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公开(公告)号：US20230263642A1
公开(公告)日：2023-08-24
申请号：US18006432
申请日：2021-07-23
发明人： Anibal Faruk ABEDRABBO HAZBUN , Oscar Javier BENAVIDES ORTIZ , Rene Santiago BERNAL BAEZ , Hector Mauricio FRANCO CARRILLO , Paula Alejandra GOMEZ VILLALOBOS , Jaime Andres MORENO RAMOS , Fabio Arturo ROJAS MORA
CPC分类号： A61F2/4644 , A61F2/28 , B33Y40/20 , A61F2002/2835 , A61F2002/4645 , B33Y80/00
摘要： A method for the execution of implants, surface finishes of implants the manufacture of a particulated bone material, and with the particulated bone material obtained, a method for the manufacture of a bone-biopolymer filament may be performed, to obtain a bone-biopolymer filament. The filament may be used, for example, in a method for the manufacture of implants by 3D-printing. A method for the manufacture of bone implants by machining; once a bone implant has been obtained by the method of manufacture of implants by 3D-printing or the method of manufacture of bone implants by machining, it is subjected to a texturisation to enable the osseointegration thereof.
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公开(公告)号：US20220290105A1
公开(公告)日：2022-09-15
申请号：US17756456
申请日：2020-11-26
申请人： CELLS FOR CELLS S.A. , CONSORCIO REGENERO, S.A. , UNIVERSIDAD DE LOS ANDES , UNIVERSITÉ DE MONTPELLIER
摘要： Mesenchymal stem cells with enhanced therapeutic properties. The present invention refers to a method for obtaining mesenchymal stem cells (MSCs) with enhanced immunosuppression, chondroprotection and chondrodifferentiation properties, and enhanced capability to promote the proliferation of chondrocytes. The method comprises contacting the MSCs; culturing MSC in a induction media supplemented with 0.01 to 100 μg/ml of an ATP-synthase inhibitor; and removing the induction media to obtain MSC with enhanced activity. Moreover, the present invention also refers to the MSCs themselves and to their use for cell therapy purposes, preferably for treating autoimmune and/or osteoarticular diseases.
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公开(公告)号：US11035864B2
公开(公告)日：2021-06-15
申请号：US16258387
申请日：2019-01-25
摘要： The present invention is focused on an in vitro method for identifying or screening human subjects at risk of suffering from a pregnancy related disease, in particular from gestational diabetes mellitus or preeclampsia, departing from the level of expression or concentration of a series of biomarkers isolated from a minimally-invasive sample such as gingival crevicular fluid (GCF). Moreover, the method of the invention offers high sensitivity and specificity at an early stage of the pregnancy (see the Examples and figures shown below), which means that it is a strong and cost-effective method for the detection of a pregnancy related disease, in particular gestational diabetes mellitus or preeclampsia, at an early stage of the disease thus procuring effective treatment, avoiding significant long-term adverse effects for both mother and baby.
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公开(公告)号：US20200222577A1
公开(公告)日：2020-07-16
申请号：US16627242
申请日：2018-06-29
摘要： The present document describes a composition and pharmaceutical composition comprising gelatin derived from a cold-adapted aquatic species, chitosan, agarose and glycerol. Further, the present document discusses a process for manufacturing a biomaterial which comprises gelatin derived from a cold-adapted aquatic species, chitosan, agarose and glycerol. The biomaterial obtained or obtainable through the process is also described. Also, the present document describes a kit which comprises: gelatin derived from a cold-adapted aquatic species, chitosan, agarose, and glycerol. Lastly, the use of the composition, pharmaceutical composition, biomaterial or kit for the production of scaffolds, dressings, beads, engineered tissues, devices or micro-devices suitable for therapeutic or diagnostic purposes or the use of the composition, biomaterial or kit for tissue engineering are also discussed.
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公开(公告)号：US20200171432A1
公开(公告)日：2020-06-04
申请号：US16617834
申请日：2018-05-28
发明人： Alberto Octavio VERGARA FERNANDEZ , Patricio Alejandro MORENO CASAS , German Eduardo AROCA ARCAYA
摘要： The invention relates to a filtering apparatus and method for treating polluted indoor air, which can be operated by gas scrubbers, adsorbers, or through the use of a microbial biodegrading medium for polluting gases, wherein said apparatus allows the biofiltration method to be efficient and applicable in indoor spaces. The technical problem of the efficiency of the filter has to do with said filter being able to process the greatest amount of pollutants during a minimum residence time and with a filter bed volume that allows the application thereof in apparatus that have an adequate size for indoor spaces, such as spaces inside the household, i.e., allowing the reactor to operate at maximum capacity without having to increase the size thereof.
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公开(公告)号：US20190331691A1
公开(公告)日：2019-10-31
申请号：US16258387
申请日：2019-01-25
IPC分类号： G01N33/68
摘要： The present invention is focused on an in vitro method for identifying or screening human subjects at risk of suffering from a pregnancy related disease, in particular from gestational diabetes mellitus or preeclampsia, departing from the level of expression or concentration of a series of biomarkers isolated from a minimally-invasive sample such as gingival crevicular fluid (GCF). Moreover, the method of the invention offers high sensitivity and specificity at an early stage of the pregnancy (see the Examples and figures shown below), which means that it is a strong and cost-effective method for the detection of a pregnancy related disease, in particular gestational diabetes mellitus or preeclampsia, at an early stage of the disease thus procuring effective treatment, avoiding significant long-term adverse effects for both mother and baby.
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7.发明申请公开(公告)号：US20190194460A1
公开(公告)日：2019-06-27
申请号：US16310780
申请日：2017-06-19
CPC分类号： C08L89/06 , B33Y70/00 , C07K14/461 , C07K14/78 , C08H1/00 , C08J3/075 , C08J2389/06 , C08K5/101 , C08L2312/00
摘要： The present invention refers to a composition comprising a solution which in turn comprises an amino acidic chain gelatin polymer derived from natural sources of cold-adapted marine species, at a concentration from 1% to 20% (w/v), which optionally further comprises a polymerizing initiator such as a photoinitiator, and is chemically functionalized to become reactive to polymerization or crosslinking in presence of free radicals. This composition is especially useful for 3D printing, extrusion systems (additive fabrication), spray systems, casting, micro- and nano fibers fabrication systems (electrospinning, solution blow spinning) or microfluidics.
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公开(公告)号：US20180304502A1
公开(公告)日：2018-10-25
申请号：US15768161
申请日：2016-10-14
申请人： Juan Pablo ACEVEDO , Camila WILKENS , Maroun KHOURY , Christopher RIVET , UNIVERSIDAD DE LOS ANDES , CELLS FOR CELLS, S.P.A
IPC分类号： B29C41/22 , B32B1/08 , B32B9/02 , B29C41/14 , A61L27/22 , A61L27/54 , A61L27/38 , A61L27/34 , A61L27/18 , A61L27/26 , A61L27/58 , A61L27/50 , A61L27/36 , A61L27/20 , A61F2/04 , A61F2/06
CPC分类号： B29C41/22 , A61F2/04 , A61F2/06 , A61F2002/047 , A61F2210/0076 , A61F2240/001 , A61L27/18 , A61L27/20 , A61L27/222 , A61L27/26 , A61L27/34 , A61L27/3679 , A61L27/3808 , A61L27/3813 , A61L27/3817 , A61L27/3826 , A61L27/3834 , A61L27/3882 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/604 , A61L2300/608 , A61L2300/64 , A61L2420/02 , A61L2420/08 , A61L2430/22 , A61L2430/32 , B29C41/14 , B29K2089/00 , B29L2031/7534 , B32B1/08 , B32B9/02 , B32B2535/00 , C08L67/04 , C08L89/06
摘要： The present invention overcomes all the above drawbacks and provides a versatile method for the fabrication of multilayer hollow tubes that uses a layer-by-layer rod dipping approach using different biomaterials. The device enables fine control over fabrication parameters, such as ascending/descending speeds, rod rotational velocity, and crosslinking or polymerization time. All these technologies allows the generation of more complex multilayer hollow tubes such as vessel-like structures, urethral grafting, prostate grafting and the like.
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公开(公告)号：US20170091935A1
公开(公告)日：2017-03-30
申请号：US15350687
申请日：2016-11-14
发明人： Ricardo Antonio Mendoza Leon , Luis Felipe Uriza Carrasco , Phillipe Charles Douek , Marcela Hernández Hoyos
CPC分类号： G06T7/0012 , A61B6/032 , A61B6/5205 , G06K9/4604 , G06T7/11 , G06T2207/10081 , G06T2207/30004 , G06T2207/30092 , G06T2207/30242
摘要： A computer-based method is herein disclosed, allowing to differentiate automatically between two tissues of interest: an extrinsic and an intrinsic tissue, from a plurality of images, obtaining a quantitative assessment of each of said tissues without requiring the intervention of an expert. Said method involves the definition of a differentiation region in images obtained from a medical imaging acquisition device using a parametric contour, after which differentiation and quantification are carried out based on the photometric characteristics of the different tissues observed in images, evaluating the local neighborhood of each voxel belonging to the differentiation region previously defined in the plurality of images. The disclosed method increases to a great extent precision in differentiation and quantification of tissues, while the shown percentage error is considered tolerable for diagnostic purposes.
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公开(公告)号：US20150328185A1
公开(公告)日：2015-11-19
申请号：US14417106
申请日：2013-08-21
CPC分类号： A61K31/40 , A61K8/4913 , A61K8/498 , A61K9/0063 , A61K31/22 , A61K31/366 , A61K31/405 , A61K31/4418 , A61Q11/00
摘要： The present invention discloses topical compositions comprising at least one statin as the main active compound for primary prevention or treatment of periodontal disease, for complementing standard treatment of periodontal disease, and for bone regeneration. The topical compositions are formulated for example, but not limited to, as toothpaste, mouthwash, tablets to dissolve in the mouth, elements or devices for intraoral slow-release of statins, dental floss, gel for being applied in dental trays, concentrated gel for irrigation of periodontal pockets, fluid (for example in blisters), powder, powder or liquid for preparing a solution, and gel. The present invention also discloses method for primary prevention or treatment of periodontal disease, for complementing standard treatment of periodontal disease, and for bone regeneration, comprising administering the topical compositions in the different formulations to a subject in need thereof.
摘要翻译： 本发明公开了包含至少一种他汀类作为主要预防或治疗牙周疾病的主要活性化合物，补充牙周病的标准治疗和骨再生的局部组合物。 将局部组合物配制成例如但不限于作为牙膏，漱口剂，溶解在口腔中的片剂，用于口服缓释他汀类药物的牙齿元件或装置，牙线，用于应用于牙盘中的凝胶，用于 灌注牙周袋，液体（例如泡罩），粉末，粉末或液体，用于制备溶液和凝胶。 本发明还公开了一种预防或治疗牙周病的方法，用于补充牙周病的标准治疗和骨再生，包括将不同制剂中的局部组合物施用于有需要的受试者。
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