公开(公告)号：US2927939A

公开(公告)日：1960-03-08

申请号：US74757458

申请日：1958-07-10

Applicant: WISCONSIN ALUMNI RES FOUND

Inventor： YUNKER JR MARTIN H ,  TAKERU HIGUCHI

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C203/00 ,  C07C201/04

公开(公告)号：US2831882A

公开(公告)日：1958-04-22

申请号：US53466355

申请日：1955-09-16

Applicant: DU PONT

Inventor： PHILIP SPAETH CHARLES

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04 ,  C07C203/00

公开(公告)号：US2166698A

公开(公告)日：1939-07-18

申请号：US16442137

申请日：1937-09-17

Applicant: SHELL DEV

Inventor： CLYVE ALLEN

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04 ,  C07C203/00

公开(公告)号：US20220002223A1

公开(公告)日：2022-01-06

申请号：US17296593

申请日：2019-11-27

Applicant: ATTGENO AB

Inventor： Per Håkan Agvald ,  Leif Christofer Adding ,  Kristofer Bo Ingemar Nilsson ,  Anna Lena Elisabeth Minidis ,  Johan Salman Malmberg ,  Alexander Bogdan Emil Minidis

IPC: C07C201/04

Abstract: Disclosed is a process for the synthesis of mono- and bis-nitrosylated propanediols, as well as compositions and pharmaceutical formulations that includes the compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. When the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. Also disclosed are methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations.

公开(公告)号：US08987496B1

公开(公告)日：2015-03-24

申请号：US14054194

申请日：2013-10-15

Applicant: Southwest Research Institute

Inventor： Joseph A. McDonough ,  Darrel W. Johnston ,  Paul M. Thompson

IPC: C07C203/04 ,  C07C203/00 ,  C07C201/04 ,  A61M5/19

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: The present disclosure relates to devices and methods for the preparation of amyl nitrite formulations at a point of use location from relatively shelf-stable reagents employing acidic cationic exchange resins.

Abstract translation: 本公开涉及在使用酸性阳离子交换树脂的相对稳定的试剂的使用位置制备亚硝酸戊酯制剂的装置和方法。

公开(公告)号：US5621000A

公开(公告)日：1997-04-15

申请号：US446624

申请日：1995-05-26

Applicant: Barbara Arena ,  Piero Del Soldato

Inventor： Barbara Arena ,  Piero Del Soldato

IPC: A61K31/21 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/407 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  A61P37/00 ,  C07C201/04 ,  C07C203/04 ,  C07C233/21 ,  C07C233/69 ,  C07C235/34 ,  C07C235/78 ,  C07C235/80 ,  C07D207/337 ,  C07D209/46 ,  C07D209/88 ,  C07D333/22 ,  C07D491/04 ,  C07D491/052

CPC classification number: C07C235/80 ,  C07C203/04 ,  C07C233/21 ,  C07C235/34 ,  C07C235/78 ,  C07D333/22

Abstract: Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation. ##STR1##

Abstract translation: PCT No.PCT / EP93 / 03193 Sec。 371日期：1995年5月26日 102（e）日期1995年5月26日PCT提交1993年11月15日PCT公布。 WO94 / 12463 PCT出版物 日期：1994年6月9日具有通式（I）的药理学活性的硝酸酯，其药物利用及其制备方法。 （一）

公开(公告)号：US4980496A

公开(公告)日：1990-12-25

申请号：US446028

申请日：1989-12-05

Applicant: Olan S. Fruchey

Inventor： Olan S. Fruchey

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04

Abstract: The invention provides a process for the production of C.sub.1 to C.sub.5 alkyl nitrite by forming an aqueous solution of C.sub.1 to C.sub.5 alkyl alcohol an alkali metal nitrite; cooling it; then slowly adding a hydrohalic acid solution while it is stirring; the reaction temperature is maintained in the range of from about -10.degree. C. to about 10.degree. C. until the reaction is substantially complete; and the two formed phases are separated in a separatory funnel.

Abstract translation: 本发明提供一种通过形成C1-C5烷基醇水溶液和碱金属亚硝酸盐来生产C1至C5烷基亚硝酸盐的方法; 冷却 然后在搅拌下缓慢加入氢卤酸溶液; 反应温度保持在约-10℃至约10℃的范围内，直至反应基本完成; 并且两个形成的相在分液漏斗中分离。

公开(公告)号：US4908466A

公开(公告)日：1990-03-13

申请号：US102367

申请日：1987-09-29

Applicant: James R. Nelson

Inventor： James R. Nelson

IPC: C07C201/02 ,  B01D3/00 ,  C07C67/00 ,  C07C201/00 ,  C07C201/04 ,  C07C203/00 ,  C07C203/02 ,  C07C203/04

CPC classification number: B01D3/009 ,  C07C201/04 ,  Y02P20/127

Abstract: A process and reaction vessel for producing alkyl nitrite is disclosed the process comprising (a) contacting nitric oxide, lower alcohol and oxygen in a reaction zone such that alkyl nitrite is formed, said reaction zone comprising a reactor section and a rectification section, (b) supplying a liquid scrubbing agent to an upper portion of the rectification section, (c) withdrawing a gaseous alkyl nitrite product stream from the upper portion of the rectification section, and (d) withdrawing a liquid stream from a lower portion of the reactor section. The reactor section provides intimate vapor-liquid contact sufficient to enhance the conversion of nitric oxide to alkyl nitrite and the rectification section provides sufficient vapor residence time to enhance conversion of oxygen, as well as sufficient rectification capabilities to reduce the amounts of water and nitric acid in the gaseous alkyl nitrite product stream.

公开(公告)号：US4487958A

公开(公告)日：1984-12-11

申请号：US428816

申请日：1982-09-30

Applicant: Bernard C. Ream ,  Joseph P. Henry ,  Louis A. Kapicak

Inventor： Bernard C. Ream ,  Joseph P. Henry ,  Louis A. Kapicak

IPC: B01J23/00 ,  B01J23/44 ,  C07B61/00 ,  C07C67/00 ,  C07C67/36 ,  C07C69/36 ,  C07C201/00 ,  C07C201/04

CPC classification number: C07C69/36

Abstract: A process is disclosed for preparing a diester of oxalic acid by contacting carbon monoxide and an ester of nitrous acid in the vapor state under a pressure in the presence of a supported palladium monolith catalyst.

Abstract translation: 公开了一种通过在负载的钯整体催化剂的存在下在压力下使一氧化碳和亚硝酸的酯接触来制备草酸二酯的方法。

公开(公告)号：US3560577A

公开(公告)日：1971-02-02

申请号：US3560577D

申请日：1968-09-18

Applicant: DU PONT

Inventor： BENJAMINS EDWIN

IPC: C07C17/42 ,  C07C201/04 ,  C07C203/00 ,  C08F36/16 ,  C07C81/00 ,  C07C81/02

CPC classification number: C07C17/42 ,  C07C201/04 ,  C08F36/16 ,  C07C21/21 ,  C07C203/00

Abstract: REACTION PRODUCTS OF NITROUS ACID AND 1.3-DICHLOROBUTENE-2 OR DISOBUTYLENE, USEFUL AS INHIBITORS OF "POPCORN" POLYMER FORMATION IN CHLOROPRENE POLYMERIZATION REACTIONS, ARE MADE BY A CONTROLLABLE PROCESS COMPRISING (1) ADDING AN ALKALI OR ALKALINE EARTH METAL NITRITE TO LIQUID 1,3-DICHLOROBUTENE-2 OR DIISOBUTYLENE WITH AGITATION, (2) SLOWLY ADDING CONCENTRATED HYDROCHLORIC OR SULFURIC ACID TO THE MIXTURE SO OBTAINED, AND (3) RECOVERING A REACTION PRODUCT OF NITROUS ACID AND 1,3-DICHLOROBUTENE2 OR DIISOBUTYLENE FROM THE BY-PRODUCT ALKALI OR ALKALINE EARTH METAL SALT FORMED.