公开(公告)号：US12123018B2

公开(公告)日：2024-10-22

申请号：US16630498

申请日：2018-07-13

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Lihi Adler-Abramovich ,  Rina Sevostianov ,  Irena Grigoriants ,  Ehud Gazit

IPC: C12N5/00

CPC classification number: C12N5/0062 ,  C12N2513/00 ,  C12N2533/20 ,  C12N2535/00

Abstract: Hybrid hydrogels, made of a three-dimensional network of fibrillar nanostructures, at least a portion of the fibrillar nanostructures being formed of at least two different types of aromatic moieties, at least one type of the aromatic moieties being an end-capping modified aromatic dipeptide and at least another type of the aromatic moieties being an amine-modified halogenated aromatic amino acid, are provided. Also provided are processes of preparing the hybrid hydrogels and uses thereof.

公开(公告)号：US20240329048A1

公开(公告)日：2024-10-03

申请号：US18443832

申请日：2024-02-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Adi Barzel ,  Iris Dotan ,  Yuval Raviv

IPC: G01N33/574 ,  C07K14/47 ,  C07K16/30 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/57484 ,  C07K14/4748 ,  C07K16/30 ,  G01N33/58 ,  G01N33/6854

Abstract: High throughput methods for identifying monoclonal antibodies (mAbs) targeted to tumor antigens, using membranal B-cell receptor (BCR) screening of immortalized B-cells are provided. Methods for identification and characterization of tumor-related antigens are also provided as well as therapeutic and diagnostic uses of the newly-identified antibodies and antigens in cancer.

公开(公告)号：US12070476B2

公开(公告)日：2024-08-27

申请号：US17584508

申请日：2022-01-26

Applicant: Ramot at Tel-Aviv University Ltd. ,  The University Court of the University of Glasgow

Inventor： Oded Rechavi ,  Shahar Bracha ,  Lilach Sheiner

IPC: A61K35/68 ,  C07K14/45 ,  C12N9/00 ,  C12N15/65 ,  C12N15/79

CPC classification number: A61K35/68 ,  C07K14/45 ,  C12N9/93 ,  C12N15/65 ,  C12N15/79 ,  C07K2319/10 ,  C12Y603/05005

Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

公开(公告)号：US20240282402A1

公开(公告)日：2024-08-22

申请号：US18641391

申请日：2024-04-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tamir TULLER ,  David SHALLOM ,  Shlomo WEISS ,  Danny NAIGER

IPC: G16B5/00

CPC classification number: G16B5/00

Abstract: A system and method of whole-cell process simulations may include: using at least one first hardware module, to produce a first predicted value, representing an expected behavior of a plurality of resource entities in a simulated biological cell; using at least one second hardware module, to produce a second predicted value, representing an interaction of a plurality of client entities with at least one of the plurality of resource entities in the simulated biological cell; using at least one third hardware module, to produce a third predicted value, representing an arbitration of interactions between the plurality of resource entities and the plurality of client entities in the simulated biological cell; and producing a simulated value of a product of a natural process in the simulated biological cell, based on said first, second and third predicted values.

公开(公告)号：US20240261599A1

公开(公告)日：2024-08-08

申请号：US18567508

申请日：2022-06-08

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Tali ILOVITSH ,  Mike Gaston Natanael BISMUTH ,  Bar GLICKSTEIN

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: Provided herein are systems, methods and compositions for noninvasive mechanical ultrasound (US) ablation of target tissue using microbubbles, nanobubbles or nanodroplets, combined with application of low frequency focused ultrasound.

公开(公告)号：US20240245720A1

公开(公告)日：2024-07-25

申请号：US18564356

申请日：2022-05-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel OFFEN ,  Nataly YOM-TOV

IPC: A61K31/785 ,  A61K9/50 ,  A61K9/51 ,  B82Y5/00

CPC classification number: A61K31/785 ,  A61K9/5068 ,  A61K9/5146 ,  A61K9/5161 ,  B82Y5/00

Abstract: The present disclosure provides a composition comprising an extracellular vesicle (EV) associated with an active agent and a polymer, wherein said polymer carries at least one positively charged moiety or has at least one positive pole and said active agent carries, independently, at least one negatively charged moiety or has at least one negative pole; and wherein said polymer and said active agent are present at a positive to negative charge or pole ratio of at least 2. A preferred example relates to a composition wherein the polymer is polyethyleneimine, the agent is a nucleic acid and the EV is an exosome. The present disclosure also provides methods for obtaining the composition and uses of the composition.

公开(公告)号：US20240167062A1

公开(公告)日：2024-05-23

申请号：US18281982

申请日：2022-03-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Iftach YACOBY ,  Itzhak GRINBERG ,  Oren BENZVI ,  Ehud GAZIT ,  Lihi ADLER-ABRAMOVICH

IPC: C12P3/00 ,  A61K9/06 ,  A61K38/05 ,  C01B3/02 ,  C01C1/02

CPC classification number: C12P3/00 ,  A61K9/06 ,  A61K38/05 ,  C01B3/02 ,  C01C1/02

Abstract: Methods which utilize a self-assembled structure formed of a plurality of peptides being of from 2 to 6 amino acids in length, and comprising at least one aromatic amino acid residue, wherein the self-assembled structure is capable of interacting with oxygen, are provided herewith. The methods may be for controlling (e.g., reducing) a concentration of free oxygen in an environment, and/or for transporting oxygen from a first environment to a second environment. Further described herein is a self-assembled structure as described herein having oxygen interacted therewith. Further described herein is a composition comprising the self-assembled structure and substance which is oxygen-sensitive and/or participates in an oxygen-sensitive reaction incorporated in the self-assembled structure, systems comprising such a composition and methods employing the composition or system. Further described herein are articles-of-manufacturing comprising any of the self-assembled structures or compositions as described herein and an oxygen-sensitive substance and uses thereof.

公开(公告)号：US20240166593A1

公开(公告)日：2024-05-23

申请号：US18263795

申请日：2022-02-02

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Srinivas RAMISHETTI ,  Dan PEER

IPC: C07C239/22 ,  A61K9/127 ,  C07C229/12 ,  C07C229/16 ,  C07C233/36 ,  C07D295/15 ,  C12N15/88

CPC classification number: C07C239/22 ,  A61K9/1272 ,  C07C229/12 ,  C07C229/16 ,  C07C233/36 ,  C07D295/15 ,  C12N15/88

Abstract: The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

公开(公告)号：US20240157363A1

公开(公告)日：2024-05-16

申请号：US18419732

申请日：2024-01-23

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Gilad YOSSIFON ,  Sinwook PARK ,  Barak SABBAGH

IPC: B01L3/00

CPC classification number: B01L3/502784 ,  B01L3/5023 ,  B01L2200/0673 ,  B01L2300/0645 ,  B01L2300/126 ,  B01L2400/0415

Abstract: Device for concentration of bioparticles for identification comprises one or more capillary flow paths from at least one inlet for advection along the path of bioparticles in a buffer solution, two or more membranes along the flow path, the membranes being individually selectable for electrical powering, thereby to controllably set up a powered membrane region at a location along said path, said powered membrane region causing localized concentration of the bioparticles, digital-like manipulation of the preconcentrated bioparticles plugs, and detection surface immobilized molecular probes located along said flow path to detect the bioparticles following localized concentration.

公开(公告)号：US20240139167A1

公开(公告)日：2024-05-02

申请号：US18277257

申请日：2022-02-16

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Or KAKHLON ,  Miguel Enrique WEIL

IPC: A61K31/4436 ,  A61P3/00

CPC classification number: A61K31/4436 ,  A61P3/00

Abstract: Disclosed herein is a polypeptide including a pharmaceutical composition for use in prevention or treatment of a disease or a disorder associated with lysosomal storage and an autophagy-misregulation associated disease. Further provided are agents that bind a region of an N-terminal domain of a lysosomal-associated membrane protein 1 (LAMP-1), and methods for treating or preventing development of a disease or a disorder associated with lysosomal storage, polyglucosan accumulation or abnormal glycogen accumulation and autophagy-misregulation in a subject in need thereof.