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    Preparation and characterization of formulations in a high throughput mode
    11.
    发明授权
    Preparation and characterization of formulations in a high throughput mode 有权
    配方在高通量模式下的制备和表征

    公开(公告)号：US07501094B2

    公开(公告)日：2009-03-10

    申请号：US10662142

    申请日：2003-09-15

    申请人： Stephen Robert Bysouth ,  Sidney Wilson Hite, III ,  John Henry Nettleton-Hammond ,  Karin Ingegärd Bergström ,  Amrish Bohara ,  Rowena Roshanthi Landham ,  Ingrid Gunborg Lukkari

    发明人： Stephen Robert Bysouth ,  Sidney Wilson Hite, III ,  John Henry Nettleton-Hammond ,  Karin Ingegärd Bergström ,  Amrish Bohara ,  Rowena Roshanthi Landham ,  Ingrid Gunborg Lukkari

    IPC分类号： B01L3/02 ,  G01N21/00

    CPC分类号： G01N35/0099 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00322 ,  B01J2219/00364 ,  B01J2219/00479 ,  B01J2219/00549 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00756 ,  C40B70/00 ,  G01N11/00 ,  G01N15/0227 ,  G01N15/0272 ,  G01N2035/00198 ,  G01N2035/00217 ,  G01N2035/00524 ,  G01N2035/00564 ,  G01N2035/00752 ,  G01N2035/0405 ,  G01N2035/103 ,  G01N2035/1032 ,  Y10T436/2575

    摘要： The invention is an automated robotic system for the production and testing of formulations at a very high throughput. It is an integrated system of hardware and software capable of preparing and evaluating hundreds of emulsions per day. The system can formulate aqueous solutions (SL), oil in water emulsions (EW), suspo-emulsions (SE), micro capsule suspensions (CS), micro-emulsions (ME), and suspension concentrates (SC) at the 1 ml to 25 ml scale. The system can process emulsions rapidly in an automated way and enable very flexible formulation recipes to be introduced.The system allows chemists to generate experimental samples of varying recipe and method to be conducted in parallel with projected throughput of up to 1200 formulations processed and characterized per day. Materials and consumables can be distributed from storage storage systems to the work stations where dispensing of ingredients in various states can be performed, including solids, liquids, gels, pastes, suspensions and waxes. The emulsions formed can be characterized using methods including phase diagnosis, turbidity analysis, viscosity and particle sizing using automated test equipment. An integrated module can also perform Tank Mix Compatibility testing in high throughput mode. The modular system allows future processes and tests to be added, either to a station, or as a new station. The software capability includes tracking of processes from start to finish and the integration of analytical data with the as-designed and as-formulated experimental results.

    摘要翻译： 本发明是一种用于以非常高的产量生产和测试制剂的自动化机器人系统。 它是一个硬件和软件的集成系统，能够每天准备和评估数百种乳液。 该系统可以配制水溶液（SL），水包油乳剂（EW），悬浮乳液（SE），微胶囊悬浮液（CS），微乳液（ME）和悬浮浓缩物（SC） 25毫升规模。 该系统可以以自动化的方式快速处理乳液，并且能够引入非常灵活的制剂配方。 该系统允许化学家生成不同配方和方法的实验样品，与每天处理和表征的高达1200种配方的预计产量并行进行。 材料和消耗品可以从储存储存系统分配到工作站，在这些工厂可以进行各种状态的成分分配，包括固体，液体，凝胶，糊剂，悬浮液和蜡。 可以使用包括相位诊断，浊度分析，使用自动化测试设备的粘度和颗粒尺寸的方法来表征形成的乳液。 集成模块还可以在高吞吐量模式下进行坦克混合兼容性测试。 模块化系统允许将未来的过程和测试添加到站点或作为新站点。 软件功能包括从开始到结束的过程跟踪以及分析数据的集成以及设计和制定的实验结果。

    Dissolution test equipment and methods for testing having improved filtration system
    12.
    发明申请
    Dissolution test equipment and methods for testing having improved filtration system 审中-公开
    溶出度测试设备和测试方法具有改进的过滤系统

    公开(公告)号：US20070092404A1

    公开(公告)日：2007-04-26

    申请号：US11584161

    申请日：2006-10-20

    申请人： Lyn Hughes

    发明人： Lyn Hughes

    IPC分类号： G01N1/18

    CPC分类号： G01N13/00 ,  G01N33/15 ,  G01N2013/006 ,  G01N2035/00198 ,  Y10T436/255

    摘要： The present invention provides a dissolution test apparatus comprising, a first chamber 2 connected in series to at least a second chamber 10, wherein the first chamber 2 is capable of transferring solid test samples to the second chamber 10 and the second chamber 10 is capable of retaining the solid test samples. Further, the apparatus includes a first reservoir 21 and at least a second reservoir 22 for continuously supplying one or more media into the first chamber 2 and the second chamber 10, respectively, the chambers having stirrers 4, 11 for mixing the solid test samples and the media together. In addition, the second chamber 10 has a filter membrane 45 overlying a base 44 of the second chamber 10, the filter membrane 45 being supported by a filter support 46, the filter support 46 being provided between the filter membrane 45 and the base 44 of the second chamber 10 to prevent distortion of the filter membrane 45. Processors 5, 16, 20 for analyzing an effluent from the chambers are also provided.

    摘要翻译： 本发明提供了一种溶解试验装置，其包括：与至少第二室10串联连接的第一室2，其中第一室2能够将固体测试样品转移到第二室10，并且第二室10能够 保留固体试样。 此外，该装置包括第一储存器21和至少第二储存器22，用于将一个或多个介质分别连续地供应到第一室2和第二室10中，所述室具有用于混合固体测试样品的搅拌器4,11 媒体在一起。 此外，第二室10具有覆盖第二室10的基部44的过滤膜45，过滤膜45由过滤器支撑件46支撑，过滤器支撑件46设置在过滤膜45和基部44之间 第二室10以防止过滤膜45变形。还提供了用于分析来自室的流出物的处理器5,16,20。

    Method and apparatus for handling samples and sample collection system
    13.
    发明授权
    Method and apparatus for handling samples and sample collection system 失效
    样品和样品收集系统的处理方法和装置

    公开(公告)号：US5460057A

    公开(公告)日：1995-10-24

    申请号：US90689

    申请日：1993-07-13

    申请人： Jan Ostrup

    发明人： Jan Ostrup

    IPC分类号： B01L3/00 ,  G01N1/28 ,  G01N33/483 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N1/04

    CPC分类号： G01N35/028 ,  B01L3/545 ,  G01N1/286 ,  G01N35/0099 ,  B01L3/505 ,  G01N2001/288 ,  G01N2035/00108 ,  G01N2035/00198 ,  G01N2035/042 ,  G01N2035/0484 ,  G01N35/00732 ,  Y10T436/110833 ,  Y10T436/112499

    摘要： Method for handling blood samples (32) wherein a blood sample is absorbed into a filter paper (30) and a sample piece (36) is taken from the filter paper from the opposite side of the absorption side. The sample piece is placed in a sample well of an uncoated micro titration plate (45) and is dissolved in a liquid so that a sample solution is formed in the well. The sample solution is transferred to a second micro titration plate (52-54) coated for the analysis. The apparatus comprises a camera (43), which identifies the filter paper (30), locates the blood sample (32), and informs the punch (47) of the location of the sample. The filter paper (30) is placed in a package, (22) having openings (25) for absorbing and punching of the sample and the covering (23) is provided with a bar code (29).

    摘要翻译： 用于处理血液样品（32）的方法，其中血液样品被吸收到滤纸（30）中，并且样品片（36）从吸收侧的相对侧从滤纸中取出。 将样品片放置在未涂覆的微量滴定板（45）的样品孔中并溶解在液体中，使得在孔中形成样品溶液。 将样品溶液转移到涂覆用于分析的第二微量滴定板（52-54）。 该装置包括识别滤纸（30）的相机（43），定位血液样本（32），并通知冲头（47）样品的位置。 滤纸（30）放置在具有用于吸收和冲压样品的开口（25）的封装（22）中，并且覆盖物（23）设置有条形码（29）。

    Automated Filter Changer
    17.
    发明申请
    Automated Filter Changer 审中-公开

    公开(公告)号：US20180045702A1

    公开(公告)日：2018-02-15

    申请号：US15790406

    申请日：2017-10-23

    申请人： Teledyne Instruments, Inc.

    发明人： Gary Charles Downes ,  Steven William Shaw

    IPC分类号： G01N33/15 ,  G01N35/00 ,  G01N35/04

    CPC分类号： G01N33/15 ,  G01N2035/00198 ,  G01N2035/00475 ,  G01N2035/0091 ,  G01N2035/0425

    摘要： An automatic filter changer that automatically inserts and removes a filter from a fluidic path. Filters are introduced into the automatic filter changer in stacks. The lead filter and each stack is removed from its respective stack one by one by a filter separator. The separated filters are deposited onto a shuttle plate which moves the filters into their respective fluidic paths. Fluid couplers connect to each filter to complete their respective fluidic paths and allow fluids to be filtered before sampling. Once collection of the samples is complete, the filters are removed from the fluidic path and discarded or saved for reuse. The shuttle path is returned to its original position to receive new filters to repeat the process again. A graphic user interface is provided to allow the user to program a specific set of instructions to automate the entire process.

    DISSOLUTION TEST EQUIPMENT
    18.
    发明申请
    DISSOLUTION TEST EQUIPMENT 有权
    溶解测试设备

    公开(公告)号：US20120034704A1

    公开(公告)日：2012-02-09

    申请号：US13196184

    申请日：2011-08-02

    申请人： Lyn Hughes ,  Donald Frederick Wright

    发明人： Lyn Hughes ,  Donald Frederick Wright

    IPC分类号： G01N1/18

    CPC分类号： G01N33/15 ,  B01F13/1013 ,  G01N1/18 ,  G01N2013/006 ,  G01N2035/00198 ,  Y10T436/255

    摘要： Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating substrates.

    摘要翻译： 提供了各种剂型活性物质溶出试验的装置和方法。 该装置具有装配和配置以模拟身体功能并连续操作的过滤细胞，并且便于测试各种剂型，包括但不限于片剂，胶囊和具有非崩解底物的剂型。

    Infrared spectrometer with automated tablet sampling
    19.
    发明授权
    Infrared spectrometer with automated tablet sampling 失效
    红外光谱仪采用自动片剂取样

    公开(公告)号：US07053373B1

    公开(公告)日：2006-05-30

    申请号：US11040350

    申请日：2005-01-19

    申请人： Joseph A. Cleary

    发明人： Joseph A. Cleary

    IPC分类号： G01N35/02 ,  G01N33/15

    CPC分类号： G01N35/025 ,  G01N2013/006 ,  G01N2035/00198

    摘要： An infrared spectrometer system with automated tablet sampling includes an infrared spectrometer providing a modulated output beam to a sample position, and reflected and transmitted light detectors. A tablet holding wheel is mounted to advance multiple tablets one at a time to the sample position. The tablet holding wheel includes a tablet wheel base having a plurality of transmission openings therein in a circular pattern around a central axis of the base, grippers adjacent to each of the transmission openings that are movable inwardly and outwardly, and a cam ring mounted to and rotatable with respect to the tablet wheel base, the cam ring being operatively engaged with the grippers to move the grippers outwardly and inwardly to engage and hold tablets over the transmission openings. The tablet holding wheel can be automatically rotated to move a tablet to the sample position where analysis can be carried out, to advance the tablet wheel to move the next tablet into position for analysis, and to repeat the process until all of the tablets have been analyzed.

    摘要翻译： 具有自动片剂采样的红外光谱仪系统包括向样品位置提供调制输出光束的红外光谱仪和反射和透射的光检测器。 安装片剂保持轮以一次一个地将多个片剂推进到样品位置。 片剂保持轮包括一个平片轮底座，其具有围绕基座的中心轴线的圆形图案中的多个传动开口，与可向内和向外移动的每个传动孔相邻的夹具和安装到其上的凸轮环 可相对于片剂轮基座旋转，凸轮环可操作地与夹持器接合，以使夹持器向外和向内移动，从而将片剂粘合并保持在传播开口上方。 片剂保持轮可以自动旋转以将片剂移动到可以进行分析的样品位置，以推进片剂轮将下一个片剂移动到位置进行分析，并重复该过程，直到所有片剂已经被 分析