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公开(公告)号:US20220416172A1
公开(公告)日:2022-12-29
申请号:US17770441
申请日:2020-10-20
申请人: Merck Patent GmbH
IPC分类号: H01L51/00 , C07D417/04 , C09K11/06 , C07D279/02 , C07D417/14 , C07D417/10 , C07D495/04 , C07D513/04 , C07D491/048 , C07D487/04
摘要: The present invention relates to an organic electroluminescent device comprising a benzothiazine derivative and it also relates to specific benzothiazine derivatives.
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公开(公告)号:US20220411433A1
公开(公告)日:2022-12-29
申请号:US17531039
申请日:2021-11-19
发明人: Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号: C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号:US20220389028A1
公开(公告)日:2022-12-08
申请号:US17615377
申请日:2020-06-01
IPC分类号: C07D495/04 , C07D403/12 , C07D491/048 , C07D413/12 , C07D405/12 , C07D519/00 , C07C13/28
摘要: A compound having formula (I) or (II) for use inhibiting Bax mediated cell death and/or apoptosis.
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公开(公告)号:US20220389025A1
公开(公告)日:2022-12-08
申请号:US17761252
申请日:2020-09-21
申请人: Shanghai Institute of Materia Medica, Chinese Academy of Sciences , China Pharmaceutical University
发明人: Wenhu DUAN , Meiyu GENG , Huibin ZHANG , Zuoquan XIE , Jinpei ZHOU , Yifei YANG , Xiyuan WANG , Xiaojun YANG , Yan ZHANG , Zhaoxue HU , Jian DING
IPC分类号: C07D491/048 , C07D519/00 , A61P35/00
摘要: Provided are a heterocyclic amide compound of general formula (I), a pharmaceutically acceptable salt thereof and a preparation method therefor, and the use of the compound in the preparation of a drug for treating diseases related to the activity of STING, in the preparation of an immunologic adjuvant, and in the preparation of a drug for activating STING.
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公开(公告)号:US20220388960A1
公开(公告)日:2022-12-08
申请号:US17812980
申请日:2022-07-15
IPC分类号: C07D211/82 , H01L51/00 , C07D401/12 , C07D401/14 , C07D403/10 , C07D491/048 , C07D493/04 , C07C15/38 , C07D333/76 , C07D409/12 , C07D487/04 , C07F3/00 , H01L51/50 , C07C15/28 , C07C15/30 , C07C209/82 , C07D409/14 , C07D519/00 , C07D307/91 , C07D405/12 , C07D403/14 , C07D495/04
摘要: An organic compound is disclosed comprising: a first chemical moiety with a structure of formula I and two second chemical moieties, independently from another with a structure of formula II, wherein the first chemical moiety is linked to each of the two second chemical moieties via a single bond.
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公开(公告)号:US20220380387A1
公开(公告)日:2022-12-01
申请号:US17764778
申请日:2021-01-22
IPC分类号: C07F5/02 , C07D493/04 , C07C211/54 , C07C15/20 , C07D209/82 , C07D405/10 , C07D491/048 , C07D409/10 , C07D405/14 , C07F7/08 , C07D403/14 , C07D409/14 , C07D487/04 , C07D471/04 , C07D409/04 , C07D401/14 , C07D251/24 , C07D403/04 , C07D403/10 , C07D333/76 , C07D307/91 , C07D235/08 , C07F9/53 , C07C13/72 , C07D519/00 , C07D487/14 , C07D495/04 , C07C15/38 , C07D413/10 , C07D491/147 , C07D413/14 , C07D495/14 , C07D401/04 , C07D487/16 , C07D241/46 , H01L51/00 , H01L51/50
摘要: An organic electroluminescence device includes an anode, a cathode, and an emitting layer disposed between the anode and the cathode. The emitting layer comprises a delayed fluorescent compound M2 having at least one deuterium atom and a compound M3 having at least one deuterium atom. A singlet energy S1(M2) of the compound M2 and a singlet energy S1(M3) of the compound M3 satisfy the relationship S1(M3)>S1(M2).
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公开(公告)号:US20220380358A1
公开(公告)日:2022-12-01
申请号:US17269817
申请日:2019-08-22
申请人: ASCENEURON S. A.
IPC分类号: C07D417/06 , C07D405/06 , C07D417/14 , C07D491/048 , C07D519/00 , C07D471/04 , C07D487/04 , A61K45/06
摘要: Compounds of formula (I′), wherein A, R1, R2, T1, T2, T3, T4, L, W, Z, R′″, m and n have the meaning according to the claims, can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
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18.
公开(公告)号:US11515487B2
公开(公告)日:2022-11-29
申请号:US16496712
申请日:2018-03-26
发明人: Young Seok No , Ju Hyon Cha , Dongjun Kim
IPC分类号: H01L51/50 , H01L51/00 , C07D209/86 , C07D405/14 , C07D487/04 , C07D491/048 , C07D495/04 , C09K11/06 , C07D403/14
摘要: The present specification relates to an organic light emitting device comprising a first electrode, a second electrode, and one or more organic material layers provided between the first electrode and the second electrode, wherein one or more layers of the organic material layers comprise a heterocyclic compound represented by Chemical Formula 1 and a heterocyclic compound represented by Chemical Formula 2 at the same time, and a composition for an organic material layer of an organic light emitting device.
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公开(公告)号:US11505558B1
公开(公告)日:2022-11-22
申请号:US17220300
申请日:2021-04-01
发明人: Adam Szymaniak , Kevin McGrath , Jianming Yu , Tyler Mann , Long Nguyen , Kaicheng Zhu , In Jong Kim , Yat Sun Or
IPC分类号: C07D471/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号:US20220363640A1
公开(公告)日:2022-11-17
申请号:US17208964
申请日:2021-03-22
发明人: Guangyi WANG , Leonid BEIGELMAN , Anh TRUONG , Carmela NAPOLITANO , Daniele ANDREOTTI , Haiying HE , Karin Ann STEIN
IPC分类号: C07D213/40 , C07D409/04 , C07D495/14 , C07D401/04 , C07D413/04 , C07D417/04 , C07D239/34 , C07D471/04 , C07D213/65 , C07D401/12 , C07D491/048 , C07D233/64 , C07D409/14 , C07D417/06 , C07D413/12 , C07D413/06 , C07D401/06 , C07D405/12 , C07D417/12 , C07D207/273 , C07D491/052 , A61K31/4436 , A61K31/4418 , A61K31/4178 , A61K31/4439 , A61K31/4365 , A61K31/422 , A61K31/4196 , A61K31/427 , A61K31/505 , A61K31/437 , A61K45/06 , A61K31/4355 , A61K31/444 , A61K31/4709
摘要: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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