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公开(公告)号：US08946433B2
公开(公告)日：2015-02-03
申请号：US13233227
申请日：2011-09-15
IPC分类号： C07D409/06 , C07D211/58
CPC分类号： C07D409/06
摘要： The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
摘要翻译： 本公开通常涉及用于制备各种哌啶衍生物的改进方法。 更具体地说，本发明涉及一种制备舒芬太尼碱（1）和相关化合物的改进方法，其有利地利用更具成本效益和/或更不危险的试剂，包括包含约50重量％至约70重量％ 基于分散体的总重量）碱金属氢化物如氢化钠，并且不需要昂贵和/或耗时的纯化技术。
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12.发明授权公开(公告)号：US08946419B2
公开(公告)日：2015-02-03
申请号：US14045009
申请日：2013-10-03
申请人： Mallinckrodt LLC
IPC分类号： C07D489/00 , C07D489/08
CPC分类号： C07D489/08
摘要： The present invention provides (+)-morphinanium compounds comprising substituted 6-hydroxy or 6-amine groups. The invention also provides methods for inhibiting microglial activation by administering the compounds of the invention.
摘要翻译： 本发明提供包含取代的6-羟基或6-胺基团的（+） - 吗啉化合物。 本发明还提供了施用本发明化合物来抑制小胶质细胞活化的方法。
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公开(公告)号：US08900187B2
公开(公告)日：2014-12-02
申请号：US11551804
申请日：2006-10-23
申请人： James R. Small , David M. Brooks , Charles S. Neer , Frank M. Fago , Gary S. Wagner , Elaine Borgemenke , Sean Lafferty
发明人： James R. Small , David M. Brooks , Charles S. Neer , Frank M. Fago , Gary S. Wagner , Elaine Borgemenke , Sean Lafferty
CPC分类号： A61M5/14566 , A61M5/007 , A61M5/16827 , A61M2205/13 , A61M2205/3362 , A61M2205/502 , A61M2205/505 , A61M2205/583 , A61M2205/6018 , G06F19/00
摘要： A dual head contrast media injection system performs a patency check or test injection, determining flow rate and/or flow volume from the programmed protocol. The tubing that connects syringes to a patient shares only a short common section near to the patient. Appropriate injection steps are taken to compensate for tubing elasticity. A wireless remote control and a touch screen control are provided, improving functionality and information delivery. The display brightness is controlled based on the ambient light, and the display panel includes a double swivel permitting re-orientation. The orientation of the display may also be controlled based on, e.g., the current step, the tilt angle of the powerhead, or a manual control. Furthermore, the display is customizable to identify the type of fluid (contrast, saline, etc.) on either side of the injector, to provide matched color coding, and to provide a folder/tab analogy for retrieving injection protocol parameters.
摘要翻译： 双头造影剂注射系统执行通畅检查或测试注射，从编程的协议确定流量和/或流量。 将注射器连接到患者的管道仅在病人附近分配一个短的共同部分。 采取适当的注射步骤来补偿管道弹性。 提供无线遥控器和触摸屏控制器，改善功能和信息传递。 基于环境光来控制显示亮度，并且显示面板包括允许重新定向的双重旋转。 还可以基于例如当前步骤，动力头的倾斜角度或手动控制来控制显示器的取向。 此外，显示器可定制以识别注射器两侧的流体类型（对比度，盐水等），以提供匹配的颜色编码，并提供用于检索注射方案参数的文件夹/片段类比。
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14.发明授权Systems and methods for assaying an eluate for technetium and molybdenum content 有权用于测定锝和钼含量的洗脱液的系统和方法公开(公告)号：US08872124B2
公开(公告)日：2014-10-28
申请号：US13800248
申请日：2013-03-13
申请人： Mallinckrodt LLC
发明人： Kevin B. Graves , Bryan S. Petrofsky , Sumit Verma
摘要： A system for assaying an eluate for Technetium-99m and Molybdenum-99 content includes an inner ionization chamber including a well configured to receive the eluate, an outer ionization chamber concentric with the inner ionization chamber, and attenuating material positioned between the inner and outer ionization chambers. A computing device is configured to determine a Technetium-99m content of the eluate based on a first current measured in the inner ionization chamber, and determine a Molybdenum-99 content of the eluate based on at least a second current measured in the outer ionization chamber.
摘要翻译： 用于测定锝-99m和钼-99含量的洗脱液的系统包括内部电离室，其包括良好构造成接收洗脱液的内部电离室，与内部电离室同心的外部电离室，以及位于内部和外部电离之间的衰减材料 房间。 计算装置被配置为基于在内部电离室中测量的第一电流来确定洗脱物的锝-99m含量，并且基于在外部电离室中测量的至少第二电流来确定洗脱液的钼-99含量 。
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公开(公告)号：US08866104B2
公开(公告)日：2014-10-21
申请号：US13353888
申请日：2012-01-19
CPC分类号： G21F5/015 , G21F5/06 , G21F5/12 , G21G1/0005
摘要： An elution tool for a radiopharmaceutical elution system includes an elution tool. The tool has a vial chamber sized and shaped for receiving an elution vial. An access opening is aligned with a septum of the elution vial when the elution vial is received in the vial chamber. An elution tool lid is secured to the elution tool body by a hinged connection. The elution tool lid is rotatable at the hinged connection and movable relative to the elution tool body between an occluded position and an exposed position. The tool also includes a latching mechanism for selectively and releasably locking the lid in the occluded position.
摘要翻译： 用于放射性药物洗脱系统的洗脱工具包括洗脱工具。 该工具具有尺寸和形状用于接收洗脱小瓶的小瓶室。 当洗脱小瓶接收在小瓶室中时，进入口与洗脱小瓶的隔膜对齐。 洗脱工具盖通过铰接连接固定在洗脱工具主体上。 洗脱工具盖可以在铰链连接处旋转并且可以在闭塞位置和暴露位置之间相对于洗脱工具本体移动。 该工具还包括用于选择性地和可释放地将盖子锁定在闭塞位置的闩锁机构。
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公开(公告)号：US08861813B2
公开(公告)日：2014-10-14
申请号：US12921785
申请日：2009-03-05
CPC分类号： A61B6/467 , A61B6/0457 , A61G13/02 , G16H40/40
摘要： A foot-activated controller (70) for an imaging system (10) is disclosed. The foot-activated controller (70) may include a first controller section (80) and a second controller section (90) that may be disposed in each of a joined or separated state or configuration. The first controller section (80) may incorporate one or more first actuators (86) that are dedicated to communicating with one or more components that provide an imaging functionality (e.g., an imaging assembly (12)), while the second controller section (90) may incorporate one or more second actuators (96) that are dedicated to communicating with one or more components that provide a physical positioning functionality (e.g., a table positioner 38, where the table positioner (38) may be activated to control/establish the position of a table (32) on which a patient may be positioned for performance of one or more medical procedures (e.g., urology)).
摘要翻译： 公开了一种用于成像系统（10）的脚踏激活控制器（70）。 足部启动控制器（70）可以包括可以以联接或分离的状态或配置中的每一个布置的第一控制器部分（80）和第二控制器部分（90）。 第一控制器部分（80）可以包括专用于与提供成像功能的一个或多个部件（例如，成像组件（12））通信的一个或多个第一致动器（86），而第二控制器部分 ）可以包括专用于与提供物理定位功能的一个或多个部件通信的一个或多个第二致动器（96）（例如，工作台定位器38，其中工作台定位器（38）可以被激活以控制/建立 用于执行一个或多个医疗程序（例如，泌尿科））的患者可以定位在其上的工作台（32）的位置。
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公开(公告)号：US08842501B2
公开(公告)日：2014-09-23
申请号：US13015223
申请日：2011-01-27
摘要： Systems and methods for tracking dosage periods are disclosed. The systems and methods may include setting a timer (140) to a predetermined value corresponding to a dosage period in response to the engagement of a cover (110) to a container (120). An indication may be provided that corresponds to a remaining period in the dosage period set by the engagement of the cover (110) and container (120). The indication may also indicate a remaining time period in the dosage period.
摘要翻译： 公开了跟踪剂量期的系统和方法。 系统和方法可以包括响应于盖（110）与容器（120）的接合而将定时器（140）设置为对应于剂量周期的预定值。 可以提供对应于通过盖（110）和容器（120）的接合设定的剂量期间中的剩余时间段的指示。 指示也可以指示剂量期间的剩余时间段。
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18.发明申请Compositions Comprising An Opioid And An Additional Active Pharmaceutical Ingredient For Rapid Onset And Extended Duration Of Analgesia That May Be Administered Without Regard To Food 审中-公开组合物包含阿片样物质和一种额外的活性药物成分，可快速开始，延长使用寿命，可以在不食用的情况下进行公开(公告)号：US20140275143A1
公开(公告)日：2014-09-18
申请号：US14188582
申请日：2014-02-24
申请人： MALLINCKRODT LLC
发明人： Krishna R. Devarakonda , Michael J. Giuliani , Vishal K. Gupta , Ralph A. Heasley , Susan Shelby
IPC分类号： A61K31/485 , A61K9/24 , A61K9/20 , A61K31/167
CPC分类号： A61K31/485 , A61K9/2031 , A61K9/209 , A61K31/167 , A61K2300/00
摘要： The present disclosure provides pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state. The present disclosure further provides pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides reduced abuse potential.
摘要翻译： 本公开提供了包含阿片样物质和另外的活性药物成分的药物组合物，其中所述组合物显示出通过组合物的物理性质和阿片样物质的释放的组合来实现的胃保持性质，其中在给予受试者时， 组合物具有至少一种药物动力学参数，当受试者处于禁食状态时与给药状态相比差异小于约30％。 本公开进一步提供了包含羟考酮和对乙酰氨基酚的药物组合物，其提供了止痛剂的快速开始，并且在给药间隔结束时接近对乙酰氨基酚的水平降低。 还提供了包含羟考酮和对乙酰氨基酚的延长释放药物组合物，其提供降低的滥用潜力。
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公开(公告)号：US08809804B2
公开(公告)日：2014-08-19
申请号：US13353923
申请日：2012-01-19
CPC分类号： G21F5/015 , A61N5/1001 , A61N2005/1021 , A61N2005/1094 , G21F5/06 , G21G1/0005
摘要： A holder for a vial containing a sterile liquid for use with a radiopharmaceutical elution system includes a holder body. The body has a top, an opposing bottom, an opening in the top and a vial chamber. The vial chamber extends from the opening in the top toward the bottom and is sized and shaped for receiving the vial therein. An access opening extends through the bottom to the vial chamber and is aligned with a septum of the elution vial when the sterile vial is received in the vial chamber. A cap is removably secured to the top of the holder body for selectively opening and closing the vial chamber. The holder body includes plastic and has a density less than the density of the cap.
摘要翻译： 用于包含用于放射性药物洗脱系统的无菌液体的小瓶的保持器包括保持器主体。 身体具有顶部，相对的底部，顶部的开口和小瓶室。 小瓶室从顶部的开口朝向底部延伸，并且其尺寸和形状用于在其中接收小瓶。 当无菌小瓶接收在小瓶室中时，进入开口延伸穿过小瓶室并与洗脱小瓶的隔膜对齐。 帽可拆卸地固定到保持器主体的顶部，用于选择性地打开和关闭小瓶室。 保持器主体包括塑料并且具有小于盖的密度的密度。
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公开(公告)号：US08753590B2
公开(公告)日：2014-06-17
申请号：US13676219
申请日：2012-11-14
申请人： Mallinckrodt LLC
IPC分类号： C01F13/00
CPC分类号： B01J39/165 , B01D15/1864 , B01D15/1871 , B01D15/22 , B01D15/36 , B01J20/0222 , B01J39/17 , B01J45/00 , C01G39/02 , C01G45/02 , C01P2004/61 , C01P2006/80 , G21C19/46 , G21F9/12 , G21G2001/0036 , Y02W30/883 , Y10T428/2982 , Y10T428/2998
摘要： A solid composition comprises: MnO2; and a compound represented by the general formula (I) wherein: R is a polymer; each Y is independently a hydrogen or a negative charge; Z is either hydrogen or is not present; each n is independently 1, 2, 3, 4, 5 or 6; wherein the MnO2 is bound to the compound of formula (I) so as to coat the surface thereof. Such a composition may be used for the separation of polyvalent metal species, such as Mo, from one or more accompanying impurities.
摘要翻译： 固体组合物包含：MnO 2; 和由通式（I）表示的化合物，其中：R是聚合物; 每个Y独立地是氢或负电荷; Z是氢或不存在; 每个n独立地为1,2,3,4,5或6; 其中所述MnO 2与式（I）的化合物结合以涂覆其表面。 这种组合物可用于从一种或多种伴随的杂质分离多价金属物质，例如Mo。
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