公开(公告)号：US20090281396A1

公开(公告)日：2009-11-12

申请号：US12414465

申请日：2009-03-30

申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

IPC分类号： A61B5/0215 ,  A61B5/0205

CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力，以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。

公开(公告)号：US20090093729A1

公开(公告)日：2009-04-09

申请号：US11866523

申请日：2007-10-03

申请人： Yunlong Zhang ,  Bin Mi ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Bin Mi ,  Yongxing Zhang

IPC分类号： A61B5/0215

CPC分类号： A61B5/02158 ,  A61B5/02007 ,  A61B5/02125 ,  A61B5/0285 ,  A61B5/029 ,  A61B5/1107 ,  A61B5/6876 ,  A61B5/6884 ,  A61B2562/0261 ,  A61B2562/0266

摘要： Embodiments of the invention are related to devices and methods for measuring arterial elasticity and/or blood pressure, amongst other things. In an embodiment, the invention includes an implantable medical device having a sensor element that is configured to engage a vessel of a patient. The sensor element is further configured to generate a signal in response to bending of the sensor element, where bending occurs as a result of changes in the pressure within the vessel. The implantable medical device further includes a controller in signal communication with the sensor element, where the controller is configured to store information regarding the signal generated by the sensor element. Other embodiments are also included herein.

摘要翻译： 本发明的实施例涉及用于测量动脉弹性和/或血压的装置和方法等。 在一个实施例中，本发明包括具有传感器元件的可植入医疗装置，该传感器元件构造成与患者的血管接合。 传感器元件还被配置为响应于传感器元件的弯曲而产生信号，其中由于容器内的压力变化而发生弯曲。 可植入医疗装置还包括与传感器元件信号通信的控制器，其中控制器被配置为存储关于由传感器元件产生的信号的信息。 本文还包括其它实施例。

公开(公告)号：US20090005829A1

公开(公告)日：2009-01-01

申请号：US11769402

申请日：2007-06-27

申请人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

发明人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

IPC分类号： A61N1/365 ,  A61B5/02

CPC分类号： A61N1/056 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/6846 ,  A61B5/6851 ,  A61N1/36514 ,  A61N1/36578

摘要： Embodiments of the invention are related to implantable devices including movement sensors and related methods for measuring cardiac performance, amongst other things. In an embodiment, the invention includes an implantable electrical stimulation lead. The electrical stimulation lead can include a lead body having a proximal end and a distal end and a sheath defining a central lumen. The lead body can further include an electrical conductor disposed within the central lumen of the sheath. The stimulation lead can further include a stimulation electrode positioned at the distal end of the lead body, the stimulation electrode in electrical communication with the electrical conductor. The electrical stimulation lead can include an flexion sensor coupled to the lead body, the movement sensor configured to generate a signal in response to movement of the lead body. In an embodiment, the invention includes a method of monitoring the condition of a heart failure patient. In an embodiment, the invention includes a method of treating unstable arrhythmia in a patient. Other embodiments are also included herein.

摘要翻译： 本发明的实施例涉及包括运动传感器和用于测量心脏性能的相关方法的可植入装置。 在一个实施例中，本发明包括可植入电刺激引线。 电刺激引线可以包括具有近端和远端的引线主体和限定中心内腔的护套。 引线体还可以包括设置在护套的中心腔内的电导体。 刺激引线还可以包括位于引线体的远端处的刺激电极，该刺激电极与电导体电连通。 电刺激引线可以包括耦合到引线主体的屈曲传感器，所述运动传感器被配置为响应于引线主体的移动而产生信号。 在一个实施例中，本发明包括监测心力衰竭患者状况的方法。 在一个实施方案中，本发明包括治疗患者不稳定性心律失常的方法。 本文还包括其它实施例。

公开(公告)号：US08068909B2

公开(公告)日：2011-11-29

申请号：US11769402

申请日：2007-06-27

申请人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

发明人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

IPC分类号： A61B5/02

CPC分类号： A61N1/056 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/6846 ,  A61B5/6851 ,  A61N1/36514 ,  A61N1/36578

摘要： Embodiments of the invention are related to implantable devices including movement sensors and related methods for measuring cardiac performance, amongst other things. In an embodiment, the invention includes an implantable electrical stimulation lead. The electrical stimulation lead can include a lead body having a proximal end and a distal end and a sheath defining a central lumen. The lead body can further include an electrical conductor disposed within the central lumen of the sheath. The stimulation lead can further include a stimulation electrode positioned at the distal end of the lead body, the stimulation electrode in electrical communication with the electrical conductor. The electrical stimulation lead can include an flexion sensor coupled to the lead body, the movement sensor configured to generate a signal in response to movement of the lead body. In an embodiment, the invention includes a method of monitoring the condition of a heart failure patient. In an embodiment, the invention includes a method of treating unstable arrhythmia in a patient. Other embodiments are also included herein.

摘要翻译： 本发明的实施例涉及包括运动传感器和用于测量心脏性能的相关方法的可植入装置。 在一个实施例中，本发明包括可植入电刺激引线。 电刺激引线可以包括具有近端和远端的引线主体和限定中心内腔的护套。 引线体还可以包括设置在护套的中心腔内的电导体。 刺激引线还可以包括位于引线体的远端处的刺激电极，该刺激电极与电导体电连通。 电刺激引线可以包括耦合到引线主体的屈曲传感器，所述运动传感器被配置为响应于引线主体的移动而产生信号。 在一个实施例中，本发明包括监测心力衰竭患者状况的方法。 在一个实施方案中，本发明包括治疗患者不稳定性心律失常的方法。 本文还包括其它实施例。

公开(公告)号：US08593107B2

公开(公告)日：2013-11-26

申请号：US12605579

申请日：2009-10-26

申请人： Avi Penner ,  Eyal Doron ,  Jeffrey E. Stahmann ,  Keith R. Maile ,  Binh C. Tran ,  Wangcai Liao ,  Bin Mi ,  Paul J. Huelskamp

发明人： Avi Penner ,  Eyal Doron ,  Jeffrey E. Stahmann ,  Keith R. Maile ,  Binh C. Tran ,  Wangcai Liao ,  Bin Mi ,  Paul J. Huelskamp

IPC分类号： H01M10/44

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/026 ,  A61N1/37217 ,  A61N1/3787

摘要： Methods, systems, and apparatus for recharging medical devices implanted within the body are disclosed. An illustrative method of recharging an implanted medical device includes delivering a charging device to a location adjacent to the implanted medical device, activating a charging element coupled to the charging device and transmitting charging energy to a receiver of the implanted medical device, and charging the implanted medical device using the transmitted charging energy from the charging device.

摘要翻译： 公开了用于对植入体内的医疗器械进行再充电的方法，系统和装置。 对植入式医疗装置再充电的说明性方法包括将充电装置传送到与植入的医疗装置相邻的位置，激活耦合到充电装置的充电元件，并将充电能量传输到植入的医疗装置的接收器， 使用来自充电装置的传输的充电能量的医疗装置。

公开(公告)号：US20130144174A1

公开(公告)日：2013-06-06

申请号：US13674639

申请日：2012-11-12

申请人： John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

发明人： John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

IPC分类号： A61B5/0205 ,  A61B5/03 ,  A61B5/20

CPC分类号： A61B5/0205 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/036 ,  A61B5/201 ,  A61B5/416 ,  A61B5/6846

摘要： An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device or in an external device/system.

摘要翻译： 用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器，用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期感测和产生 以周期性间隔代表患者的腹内压力值的输出。 提供至少一个第二可植入传感器用于感测和产生代表患者的第二生理参数的输出。 另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。 处理器可以驻留在另一个可植入设备中或外部设备/系统中。

公开(公告)号：US20110190669A1

公开(公告)日：2011-08-04

申请号：US13082954

申请日：2011-04-08

申请人： Bin Mi ,  Abhijeet V. Chavan ,  Keith R. Maile

发明人： Bin Mi ,  Abhijeet V. Chavan ,  Keith R. Maile

IPC分类号： A61N7/00

CPC分类号： A61N1/37288 ,  A61B5/0028 ,  A61N1/37217

摘要： Implantable medical devices including an ultrasonic transducer and methods of optimizing an ultrasonic transducer of an implantable medical device are disclosed. The implantable medical device can include a housing, an ultrasonic transducer disposed within an interior of the housing, and a limiting structure configured to constrain deformation of the ultrasonic transducer. The limiting structure can include a separate structure coupled to the housing, or can comprise a resonant portion of the housing itself. During operation, the ultrasonic transducer is configured to communicate at a frequency at or near a resonant frequency of the housing.

摘要翻译： 公开了包括超声换能器和优化可植入医疗装置的超声换能器的方法的可植入医疗装置。 可植入医疗装置可以包括壳体，设置在壳体内部的超声波换能器以及限制超声换能器变形的限制结构。 限制结构可以包括耦合到壳体的单独结构，或者可以包括壳体本身的谐振部分。 在操作期间，超声波换能器被配置为在壳体的谐振频率处或接近谐振频率处的频率进行通信。

公开(公告)号：US07912548B2

公开(公告)日：2011-03-22

申请号：US11781023

申请日：2007-07-20

申请人： Bin Mi ,  Abhijeet V. Chavan ,  John H. Tangren

发明人： Bin Mi ,  Abhijeet V. Chavan ,  John H. Tangren

IPC分类号： A61N1/375

CPC分类号： A61N1/37217

摘要： An implantable medical device comprising a housing and a limiting structure defining a resonant region in the housing. An acoustic transducer is connected to the limiting structure and extends into the resonant region so that the resonant region mechanically amplifies the deformation of the acoustic transducer at a resonant frequency. An implantable medical device comprising a housing and a limiting structure defining a resonant region in the housing. An acoustic transducer having the shape of a beam is mechanically coupled to the limiting structure and partially extends into the resonant region so that the resonant region mechanically amplifies the deformation of the acoustic transducer at a resonant frequency. An implantable medical device comprising a housing, an acoustic transducer coupled to the housing, and a means for mechanically amplifying the deformation of the acoustic transducer at a resonant frequency. The means defines a resonant region in the housing.

摘要翻译： 一种可植入医疗装置，其包括壳体和限定壳体中的谐振区域的限制结构。 声学换能器连接到限制结构并延伸到谐振区域，使得谐振区域以谐振频率机械放大声学换能器的变形。 一种可植入医疗装置，其包括壳体和限定壳体中的谐振区域的限制结构。 具有光束形状的声换能器机械耦合到限制结构，并且部分地延伸到谐振区域中，使得谐振区域以谐振频率机械放大声换能器的变形。 一种可植入医疗装置，包括壳体，耦合到壳体的声换能器，以及用于以谐振频率机械放大声换能器的变形的装置。 该装置限定壳体中的谐振区域。

公开(公告)号：US20100317978A1

公开(公告)日：2010-12-16

申请号：US12774990

申请日：2010-05-06

申请人： Keith R. Maile ,  Abhijeet V. Chavan ,  Thomas W. Piaget ,  Bin Mi

发明人： Keith R. Maile ,  Abhijeet V. Chavan ,  Thomas W. Piaget ,  Bin Mi

IPC分类号： A61B5/0215 ,  A61B5/00 ,  A61B5/03 ,  H02N2/18

CPC分类号： H01L41/1138 ,  A61B5/0031 ,  A61B5/0215 ,  H02N2/18

摘要： Methods, systems, and apparatus for powering and/or recharging medical devices implanted within the body are described. An illustrative implantable sensor for sensing one or more physiologic parameters within a body lumen includes a housing having an exterior wall that has an inner surface and an outer surface and that defines an internal cavity. A portion of the housing includes an electrically conductive material that functions as a first electrical conductor. A flexible piezoelectric layer is disposed adjacent to a portion of the exterior wall and a second electrical conductor is disposed adjacent to the piezoelectric layer. The piezoelectric layer is configured to displace in response to periodic pressure pulses within the body lumen and generate a voltage differential between the first and second electrical conductors.

摘要翻译： 描述了植入体内的医疗装置的供电和/或再充电的方法，系统和装置。 用于感测体腔内的一个或多个生理参数的说明性可植入传感器包括具有外壁的壳体，所述外壁具有内表面和外表面，并且限定内腔。 壳体的一部分包括用作第一电导体的导电材料。 柔性压电层设置成与外壁的一部分相邻，并且第二电导体邻近压电层设置。 压电层被配置为响应于体腔内的周期性压力脉冲而移位，并在第一和第二电导体之间产生电压差。

公开(公告)号：US20100049269A1

公开(公告)日：2010-02-25

申请号：US12611686

申请日：2009-11-03

申请人： Binh C. Tran ,  Robert S. Harguth ,  Bin Mi ,  Keith R. Maile

发明人： Binh C. Tran ,  Robert S. Harguth ,  Bin Mi ,  Keith R. Maile

IPC分类号： A61N1/08 ,  A61N1/365

CPC分类号： A61N1/3787 ,  A61N1/37217

摘要： An acoustic energy delivery system for delivering acoustic energy to an implantable medical device (“IMD”). The system includes an IMD having a power source and an energy delivery device. The energy delivery device includes a controller and an array of ultrasonic elements electrically coupled to the controller and configured to deliver acoustic energy to the IMD. Methods of delivering acoustic energy to an IMD are also disclosed.

摘要翻译： 用于将声能递送到可植入医疗装置（“IMD”）的声能递送系统。 该系统包括具有电源和能量输送装置的IMD。 能量输送装置包括控制器和电耦合到控制器并被配置为向IMD传送声能的超声波元件阵列。 还公开了向IMD传递声能的方法。