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281 条记录 (耗时 0.024 秒)

    Process for the preparation of stable polymer concentrates
    11.
    发明授权
    Process for the preparation of stable polymer concentrates 失效
    制备稳定聚合物浓缩物的方法

    公开(公告)号：US07300914B2

    公开(公告)日：2007-11-27

    申请号：US10817399

    申请日：2004-04-02

    申请人： Matthias Loeffler ,  Roman Morschhaeuser

    发明人： Matthias Loeffler ,  Roman Morschhaeuser

    IPC分类号： C11D3/37 ,  C11D3/43 ,  C08F291/00

    CPC分类号： A61K8/8158 ,  A61Q19/00 ,  C08F6/12 ,  C08F20/58

    摘要： Process for preparing stable polymer concentrates, wherein acryloyldimethyltaurine and/or acryloyldimethyltaurate are free-radically polymerized with at least one further component in the presence of a polymerization medium, a higher-boiling solvent or solvent mixture is added to the resulting reaction product or reaction mixture, and the lower-boiling polymerization medium is removed, optionally under reduced pressure.

    摘要翻译： 制备稳定的聚合物浓缩物的方法，其中丙烯酰基二甲基牛磺酸和/或丙烯酰基二甲基牛磺酸酯在聚合介质存在下与至少一种其它组分自由基聚合，向所得反应产物或反应混合物中加入高沸点溶剂或溶剂混合物 ，并且任选地在减压下除去低沸点聚合介质。

    Process for the preparation of stable polymer concentrates
    13.
    发明申请
    Process for the preparation of stable polymer concentrates 审中-公开
    制备稳定聚合物浓缩物的方法

    公开(公告)号：US20040260010A1

    公开(公告)日：2004-12-23

    申请号：US10817364

    申请日：2004-04-02

    申请人： Clariant GmbH

    发明人： Matthias Loeffler ,  Roman Morschhaeuser

    IPC分类号： C10M101/00

    CPC分类号： C08F6/12 ,  A61K8/8152 ,  A61Q17/04 ,  A61Q19/00 ,  C08F20/58

    摘要： A process for the preparation of concentrates which comprise 5 to 80% by weight of a copolymer based on acryloyldimethyltauric acid or salts thereof, 20 to 95% by weight of one or more emulsifiers and/or a solvent or solvent mixture and 0 to 30% by weight of water is described. The concentrates can, for example, be used for the preparation of cosmetic, pharmaceutical and dermatological preparations.

    摘要翻译： 一种制备浓缩物的方法，其包含5-80重量％的基于丙烯酰基二甲基牛磺酸或其盐的共聚物，20至95重量％的一种或多种乳化剂和/或溶剂或溶剂混合物和0至30％ 的水被描述。 浓缩物可以例如用于制备化妆品，药​​物和皮肤病学制剂。

    (Meth)acryloyloxy substituted acetylsalicylates and polymers thereof
    16.
    发明授权
    (Meth)acryloyloxy substituted acetylsalicylates and polymers thereof 失效
    （甲基）丙烯酰氧取代的乙酰水杨酸酯及其聚合物

    公开(公告)号：US5693320A

    公开(公告)日：1997-12-02

    申请号：US614016

    申请日：1996-03-12

    申请人： Masamune Sakai ,  Hiroyuki Ikeda ,  Noriaki Kaneko ,  Yutaka Tamura

    发明人： Masamune Sakai ,  Hiroyuki Ikeda ,  Noriaki Kaneko ,  Yutaka Tamura

    IPC分类号： C07C233/55 ,  C08F20/30 ,  C08F20/58 ,  C07C229/00 ,  C08F20/18 ,  C08K5/01

    CPC分类号： C08F20/30 ,  C07C233/55 ,  C08F20/58

    摘要： Novel acetylsalicylic acid derivatives having general formula (I) are provided, in which R.sup.1 is hydrogen or methyl; R.sup.2 is --O-- or --NH--; and W is hydroxy, halogen, lower alkoxy, lower alkenyloxy, lower alkynyloxy, cycloalkyloxy, aryloxy, aralkyloxy, acyloxy, or --N(R.sup.3)(R.sup.4) wherein the lower alkoxy, the lower alkenyloxy, the lower alkynyloxy, the cycloalkyloxy, the aryloxy, the aralkyloxy, and the acyloxy are optionally substituted with hydroxy, carboxyl, lower alkoxy, lower alkyl, halogen, nitro, and amino. The invention also pertains to a polymer made from such derivatives and a medical equipment containing the polymer. The polymer is useful in the prevention of platelet aggregation thereon. ##STR1##

    摘要翻译： 提供了具有通式（I）的新型乙酰水杨酸衍生物，其中R 1是氢或甲基; R2是-O-或-NH-; 并且W是羟基，卤素，低级烷氧基，低级链烯氧基，低级炔氧基，环烷氧基，芳氧基，芳烷氧基，酰氧基或-N（R3）（R4），其中低级烷氧基，低级烯氧基，低级炔氧基，环烷氧基， 芳氧基，芳烷氧基和酰氧基任选被羟基，羧基，低级烷氧基，低级烷基，卤素，硝基和氨基取代。 本发明还涉及由这样的衍生物制成的聚合物和含有聚合物的医疗设备。 聚合物可用于预防血小板聚集。

    Formulations for polyacrylamide matrices in electrokinetic and chromatographic methodologies
    18.
    发明授权
    Formulations for polyacrylamide matrices in electrokinetic and chromatographic methodologies 失效
    电动和色谱方法中聚丙烯酰胺基质的配方

    公开(公告)号：US5470916A

    公开(公告)日：1995-11-28

    申请号：US244608

    申请日：1994-06-03

    申请人： Pier G. Righetti ,  Marcella Chiari

    发明人： Pier G. Righetti ,  Marcella Chiari

    IPC分类号： C08F20/56 ,  B01J20/26 ,  B01J20/285 ,  B01J20/291 ,  C08F2/00 ,  C08F2/46 ,  C08F20/52 ,  C08F20/58 ,  C08F220/58 ,  G01N27/447 ,  G01N30/88 ,  C08F120/58

    CPC分类号： B01J20/291 ,  B01J20/26 ,  C08F20/58 ,  G01N27/44747 ,  B01J2220/54

    摘要： Matrices for electrokinetic and chromatographic separations, based on a unique class of mono- and disubstituted (on the amido nitrogen) acrylamides (e.g., acrylamido-N-ethoxy ethanol, acrylamido-N,N-diethoxy ethanol) off erthe following advantages: a) strong resistance to the alkaline hydrolysis (most zone separations occurring at basic pH values); b) a high hydrophilicity; and c) greater porosity, due to the larger M.sub.r value of the monomers. Such matrices can be prepared as `chemically crosslinked` gels or as `physical` gels, the latter consisting of strings of monofunctional monomer in the absence of crosslinker, at concentrations above the entanglement threshold. It is moreover possible to further increment the gel porosity by polymerizing it in the presence of laterally aggregating agents (e.g., polyethylene glycol of M.sub.r 6-20,000 Da), thus obtaining matrices which allow better resolution of large M.sub.r proteins and of nucleic acid fragments; by polymerizing the matrix in the presence of a gradient of the laterally aggregating agent, it is possible to obtain a porosity gradient even at a constant percent of monomers in the gel. Finally, photopolymerization (e.g., with methylene blue and a redox couple, sodium toluene sulfinate and diphenyliodonium chloride and light), instead with the standard red/ox catalysts, prevents formation of N-oxides of amines present in the polymerizing solution.

    摘要翻译： PCT No.PCT / EP92 / 01772 Sec。 371日期：1994年6月3日 102（e）日期1994年6月3日PCT提交1992年8月5日PCT公布。 公开号WO93 / 11174 日期6月10日，电动和色谱分离的基础，基于单和二取代（在酰氨基氮）丙烯酰胺（例如丙烯酰胺-N-乙氧基乙醇，丙烯酰氨基-N，N-二乙氧基乙醇）上的独特类型， 具有以下优点：a）对碱性水解的强抗性（在碱性pH值下发生的大多数区域分离）; b）高亲水性; 和c）由于单体的Mr值越大，孔隙率越大。 这样的基质可以制备成“化学交联的”凝胶或者称为“物理”凝胶，后者由不含交联剂的单官能单体串组成，浓度高于纠缠阈值。 此外，还可以通过在横向聚集剂（例如，6-20,000Da的聚乙二醇）存在下聚合来进一步增加凝胶孔隙度，从而获得能够更好地分辨大的Mr蛋白质和核酸片段的基质; 通过在侧向聚集剂的梯度存在下聚合基质，即使在凝胶中单体的百分比恒定也可获得孔隙度梯度。 最后，光聚合（例如，亚甲基蓝和氧化还原对，甲苯磺酸钠和二苯基碘鎓氯化物和光）代替标准的红/氧催化剂，防止聚合溶液中存在的胺的N-氧化物的形成。

    Polymeric supports
    19.
    发明授权
    Polymeric supports 失效
    聚合物载体

    公开(公告)号：US5403902A

    公开(公告)日：1995-04-04

    申请号：US183063

    申请日：1994-01-18

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    IPC分类号： A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/48 ,  C08F20/58 ,  C12N11/08 ,  C08F26/06 ,  C08F220/10 ,  C08F220/54

    CPC分类号： C12N11/08 ,  A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00 ,  C08F8/48

    摘要： Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional supports have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1, the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物载体是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及酶或其它生物活性载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯官能载体具有下式的单元：其中R 1为H或CH 3，R 2和R 3可独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基，芳基 具有5至12个环原子，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成含有4至 12个环原子，n为0或1的整数，所述吖内酯官能载体中含有0.1至99摩尔份的交联单体。

    Low molecular weight acrylamidoglycolate crosslinker and process
    20.
    发明授权
    Low molecular weight acrylamidoglycolate crosslinker and process 失效
    低分子量丙烯酰氨基乙酸酯交联剂和工艺

    公开(公告)号：US5369204A

    公开(公告)日：1994-11-29

    申请号：US18483

    申请日：1993-02-16

    申请人： Kuang-Jong Wu ,  Howard R. Lucas ,  Robert G. Lees ,  Nicholas J. Albrecht

    发明人： Kuang-Jong Wu ,  Howard R. Lucas ,  Robert G. Lees ,  Nicholas J. Albrecht

    IPC分类号： C08F20/58 ,  C08F212/06 ,  C08F214/02 ,  C08F214/18 ,  C08F218/02 ,  C08F220/28 ,  C08F220/42 ,  C08F220/54

    CPC分类号： C08F20/58

    摘要： Low molecular weight crosslinking agents useful in coatings based on esters of acrylamidoglycolate ethers are disclosed. The copolymeric crosslinking agents of the invention are prepared by copolymerizing a reactive acrylamidoglycolate monomer such as MAGME.RTM. methyl acrylamidoglycolate methyl ether with comonomers such as methyl methacrylate or butyl acrylate. The process of preparing the copolymeric crosslinkers of the invention makes use of chain transfer agents to limit the molecular weight of the crosslinking agents to 10,000 or less.

    摘要翻译： 公开了可用于基于丙烯酰胺基乙醇酸酯的酯的涂料中的低分子量交联剂。 本发明的共聚交联剂是通过使丙烯酰氨基乙酸酯单体如MAGME TM甲基丙烯酰胺基乙醇酸甲酯与共聚单体如甲基丙烯酸甲酯或丙烯酸丁酯共聚来制备的。 制备本发明的共聚交联剂的方法利用链转移剂将交联剂的分子量限制在10,000以下。