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    Cyanine dye labelling reagents with meso-substitution
    15.
    发明授权
    Cyanine dye labelling reagents with meso-substitution 有权
    花青染料标记试剂与中观取代

    公开(公告)号：US07172907B2

    公开(公告)日：2007-02-06

    申请号：US10394108

    申请日：2003-03-21

    申请人： Chung-Yuan Chen ,  Shiv Kumar

    发明人： Chung-Yuan Chen ,  Shiv Kumar

    IPC分类号： G01N33/533 ,  C07K17/02 ,  C07D413/06 ,  C07D417/06 ,  C07D403/06

    CPC分类号： C09B23/164 ,  C07D209/24 ,  C09B23/0058 ,  C09B23/02 ,  G01N33/582

    摘要： Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the atoms necessary to complete one ring, or two fused ring aromatic or heteroaromatic systems, each ring having five or six atoms selected from carbon atoms and optionally no more than two atoms selected from oxygen, nitrogen and sulphur; X and Y are the same or different and are selected from oxygen, sulphur, —CH═CH— and the group: at least one of groups R1, R2, R3, R4, R5, R6 (and R8 and R9 if present) is the group -E-F where E is a spacer group and F is a target bonding group; one of groups R7 is selected from —CN, —Cl, —F, —CF3 and —C(O)R10 wherein R10 is selected from H, C1–C6 alkyl and aryl. Preferred group R7 is meso-substituted —CN, which confers an unexpected hypsochromic shift of approximately 40 nm in the emission spectrum, when compared with the corresponding unsubstituted analogue. The dyes are useful for labelling and detecting a variety of target molecules.

    摘要翻译： 公开了在连接杂环体系的聚甲炔链中具有内消旋取代基的花青染料。 染料具有式（1）：其中R 3和R 4基团连接到Z 1 O 1环结构， SUP> 5和R 6连接到Z 2 O 2环结构，n = 1,2或3; Z 1和Z 2独立地表示完成一个环或两个稠环芳族或杂芳族体系所必需的原子，每个环具有选自碳原子的五或六个原子， 任选不超过两个选自氧，氮和硫的原子; X和Y相同或不同，并且选自氧，硫，-CH-CH-和基团R 1，R 2，R 2， R 3，R 4，R 5，R 6和R 8， 和R 9如果存在）是基团-EF，其中E是间隔基团，F是目标键合基团; R 7中的一个选自-CN，-Cl，-F，-CF 3和-C（O）R 10，其中 R 10选自H，C 1 -C 6烷基和芳基。 优选的基团R 7是内消旋的-CN，当与相应的未取代的类似物进行比较时，它们在发射光谱中赋予约40nm的意外的变色色移。 染料可用于标记和检测各种靶分子。

    Methine-substituted cyanine dye compounds
    16.
    发明申请
    Methine-substituted cyanine dye compounds 有权
    甲基取代的花青染料化合物

    公开(公告)号：US20050208534A1

    公开(公告)日：2005-09-22

    申请号：US11005861

    申请日：2004-12-06

    申请人： Jason Dallwig ,  David Hagen ,  Ching-Ying Cheung ,  Gerald Thomas ,  Stephen Yue

    发明人： Jason Dallwig ,  David Hagen ,  Ching-Ying Cheung ,  Gerald Thomas ,  Stephen Yue

    IPC分类号： C07D413/02 ,  C07D417/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C09B23/164 ,  C07D277/64 ,  C07D417/06 ,  C09B23/0008 ,  C09B23/04 ,  C09B23/06 ,  C09B23/107 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q2600/16 ,  G01N33/5308 ,  Y10T436/143333

    摘要： Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

    摘要翻译： 具有作为核酸污渍的取代的次甲基部分的花青染料化合物，特别是用于RNA的荧光染色，包括具有下式的化合物：其中R 1是C 1 -C 3烷基， 烷基，磺基烷基，羧基烷基或C 1 -C 6烷氧基; 每个R 2独立地选自H，C 1 -C 6烷基，C 1至C 6烷基， -C 6烷氧基，稠合的苯并，三氟甲基，氨基，磺基，羧基和卤素，其任选进一步被取代; R 3，R 4和R 5中的至少一个是任选地是烷基，芳基，杂芳基，环状或杂环部分 被烷基，氨基，氨基烷基，羧基，硝基或卤素取代; 而其余的R 3，R 4或R 5是氢; X是S，O或Se; 并且D是取代或未取代的吡啶鎓，喹啉鎓或苯并咪唑鎓部分。

    Cationic compounds
    18.
    发明授权
    Cationic compounds 失效
    阳离子化合物

    公开(公告)号：US4380627A

    公开(公告)日：1983-04-19

    申请号：US251421

    申请日：1981-04-06

    申请人： Willy Stingelin ,  Peter Loew

    发明人： Willy Stingelin ,  Peter Loew

    IPC分类号： C09B23/00 ,  C09B23/16 ,  C09B26/02 ,  D21H21/28 ,  C07D251/70 ,  C07D401/14 ,  C07D417/04 ,  C07D417/12

    CPC分类号： C09B23/164 ,  D21H21/28

    摘要： There are described novel cationic compounds of the formula ##STR1## wherein Z's independently of one another are each a radical of the formula ##STR2## B is identical to Z or is a cationic radical different from Z; R's independently of one another are each hydrogen, unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl, unsubstituted or substituted C.sub.1 -C.sub.4 -alkoxy, the NO.sub.2 group, unsubstituted or substituted acylamino, halogen or the CN group;R.sub.1 's independently of one another are each unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl or C.sub.3 -C.sub.4 -alkenyl;X is a sulfur atom or the group ##STR3## in which both R.sub.1 radicals can be linked with each other to form a carbocyclic 5- or 6-membered ring;A is the direct bond, --NH-alkylene (C.sub.1 -C.sub.4), --O-alkylene (C.sub.1 -C.sub.4), alkylene (C.sub.1 -C.sub.4), phenylene, --O-phenylene or --NH-phenylene;Y is --NH--, --NR.sub.1 --, --O-- or --S--; andAn is an anion,and also processes for producing them and their use as dyes for dyeing and printing textile materials, such as polyacrylonitrile materials, leather and in particular paper, with greenish- to reddish-yellow shades being obtained which are distinguished by good general fastness properties.

    摘要翻译： 描述了式（I）的新型阳离子化合物，其中Z彼此独立地为下式的基团，其中Z是与Z相同或是不同于Z的阳离子基团; R 2各自独立地为氢，未取代或取代的C 1 -C 4 - 烷基，未取代或取代的C 1 -C 4 - 烷氧基，NO 2基团，未取代或取代的酰基氨基，卤素或CN基团; R 1彼此独立地是各自未取代或取代的C 1 -C 4 - 烷基或C 3 -C 4 - 烯基; X是硫原子或其中两个R 1基团可以彼此连接形成碳环5或6元环的基团; A是直接键，-NH-亚烷基（C1-C4）， - O-亚烷基（C1-C4），亚烷基（C1-C4），亚苯基，-O-亚苯基或-NH-亚苯基; Y是-NH-，-NR1-，-O-或-S-; 并且An是阴离子，并且它们也用于生产它们，并且它们用作染色和印刷纺织材料的染料，例如聚丙烯腈材料，皮革，特别是纸，具有绿色至红色 - 黄色的色调，其被良好的区分 一般坚牢性。