利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.054 秒)

    5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE
    13.
    发明申请
    5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE 有权
    5-羟基嘧啶-4-羧酰胺衍生物

    公开(公告)号：US20120220609A1

    公开(公告)日：2012-08-30

    申请号：US13503340

    申请日：2010-10-20

    申请人： Takeshi Kuribayashi ,  Hideki Kubota ,  Naoki Tanaka ,  Takeshi Fukuda ,  Takashi Tsuji ,  Riki Goto

    发明人： Takeshi Kuribayashi ,  Hideki Kubota ,  Naoki Tanaka ,  Takeshi Fukuda ,  Takashi Tsuji ,  Riki Goto

    IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P7/06 ,  C07D401/06

    CPC分类号： C07D401/06 ,  C07D401/14

    摘要： The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): [wherein, R1: formula (1A): [wherein, R4 and R5: H, halogen, or alkyl; R6: H, halogen, alkyl, or the like; R7: substitutable hydroxyalkyl, substitutable hydroxyhalo alkyl, substitutable alkoxyalkyl, or the like; substituent group α: oxo, hydroxy, amino, or the like; ring Q1: a monocyclic heterocyclic group; ring Q2: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; ring Q3: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; X: a single bond, methylene, ethylene, or the like]; R2: alkyl, or methylsulfanyl; and R3: H, or methyl], or the like.

    摘要翻译： 本发明提供了促进促红细胞生成素生成的化合物。 本发明提供由式（1）表示的化合物：[其中，R1：式（1A）：[其中，R4和R5：H，卤素或烷基; R6：H，卤素，烷基等; R7：可取代的羟烷基，可取代的羟基卤代烷基，可取代的烷氧基烷基等; 取代基组α：氧代，羟基，氨基等; 环Q1：单环杂环基; 环Q2：单环烃环基或单环杂环基; 环Q3：单环烃环基或单环杂环基; X：单键，亚甲基，亚乙基等）; R2：烷基或甲硫基; 和R 3：H或甲基]等。

    Tricyclic pyrrole or pyrazole derivative
    16.
    发明授权
    Tricyclic pyrrole or pyrazole derivative 失效
    三环吡咯或吡唑衍生物

    公开(公告)号：US06245796B1

    公开(公告)日：2001-06-12

    申请号：US09445104

    申请日：1999-12-02

    申请人： Kyoichi Maeno ,  Ken-ichi Kazuta ,  Hideki Kubota ,  Itsuro Shimada ,  Tetsuya Kimizuka ,  Shuichi Sakamoto ,  Fumikazu Wanibuchi

    发明人： Kyoichi Maeno ,  Ken-ichi Kazuta ,  Hideki Kubota ,  Itsuro Shimada ,  Tetsuya Kimizuka ,  Shuichi Sakamoto ,  Fumikazu Wanibuchi

    IPC分类号： A01N4356

    CPC分类号： C07D231/54 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

    摘要： A tricyclic pyrrole or pyrazole derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof, which shows strong affinity and selectivity for the 5-HT2C receptor and is useful for the treatment of central nervous system diseases such as sexual disorders, eating disorders, anxiety, depression and sleeping disorders. (In the above formula, each symbol means as follows; Y ring: an unsaturated five-membered ring which may have 1 to 3 of one or more types of hetero atom(s) each selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom or an unsaturated six-membered ring having 1 or 2 nitrogen atom(s), X: a bond or a carbon atom, a double bond or a single bond, V: a nitrogen atom or a group represented by a formula CH, and A: a straight or branched lower alkylene group which may be substituted with a halogen atom or a cycloalkyl group).

    摘要翻译： 由以下通式（I）表示的三环吡咯或吡唑衍生物或其药学上可接受的盐对5-HT 2C受体表现出强亲和力和选择性，可用于治疗中枢神经系统疾病如性功能障碍 （进食障碍，焦虑症，抑郁症和睡眠障碍）（上式中，每个符号表示如下：Y环：每个可以具有1至3个一个或多个杂原子的不饱和五元环 选自氮原子，氧原子和硫原子或具有1或2个氮原子的不饱和六元环，X：键或碳原子，双键或单键，V为氮原子或式CH所示基团，A为直链或支链低级亚烷基， 可以被卤素原子或环烷基取代）。