公开(公告)号：US20230330051A1

公开(公告)日：2023-10-19

申请号：US18027168

申请日：2021-09-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Leviel FLUHR ,  Uria MOR

IPC: A61K31/201 ,  A61K31/198 ,  A61K31/465 ,  A61K45/06 ,  A23G4/12

CPC classification number: A61K31/201 ,  A61K31/198 ,  A61K31/465 ,  A61K45/06 ,  A23G4/12

Abstract: A method of treating obesity in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that specifically increases the amount of hexadecadienoate (16:2n6), N-acetylglycine, 1-palmitoyl-2-gamma-linolenoyl-GPC (16:0/18:3n6) and/or Hexanoylglycine; or an agent that decreases the amount of dimethylglycine (DMG) in the fecal metabolome of the subject. Agents suitable for same are also disclosed.

公开(公告)号：US11732046B2

公开(公告)日：2023-08-22

申请号：US17222370

申请日：2021-04-05

Applicant: ImmunoBrain Checkpoint, Inc. ,  Yeda Research and Development Co. Ltd.

Inventor： Ester Yoles ,  Berit Olsen Krogh ,  Allan Jensen ,  Jan Egebjerg ,  Carol David ,  Kuti Baruch ,  Michal Eisenbach-Schwartz

IPC: C07K16/28 ,  A61P25/00 ,  A61K39/00

CPC classification number: C07K16/2827 ,  A61K2039/505 ,  C07K2317/515 ,  C07K2317/56

Abstract: The present specification discloses modified anti-PD-L1 antibodies that abolishes Fc-related effector function and enhances clearance rate while maintaining therapeutic efficacy for neurodegenerative disease modification. The present specification also discloses nucleic acid sequences and expression constructs encoding such modified anti-PD-L1 antibodies as well as methods of making such modified anti-PD-L1 antibodies. In addition, the present specification discloses methods of treatment and uses that employ an administration regime of the disclosed anti-PD-L1 antibodies that ensures the antibodies are present for only a specific period of time and then are sufficiently cleared from the body to ensure treatment efficacy is maintained.

公开(公告)号：US11718893B2

公开(公告)日：2023-08-08

申请号：US16759751

申请日：2018-11-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Igor Lubomirsky ,  Valery Kaplan ,  Nurlan Dosmukhamedov ,  Erzhan Zholdasbay

IPC: C22B11/06 ,  C22B1/00 ,  C22B11/02

CPC classification number: C22B11/06 ,  C22B1/005 ,  C22B11/025

Abstract: A method for recovery of gold from gold-containing materials, such as electronic waste material, minerals and sands is described. The method includes crushing the gold containing material to obtain a particulate material. The particulate material is then preheated in an oxygen-containing gas environment in a preheating zone. The method also includes mixing the oxidized particulate material with a chlorine-containing material and treating the mixture in a reaction zone. The treatment is carried out by heating the mixture to provide thermal decomposition of the chlorine-containing material and produce a chlorine-containing gas mixture, and by applying an electromagnetic field to the chlorine-containing gas mixture to provide ionization of chlorine. A volatile gold-containing chloride product, produced in the reaction zone as a result of a chemical reaction between gold and chlorine ions, is then cooled to convert the volatile gold-containing chloride product into solid phase gold-containing materials.

公开(公告)号：US11679133B2

公开(公告)日：2023-06-20

申请号：US15780153

申请日：2016-11-28

Applicant: Kadimastem Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Kfir Molakandov ,  Neta Lavon ,  Avital Beck ,  Michel Revel ,  Ofer Elhanani ,  Yoav Soen ,  Michael Walker ,  Arik Hasson

IPC: A61K35/39 ,  C12N5/00 ,  C12N5/071 ,  A61P5/50 ,  A61P3/10

CPC classification number: A61K35/39 ,  A61P3/10 ,  A61P5/50 ,  C12N5/0676 ,  C12N2500/25 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2501/599 ,  C12N2506/02 ,  C12N2506/45

Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.

公开(公告)号：US11674938B2

公开(公告)日：2023-06-13

申请号：US16894916

申请日：2020-06-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Noam Sobel ,  Shani Agron ,  Kobi Snitz ,  Ethan Livne ,  Ofer Perl ,  Kineret Weissler ,  Aharon Ravia ,  Danielle Ricca Honigstein ,  Maya Finkel

IPC: G01N33/00

CPC classification number: G01N33/0036 ,  G01N33/0031

Abstract: A method of assessing odors, comprises providing an electronic nose that extracts measurements from odors, from which measurements at least n chemical descriptors are extracted where n is greater than unity, and typically around 18. The electronic nose is applied to an odor, and odor information is extracted. The information is plotted to a first location on an n-dimensional sample space, each dimension being related to a respective one of the n chemical descriptors or otherwise optimized for the particular enose and the measurements it makes; and an assessment of the odor is provided based on the plotted location. The assessment may be a description based on odor describing terms, or may be a chemical description in terms of chemicals that can synthesize the odor, and the odor may then be synthesized based on the chemical description.

公开(公告)号：US20230167158A1

公开(公告)日：2023-06-01

申请号：US18096167

申请日：2023-01-12

Applicant: ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Amer M NAJJAR ,  Anat GLOBERSON LEVIN ,  Tova WAKS ,  Galit HORN

IPC: C07K14/005 ,  C07K16/28 ,  C07K14/705 ,  A61P35/00

CPC classification number: C07K14/005 ,  C07K16/2809 ,  C07K14/70517 ,  A61P35/00 ,  C12N2760/20023 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2760/20222 ,  C12N2760/20242 ,  C12N2760/20271 ,  A61K2039/505

Abstract: The present invention discloses a fusion protein comprising a vesicular stomatitis virus envelope glycoprotein (VSVG) extracellular domain or a fragment or an analog thereof linked to a polypeptide comprising an antigen binding domain specific to cluster of differentiation 3 (CD3). The application also discloses pseudotyped viruses comprising the fusion protein and pseudotyped viruses encoding for a chimeric antigen receptor (CAR) or T-cell receptor pseudotyped in which the receptor is expressed under a CD3 promoter. Pseudotyped viruses combining these properties are encompassed as well. The application further discloses use of these pseudotyped viruses and method of producing these pseudotyped viruses.

公开(公告)号：US20230132790A1

公开(公告)日：2023-05-04

申请号：US17915500

申请日：2021-03-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Anthony H. FUTERMAN ,  Israel SILMAN ,  Joel L. SUSSMAN ,  Sarel FLEISHMAN ,  Adi GOLDENZWEIG ,  Sarka POKORNA ,  Yaacov ASHANI ,  Olga KHERSONSKY

IPC: C12N9/24

Abstract: A genetically modified human beta-glucocerebrosidase (GCase) is disclosed. The genetically modified GCase comprising an amino acid sequence at least 85% identical to SEQ ID NO: 2; and comprising mutations at coordinates L34P, K224N/G, T369E and N370D, where the coordinates correspond to said SEQ ID NO: 2; and capable of catalyzing hydrolysis of a glycolipid glucosylceramide (GlcCer). Pharmaceutical compositions comprising the genetically modified GCase and therapeutic methods of using same are also disclosed.

公开(公告)号：US20230078148A1

公开(公告)日：2023-03-16

申请号：US17990770

申请日：2022-11-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Amos TANAY ,  Elad CHOMSKY ,  Yonatan STELZER ,  Raz BEN-YAIR

IPC: G01N33/58 ,  G01N1/30 ,  G06V20/69

Abstract: A method of identifying a molecular composition and a spatial position of a single cell comprised in a 3 dimensional structure comprising a plurality of cells is provided.

公开(公告)号：US20230045855A1

公开(公告)日：2023-02-16

申请号：US17936729

申请日：2022-09-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Rachel SOREK ,  Keren JAKOBI-BROOK ,  Pennina SAFER ,  Irun R. COHEN

IPC: G01N33/564 ,  G01N33/577

Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.

公开(公告)号：US20230004850A1

公开(公告)日：2023-01-05

申请号：US17781389

申请日：2020-12-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  UNIVERSITY OF COPENHAGEN

Inventor： Yuval OREG ,  Gal SHAVIT ,  Omri LESSER ,  Erez BERG ,  Adiel STERN ,  Karsten FLENSBERG

IPC: G06N10/40 ,  H01L39/12 ,  H01L39/22

Abstract: Provided is a quantum computing device comprising a carbon nanotube, a superconducting substrate in quantum proximity to the nanotube and being in a superconducting state having a pairing correlation matrix with a substantial spin-triplet component in a direction perpendicular to the nanotube, and a magnet arranged to provide a longitudinal magnetic field along a longitudinal axis of the nanotube. Further provided is a quantum computing device comprising at least three substrates made of a superconductor material and each in a superconducting state, and a non-superconducting structure made of a material in which the electrons' closed trajectories experience strong spin-orbit coupling interactions and being in quantum proximity to the substrates. The sum of the phase differences between the order parameters of all of the substrates is at least π.