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公开(公告)号：US09637732B2
公开(公告)日：2017-05-02
申请号：US13824087
申请日：2011-11-04
CPC分类号： C12N15/01 , C12N5/0696 , C12N9/12 , C12N9/18 , C12N15/86 , C12N2501/405 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/999
摘要： Provided is a method of improving the efficiency of iPS cell establishment, comprising bringing one or more factors selected from the group consisting of proteins belonging to cyclin D family and nucleic acids that encode the same into contact with a somatic cell, in the step of nuclear reprogramming of the somatic cell. Also provided are a method of producing an iPS cell comprising the step of bringing the factor(s) and nuclear reprogramming substance(s) into contact with a somatic cell, an iPS cell comprising a nucleic acid that encodes a protein belonging to cyclin D family that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate.
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12.发明授权Method for producing induced pluripotent stem cells and method for culturing the same 有权诱导多能干细胞的制备方法及其培养方法公开(公告)号：US09045738B2
公开(公告)日：2015-06-02
申请号：US13322445
申请日：2010-05-28
CPC分类号： C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/00 , C12N2502/13 , C12N2502/1323 , C12N2510/00
摘要： Induced pluripotent stem cells are produced from human somatic cells by co-culturing human somatic cells having a reprogrammed nucleus with human cells as feeder cells. Induced pluripotent stem cells are produced from somatic cells by co-culturing somatic cells having a reprogrammed nucleus with autologous cells as feeder cells. Induced pluripotent stem cells are cultured with culture supernatant of somatic cells.
摘要翻译： 通过将具有重编程核的人体细胞与人细胞作为饲养细胞共培养，从人体细胞产生诱导的多能干细胞。 通过将具有重编程核的体细胞与自体细胞共培养为饲养细胞，从体细胞产生诱导的多能干细胞。 诱导的多能干细胞与体细胞的培养上清液一起培养。
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13.发明授权公开(公告)号：US08278104B2
公开(公告)日：2012-10-02
申请号：US12213035
申请日：2008-06-13
CPC分类号： C07K14/4702 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2510/00 , C12N2740/15043
摘要： The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
摘要翻译： 本发明涉及具有重新编程分化的体细胞以产生诱导多能干细胞（iPS）细胞的作用的核重编程因子。 本发明还涉及上述iPS细胞，产生和维持iPS细胞的方法，以及使用iPS细胞的方法，包括筛选和测试方法以及干细胞治疗方法。 本发明还涉及通过诱导上述iPS细胞的分化衍生的体细胞。
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公开(公告)号：US20120113208A1
公开(公告)日：2012-05-10
申请号：US13280173
申请日：2011-10-24
IPC分类号： B41J2/435
CPC分类号： B41J2/451
摘要： An optical print head including, a first element row in which a plurality of light emitting elements aligns in a predetermined direction; a second element row in which a plurality of light emitting elements aligns in a predetermined direction, which aligns with the first element row in a direction orthogonal to the predetermined direction, and deviates in the predetermined direction with respect to the first element row; a data sorting circuit which outputs image data corresponding to an exposure region formed on a photoconductor due to light emitting of the first element row, and image data corresponding to an exposure region formed on the photoconductor due to light emitting of the second element row, at timings which are different from each other; and a driver which drives the light emitting elements in the first element row and the second element row, by receiving an output from the data sorting circuit.
摘要翻译： 一种光学打印头，包括：第一元件列，其中多个发光元件沿预定方向排列; 第二元件行，其中多个发光元件沿与预定方向正交的方向与第一元件行对齐的预定方向排列，并相对于第一元素行在预定方向上偏移; 数据排序电路，其输出由于第一元素行的发光而形成在光电导体上的曝光区域的图像数据，以及由于第二元件列的发光而形成在感光体上的曝光区域的图像数据 时间不同; 以及驱动器，其通过接收来自数据分类电路的输出来驱动第一元件行和第二元件行中的发光元件。
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公开(公告)号：US20120082484A1
公开(公告)日：2012-04-05
申请号：US13251474
申请日：2011-10-03
申请人： Shoko Shimmura , Satoshi Kinouchi , Shigeru Fujiwara , Ryota Saeki , Kazutoshi Takahashi , Toshihiro Sone , Takafumi Amano
发明人： Shoko Shimmura , Satoshi Kinouchi , Shigeru Fujiwara , Ryota Saeki , Kazutoshi Takahashi , Toshihiro Sone , Takafumi Amano
IPC分类号： G03G15/01
CPC分类号： G03G15/0126 , G03G15/08 , G03G2215/0132 , G03G2215/0141
摘要： According to one embodiment, there are provided a developing section storing a color erasable developing agent that includes capsule colorant particles with a core in which a color developable compound, a color developing agent, and a color erasing agent are contained, and a developing section storing a binder resin-containing transparent developing agent. A transparent developing agent image is transferred to a region capable of covering a color erasable developing agent image and the resulting image is fixed.
摘要翻译： 根据一个实施方案，提供了一种存储可消色显影剂的显影部分，其包含胶囊着色剂颗粒与其中含有可显色化合物，彩色显影剂和消色剂的核心，以及显影部分储存 含粘合剂树脂的透明显影剂。 将透明显影剂图像转印到能够覆盖可擦除显影剂图像的区域，并且所得到的图像是固定的。
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16.发明授权Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells 有权Oct3 / 4，Klf4，c-Myc和Sox2产生诱导的多能干细胞公开(公告)号：US08058065B2
公开(公告)日：2011-11-15
申请号：US12457356
申请日：2009-06-09
CPC分类号： C07K14/4702 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2510/00 , C12N2740/15043
摘要： The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
摘要翻译： 本发明涉及具有重新编程分化的体细胞以产生诱导多能干细胞（iPS）细胞的作用的核重编程因子。 本发明还涉及上述iPS细胞，产生和维持iPS细胞的方法，以及使用iPS细胞的方法，包括筛选和测试方法以及干细胞治疗方法。 本发明还涉及通过诱导上述iPS细胞的分化衍生的体细胞。
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公开(公告)号：US20110242261A1
公开(公告)日：2011-10-06
申请号：US13073468
申请日：2011-03-28
IPC分类号： B41J2/435
CPC分类号： H04N1/02815 , B41J2/451 , H04N1/02845 , H04N1/02855 , H04N1/02865 , H04N1/02895
摘要： An optical head includes a light-emitting element to emit light, a substrate to which the light-emitting element is fixed, a heat radiation member to which the substrate is fixed, a filling member filled between the substrate and the heat radiation member, and a lens to focus the light emitted from the light-emitting element.
摘要翻译： 光头包括发光的发光元件，固定有发光元件的基板，固定有基板的散热构件，填充在基板和散热构件之间的填充构件，以及 用于聚焦从发光元件发射的光的透镜。
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18.发明申请OPTICAL HEAD, IMAGE FORMING APPARATUS, AND MANUFACTURING OF THE OPTICAL HEAD 审中-公开光学头，图像形成装置和光学头的制造公开(公告)号：US20110242253A1
公开(公告)日：2011-10-06
申请号：US13069289
申请日：2011-03-22
CPC分类号： B41J2/451 , G03G15/04045 , G03G15/326
摘要： According to one embodiment, an optical head includes a light emitting substrate emitting light and allow light of specific wavelength to pass; a mounting base to which the light emitting substrate is fixed and which includes a groove formed in an area overlapping the light emitting substrate; an adhesive filled in the groove of the mounting base and cured by receiving the light having the specific wavelength; and a lens condensing the light emitted from the light emitting substrate.
摘要翻译： 根据一个实施例，光头包括发射光并允许特定波长的光通过的发光基板; 固定发光基板的安装基座，其包括形成在与发光基板重叠的区域中的槽; 填充在安装基座的槽中并通过接收具有特定波长的光而固化的粘合剂; 以及会聚从发光基板发出的光的透镜。
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公开(公告)号：US20110117645A1
公开(公告)日：2011-05-19
申请号：US12922244
申请日：2009-03-31
IPC分类号： C12N5/071
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2500/10 , C12N2500/12 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/98 , C12N2533/52
摘要： For efficient proliferation of pluripotent stem cells in a system free from any animal-derived material such as feeder cells or serum, the present invention provides a method for proliferation of pluripotent stem cells, which comprises culturing the pluripotent stem cells in a medium free from both feeder cells and serum in a system containing laminin-5.
摘要翻译： 为了在不含任何动物来源的材料如饲养细胞或血清的系统中有效增殖多能干细胞，本发明提供了多能干细胞增殖的方法，其包括在不含两者的培养基中培养多能干细胞 饲养细胞和血清在含有层粘连蛋白-5的系统中。
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20.发明授权Laser exposure device and optical axis adjustment method in laser exposure device 有权激光曝光装置中的激光曝光装置和光轴调整方法公开(公告)号：US07557821B2
公开(公告)日：2009-07-07
申请号：US11675421
申请日：2007-02-15
IPC分类号： B41J2/44
CPC分类号： G03G15/04072 , G03G15/0435
摘要： In a laser exposure device according to the present invention, a positioning pin, which is formed in a lens holder supporting a lens system, is inserted through an elongated hole for restriction of a board holder supporting a laser diode. An eccentric cam is inserted into an elongated hole for rotation movement formed in a board holder and a circular hole for rotation movement which is formed in the lens holder and which faces the elongated hole for rotation movement. An eccentric cam is inserted into an elongated hole for slide movement formed in the board holder and a circular hole for slide movement which is formed in the lens holder and which faces the elongated hole for slide movement. The eccentric cams are rotated to relatively move the board holder and lens holder with respect to each other to thereby establish alignment between the optical axes of the laser diode and lens system. In a state where the eccentric cams are fitted into the elongated holes, the board holder and lens holder are fixed to each other by screws.
摘要翻译： 在根据本发明的激光曝光装置中，形成在支撑透镜系统的透镜支架中的定位销被插入通过长孔，用于限制支撑激光二极管的板支架。 偏心凸轮被插入到用于旋转运动的长孔中，形成在板保持器中的旋转运动和用于旋转运动的圆形孔，其形成在透镜保持器中并面向用于旋转运动的细长孔。 偏心凸轮被插入到用于滑动运动的细长孔中，形成在板保持器中，并且用于滑动运动的圆形孔形成在透镜保持器中并面对用于滑动运动的长孔。 偏心凸轮旋转以相对于彼此相对地移动板保持器和透镜保持器，从而在激光二极管和透镜系统的光轴之间建立对准。 在将偏心凸轮装配到细长孔中的状态下，通过螺钉将板保持器和透镜保持器彼此固定。
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