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公开(公告)号：US4782151A
公开(公告)日：1988-11-01
申请号：US149706
申请日：1988-01-29
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
IPC分类号： C07D295/18 , A61K31/16 , A61K31/195 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/535 , A61K31/5375 , A61P1/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/05 , C07C233/09 , C07C233/18 , C07C233/20 , C07C233/31 , C07C233/36 , C07C235/76 , C07D207/20 , C07D207/325 , C07D233/60 , C07D295/185 , C07D521/00 , C07D265/30 , C07D233/00 , C07D239/00 , C07D295/00
CPC分类号： C07D295/185 , C07D207/20 , C07D231/12 , C07D233/56 , C07D249/08
摘要： A novel polyprenyl compound is identified with the formula and useful for a pharmaceutical drag. ##STR1## wherein X represents a group of the formula: ##STR2## (wherein R.sup.1 and R.sup.2, which may be the same or differnt, represent each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group, or a lower alkenyl group); a group of the formula: ##STR3## (wherein A including the nitrogen atom shown represents a ring containing nitrogen and oxygen atoms); or a group of the formula: ##STR4## (wherein R.sup.3 represents a hydrogen atom or a lower alkyl group, and R.sup.4 represents a lower alkyl group); Y represents a group of the formula: ##STR5## or a group of the formula: ##STR6## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group), and n represents an integer of from 2 to 5.
摘要翻译： 用该配方鉴定出新的聚异戊二烯基化合物，并可用于药物阻力。 其中X表示下式的基团：其中R 1和R 2可以相同或不同，表示氢原子，低级烷基，羟基烷基或低级烯基） ; 下式的基团：其中A包括所示的氮原子代表含有氮和氧原子的环; 或下式的基团：其中R 3表示氢原子或低级烷基，R 4表示低级烷基。 Y表示下式的基团：
或下式的基团：其中R 5表示氢原子或低级烷基，n表示2〜5的整数。 -
公开(公告)号：US4599328A
公开(公告)日：1986-07-08
申请号：US684871
申请日：1984-12-21
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Kouichi Katayama , Hajime Tsunoda , Manabu Murakami , Hideki Ono , Kouji Yamada
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Kouichi Katayama , Hajime Tsunoda , Manabu Murakami , Hideki Ono , Kouji Yamada
IPC分类号： A61K31/045 , A61K31/66 , A61P3/08 , A61P3/10 , A61K31/035
CPC分类号： A61K31/045 , A61K31/66 , Y10S514/866
摘要： Dolichol or phosphate thereof is useful as a therapeutically treating and preventive agent, in particular, for hyperuricuria, hyperlipemia, diabetes and hepatic diseases.
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公开(公告)号：US4454126A
公开(公告)日：1984-06-12
申请号：US434454
申请日：1982-10-15
申请人： Isao Yamatsu , Yuichi Inai , Takeshi Suzuki , Shinya Abe , Masaru Satoh , Naosuke Seto
发明人： Isao Yamatsu , Yuichi Inai , Takeshi Suzuki , Shinya Abe , Masaru Satoh , Naosuke Seto
CPC分类号： C07F9/222
摘要： Phosphoramide derivatives of the general formula: ##STR1## are disclosed wherein X and Y each represents a hydrogen atom or X and Y are removed to form a double bond between the respective adjoining carbon atoms, and n represents an integer of 0 to 2. A process for the preparation of these compounds and pharmaceutical compositions containing these phosphoramide derivatives are also disclosed. The phosphoramide derivatives of the invention are used to treat urethral calculosis and pyelonephritis.
摘要翻译： 公开了下列通式：的磷酰胺衍生物，其中X和Y各自表示氢原子，除去X和Y以形成相邻的碳原子之间的双键，n表示0-2的整数。 还公开了制备这些化合物的方法和含有这些磷酰胺衍生物的药物组合物。 本发明的磷酰胺衍生物用于治疗尿道结石和肾盂肾炎。
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14.发明授权
公开(公告)号：US4382151A
公开(公告)日：1983-05-03
申请号：US296728
申请日：1981-08-27
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Toshiharu Ohgoh , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Toshiharu Ohgoh , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
IPC分类号： A61K31/045 , A61P1/04 , A61P35/00 , C07C27/00 , C07C29/143 , C07C33/02 , C07C67/00
CPC分类号： C07C33/02
摘要： 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraene-2-ols of the general formula: ##STR1##
摘要翻译： 6,10,14,18-四甲基-5,9,13,17-十九四烯-2-醇，其通式如下：
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15.发明授权
公开(公告)号：US4917829A
公开(公告)日：1990-04-17
申请号：US865934
申请日：1986-05-16
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Koichi Abe , Kouji Yamada
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Koichi Abe , Kouji Yamada
IPC分类号： A61K8/36 , A61K31/19 , A61K31/20 , A61P35/00 , A61Q19/00 , C07C27/00 , C07C27/02 , C07C51/00 , C07C51/347 , C07C57/03 , C07C67/00 , C07C69/587 , C07C317/44
CPC分类号： A61Q19/00 , A61K31/19 , A61K8/361 , C07C317/44 , C07C57/03 , C07C69/587
摘要： A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an anticancer agent are also disclosed.
摘要翻译： 公开了一种新的化合物3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸及其盐以及许多制备该化合物的不同方法。 还公开了新化合物作为抗癌剂的用途。
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公开(公告)号：US4888439A
公开(公告)日：1989-12-19
申请号：US729444
申请日：1985-05-01
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
IPC分类号： C07D295/18 , A61K31/16 , A61K31/195 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/535 , A61K31/5375 , A61P1/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/05 , C07C233/09 , C07C233/18 , C07C233/20 , C07C233/31 , C07C233/36 , C07C235/76 , C07D207/20 , C07D207/325 , C07D233/60 , C07D295/185 , C07D521/00
CPC分类号： C07D295/185 , C07D207/20 , C07D231/12 , C07D233/56 , C07D249/08
摘要： A novel polyprenyl compound is identified with the formula and useful for a pharmaceutical drag. ##STR1## wherein X represents a group of the formula: ##STR2## (wherein R.sup.1 and R.sup.2, which may be the same or different, represent each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group, or a lower alkenyl group); a group of the formula: ##STR3## (wherein A including the nitrogen atom shown represents a ring containing nitrogen and oxygen atoms); or a group of the formula: ##STR4## (wherein R.sup.3 represents a hydrogen atom or a lower alkyl group, and R.sup.4 represents a lower alkyl group); Y represents a group of the formula: ##STR5## or a group of the formula: ##STR6## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group), and n represents an integer of from 2 to 5.
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公开(公告)号：US4835183A
公开(公告)日：1989-05-30
申请号：US451318
申请日：1982-12-20
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Kouichi Abe , Kouji Yamada
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Kouichi Abe , Kouji Yamada
IPC分类号： A61K31/165 , A61K31/12 , A61K31/16 , A61K31/20 , A61K31/23 , A61P35/00 , C07C49/203 , C07C57/03
CPC分类号： A61K31/16 , A61K31/12 , A61K31/23 , C07C49/203 , C07C57/03 , Y10S514/886
摘要： An anti-cancer agent which comprises a polyprenvl compound having the formula (I): ##STR1## in which each of n and m is 0, 1 or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.2 is the hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or ##STR5## if n is 1, m is 0, A is ##STR6## and B is ##STR7##
摘要翻译： 一种抗癌剂，其包含其中n和m各自为0,1或2，n + m为0,1或2的式（I）的聚肾素化合物：其中， IMAGE>和B是其中R表示羟基，低级烷氧基或
（其中R1和R2各自为氢原子，低级烷基或芳基）的 + TR ）]; 条件是R为低级烷氧基或如果n为1，则为“IMAGE”，m为0，A为“IMAGE”，B为“IMAGE” -
公开(公告)号：US4655973A
公开(公告)日：1987-04-07
申请号：US260869
申请日：1981-05-06
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Kouichi Abe , Kouji Yamada
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Kouichi Abe , Kouji Yamada
IPC分类号： C07C69/587 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/22 , A61K31/23 , A61P35/00 , C07C51/00 , C07C57/03 , C07C67/00 , C07C231/00 , C07C233/09 , C07C103/133 , C07C103/58
摘要： A conjugated polyprenylcarboxylic acid and its derivative having the formula: ##STR1## in which each of n and m is 0, 1 or 2, n+m is 1 or 2, A is ##STR2## and R is the hydroxyl group, a lower alkoxy group or ##STR3## wherein each of R.sub.1 and R.sub.2 represents the hydrogen atom, a lower alkyl group, or an aryl group; provided that R is ##STR4## if A is ##STR5## n is 1 and m is 0.
摘要翻译： 具有下式的共轭聚异戊二烯基羧酸及其衍生物：其中n和m各自为0,1或2，n + m为1或2，A为
，R为羟基，较低 烷氧基或 ，其中R 1和R 2各自表示氢原子，低级烷基或芳基; 如果A为 ，则R为 ，n为1，m为0。 -
公开(公告)号：US4613593A
公开(公告)日：1986-09-23
申请号：US684875
申请日：1984-12-21
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Kouichi Katayama , Hajime Tsunoda , Manabu Murakami , Hideki Ono , Kouji Yamada
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Kouichi Katayama , Hajime Tsunoda , Manabu Murakami , Hideki Ono , Kouji Yamada
IPC分类号： A61K31/045 , A61K31/66 , A61P3/06 , A61P9/10
CPC分类号： A61K31/045 , A61K31/66
摘要： Dolichol or phosphate thereof is useful as a therapeutically treating and preventive agent, in particular, for hyperuricuria, hyperlipemia, diabetes and hepatic diseases.
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公开(公告)号：US4603126A
公开(公告)日：1986-07-29
申请号：US684893
申请日：1984-12-21
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Kouichi Katayama , Hajime Tsunoda , Manabu Murakami , Hideki Ono , Kouji Yamada
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Kouichi Katayama , Hajime Tsunoda , Manabu Murakami , Hideki Ono , Kouji Yamada
IPC分类号： A61K31/045 , A61K31/66 , A61P19/06
CPC分类号： A61K31/66 , A61K31/045
摘要： Dolichol or phosphate thereof is useful as a therapeutically treating and preventive agent, in particular, for hyperuricuria, hyperlipemia, diabetes and hepatic diseases.
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