公开(公告)号：US20200232973A1

公开(公告)日：2020-07-23

申请号：US16732850

申请日：2020-01-02

Applicant: Shionogi & Co., Ltd. ,  Osaka University

Inventor： Tetsuya Yoshida ,  Yujiro Kidani ,  Mitsunobu Matsumoto ,  Takayuki Kanazawa ,  Satomi Shinonome ,  Kanji Hojo ,  Naganari Ohkura ,  Shimon Sakaguchi ,  Atsushi Tanaka ,  Hisashi Wada ,  Atsunari Kawashima ,  Norio Nonomura

IPC: G01N33/50 ,  C07K16/28 ,  A61K9/00

Abstract: The disclosure provides a method of measuring an efficacy of a drug composition for cancer and a method for treating a cancer by administering to a subject an effective amount of a pharmaceutical composition having a polypeptide that binds to a peptide produced by cDNA of GenBank ACC No. NM_005201.3 or NM_007720.2.

公开(公告)号：US20200230431A1

公开(公告)日：2020-07-23

申请号：US16842124

申请日：2020-04-07

Applicant: THE UNIVERSITY OF TOKYO ,  OSAKA UNIVERSITY

Inventor： Youichi SAITOH ,  Masaki SEKINO ,  Keita YAMAMOTO

IPC: A61N2/02 ,  A61N1/40 ,  A61N2/00 ,  A61F2/04 ,  A61B5/00

Abstract: A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided to further increase an electric field intensity on a head surface. The coil apparatus includes a wound-wire coil disposed on or near a head surface so as to generate a current by an induced electric field through electromagnetic induction in a magnetic stimulation-target region of a brain for stimulating neurons. The wound-wire coil includes a near-head-surface conductive wire portion disposed on or near the head surface, and a far-head-surface conductive wire portion disposed farther from the head surface than the near-head-surface conductive wire portion. A distance between the near-head-surface conductive wire portion and the far-head-surface conductive wire portion is set to be changed so that an intensity of the induced electric field becomes larger than that of a surrounding region of the magnetic stimulation-target region.

公开(公告)号：US20200223915A1

公开(公告)日：2020-07-16

申请号：US16467751

申请日：2017-12-04

Applicant: OSAKA UNIVERSITY

Inventor： Yoshiaki OKADA ,  Masuo KONDOH ,  Yosuke HASHIMOTO ,  Keisuke SHIRAKURA ,  Takefumi DOI ,  Kiyohito YAGI ,  Hiroyuki TAKEDA ,  Tatsuya SAWASAKI

IPC: C07K16/28 ,  A61K39/395

Abstract: Provided is a novel technique for controlling the blood-brain barrier. An antibody whose epitope is a region within an extracellular domain of Claudin 5 protein.

公开(公告)号：US20200206300A1

公开(公告)日：2020-07-02

申请号：US16619879

申请日：2018-06-12

Applicant: OSAKA UNIVERSITY

Inventor： Susumu TANAKA ,  Mikihiko KOGO ,  Hirofumi YAMAMOTO ,  Naomasa KAWAGUCHI ,  Yoshinosuke HAMADA

IPC: A61K38/08 ,  A61K38/39 ,  A61P21/00

Abstract: The present invention provides an agent for promoting skeletal muscle injury repair which agent comprises at least one peptide selected from the following (1) to (4): (1) a peptide consisting of the amino acid sequence of SEQ ID NO: 1, (2) a peptide consisting of the amino acid sequence of SEQ ID NO: 2, (3) a peptide consisting of the amino acid sequence of SEQ ID NO: 3, and (4) a peptide which is a human osteopontin fragment and has the amino acid sequence of SEQ ID NO: 1, 2, or 3 at the C-terminus, or a salt thereof as an active ingredient.

公开(公告)号：US20200171092A1

公开(公告)日：2020-06-04

申请号：US16620655

申请日：2018-05-08

Applicant: OSAKA UNIVERSITY ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yoshiki Sawa ,  Shigeru Miyagawa ,  Daisuke Kajita ,  Hayato Kurata ,  Kotoe Tamada ,  Hiroyuki Nishida

IPC: A61K35/28 ,  A61K9/14 ,  A61K38/20 ,  A61K38/18 ,  A61K38/17 ,  A61P9/10

Abstract: The purpose of the present invention is to provide a therapeutic agent for dilated cardiomyopathy disease which produces excellent effects in the treatment of dilated cardiomyopathy (DCM) and provides a given benefit to a large number of patients. The present invention is a therapeutic agent for dilated cardiomyopathy comprising at least one selected from the group consisting of mesenchymal stem cell and microparticles derived from the mesenchymal stem cell. It is preferable that the mesenchymal stem cell is a cell having the ability to contain or secrete microparticles, that the microparticles have an average particle size of 1000 nm or less, and that they are exosomes.

公开(公告)号：US10669529B2

公开(公告)日：2020-06-02

申请号：US15745425

申请日：2016-07-14

Applicant: Kyoto University ,  Osaka University

Inventor： Tatsutoshi Nakahata ,  Megumu Saito ,  Akira Niwa ,  Ryo Ota ,  Kiyotoshi Sekiguchi

IPC: C12N5/10 ,  C12N15/09 ,  A61K35/44 ,  C12N5/071 ,  C07K14/78 ,  A61L27/00

Abstract: Provided is a method for producing vascular endothelial cells from pluripotent stem cells, the method comprising the following steps (i) to (iii): (i) a step of culturing pluripotent stem cells in a culture medium comprising a BMP, on a culture vessel coated with a first matrix, to produce mesodermal progenitor cells; (ii) a step of dissociating the resulting cells into single cells; and (iii) a step of culturing the resulting cells in a culture medium comprising VEGF, on a culture vessel coated with a second matrix selected from the group consisting of laminin-411 or a fragment thereof, laminin-511 or a fragment thereof, Matrigel, type IV collagen and fibronectin.

公开(公告)号：US10602955B2

公开(公告)日：2020-03-31

申请号：US16250564

申请日：2019-01-17

Applicant: OSAKA UNIVERSITY

Inventor： Hitomi Nakamura ,  Tadashi Kimura ,  Takayoshi Hosono

IPC: A61B5/053 ,  A61B5/00 ,  A61B10/00

Abstract: A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and a fixation device configured to fix the interval of arrangement of the electrodes. Second and third uterine evaluation device include: a flexible and rod-shaped main body for insertion into a uterine cavity; and four or two impedance electrodes arranged with a predetermined interval therebetween in an insertion direction of the main body and brought into contact with an endometrium of the uterine cavity to measure a uterine endometrial impedance generated between the endometrium and each of the electrodes.

公开(公告)号：US10589355B2

公开(公告)日：2020-03-17

申请号：US15772465

申请日：2016-10-12

Applicant: Nissan Motor Co., Ltd. ,  Osaka University

Inventor： Masaru Uenohara ,  Takashi Furuya ,  Koichi Nakazawa ,  Shinichirou Fujikawa ,  Seiji Kawai ,  Kenichi Machida ,  Genya Yamato

IPC: B22F3/12 ,  B22F3/24 ,  B22F1/00 ,  B22F1/02 ,  B22F9/04 ,  H01F1/057 ,  H01F41/02 ,  C23C24/00 ,  B22F3/26 ,  B22F9/06 ,  C22C28/00 ,  C22C38/00 ,  C22C1/04

Abstract: An improvement of coercive force of Nd—Fe—B base sintered magnet can be realized while suppressing a decrease in remanent magnetic flux density to the minimum using a method for modifying grain boundary which comprises heat-treating an Nd—Fe—B base magnet with a specific alloy disposed on its surface, the alloy having the following Formula 1: RxAyBz  (1) wherein R represents at least one rare earth element including Sc and Y, A represents Ca or Li, B represents an unavoidable impurity, and 2≤x≤99, 1≤y

公开(公告)号：US20200080180A1

公开(公告)日：2020-03-12

申请号：US16467225

申请日：2018-08-08

Applicant: OSAKA UNIVERSITY ,  KOMATSU LTD.

Inventor： Yoritoshi MINAMINO ,  Koji HAGIHARA ,  Koji YAMAMOTO ,  Shohei IKURUMI ,  Yusuke HIRATSUKA ,  Takeshi FUJIMATSU ,  Toshiyuki SUGIMOTO

IPC: C22C38/46 ,  C22C38/44 ,  C22C38/06 ,  C22C38/04 ,  C22C38/02 ,  C22C38/00 ,  C21D6/00 ,  C21D6/02 ,  C21D1/28

Abstract: A steel with high hardness and excellent toughness contains, in mass %, 0.40-1.00% C, 0.10-2.00% Si, 0.10-1.00% Mn, 0.030% or less P, 0.030% or less S, 1.10-3.20% Cr, 0.010-0.10% Al, and 0.15-0.50% V, and further contains at least one or two of 2.50% or less Ni and 1.00% or less Mo, with an amount of (C+V) being 0.60% or more in mass %, with the balance consisting of Fe and unavoidable impurities. The steel has a microstructure which is a martensitic structure with finely dispersed Fe-based ε carbides, with its prior austenite grain size being 20 μm or less.

公开(公告)号：US20200072917A1

公开(公告)日：2020-03-05

申请号：US16548121

申请日：2019-08-22

Applicant: Osaka University ,  JEOL Ltd.

Inventor： Toshimichi Fujiwara ,  Yoh Matsuki ,  Yuki Endo ,  Shinji Nakamura ,  Hiroki Takahashi

IPC: G01R33/30 ,  G01R33/28 ,  G01R33/36

Abstract: A container has a sample installation unit and an NMR circuit therein, and is connected to a bearing gas supply path and a drive gas supply path for supplying gas to the inside of that container. This container is also connected to an exhaust path that exhausts the gas from the inside of the container. The exhaust path has a pressure control valve as an adjustment mechanism for adjusting the pressure in the container.