TOUGH TISSUE SEALANTS AND THE USE THEREOF

    公开(公告)号:US20220378975A1

    公开(公告)日:2022-12-01

    申请号:US17772399

    申请日:2020-11-18

    摘要: The invention provides injectable, tough hydrogels that can be crosslinked in situ on demand using minimally-invasive methods, such as visible light exposure is an unmet medical challenge. Among the emerging biopolymers for tissue sealing, gelatin methacryloyl (GelMA), a naturally-derived biopolymer obtained from denatured collagen, has secured a promising role as a result of its excellent bioadhesion, biodegradation, and biocompatibility. To overcome one of the main shortcomings of GelMA, i.e., brittleness, we hybridized it using methacrylate-modified alginate (AlgMA) to impart ion-induced reversible crosslinking that can dissipate energy under strain. The hybrid GelMA-AlgMA hydrogels provide a photocrosslinkable, injectable, and adhesive platform with an excellent toughness that can be engineered using divalent cations, such as calcium. This class of novel hybrid biopolymers with more than 600% improved toughness may set the stage for durable, mechanically-resilient, and cost-effective tissue sealants in minimally invasive procedure, especially for stretchable tissues.

    METHOD OF PREPARING VINYL COLLAGEN MICROSPHERE POLYAMIDE FIBER COMPOSITE MATERIAL

    公开(公告)号:US20220213318A1

    公开(公告)日:2022-07-07

    申请号:US17498181

    申请日:2021-10-11

    摘要: A method of preparing a vinyl collagen microsphere polyamide fiber composite material includes the following steps: step 1: modifying a collagen with methacrylic anhydride to obtain a vinyl collagen, then emulsifying and cross-linking the vinyl collagen to obtain vinyl collagen microspheres; step 2: treating a polyamide fiber substrate with formaldehyde to obtain a hydroxylated polyamide fiber substrate, treating the hydroxylated polyamide fiber with (3-mercaptopropyl)trimethoxysilane (MPS) to obtain a sulfhydrylated polyamide fiber substrate; and step 3: modifying the sulfhydrylated polyamide fiber substrate with the vinyl collagen microspheres to obtain the vinyl collagen microsphere polyamide fiber composite material.

    THERMOPLASTIC COMPOSITE MATERIAL
    18.
    发明申请

    公开(公告)号:US20220204707A1

    公开(公告)日:2022-06-30

    申请号:US17603307

    申请日:2020-03-18

    申请人: NABORE GmbH

    发明人: Ewald WILKA

    摘要: The present invention relates to a thermoplastic composite material comprising an organic fibrous material and a thermoplastic binding agent, wherein the thermoplastic binding agent is selected from a polymer from the group comprising styrene-acrylate. Furthermore, the invention relates to a method for producing a thermoplastic composite material and to the use of the thermoplastic composite material.

    GELATIN AND USES THEREOF
    19.
    发明申请

    公开(公告)号:US20220184274A1

    公开(公告)日:2022-06-16

    申请号:US17491570

    申请日:2020-04-03

    IPC分类号: A61L27/22 C08L89/06 B33Y70/00

    摘要: The present invention relates to a gelatin having improved properties, in particular improved dispensing properties, more particularly improved printing properties. The present invention further relates to a construct produced with the gelatin of the present invention and to a process to produce said construct. Further the present invention relates to the use of the gelatin of the present invention to solve existing problems encountered with dispensing systems, in particular with 3D printing and more particularly for applications in the medical field. The gelatin of the present invention is particularly suitable for bio-printing in the medical field and may also be used in cosmetic and in food applications.