公开(公告)号：US20210221892A1

公开(公告)日：2021-07-22

申请号：US17101966

申请日：2020-11-23

Applicant: Genentech, Inc.

Inventor： Ying YANG ,  Sreedhara ALAVATTAM

IPC: C07K16/28 ,  A61K39/395

Abstract: The invention provides stable aqueous pharmaceutical formulations comprising an anti-PDL1 antibody. The invention also provides methods for making such formulations and methods of using such formulations.

公开(公告)号：US11066463B2

公开(公告)日：2021-07-20

申请号：US16131608

申请日：2018-09-14

Applicant: Genentech, Inc.

Inventor： Vishva Dixit ,  Robert F. Kelley ,  Marissa L. Matsumoto

IPC: G01N33/53 ,  C07K16/18 ,  C07K14/47 ,  G01N33/68 ,  C12N15/10

Abstract: The invention provides anti-polyubiquitin antibodies and methods of using the same.

公开(公告)号：US20210214462A1

公开(公告)日：2021-07-15

申请号：US17148456

申请日：2021-01-13

Applicant: Genentech, Inc.

Inventor： Shahram MISAGHI ,  John B. LOWE ,  Bradley Richard SNEDECOR

IPC: C07K16/44 ,  C07K14/435 ,  G01N33/68

Abstract: The present application relates to methods of producing a protein in fucosydated and afucosylated forms at a predetermined ratio.

公开(公告)号：US20210214336A1

公开(公告)日：2021-07-15

申请号：US17056325

申请日：2019-05-21

Applicant: GENENTECH, INC.

Inventor： Steven MCKERRALL ,  Ramsay BEVERIDGE ,  Kwong Wah LAI ,  Philippe BERGERON

IPC: C07D401/12 ,  A61P17/04 ,  A61K9/00 ,  A61P29/00

Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain

公开(公告)号：US20210213130A1

公开(公告)日：2021-07-15

申请号：US17129096

申请日：2020-12-21

Applicant: GENENTECH, INC.

Inventor： Gail Lewis Phillips ,  Deepak Sampath ,  Ingrid Wertz

IPC: A61K39/395 ,  C07K16/32 ,  G01N33/574 ,  A61K47/68 ,  A61K31/635 ,  A61K45/06 ,  A61P35/00 ,  A61K31/496

Abstract: The present invention is directed to a combination therapy involving an anti-HER2 antibody-drug conjugate and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a HER2-expressing cancer.

公开(公告)号：US20210208145A1

公开(公告)日：2021-07-08

申请号：US17207165

申请日：2021-03-19

Applicant: Genentech, Inc.

Inventor： Luciana Lorena MOLINERO ,  Stephen CHUI ,  Roel FUNKE

IPC: G01N33/574 ,  A61K39/395 ,  A61P35/00

Abstract: The invention provides methods and compositions for diagnosing and treating locally advanced or metastatic breast cancer (e.g., TNBC). In some embodiments, the methods include determining the presence and/or expression level of one or more of PD-L1, CD8, and/or stromal tumor-infiltrating lymphocytes (sTILs). Provided herein are methods for identifying a patient suffering from a locally advanced or metastatic TNBC who is likely to respond to treatment with an anti-cancer therapy that includes a PD-1 axis binding antagonist (e.g., an anti-PD-L1 antibody (e.g., atezolizumab) or an anti-PD-1 antibody) and a taxane (e.g., nab-paclitaxel or paclitaxel). Also provided are methods of selecting a therapy for a patient suffering from a locally advanced or metastatic TNBC. Further provided are methods of treating a patient suffering from locally advanced or metastatic TNBC. In some embodiments, the methods include administering a PD-1 axis binding antagonist (e.g., atezolizumab) and a taxane (e.g., nab-paclitaxel or paclitaxel) to the patient, for example, a patient identified as one who is likely to respond to the treatment. Also provided are pharmaceutical compositions for use in treating a patient suffering from locally advanced or metastatic TNBC.

公开(公告)号：US20210207219A1

公开(公告)日：2021-07-08

申请号：US17147061

申请日：2021-01-12

Applicant: Genentech, Inc.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/6883

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

公开(公告)号：US20210206877A1

公开(公告)日：2021-07-08

申请号：US17113711

申请日：2020-12-07

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan Wu ,  Eric Krauland ,  Michael Feldhaus

IPC: C07K16/40 ,  A61K47/68 ,  G01N33/573

Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders

公开(公告)号：US20210206871A1

公开(公告)日：2021-07-08

申请号：US17085750

申请日：2020-10-30

Applicant: Genentech, Inc.

Inventor： Yvonne Chinn ,  Julie Q. Hang ,  Christian W. Siebel ,  Yan Wu ,  Daniel Lafkas

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/395

Abstract: The invention provides anti-Jagged1 antibodies and methods of using the same.

公开(公告)号：US20210198316A9

公开(公告)日：2021-07-01

申请号：US16539947

申请日：2019-08-13

Applicant: RQx Pharmaceuticals, Inc. ,  Genentech, Inc.

Inventor： Peter Andrew SMITH ,  Tucker Curran ROBERTS ,  Robert I. HIGUCHI ,  Prasuna PARASELLI ,  Michael F. T. KOEHLER ,  Jacob Bradley SCHWARZ ,  James John CRAWFORD ,  Cuong Q. LY ,  Emily J. HANAN ,  Huiyong HU ,  Yongsheng CHEN ,  Zhiyong YU ,  Paul Colin Michael WINSHIP ,  Calum McCleod ,  Toby Blench

IPC: C07K5/11 ,  A61P31/04 ,  A61K9/00 ,  A61K45/06 ,  A61K38/07 ,  C07K5/107 ,  C07K5/083 ,  C07K7/06 ,  A61K38/08 ,  C07K5/097 ,  A61K38/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.