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公开(公告)号：US20190029625A1
公开(公告)日：2019-01-31
申请号：US15563547
申请日：2016-03-30
Inventor： Liang ZHONG , Ru San TAN , Weimin HUANG , Jiayin ZHOU , Yuping DUAN , Wei XIONG , Yanling CHI , Kyaw Kyar TOE
CPC classification number: A61B6/5217 , A61B5/02007 , A61B5/055 , A61B5/1075 , A61B5/1076 , A61B5/489 , A61B6/032 , A61B6/504 , A61B6/507 , A61B8/12 , G06T7/0012 , G06T7/12 , G06T7/62 , G06T2207/10081 , G06T2207/20168 , G06T2207/30104 , G06T2207/30172
Abstract: A method for assessing blood vessel stenosis using image data of a subject is disclosed. The image data represents a vascular structure of the subject. The method comprises: (a) segmenting, from the image data, a vessel segment representing a segment of a blood vessel, (b) obtaining, using the image data, a plurality of two-dimensional images of the vessel segment; said plurality of two-dimensional images representing respective cross-sections of the vessel segment, (c) identifying, for each of the plurality of two-dimensional images, a lumen area comprising lumen pixels representing a lumen of the corresponding cross-section, (d) obtaining a quantitative measure using the lumen areas of successive cross-sections of the vessel segment, and (e) assessing blood vessel stenosis using the quantitative measure. A computer system for performing the above method is disclosed.
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222.发明授权公开(公告)号：US10183099B2
公开(公告)日：2019-01-22
申请号：US14047056
申请日：2013-10-07
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research
Inventor： Xin Ding , James L. Hedrick , Chuan Yang , Yi Yan Yang
Abstract: Catechol-bearing polycarbonates (catechol polymers) were prepared comprising i) a catechol repeat unit comprising a side chain catechol group, ii) a cationic repeat unit comprising a side chain cationic group selected from the group consisting of quaternary amine groups, quaternary phosphine groups, and combinations thereof, and iii) a PEG repeat unit comprising a side chain poly(ethylene oxide) group having a degree of polymerization of about 5 to about 30. The catechol polymers form antimicrobial and antifouling films on a variety of substrate surfaces, in particular silicone rubber.
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223.发明申请公开(公告)号：US20190018176A1
公开(公告)日：2019-01-17
申请号：US16071454
申请日：2016-12-15
Applicant: Agency for Science, Technology and Research
Inventor： Arseniy Kuznetsov , Ramon Jose Paniagua Dominguez
CPC classification number: G02B5/3025 , G02B1/11 , G02B5/1809 , G02B5/30 , G02B5/3008 , G02B27/283
Abstract: Various embodiments may provide a polarization device for polarizing electromagnetic waves. The polarization device may include a stacked arrangement including a medium and an anti-reflection coating in contact with the medium. The polarization device may also include a periodic array of polarization elements in contact with the medium. The polarization device may be configured to, based on an electric response and a magnetic response of the periodic array of the polarization elements, transmit first polarized electromagnetic waves having a first polarization and reflect second polarized electromagnetic waves having a second polarization upon receiving the electromagnetic waves.
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公开(公告)号：US20190000668A1
公开(公告)日：2019-01-03
申请号：US15748513
申请日：2016-07-29
Applicant: Agency for Science, Technology and Research , National University Hospital (Singapore) Pte Ltd , Singapore Health Services Pte Ltd
Inventor： Prusothman M Sina Raja , Angela Renayanti Dharmawan , Chee Keong Tee , Yao Wang , Sheau Huei Frances Lim , Zhengtao Keith Chong
Abstract: There is provided a device for insertion into a body cavity, the device includes an insertion member configured to be inserted into the body cavity, an expandable member coupled to the insertion member, the expandable member capable of being expanded to apply pressure onto tissue within the body cavity, a first member configured for storing a first endothermic reactant therein, and a second member configured for storing a second endothermic reactant therein. In particular, the first and second members are configured to, in a state of the device (e.g., compressed state), allow the first and second endothermic reactants to cooperate to effect an endothermic reaction to generate an endothermic product. Furthermore, the expandable member is configured to receive at least one of the first or second endothermic reactant and the endothermic product through a channel within the insertion member. There is also provided a method of fabricating a device for inserting into a body cavity.
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公开(公告)号：US10167267B2
公开(公告)日：2019-01-01
申请号：US15023668
申请日：2014-09-17
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Guangshun Yi , Yugen Zhang
IPC: C07D307/02 , C07D307/68 , B01J23/52 , C07D307/48 , B01J37/03 , B01J23/00 , B01J23/66 , B01J35/00
Abstract: The present invention relates to a method for synthesizing an optionally substituted furoic acid by dehydrating a biomass and oxidizing the optionally substituted furan derived from the dehydration reaction. Water extraction has been incorporated as a step between the dehydration and the oxidation in order to purify the intermediate optionally substituted furan before having it oxidized. Prior to this water extraction, the organic solvent used for dehydration may be separated by evaporation. The provision of the water extraction allows impurities to be separated from the intermediate optionally substituted furan.
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Patent Agency Ranking
公开(公告)号：US20180368914A1
公开(公告)日：2018-12-27
申请号：US16063242
申请日：2016-12-15
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Ming-Yuan CHENG , Songsong ZHANG , Alex Yuandong GU , Andrew Benson RANDLES , Ee Lim TAN , Pushpapraj SINGH , Kwan Ling TAN , Weiguo CHEN , Ruiqi LIM , Ramona DAMALERIO , Surasit CHUNGPAIBOONPATANA
IPC: A61B18/14
Abstract: A device for vascular denervation comprising a catheter for insertion into a vessel, at least one elongated catheter arm having alternating regions of flexible joints and rigid blocks along the at least one catheter arm, wherein each of the at least one catheter arm comprises at least one tactile sensor and at least one temperature sensor; at least one electrode and electrical circuitry disposed on each of the at least one catheter arm and at least one linkage connected to all of the elongated catheter arms. A method for batch fabricating a plurality of catheter arms for the vascular denervation device is also provided and comprises the steps of depositing a first polymer coating on a semiconductor substrate, forming metal traces on the first polymer coating, patterning and etching the substrate to the first polymer coating to create flexible joint regions.
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公开(公告)号：US20180362655A1
公开(公告)日：2018-12-20
申请号：US16112008
申请日：2018-08-24
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Cheng-I Wang , Peter Brauer , Siok Ping Yeo , Hwee Ching Tan , John Edward Connolly
Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
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公开(公告)号：US20180354989A1
公开(公告)日：2018-12-13
申请号：US16038603
申请日：2018-07-18
Applicant: Agency for Science, Technology and Research
Inventor： Brian Cheng San Chia
IPC: C07K5/087 , C07K5/117 , C07K5/072 , C07K5/065 , C07K5/02 , C07K1/10 , C07K1/06 , C07K1/00 , A61K38/00
Abstract: The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L1, L2, L3, R1, R2, R3, R4, R5, R6, n, m, Q, X, Z1 and Z2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.
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公开(公告)号：US20180346626A1
公开(公告)日：2018-12-06
申请号：US15779513
申请日：2016-11-22
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Jackie Y. YING , Nandanan ERATHODIYIL , Hong WU , Hsi-Min CHAN
IPC: C08F220/18 , C08K5/09 , C08L33/24 , A61L27/34 , A61L27/52
Abstract: A polymeric composition comprising (i) a plurality of monomers selected from (a) a carboxylic acryloyi monomer; (b) a sulfonic acryloyi monomer; (c) an amine acryloyi monomer; (d) a hydroxyl acryloyi monomer; (e) an alkyl acryloyi monomer; and (f) a polyalkylene hydroxyl acryloyi monomer; (ii) a divalent metallic crosslinking agent; and (c) a stabilizing agent is disclosed herein. Also provided are the use of said polymeric composition as a hydrogel coating material, a method of synthesizing the polymeric composition and the use of the hydrogel material.
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公开(公告)号：US20180344650A1
公开(公告)日：2018-12-06
申请号：US15771399
申请日：2016-10-26
Inventor： Harjinder SINGH , Brendan HAIGH , Nicole ROY , Maxim KIRYUKHIN , Maria ANTIPINA , Marina NOVOSELOVA , Gleb SUKHORUKOV
CPC classification number: A61K9/4825 , A61K9/19 , A61K9/4833 , A61K9/4891 , A61K9/5073 , A61K47/34 , A61K47/38 , A61K47/42
Abstract: Disclosed herein is a core-shell composite material comprising: a core optionally comprising an active ingredient compound; a shell structure comprising at least two alternating layers; the alternating layers being a protein layer and a polyphenol layer; and optionally a polyelectrolyte layer interfacing said core and said shell structure, said polyelectrolyte layer being disposed adjacent to said protein layer or said polyphenol layer, wherein said shell structure is selected to be resistant to degradation under gastric conditions but is degradable by one or more intestinal enzymes. In a preferred embodiment the protein is bovine serum albumin (BSA) or pepsin, the polyphenol layer is tannin or tannic acid, and the shell structure is degradable by pepsin.
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