernando Ulloa-Montoya
发明人： Vincent Brichard , Benjamin Georges Elie Lea Ghislain Dizier , Olivier Gruselle , Jamila Louahed , Fernando Ulloa-Montoya
IPC分类号： A61K39/00 , C12Q1/68 , C40B30/00 , C40B40/06 , C07H21/00 , C07K2/00 , C07K14/47 , A61P35/00 , A61P37/04
CPC分类号： C12Q1/6809 , C12Q2600/106 , C12Q2565/501
摘要： Methods for characterisation of patients as responders or non-responders to therapy based on differential expression of one or more genes are provided. Gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and new diagnostic kits and methods of treatment are also provided. The kits and methods relate to the treatment of specific populations of, for example, cancer patients, as characterised by their gene expression profile, suffering from MAGE expressing tumours.
摘要翻译： 提供了基于一个或多个基因的差异表达来表征患者作为应答者或不应答者的方法。 还提供了基因表达谱，包含代表基因表达谱的核酸序列的微阵列，以及新的诊断试剂盒和治疗方法。 试剂盒和方法涉及治疗特定人群，例如癌症患者，其特征在于其基因表达谱，患有MAGE表达肿瘤。
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