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公开(公告)号：US20210284620A1
公开(公告)日：2021-09-16
申请号：US17260630
申请日：2019-07-16
发明人： Mahel ZEGHOUF , Raphaël RODRIGUEZ , Jacqueline CHERFILS , Agata NAWROTEK , Sarah BENABDI , Supaporn NIYOMCHON
IPC分类号： C07D311/22 , A61P35/00
摘要： The present invention relates to molecules having the following chemical structure (I). The present invention concerns molecules, in particular active as BRAG2 inhibitors and applications thereof. In particular, the invention concerns BRAG2 inhibitors in the treatment of a cancer or angiogenesis.
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公开(公告)号：US20210030022A1
公开(公告)日：2021-02-04
申请号：US17041861
申请日：2019-03-29
申请人： DSM IP ASSETS B.V.
IPC分类号： A23K20/121 , C07D311/20 , A23K30/00 , C07D311/58 , A23K20/158 , A23K50/40 , C07D311/70 , A23K20/147 , A23K50/80 , C07D311/22 , A23K20/111 , A23K50/75
摘要： The present invention is directed towards the use of substituted chroman-6-ols of formula (I) wherein R1 and R2 are independently from each other H or C1-11-alkyl or (CH2)n—OH with n being an integer from 1 to 4, or R1 and R2 represent together a keto group, 10 A is CHR3 or C(═O), and wherein R3, R4 and R6 are independently from each other H or C1-4-alkyl, and wherein R5 is H or OH or C1-4-alkyl or C1-4-alkoxy, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such substituted chroman-6-ols of formula (I).
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公开(公告)号：US10696663B2
公开(公告)日：2020-06-30
申请号：US16287771
申请日：2019-02-27
申请人： Artax Biopharma Inc.
IPC分类号： C07D311/22 , C07D413/06 , A61P37/02 , C07D405/14 , C07D413/14 , C07D405/06 , A61P35/00 , C07D405/12 , A61P37/00 , A61P17/00 , A61P11/06 , C07D413/12 , A61P29/00 , C07D311/58 , A61P3/10
摘要： The present invention provides compounds that modulate the interaction of TCR with Nck, compositions thereof, and methods of treatment using the same.
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公开(公告)号：US20190308958A1
公开(公告)日：2019-10-10
申请号：US16392732
申请日：2019-04-24
IPC分类号： C07D405/14 , C07D471/04 , C07D405/04 , C07D311/22 , A61K31/519 , A61P25/28 , A61K31/4192 , A61K31/352 , A61P27/04 , A61K31/4709
摘要： The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X═Y—Z, X—Y═Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.
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公开(公告)号：US10336733B2
公开(公告)日：2019-07-02
申请号：US15767371
申请日：2016-11-28
申请人： Merck Sharp & Dohme Corp. , Yongxin Han , Jongwon Lim , Satyanarayana Tummanapalli , Phieng Siliphaivanh , Kerrie Spencer
IPC分类号： C07D417/06 , C07D413/06 , C07D311/22 , C07D405/06 , A61K31/353 , A61K9/20
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leukotriene B4 receptor 1 (BLT1). The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, insulin resistance, hyperglycemia, dyslipidemia, lipid disorders, obesity, hypertension, Non-alcoholic fatty liver disease/nonalcoholic steatoepatitis, metabolic syndrome, atherosclerosis, and cancer.
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公开(公告)号：US20190105324A9
公开(公告)日：2019-04-11
申请号：US15677614
申请日：2017-08-15
发明人： Dhanapalan Nagarathnam , Swaroop K. Vakkalanka , Meyyappan Muthuppalaniappan , Srikant Viswanadha , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： A61K31/519 , A61K45/06 , C07D311/36 , C07D405/06 , C07D473/18 , C07D473/34 , C07D473/40 , C07D311/22 , A61K31/52 , A61K31/5377 , A61K31/185 , A61K31/5355 , C07D487/04
摘要： The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
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公开(公告)号：US20190084956A1
公开(公告)日：2019-03-21
申请号：US16087103
申请日：2017-03-20
申请人： Yu-Jen CHEN
发明人： Yu-Jen CHEN , Lie-Chwen LIN
IPC分类号： C07D311/22 , A61P35/00 , A61P37/06 , A61P25/28
CPC分类号： C07D311/22 , A61P25/28 , A61P35/00 , A61P37/06
摘要： Disclosed herein are novel compounds and uses thereof. The present compounds may suppress the activity of farnesyl transferase and thus, may act as modulators of immune cells; therefor, they are useful for the development of a medicament for treating diseases that are associated with or caused by excessive levels of farnesyl transferase or immune response. Also disclosed herein are pharmaceutical compositions containing the present compounds.
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公开(公告)号：US20180215707A1
公开(公告)日：2018-08-02
申请号：US15128932
申请日：2015-03-25
IPC分类号： C07C317/32 , C07D335/06 , C07D295/088 , C07D295/192 , C07D207/27 , C07C237/52 , C07D295/26 , C07D311/22 , C07D265/36 , C07C311/21 , C07C381/10 , C07D213/30 , C07D231/12 , C07D233/58 , C07D257/04 , C07D305/08 , C07D211/14 , C07D295/135
CPC分类号： C07C317/32 , A61K31/165 , A61K31/18 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/402 , A61K31/5375 , C07C205/36 , C07C211/45 , C07C215/70 , C07C217/48 , C07C217/76 , C07C217/88 , C07C225/22 , C07C229/42 , C07C233/29 , C07C233/54 , C07C237/22 , C07C237/52 , C07C255/46 , C07C255/50 , C07C309/89 , C07C311/08 , C07C311/21 , C07C311/37 , C07C317/24 , C07C317/44 , C07C323/09 , C07C381/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D207/27 , C07D211/14 , C07D213/30 , C07D231/12 , C07D233/58 , C07D257/04 , C07D265/36 , C07D295/088 , C07D295/135 , C07D295/192 , C07D295/26 , C07D305/08 , C07D311/22 , C07D317/72 , C07D335/06 , C07F5/025 , C07F7/1804
摘要： The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparation. The invention further relates to pharmaceutical compositions containing the compounds and their use in the treatment of diseases or disorders mediated by RORγ.
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19.发明申请公开(公告)号：US20180208587A1
公开(公告)日：2018-07-26
申请号：US15848241
申请日：2017-12-20
申请人： Lycera Corporation
IPC分类号： C07D413/12 , C07D215/58 , C07D417/12 , C07D401/12 , C07D413/14 , C07D498/08 , C07D471/04 , C07D513/04 , C07D417/06 , C07D417/14 , C07D265/36 , C07D401/06 , C07D487/04 , C07D311/22 , C07D413/06 , C07D279/16 , C07D491/10
CPC分类号： C07D413/12 , C07D215/58 , C07D265/36 , C07D279/16 , C07D311/22 , C07D401/06 , C07D401/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/08 , C07D513/04
摘要： The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.
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公开(公告)号：US20180110783A1
公开(公告)日：2018-04-26
申请号：US15677614
申请日：2017-08-15
发明人： Dhanapalan Nagarathnam , Swaroop K. Vakkalanka , Meyyappan Muthuppalaniappan , Srikant Viswanadha , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： A61K31/519 , A61K45/06 , C07D311/36 , C07D405/06 , C07D473/18 , C07D473/34 , C07D473/40 , C07D311/22 , A61K31/52 , A61K31/5377 , A61K31/185 , A61K31/5355 , C07D487/04
CPC分类号： A61K31/519 , A61K31/185 , A61K31/52 , A61K31/5355 , A61K31/5377 , A61K45/06 , C07D311/22 , C07D311/36 , C07D405/06 , C07D473/18 , C07D473/34 , C07D473/40 , C07D487/04 , Y02A50/422
摘要： The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
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