公开(公告)号：US5798315A

公开(公告)日：1998-08-25

申请号：US797452

申请日：1997-02-06

申请人： Kei Etoh ,  Akira Hirasawa ,  Hisano Higurashi ,  Makoto Kawamura

发明人： Kei Etoh ,  Akira Hirasawa ,  Hisano Higurashi ,  Makoto Kawamura

IPC分类号： B41M5/165 ,  B41M5/28 ,  C09D11/02

CPC分类号： C09D11/02 ,  B41M5/165 ,  B41M5/287 ,  Y10T428/249997 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987 ,  Y10T428/2989

摘要： A microcapsule-containing oil-based coating liquid wherein the coating liquid comprises a hydrophobic core material-containing microcapsule particles dispersed individually in a state of primary particle in an oil varnish for ink use or a resin for coating use, and a solvent having an affinity for both the varnish or the resin and the surface of the microcapsule wall material in a state of having been attracted with the affinity to both the varnish or the resin and the surface layer of the microcapsule wall material. The preferred solvent is a lower divalent or multivalent alcohol. A preparative method of the foregoing coating liquid by utilizing vacuum distillation is also proposed. A sheet, like a duplicating sheet of paper coated with the foregoing oil-based coating liquid is further provided. According to the present invention, a water-based microcapsules system can be advantageously converted into an oil-based one without coagulating the primary microcapsule particles. There is no hardening and breakdown of the wall material during the process, and the original strength and the flexibility of the microcapsule wall material can be retained intact. Conventional pressure transferring-type printing machine may be employed to printing a selected area of the sheet.

摘要翻译： 一种含微胶囊的油性涂布液，其中，所述涂布液包含分散在油墨用油性油墨中的一次粒子状态的分散的含疏水性芯材料的微胶囊粒子，或者涂布用树脂，以及具有亲和性的溶剂 对于清漆或树脂以及微胶囊壁材料的表面以与清漆或树脂和微胶囊壁材料的表面层的亲和性吸引的状态。 优选的溶剂是低级二价或多价醇。 还提出了通过利用真空蒸馏的上述涂布液的制备方法。 进一步提供如同涂覆有上述油性涂料的复印纸一样的片材。 根据本发明，可以有利地将水性微胶囊体系转化为油性微胶囊体系而不使一级微胶囊颗粒凝结。 在该过程中没有壁材料的硬化和分解，并且微胶囊壁材料的原始强度和柔韧性可以保持完整。 传统的压力传送型印刷机可用于印刷片材的选定区域。

公开(公告)号：US20130337243A1

公开(公告)日：2013-12-19

申请号：US14002065

申请日：2012-02-14

申请人： Shigeo Ishikawa ,  Akira Hirasawa

发明人： Shigeo Ishikawa ,  Akira Hirasawa

IPC分类号： A47K10/16

CPC分类号： A47K10/16 ,  D21H27/002 ,  Y10T428/24934

摘要： To solve problems such as tearing in using or manufacturing sanitary thin paper for household use that is embossed and applied with aqueous chemicals. The problem is solved by a method for manufacturing toilet paper, comprising: a chemicals applying step of printing and applying aqueous lotion chemicals onto band-like continuous crepe paper by a printer, while a pattern with a non-chemicals-application portions and chemicals-application portions is formed; and an embossing step where the embossing convex portions are brought into press-contact only to the non-chemicals-application portions of the continuous crepe paper so that the continuous crepe paper is embossed.

摘要翻译： 解决使用或制造压花和应用水性化学品的家用卫生薄页纸等问题。 该问题是通过一种用于制造卫生纸的方法来解决的，包括：一种化学品施加步骤，通过打印机将水性洗剂化学品印刷并施加到带状连续起皱纸上，而具有非化学品施加部分和化学品 - 形成施加部分; 以及压花步骤，其中压花凸部仅与连续皱纹纸的非化学品施加部分进行压力接触，使得连续的皱纹纸被压花。

公开(公告)号：US08318781B2

公开(公告)日：2012-11-27

申请号：US12597281

申请日：2008-04-25

申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

IPC分类号： A01N43/40 ,  A01N43/78 ,  A01N37/12 ,  A01N37/44 ,  A01N43/00 ,  A61K31/445 ,  A61K31/425 ,  A61K31/33 ,  C07D213/72 ,  C07D213/78 ,  C07D277/82 ,  C07C63/00 ,  C07C65/00

CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

公开(公告)号：US20120088816A1

公开(公告)日：2012-04-12

申请号：US13263800

申请日：2010-04-16

申请人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

发明人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

IPC分类号： A61K31/713 ,  A61P35/00 ,  A61P35/04 ,  C07H21/02

CPC分类号： A61K31/7088 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141

摘要： It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.

摘要翻译： 它提供了一种新型的头颈部肿瘤增殖抑制剂，头颈部肿瘤转移抑制剂和用于治疗头颈部肿瘤的药物组合物。 本发明的特征在于使用在头颈部肿瘤中其表达降低的头颈部肿瘤和/或其表达降低的促进物质的微小RNA的抑制物质。 在头颈部肿瘤中表达增加的微小RNA的优选实例包括miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR-21和 miR-31。 在头颈部肿瘤中表达降低的微小RNA的优选实例包括miR-133b，miR-145和miR-375。

公开(公告)号：US20110166041A1

公开(公告)日：2011-07-07

申请号：US12999124

申请日：2009-06-25

申请人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

发明人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

IPC分类号： C40B40/06 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Disclosed are: a method for using a particular microRNA as a biomarker for gynecological cancer; a method for the determination of gynecological cancer; a kit for the determination of gynecological cancer, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-592, miR-629*, miR-517a, miR-205, miR-184, miR-509-5p, miR-135a*, miR-137, miR-602, miR-186*, miR-181a-2*, miR-193b*, miR-377*, miR-449b, miR-449a, miR-369-3p, miR-323-3p, miR-329, miR-299-5p, miR-34b, miR-411, miR-34c-5p, miR-376b, miR-885-5p, miR-337-3p, miR-337-5p, miR-127-3p, miR-138, miR-203, miR-488, miR-489, miR-643, miR-888, miR-424, miR-432, miR-433, miR-450a, miR-503, miR-542-3p, miR-542-5p and miR-584 is used as a biomarker for gynecological cancer.

摘要翻译： 公开的是：使用特定微小RNA作为妇科癌症生物标志物的方法; 确定妇科癌症的方法; 用于确定妇科癌症的试剂盒等。 本发明的特征在于，至少一种选自miR-592，miR-629 *，miR-517a，miR-205，miR-184，miR-509-5p，miR-135a * ，miR-137，miR-602，miR-186 *，miR-181a-2 *，miR-193b *，miR-377 *，miR-449b，miR-449a，miR-369-3p，miR-323-3p ，miR-329，miR-299-5p，miR-34b，miR-411，miR-34c-5p，miR-376b，miR-885-5p，miR-337-3p，miR-337-5p，miR-127 -3p，miR-138，miR-203，miR-488，miR-489，miR-643，miR-888，miR-424，miR-432，miR-433，miR-450a，miR-503，miR-542 -3p，miR-542-5p和miR-584用作妇科癌症的生物标志物。

公开(公告)号：US07815769B2

公开(公告)日：2010-10-19

申请号：US11973695

申请日：2007-10-09

申请人： Akira Hirasawa

发明人： Akira Hirasawa

IPC分类号： D21F11/00

CPC分类号： D21H21/22 ,  A47K10/16 ,  D21H21/14 ,  D21H21/38 ,  D21H27/002

摘要： It is intended to provide sanitary paper which is excellent in texture such as moistness and softness and scarcely causes skin irritation or blushing even if it is brought into contact with the skin frequently. Namely, sanitary paper having an oil absorbance specified in JIS P8141 of 7 mm or less and a moisture content of from 9.50 to 15.00% (measured in accordance with JIS P8127 after conditioning in accordance with JIS P8111); carrying a solution, which contains a moistening agent, a softener, an antioxidant and so on, coated in a dose of 46.0 to 160.0 mg/cm3 of the paper base; and having a bending hardness B measured with the use of a pure bending machine of from 0.0040 to 0.0060 g·cm2/cm.

摘要翻译： 其目的在于提供湿度和柔软度等质地优异的卫生纸，即使经常与皮肤接触，也几乎不引起皮肤刺激或白化。 即，JIS P8141中规定的吸油量为7mm以下，湿度为9.50〜15.00％（根据JIS P8127，按照JIS P8111调理后测定）的卫生纸; 携带含有作为纸基的46.0〜160.0mg / cm3的剂量的润湿剂，软化剂，​​抗氧化剂等的溶液。 并且具有使用纯度为0.0040〜0.0060g·cm 2 / cm的纯弯曲机测定的弯曲硬度B。

公开(公告)号：US20080257903A1

公开(公告)日：2008-10-23

申请号：US11579792

申请日：2005-05-06

申请人： Akira Hirasawa ,  Hiroshi Ono

发明人： Akira Hirasawa ,  Hiroshi Ono

IPC分类号： A47K10/24 ,  B65H1/00

CPC分类号： B65D83/0894 ,  B65D83/0805

摘要： In a household sanitary tissue paper container 1 that has a slender taking-out opening 2 where a film for supporting a household sanitary tissue paper 10 is not provided at the taking-out opening 2, the taking-out opening 2 having finger inserting portions 2B and supporting portions 2A for supporting a pulled-out household sanitary tissue paper 10 is provided, and in outside positions of edges of the supporting portions 2A in a width direction, crush portions for raising 5 along a longitudinal direction are formed respectively so as to continue into the taking-out opening 2.

摘要翻译： 在取出开口2上没有设置有用于支撑家用卫生薄页纸10的薄片的细长的取出开口2的家用卫生纸容器1中，具有手指插入部分2的取出开口2 B和用于支撑拉出的家用卫生薄页纸10的支撑部分2A设置在支撑部分2A的沿宽度方向的边缘的外侧位置，分别形成沿着纵向方向升高5的挤压部分 继续进入出口2。

公开(公告)号：US5229400A

公开(公告)日：1993-07-20

申请号：US770892

申请日：1991-10-04

申请人： Akira Hirasawa ,  Masataka Shoji ,  Ryota Yoshimoto ,  Yuichi Gyotoku ,  Chikahiko Eguchi

发明人： Akira Hirasawa ,  Masataka Shoji ,  Ryota Yoshimoto ,  Yuichi Gyotoku ,  Chikahiko Eguchi

IPC分类号： C07D211/22 ,  C07D211/32 ,  C07D211/70 ,  C07D295/192 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D521/00

CPC分类号： C07D295/192 ,  C07D211/22 ,  C07D211/32 ,  C07D211/70 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04

摘要： A piperidine derivative of general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein ##STR2## is any of several specified aromatic-containing groups; X is selected from one of several hetero atom-containing groups or C.sub.2 alkylene or a cyano-containing group; and Q is phenyl, cyclohexyl, piperidinyl, tetrahydropyranyl, pyridyl, pyrrolyl, N-methylpyrrolyl, thienyl, furyl, 1-hexyl, or cyano; from 1 to 3 hydrogen atoms in Q may be independently substituted by alkyl of from 1 to 3 carbon atoms, perfluoroalkyl of from 1 to 3 carbon atoms, acylamino of from 1 to 6 carbon atoms, perfluoroacylamino of from 1 to 3 carbon atoms, alkoxy of from 1 to 3 carbon atoms, alkanesulfonylamino of from 1 to 3 carbon atoms, perfluoroalkanesulfonylamino of from 1 to 3 carbon atoms, acetoxy of from 1 to 3 carbon atoms, aminocarbonyl, aminosulfonyl, fluoro, chloro, cyano, hydroxy, nitro, amino, imidazolylmethyl, cinnamoylamino, p-fluorobenzoyl, cyanomethyl, cyanoethyl, methoxyacetoxy, alkoxycarbonyl of from 1 to 3 carbon atoms; 1 is an integer of from 0 to 1; m is an integer of from 0 to 1; n is an integer of from 0 to 6.The derivatives are useful as antiarrhythmic agents.

公开(公告)号：US20140292223A1

公开(公告)日：2014-10-02

申请号：US14241847

申请日：2011-08-31

申请人： Akira Hirasawa ,  Yuhki Terao

发明人： Akira Hirasawa ,  Yuhki Terao

IPC分类号： H05B33/08

CPC分类号： H05B33/0896 ,  H01L27/3211 ,  H01L2251/5361 ,  H05B33/0857

摘要： A lighting apparatus includes: a plurality of light emission units that respectively emit lights in luminescent colors different from each other; and a control unit that controls in luminance the respective light, which are emitted from said plurality of light emission units, for the respective luminescent colors. In response to a control input, said control unit switches between a first light emission mode that it makes said light emission units emit light with luminance set for the respective luminescent colors and a second light emission mode that makes it light emission units corresponding to at least one luminescent color turn off or emit light with luminance lower than the luminance in the first light emission mode.

摘要翻译： 照明装置包括：多个发光单元，其分别发射彼此不同的发光颜色的光; 以及控制单元，其控制从所述多个发光单元发射的各个发光颜色的各个亮度的亮度。 响应于控制输入，所述控制单元在其使得所述发光单元发光的第一发光模式与针对各个发光颜色设定的亮度之间切换，并且使其使得至少对应于发光单元的第二发光模式 一种发光颜色在亮度低于第一发光模式下的亮度时熄灭或发光。

公开(公告)号：US20130323453A1

公开(公告)日：2013-12-05

申请号：US14000724

申请日：2012-02-14

申请人： Akira Hirasawa

发明人： Akira Hirasawa

IPC分类号： A47K10/16 ,  B31F1/07

CPC分类号： B31F1/07 ,  A47K10/16 ,  B31B70/006 ,  B31F2201/0761 ,  B65H2301/41484 ,  B65H2701/1762 ,  D21H23/48 ,  D21H27/005 ,  D21H27/30 ,  D21H27/40 ,  Y10T428/15

摘要： Provided are an electrolytic cathode structure that can suppress the degradation of an activated cathode even if a reverse current flows upon the stoppage of operation of an electrolyzer in an electrode structure allowing the distance between the electrode and an electrode current collector to be maintained at an approximately constant value, and an electrolyzer using the same.The electrolytic cathode structure includes a metal elastic cushion member 1 compressed and accommodated between an activated cathode 2 and a cathode current collector 3. At least a surface layer of the cathode current collector 3 consumes a larger oxidation current per unit area than the activated cathode. The electrolyzer is partitioned by an ion exchange membrane into an anode chamber for accommodating an anode and a cathode chamber for accommodating a cathode. The electrolytic cathode structure is used for the cathode.

摘要翻译： 提供了一种电解阴极结构，即使在电极结构中的电解槽停止操作时反向电流也能够抑制活性阴极的劣化，使电极和电极集电体之间的距离保持在约 恒定值，以及使用该值的电解槽。 电解阴极结构包括压缩并容纳在活性阴极2和阴极集电体3之间的金属弹性缓冲构件1.至少阴极集电体3的表面层消耗比活化阴极更大的每单位面积的氧化电流。 电解槽被离子交换膜分隔成阳极室，用于容纳用于容纳阴极的阳极和阴极室。 电解阴极结构用于阴极。