公开(公告)号：US06929040B2

公开(公告)日：2005-08-16

申请号：US10600525

申请日：2003-06-19

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/08 ,  A61B20060101 ,  A61L2/08 ,  B65B1/04 ,  B65B3/04 ,  B65B7/28 ,  B65B55/02 ,  B65B55/04 ,  B67C3/00

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through an e-beam chamber, wherein an electron beam is directed onto a penetrable surface of the stopper to sterilize the penetrable surface. A needle is mounted within the e-beam chamber and moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. The needle is then withdrawn from the stopper and the filled container is transported outside of the e-beam chamber. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可热再封塞的塞子和用于在其中容纳物质的腔室。 密封的空容器经受能够穿过塞子和室的辐射，以对容器进行灭菌。 先前灭菌的容器然后通过电子束室传送，其中电子束被引导到塞子的可穿透表面上以对可穿透表面进行消毒。 针安装在电子束室内并与止动器接合，以刺穿塞子的消毒的可渗透表面并将物质通过针头注入容器的腔室。 然后将针从止动器中取出，并将填充的容器运送到电子束室外部。 然后将激光能量传递到塞子的穿透表面上，以使塞子材料熔化并密封地重新密封塞子。

公开(公告)号：USD507680S1

公开(公告)日：2005-07-19

申请号：US29198305

申请日：2004-01-27

Applicant: Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

公开(公告)号：US20050150903A1

公开(公告)日：2005-07-14

申请号：US11008887

申请日：2004-12-09

Applicant: Daniel Py ,  Julian Chan ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Julian Chan ,  Giovanni Rodriguez

IPC: B65D47/20 ,  B65D51/22 ,  B67D7/74 ,  B67D99/00 ,  B67D5/00 ,  B67D5/56

CPC classification number: B65D51/226 ,  B65D47/2075

Abstract: A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a head located at one end of the body and a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber, and a first connecting portion for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and at least one piercing portion engageable with the pierceable wall of the container. The valve assembly includes a second connecting portion that is connectable to the first connecting portion of the container for fixedly securing the valve assembly to the container when the valve assembly and container are located in the second position. The valve assembly includes a valve seat and at least one flow aperture extending through the valve body adjacent to the valve seat and in fluid communication with the second passageway for receiving the substance from the storage chamber therethrough.

Abstract translation: 用于存储和分配物质的装置包括具有在其中限定有用于接收和存储物质的储存室的主体的容器。 容器包括位于主体一端的头部和与主体的储存室流体连通并限定其间的流路的第一通道。 容器还包括位于通道相对于储存室的相对侧上的可穿透壁，以及用于将另一部件连接到其上的第一连接部分。 该装置还包括单向阀组件，该单向阀组件包括阀体，该阀体包括限定第二通道的主体基座和与容器的可刺穿壁可接合的至少一个穿孔部分。 阀组件包括可连接到容器的第一连接部分的第二连接部分，用于当阀组件和容器位于第二位置时将阀组件固定地固定到容器。 阀组件包括阀座和至少一个流动孔，其延伸穿过与阀座相邻的阀体，并与第二通道流体连通，用于通过其从储存室接收物质。

公开(公告)号：US20050145295A1

公开(公告)日：2005-07-07

申请号：US10983178

申请日：2004-11-05

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy

IPC: A61M20060101 ,  B65B1/04 ,  B65B3/00

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one needle assembly and is adjustable to receive a plurality of needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of vials that are to be filled concurrently and adjusting an assembly to include at least one needle assembly and at least one seal assembly. A number of the needle assemblies and the seal assemblies equals the number of vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个针组件，并且可调节以接收多个针组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的小瓶的数量并且调整组件以包括至少一个针组件和至少一个密封组件。 许多针组件和密封组件等于小瓶的数量。

公开(公告)号：US06892906B2

公开(公告)日：2005-05-17

申请号：US10640500

申请日：2003-08-13

Applicant: Daniel Py ,  Norbert M. Assion ,  Julian V. Chan

Inventor： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan

IPC: A45D40/26 ,  B65D25/40 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D35/44 ,  B65D35/50 ,  B65D37/00 ,  B65D47/20

CPC classification number: B65D47/205 ,  A45D40/26 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D83/0055

Abstract: A container including a nozzle and body depending therefrom. The body is preferably tubular and defines an interior which retains a product to be dispensed. A cap engages the nozzle to prevent inadvertent release of the product. In order to dispense the product, the cap is removed and pressure is applied to the body and the nozzle allows release of the product. The nozzle releases the product without exposing the remaining product to the external atmosphere, thus the sterility of the interior of the body is maintained and the shelf life of the product is increased. The nozzle includes an inner body, coupled to the tubular body, surrounded by a flexible outer cover. A seam between the inner body and flexible outer cover forms a one-way release valve wherein a portion of the seam remains closed during dispensing the product.

公开(公告)号：US20050089358A1

公开(公告)日：2005-04-28

申请号：US10893686

申请日：2004-07-16

Applicant: Daniel Py ,  Julian Chan ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Julian Chan ,  Giovanni Rodriguez

IPC: B43K5/02 ,  B67D7/60

CPC classification number: B65D35/28 ,  A45D34/04 ,  A45D2034/007 ,  A45D2200/055

Abstract: A dispenser for dispensing a substance, such as a liquid lipstick or other product, has a body defining a variable-volume storage chamber for storing the product. A dispensing portion is connected with the body and defines a bore coupled in fluid communication with the storage chamber for receiving product therefrom, and an outlet aperture coupled in fluid communication with the bore. A piston is received within the bore, and a one-way valve is mounted on the dispensing portion for dispensing metered amounts of product therethrough. The one-way valve has an axially-extending valve seat, and an axially-extending visco-elastic valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat, and the seam is connectable in fluid communication with the outlet aperture to allow the passage of product through the seam and out of the dispenser. An actuator is drivingly connected to the piston for moving the piston within the bore and dispensing a predetermined amount of product within the bore through the outlet aperture.

Abstract translation: 用于分配诸如液体口红或其他产品的物质的分配器具有限定用于存储产品的可变容积储存室的主体。 分配部分与主体连接并且限定了与储存室流体连通以与其接收产品的孔，以及与孔流体连通的出口孔。 活塞被容纳在孔内，并且单向阀安装在分配部分上，用于分配计量的产品通过其中。 单向阀具有轴向延伸的阀座和位于阀座上的轴向延伸的粘弹性阀盖，并且在其间形成常闭的轴向延伸的接缝，在其之间形成流体密封的密封件 和阀座。 柔性阀盖可相对于阀座移动，并且接缝可与出口孔流体连通以允许产品通过接缝并从分配器中通过。 致动器驱动地连接到活塞上，用于在孔内移动活塞并且通过出口孔在孔内分配预定量的产品。

公开(公告)号：US20050029307A1

公开(公告)日：2005-02-10

申请号：US10691270

申请日：2003-10-21

Applicant: Daniel Py ,  Norbert Assion ,  Julian Chan ,  Joseph Ting

Inventor： Daniel Py ,  Norbert Assion ,  Julian Chan ,  Joseph Ting

IPC: B67D7/60 ,  A61F9/00 ,  B05B11/00 ,  B65D81/24 ,  B67D7/84 ,  B67D5/42

CPC classification number: A61F9/0008 ,  B05B11/00412 ,  B05B11/0054 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3092 ,  B05B11/3094 ,  B65B3/003 ,  B65D81/245 ,  Y10T29/49826

Abstract: An ophthalmic dispenser has a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. A spring is drivingly connected to the housing and moves at least one of the pump and housing relative to the other to actuate the pump. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump.

Abstract translation: 眼科分配器具有限定流体接收室的刚性壳体，可接收在流体接收室内的柔性气囊，与流体接收室流体连通的泵，以及具有限定环形轴向 - 延伸阀座，联接在阀座和泵之间流体连通的出口孔，以及围绕阀座延伸并在其间形成环形的轴向延伸的接口的柔性阀盖。 阀接口可连接到出口孔流体连通，并且阀盖的至少一部分可在（i）常闭位置与阀盖之间移动，阀盖与阀座接合以闭合界面并形成流体密封 ，并且（ii）打开位置，其中阀盖的至少一部分响应于在大于阀打开压力的压力下流过出口孔的泵送流体而与阀座间隔开，以允许加压流体在其间通过 。 弹簧驱动地连接到壳体并且相对于另一个移动泵和壳体中的至少一个以致动泵。 刚性壳体可安装在盒中，其又可安装在分配器壳体内，该分配器壳体包括用于同时致动眼睑下压器和泵的眼睑下压器和触发器。

公开(公告)号：USD495946S1

公开(公告)日：2004-09-14

申请号：US29175061

申请日：2003-01-28

Applicant: Daniel Py ,  Julian V. Chan ,  Norbert M. Assion

Designer： Daniel Py ,  Julian V. Chan ,  Norbert M. Assion

公开(公告)号：US06302101B1

公开(公告)日：2001-10-16

申请号：US09460050

申请日：1999-12-14

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M1100

CPC classification number: B05B11/3066 ,  A61M11/001 ,  A61M11/06 ,  A61M15/0025 ,  A61M15/0026 ,  A61M15/0065 ,  A61M2205/073 ,  A61M2206/16 ,  B05B1/341 ,  B05B1/3436 ,  B05B11/0038 ,  B05B11/00412 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/0075 ,  B05B11/3001 ,  B05B11/3011 ,  B05B11/3074 ,  B05B11/3076 ,  B05B11/3077 ,  B05B11/309 ,  B05B11/3092 ,  B05B11/3095

Abstract: A pump-type dispenser for dispensing predetermined doses of medicament in droplets or in spray form to the nasal area incorporates a rigid vial for medicament, an expandable pouch located within the rigid vial, a nasal screen, a one-way actuation mechanism, a one-way valve mechanism in the nozzle area and a spring element, both the valve mechanism and the spring element being formed as integral portions of the pump body. The nasal screen aligns the dispenser nozzle with the nasal passage and also allows the user to discreetly hide the nasal area from public view. The one-way valve mechanism in the nozzle area ensures a one-way movement of medicament from the dispenser, thereby preserving substantially perfect sterility of the medicament in the dispenser regardless of the environment surrounding the dispenser, without requiring the use of preservatives. The one-way actuation mechanism enables the user to load and dispense a uniform quantity of medicament with a uniform actuation force and speed via a single continuous motion of the actuation mechanism upon application of a very small force on the actuation trigger mechanism by the user. By preventing the pump mechanism from being left in a loaded state for a prolonged period of time, the one-way actuation mechanism prevents the spring element from experiencing the “fatigue” phenomenon. The rigid vial/expandable-pouch combination facilitates improved long term use, as well as uniformity of dosage independent of the pump orientation.

Abstract translation: 用于将液滴或喷雾形式的预定剂量的药剂分配到鼻区域的泵型分配器包括用于药物的刚性小瓶，位于刚性小瓶内的可膨胀袋，鼻屏，单向致动机构，一个 在喷嘴区域中具有一个阀门机构和一个弹簧元件，阀机构和弹簧元件都形成为泵体的整体部分。 鼻屏幕使分配器喷嘴与鼻通道对准，并且还允许使用者谨慎地隐藏鼻部区域以免公众观察。 喷嘴区域中的单向阀机构确保药物从分配器的单向移动，从而在不需要使用防腐剂的情况下，保持药剂在分配器中基本上完美的无菌性，无论分配器周围的环境如何。 单向致动机构使得用户能够通过使用者在致动触发机构上施加非常小的力而经由致动机构的单一连续运动以均匀的致动力和速度来加载和分配均匀量的药物。 通过防止泵机构长时间处于负载状态，单向致动机构防止弹簧元件发生“疲劳”现象。 刚性小瓶/可膨胀袋组合有助于改善长期使用，以及独立于泵取向的剂量均匀性。

公开(公告)号：US6053433A

公开(公告)日：2000-04-25

申请号：US192843

申请日：1998-11-16

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D83/14 ,  A61M11/00 ,  B05B1/34 ,  B05B11/00 ,  B05B1/30

CPC classification number: B05B11/007 ,  B05B1/341 ,  B05B1/3436 ,  B05B11/0072 ,  B05B11/0075

Abstract: A nozzle mechanism for generating an aerosol-type liquid discharge is provided, which nozzle mechanism ensures one-way movement of liquid during discharge and also has a substantially zero "dead volume" at the tip of the nozzle. The nozzle mechanism includes a flexible nozzle portion with an outlet and a fluid channel, a rigid shaft received within the flexible nozzle portion, and a rigid housing surrounding the flexible nozzle portion and exposing the outlet. The rigid shaft interfaces the outlet to form a first normally-closed, one-way valve, as well as to define a swirling chamber for collecting the liquid which has been channeled from the liquid reservoir, prior to being discharged via the outlet. The outlet has a tubular wall with thickness that decreases along the elongated axis of symmetry for the outlet toward the tip of the outlet. The fluid channel is circumferentially positioned within the flexible nozzle portion to create swirling action of the liquid delivered to said swirling chamber. Once the pressure on the swirling liquid reaches a threshold pressure sufficient to radially deform the portion of the outlet forming the first normally-closed valve, the liquid in the swirling chamber is discharged through the outlet. The nozzle mechanism is coupled to a flexible body portion which has a substantially tubular shape and a wall thickness which decreases from the bottom of the body portion toward the flexible nozzle portion. The rigid shaft received within the flexible nozzle portions extends down into the flexible body portion so that a second portion of the rigid shaft interfaces the flexible body portion to form a second normally-closed, one-way valve in the fluid communication path between the liquid reservoir and the swirling chamber.

Abstract translation: 提供了一种用于产生气溶胶型液体排出口的喷嘴机构，该喷嘴机构确保了排出期间液体的单向移动，并且在喷嘴的尖端处也具有基本为零的“死体积”。 喷嘴机构包括具有出口和流体通道的柔性喷嘴部分，容纳在柔性喷嘴部分内的刚性轴以及围绕柔性喷嘴部分并暴露出口的刚性壳体。 刚性轴将出口接合以形成第一常闭单向阀，并且在通过出口排出之前，限定用于收集已经从液体储存器引导的液体的旋转室。 出口具有管状壁，其厚度沿着用于出口朝向出口的尖端的细长对称轴线减小。 流体通道周向地定位在柔性喷嘴部分内，以产生输送到所述旋转室的液体的旋转作用。 一旦旋转液体上的压力达到足以使形成第一常闭阀的出口的部分径向变形的阈值压力，则旋转室中的液体通过出口排出。 喷嘴机构联接到柔性主体部分，其具有基本上管状的形状和从主体部分的底部向柔性喷嘴部分减小的壁厚。 容纳在柔性喷嘴部分内的刚性轴向下延伸到柔性主体部分中，使得刚性轴的第二部分接合柔性主体部分，以在液体之间的流体连通路径中形成第二常闭单向阀 水库和旋转室。