公开(公告)号：US11730799B2

公开(公告)日：2023-08-22

申请号：US17304953

申请日：2021-06-29

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  THE UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRS

发明人： David M. Lubaroff ,  Delbert L. Harris

IPC分类号： A61K39/00 ,  A61P35/00 ,  C12N7/00

CPC分类号： A61K39/001193 ,  A61K39/001194 ,  A61K39/001195 ,  A61P35/00 ,  C12N7/00 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/884 ,  C12N2710/10341 ,  C12N2770/36123 ,  C12N2770/36143

摘要： A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer.

公开(公告)号：US20230190903A1

公开(公告)日：2023-06-22

申请号：US18080634

申请日：2022-12-13

申请人： Janssen Biotech, Inc.

发明人： Patrick WILKINSON ,  Manuel Alejandro SEPULVEDA ,  Charles George DRAKE ,  Derick Siegel

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/001193 ,  A61K39/3955 ,  A61P35/00 ,  A61K2039/5256 ,  A61K2039/70 ,  A61K2039/545

摘要： Disclosed herein are methods of treating or preventing prostate cancer in a subject, the methods comprising administering to the subject a treatment regimen comprising two or more vaccines comprising a great ape adenovirus serotype 20 (GAd20) virus that, in turn, comprises a nucleotide sequence encoding the amino acid sequence of SEQ ID NO: 1 and one or more vaccines comprising a Modified Vaccinia Ankara (MVA) virus that, in turn, comprises a nucleotide sequence encoding the amino acid sequence of SEQ ID NO: 3 to thereby treat or prevent the prostate cancer.

公开(公告)号：US20240216493A1

公开(公告)日：2024-07-04

申请号：US18607029

申请日：2024-03-15

申请人： HDT Bio Corp

发明人： Steven Gregory Reed ,  Darrick Albert Carter ,  Malcolm Scott Duthie ,  Lars Peter Aksel Berglund ,  Jesse Hong-Sae Erasmus ,  Jiho Kim

IPC分类号： A61K39/00 ,  A61K9/48 ,  A61K9/50 ,  A61K9/51 ,  C12N15/86

CPC分类号： A61K39/001193 ,  A61K9/4858 ,  A61K9/5015 ,  A61K9/5115 ,  A61K9/5123 ,  A61K39/001156 ,  A61K39/001186 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/6075 ,  C12N2720/12143

摘要： The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Compositions described herein include lipid carriers, optionally including an inorganic particle, capable of admixing with nucleic acids. Nucleic acids provided herein include those encoding for cancer antigens (full length proteins or fragments) as well as antibodies. Methods of using the compositions as a therapeutic vaccine for the treatment of a cancer are also provided.

公开(公告)号：US20240122992A1

公开(公告)日：2024-04-18

申请号：US18350557

申请日：2023-07-11

申请人： Northwestern University

发明人： Jonathan F. Anker ,  Praveen Thumblkat ,  Sarki A. Abdulkadir ,  Anthony J. Schaeffer

IPC分类号： A61K35/74 ,  A61K39/00 ,  A61K39/108 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28

CPC分类号： A61K35/74 ,  A61K39/001193 ,  A61K39/001194 ,  A61K39/0258 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505 ,  A61K2039/523 ,  A61K2039/585 ,  A61K2039/884 ,  C12N2740/16043

摘要： Provided herein are composition and methods for the treatment of cancer by the administration of uropathogenic bacteria. In particular, CP1 E. coli is administered for the treatment of prostate cancer.

公开(公告)号：US20240115684A1

公开(公告)日：2024-04-11

申请号：US18492311

申请日：2023-10-23

申请人： Madison Vaccines Inc.

发明人： Doug McNeel ,  Richard Lesniewski

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04 ,  C07K16/28

CPC分类号： A61K39/001193 ,  A61K39/0011 ,  A61K39/001163 ,  A61K39/3955 ,  A61P35/00 ,  A61P35/04 ,  C07K16/2818 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/545 ,  C07K16/3069

摘要： Provided herein is technology relating to cancer treatment and prevention and particularly, but not exclusively, to compositions and methods related to therapies for prostate cancer.

公开(公告)号：US11892452B2

公开(公告)日：2024-02-06

申请号：US17328364

申请日：2021-05-24

申请人： The Regents of the University of California

发明人： Lawrence H. Fong ,  Serena Kwek MacPhee

IPC分类号： C07K14/705 ,  C07K16/30 ,  G01N33/564 ,  A61P35/00 ,  A61P37/04 ,  G01N33/574 ,  A61K39/395 ,  C07K14/47 ,  A61K39/00

CPC分类号： G01N33/57434 ,  A61K39/0011 ,  A61K39/001193 ,  A61K39/39558 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/30 ,  G01N33/564 ,  C07K2317/24 ,  G01N2800/042 ,  G01N2800/104 ,  G01N2800/50 ,  G01N2800/52 ,  Y02A50/30 ,  A61K39/39558 ,  A61K2300/00

摘要： The present disclosure provides synthetic antibodies specific for a disease-associated antigen, and methods of using the antibodies in disease therapy. The present disclosure further provides diagnostic assays involving detecting the presence and/or level in biological sample of an antibody specific for a disease-associated antigen.

公开(公告)号：US11771759B2

公开(公告)日：2023-10-03

申请号：US16491550

申请日：2018-01-24

申请人： FUDAN UNIVERSITY

发明人： Bin Wang ,  Weidong Zhao ,  Gan Zhao ,  Yiwei Zhong

IPC分类号： A61K39/29 ,  A61P35/00 ,  A61K39/00 ,  A61K39/09 ,  A61K39/39 ,  C12N7/00 ,  C07K14/52 ,  C07K14/535 ,  C07K14/565

CPC分类号： A61K39/29 ,  A61K39/001157 ,  A61K39/001186 ,  A61K39/001193 ,  A61K39/092 ,  A61K39/39 ,  A61P35/00 ,  C07K14/52 ,  C07K14/535 ,  C07K14/565 ,  C12N7/00 ,  A61K2039/545 ,  A61K2039/55522 ,  A61K2039/804 ,  A61K2039/812 ,  A61K2039/868 ,  A61K2039/884 ,  A61K2039/892 ,  C12N2730/10011 ,  C12N2730/10034 ,  C12N2730/10134

摘要： An immune enhancer comprising at least an interferon and a granulocyte-macrophage colony-stimulating factor, and an immunotherapeutic phar-maceutical composition comprising at least an antigen and the above-mentioned immune enhancers is disclosed. A preparation method of the immunotherapeutic pharmaceutical composition, the use of the immune enhancer and the immunotherapeutic pharmaceutical composition are also disclosed. The immune enhancer can be applied to disease and tumor treatments caused by viruses, bacteria, and other microorganisms.

公开(公告)号：US20230201341A1

公开(公告)日：2023-06-29

申请号：US18053659

申请日：2022-11-08

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： Douglas McNeel ,  Donghwan Jeon

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P35/00

CPC分类号： A61K39/39 ,  A61K39/001193 ,  A61P35/00 ,  A61K2039/53 ,  A61K2039/55561 ,  A61K2039/55511

摘要： The present invention provides the combination of TLR3 agonist and TLR9 agonist can be used to increase the anti-tumor immune response to vaccines, particularly nucleic acid vaccines. Methods of treating cancer and inducing anti-tumor immune responses by treating with a TLR3 agonist and a TLR9 agonist in combination with administration of an anti-tumor vaccine are provided. The TLR3 agonist, TLR9 agonist and the vaccine may be co-administered in a unitary composition or the agonists may be administered in advance of the vaccine.

公开(公告)号：US12042530B2

公开(公告)日：2024-07-23

申请号：US17170044

申请日：2021-02-08

申请人： University of Virginia Patent Foundation ,  The University of Birmingham

发明人： Donald F. Hunt ,  Jeffrey Shabanowitz ,  Stacy Alyse Malaker ,  Victor H. Engelhard ,  Angela L. Ambakhutwala ,  Kara L. Cummings ,  Rebecca C. Obeng ,  Mark Cobbold

IPC分类号： A61K38/00 ,  A61K35/15 ,  A61K35/17 ,  A61K39/00 ,  A61K45/06 ,  C07K16/28 ,  G01N33/574 ,  G01N33/68

CPC分类号： A61K39/0011 ,  A61K35/15 ,  A61K35/17 ,  A61K39/001106 ,  A61K39/00111 ,  A61K39/001113 ,  A61K39/001132 ,  A61K39/001151 ,  A61K39/001156 ,  A61K39/001157 ,  A61K39/001162 ,  A61K39/001164 ,  A61K39/001166 ,  A61K39/001181 ,  A61K39/001182 ,  A61K39/001184 ,  A61K39/001186 ,  A61K39/001188 ,  A61K39/001189 ,  A61K39/00119 ,  A61K39/001192 ,  A61K39/001193 ,  A61K39/001194 ,  A61K39/001195 ,  A61K39/001197 ,  A61K45/06 ,  C07K16/2809 ,  C07K16/2833 ,  G01N33/57496 ,  G01N33/6863 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55516 ,  A61K2039/57 ,  C07K2317/31

摘要： A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.

公开(公告)号：US12005078B2

公开(公告)日：2024-06-11

申请号：US15756937

申请日：2016-09-06

申请人： The UAB Research Foundation ,  Emory University ,  Children's Healthcare of Atlanta, Inc.

发明人： Lawrence S. Lamb ,  H. Trent Spencer ,  G. Yancey Gillespie

IPC分类号： A61K35/17 ,  A61K31/495 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C07K14/715 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  C12N9/12

CPC分类号： A61K35/17 ,  A61K31/495 ,  A61K39/0011 ,  A61K39/001104 ,  A61K39/001106 ,  A61K39/001109 ,  A61K39/00111 ,  A61K39/001112 ,  A61K39/001113 ,  A61K39/001119 ,  A61K39/001122 ,  A61K39/001124 ,  A61K39/001126 ,  A61K39/001129 ,  A61K39/00115 ,  A61K39/001151 ,  A61K39/001164 ,  A61K39/001166 ,  A61K39/001168 ,  A61K39/001171 ,  A61K39/001174 ,  A61K39/001181 ,  A61K39/001182 ,  A61K39/001188 ,  A61K39/001189 ,  A61K39/00119 ,  A61K39/001193 ,  A61K39/001195 ,  A61K45/06 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/7155 ,  C07K16/30 ,  C12N5/0636 ,  C12N5/0638 ,  C12N5/0646 ,  C12N9/12 ,  C12Y207/10001 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2300/00 ,  C07K2319/70 ,  C12N2501/72 ,  C12N2510/00 ,  A61K31/495 ,  A61K2300/00

摘要： The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.