公开(公告)号：US10271744B2

公开(公告)日：2019-04-30

申请号：US15136268

申请日：2016-04-22

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： Sanjiv Narayan ,  Carey Robert Briggs ,  Ruchir Sehra

IPC分类号： A61B5/024 ,  A61B5/00 ,  A61B5/042 ,  A61B5/04 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/046

摘要： In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.

公开(公告)号：US09895072B2

公开(公告)日：2018-02-20

申请号：US14247330

申请日：2014-04-08

申请人： Topera, Inc.

发明人： Thomas F. Kordis ,  Eric T. Johnson ,  Phillip C. Burke ,  Darrin J. Kent ,  Robert Ryan Ragland

IPC分类号： A61B5/042 ,  A61B5/00 ,  A61B18/14 ,  A61B18/00

CPC分类号： A61B5/0422 ,  A61B5/042 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2562/17 ,  F04C2270/0421 ,  Y10T29/49117

摘要： A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.

公开(公告)号：US09504399B2

公开(公告)日：2016-11-29

申请号：US13929838

申请日：2013-06-28

申请人： Topera, Inc.

发明人： Thomas F. Kordis ,  Eric T. Johnson ,  Phillip C. Burke ,  Darrin J. Kent ,  Kevin M. Magrini ,  Jeff A. Burke ,  Robert Ryan Ragland

IPC分类号： A61B18/18 ,  A61B5/042 ,  A61B5/00 ,  A61B18/14 ,  A61B5/04 ,  A61B18/00

CPC分类号： A61B5/0422 ,  A61B5/042 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2562/17 ,  F04C2270/0421 ,  Y10T29/49117

摘要： A system for sensing monophasic action potentials from endocardial tissue of a heart, includes: a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines; a tip for securably affixing the distal portions of the splines; and a polymeric member including opposed a first open end and a second open end defining an open lumen therein between, where at least one of the plurality of flexible splines is at least partially disposed within the lumen of the polymeric member; a flexible electrode assembly strip with two or more exposed electrodes oppositely disposed on at least a portion of the outer surface of the polymeric member.

摘要翻译： 用于感测来自心脏心内膜组织的单相动作电位的系统包括：多个柔性花键; 锚固件，用于牢固地固定花键的近端部分; 用于牢固地固定花键的远端部分的尖端; 以及聚合物构件，其包括相对的第一开口端和限定其中的开放腔的第二开口端，其中所述多个柔性花键中的至少一个至少部分地设置在所述聚合构件的内腔内; 具有两个或多个暴露电极的柔性电极组合带，所述两个或多个暴露电极相对设置在聚合物构件的外表面的至少一部分上。

公开(公告)号：US08868169B2

公开(公告)日：2014-10-21

申请号：US14137929

申请日：2013-12-20

申请人： Sanjiv Narayan ,  Ruchir Sehra

发明人： Sanjiv Narayan ,  Ruchir Sehra

IPC分类号： A61B5/0456 ,  A61B5/0464 ,  A61B5/042 ,  A61B5/0472 ,  A61B5/046 ,  A61B5/0452 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0432 ,  A61B5/044 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/4857 ,  A61B5/6852 ,  A61B5/7221 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7278

摘要： System, assembly and method are provided to facilitate reconstruction of cardiac information representing a complex rhythm disorder associated with a patient's heart to indicate a source of the heart rhythm disorder. The complex rhythm disorder can be treated by application of energy to modify the source of the rhythm disorder.

摘要翻译： 提供系统，组装和方法以便于重建表示与患者心脏相关联的复杂节律紊乱的心脏信息，以指示心律失常的来源。 可以通过施加能量来改变节律紊乱的来源来治疗复杂的节律紊乱。

公开(公告)号：US20140066787A1

公开(公告)日：2014-03-06

申请号：US14074619

申请日：2013-11-07

申请人： Topera, Inc. ,  The Regents of the University of California

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/0205 ,  A61B5/0452

CPC分类号： A61B5/02405 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/743 ,  A61B18/02 ,  A61B18/12 ,  A61B18/18 ,  A61B2018/00577 ,  A61B2562/046

摘要： An example system and method of processing cardiac activation information are disclosed. The method includes accessing a first cardiac signal and a second cardiac signal obtained from a patient. The first cardiac signal and the second cardiac signal are processed to determine whether there is a point of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to a derivative of the second cardiac signal above a threshold. An activation onset time is assigned in the first cardiac signal at the point of change to define a cardiac activation if the point of change is in the first cardiac signal.

摘要翻译： 公开了一种处理心脏激活信息的示例系统和方法。 该方法包括访问从患者获得的第一心脏信号和第二心脏信号。 处理第一心脏信号和第二心脏信号以确定在第一心脏信号中是否存在相对于高于阈值的第二心脏信号的导数发散的第一心脏信号的导数的改变点。 如果变化点在第一心脏信号中，则在改变点的第一心脏信号中分配激活起始时间以定义心脏激活。

公开(公告)号：US20130150742A1

公开(公告)日：2013-06-13

申请号：US13470705

申请日：2012-05-14

申请人： Carey Robert Briggs ,  Sanjiv Narayan

发明人： Carey Robert Briggs ,  Sanjiv Narayan

IPC分类号： A61B5/0452

CPC分类号： A61B5/0468 ,  A61B5/002 ,  A61B5/02405 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7257 ,  A61B5/7425 ,  A61B5/743 ,  A61B8/02

摘要： An example system and method of determining regularity associated with a rhythm disorder of a heart are disclosed. In accordance with the method, a derivative of a first cardiac signal at a plurality of first time points is processed against a derivative of a second cardiac signal at a plurality of second time points to define a plurality of coordinate pairs of the first cardiac signal against the second cardiac signal. Thereafter, an index of regularity that exceeds a threshold is determined. The index of regularity indicates an approximate congruence of the plurality of coordinate pairs among the first cardiac signal and the second cardiac signal.

摘要翻译： 公开了一种确定与心律紊乱有关的规律性的实例系统和方法。 根据该方法，在多个第二时间点针对多个第一时间点的第一心脏信号的导数来处理第一心脏信号的导数，以定义第一心脏信号的多个坐标对与 第二个心脏信号。 此后，确定超过阈值的规律性指数。 规律性指数表示第一心脏信号和第二心脏信号之间的多个坐标对的近似一致性。

公开(公告)号：US08364236B2

公开(公告)日：2013-01-29

申请号：US13409352

申请日：2012-03-01

申请人： Jeff A. Burke ,  Eric T. Johnson ,  Thomas F. Kordis ,  Darrin J. Kent ,  Kevin M. Magrini

发明人： Jeff A. Burke ,  Eric T. Johnson ,  Thomas F. Kordis ,  Darrin J. Kent ,  Kevin M. Magrini

IPC分类号： A61B5/042

CPC分类号： A61B5/0422 ,  A61B5/042 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2562/17 ,  F04C2270/0421 ,  Y10T29/49117

摘要： A device for insertion into a body lumen, includes: an electrode assembly strip with exposed electrodes including: a polymeric substrate having an upper surface and an opposed lower surface; one or more electrodes disposed over a portion of the upper surface of the polymeric substrate; one or more electrical traces disposed over a portion of the lower surface of the polymeric substrate in electrical communication with the one or more electrodes by way of metal plated holes through the substrate; and a flexible polymeric substrate having a substrate surface and a substrate wall; wherein the electrode assembly strip is compressingly and thermally bonded to the substrate surface of the flexible polymeric substrate to define a flexible electrode assembly strip; and wherein the electrode assembly strip has a thickness from about 0.0005 inches to about 0.008 inches.

摘要翻译： 一种用于插入体腔的装置，包括：具有暴露电极的电极组件带，包括：具有上表面和相对的下表面的聚合物基底; 设置在聚合物基材的上表面的一部分上的一个或多个电极; 一个或多个电迹线设置在所述聚合物基底的下表面的一部分上，通过穿过所述基底的金属电镀孔与所述一个或多个电极电连通; 以及具有衬底表面和衬底壁的柔性聚合物衬底; 其中所述电极组合条被压缩并热粘合到所述柔性聚合物基底的所述基底表面以限定柔性电极组合带; 并且其中所述电极组件条的厚度为约0.0005英寸至约0.008英寸。

公开(公告)号：US20130006131A1

公开(公告)日：2013-01-03

申请号：US13462534

申请日：2012-05-02

申请人： Sanjiv Narayan ,  Carey Robert Briggs

发明人： Sanjiv Narayan ,  Carey Robert Briggs

IPC分类号： A61B5/02 ,  A61B18/12

CPC分类号： A61B5/04012 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4029 ,  A61B5/4064 ,  A61B5/4839 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M5/00 ,  A61N1/0565 ,  G06F19/00

摘要： Provided is a system and method to target a biological rhythm disorder, such as a heart rhythm disorder. The system and method include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the heart rhythm disorder.

摘要翻译： 提供了一种靶向生物节律紊乱（如心律失常）的系统和方法。 该系统和方法包括经由计算设备处理心脏信号，以确定由与生物节律紊乱相关联的源所限定的组织区域中的形状，该生物节律障碍在空间上或在该形状内迁移，以及识别组织的至少一部分 以使得能够选择性地修饰组织的至少一部分以终止或改变心律失常的形状。

公开(公告)号：US20120271140A1

公开(公告)日：2012-10-25

申请号：US13409332

申请日：2012-03-01

申请人： Thomas F. Kordis ,  Eric T. Johnson ,  Phillip C. Burke ,  Darrin J. Kent ,  Robert Ryan Ragland

发明人： Thomas F. Kordis ,  Eric T. Johnson ,  Phillip C. Burke ,  Darrin J. Kent ,  Robert Ryan Ragland

IPC分类号： A61B5/04

CPC分类号： A61B5/0422 ,  A61B5/042 ,  A61B5/6858 ,  A61B5/6859 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2562/17 ,  F04C2270/0421 ,  Y10T29/49117

摘要： A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: a first elongate tubular member having a lumen, a proximal end and a distal end; and a basket assembly including: a plurality of flexible splines for guiding a plurality of exposed electrodes, the splines having proximal portions and distal portions; an anchor for securably affixing the proximal portions of the splines; the anchor being secured at the distal end of the first elongate tubular member; an encapsulated and filament-wrapped distal tip including an encapsulant and a filament for securably affixing the distal portions of the splines in a predetermined angular relationship at the distal tip; wherein the splines comprise a superelastic material; and wherein the basket assembly has a radially expanded non-cylindrical shape.

摘要翻译： 一种用于感测来自心脏心内膜表面的多个局部电压的系统，包括：具有内腔，近端和远端的第一细长管状构件; 以及篮组件，其包括：多个柔性花键，用于引导多个暴露的电极，所述花键具有近端部分和远端部分; 锚固件，用于牢固地固定花键的近端部分; 所述锚固件固定在所述第一细长管状构件的远端处; 封装和长丝缠绕的远端尖端，其包括密封剂和长丝，用于以预定的角度关系在所述远侧末端固定所述花键的远端部分; 其中所述花键包括超弹性材料; 并且其中所述筐组件具有径向膨胀的非圆柱形形状。

公开(公告)号：US10856760B2

公开(公告)日：2020-12-08

申请号：US15649494

申请日：2017-07-13

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  TOPERA, INC.

发明人： Sanjiv M. Narayan ,  Ruchir Sehra

IPC分类号： A61B5/04 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/042 ,  A61B5/0472 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/00 ,  A61B5/0255 ,  A61B5/0432 ,  A61B5/044

摘要： A system for processing cardiac activation information associated with a complex rhythm disorder identifies a location of the heart rhythm disorder by determining activations within cardiac signals obtained at neighboring locations of the heart and arranging the activations to identify an activation trail. The activation trail may define a rotational pattern or radially emanating pattern corresponding to an approximate core of the heart rhythm disorder.