公开(公告)号：USD966732S1

公开(公告)日：2022-10-18

申请号：US29787618

申请日：2021-06-08

Applicant: Bin Liu

Designer： Bin Liu

公开(公告)号：USD962011S1

公开(公告)日：2022-08-30

申请号：US29704425

申请日：2019-09-04

Applicant: Bin Liu

Designer： Bin Liu

公开(公告)号：US20190194655A1

公开(公告)日：2019-06-27

申请号：US16060171

申请日：2016-12-08

Applicant: Curt W. Bradshaw ,  Sukumar Sakamuri ,  Bryan R. Meade ,  Laxman Eltepu ,  Giuseppe Dello Iacono ,  Son Lam ,  Joseph Stock ,  Dingguo Liu ,  Bin Liu ,  Solstice Biologics, Ltd.

Inventor： Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Bryan R. MEADE ,  Laxman ELTEPU ,  Giuseppe Dello IACONO ,  Son LAM ,  Joseph STOCK ,  Dingguo LIU ,  Bin LIU

IPC: C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K47/549 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/65616 ,  C12N2310/311 ,  C12N2310/312 ,  C12N2310/315 ,  C12N2310/351

Abstract: The invention features a hybridized polynucleotide construct including a passenger strand, a guide strand loadable into a RISC complex, and one or more auxiliary moieties. At least one of the auxiliary moieties is non-bioreversibly linked to an internucleoside phosphate or phosphorothioate in the passenger strand. The invention further features methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell. The methods typically involve contacting the cell with the hybridized polynucleotide construct.

公开(公告)号：US10304980B2

公开(公告)日：2019-05-28

申请号：US14692886

申请日：2015-04-22

Applicant: Peidong Yang ,  Chong Liu ,  Jinyao Tang ,  Hao Ming Chen ,  Bin Liu

Inventor： Peidong Yang ,  Chong Liu ,  Jinyao Tang ,  Hao Ming Chen ,  Bin Liu

IPC: H01L31/0352 ,  C25B1/00 ,  C25B3/04 ,  C25B9/18

Abstract: This disclosure provides systems, methods, and apparatus related to solar water splitting. In one aspect, a structure includes a plurality of first nanowires, the plurality of first nanowires comprising an n-type semiconductor or a p-type semiconductor. The structure further includes a second nanowire, the second nanowire comprising the n-type semiconductor or the p-type semiconductor, the second nanowire being a different composition than the plurality of first nanowires. The second nanowire includes a first region and a second region, with the first region having a conductive layer disposed thereon, and each of the plurality of first nanowires being disposed on the conductive layer.

公开(公告)号：US20170114341A1

公开(公告)日：2017-04-27

申请号：US15315608

申请日：2015-06-08

Applicant: Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Laxman ELTEPU ,  Son LAM ,  Dingguo LIU ,  Bryan MEADE ,  Giuseppe Dello IACONO ,  Joseph STOCK ,  Bin LIU ,  Solstice Biologics, Ltd.

Inventor： Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Laxman ELTEPU ,  Son LAM ,  Dingguo LIU ,  Bryan MEADE ,  Giuseppe Dello IACONO ,  Joseph STOCK ,  Bin LIU

IPC: C12N15/113 ,  C07H19/20 ,  C07H21/02 ,  C07H19/10 ,  C12N15/85 ,  C07H21/04

CPC classification number: C12N15/113 ,  C07H19/10 ,  C07H19/20 ,  C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/32 ,  C12N2310/346 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2330/30

Abstract: The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3′-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5′-terminal, a 3′-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5′-terminal, a 3′-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.

公开(公告)号：US09631196B2

公开(公告)日：2017-04-25

申请号：US14124447

申请日：2012-05-10

Applicant: Liang Hui Ji ,  Yan Bin Liu ,  John Chong Mei Koh ,  Long Hua Sun

Inventor： Liang Hui Ji ,  Yan Bin Liu ,  John Chong Mei Koh ,  Long Hua Sun

IPC: A61K39/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/80 ,  C07K14/38 ,  C12N15/10

CPC classification number: C12N15/80 ,  C07K14/38 ,  C12N15/1086

Abstract: The present invention relates to the application of isolated promoters and synthetic dominant selection constructs and enhancers for gene targeting for efficient production of genetically modified cells in a species selected from the Pucciniomycotina and Ustilaginomycotina subphyla, in particular, species selected from the Rhodosporidium, Sporisorium, Sporobolomyces or Ustilago genera.

公开(公告)号：US20160231581A1

公开(公告)日：2016-08-11

申请号：US14616882

申请日：2015-02-09

Applicant: Bin Liu

Inventor： Bin Liu

IPC: G02B27/28

CPC classification number: G02B27/283

Abstract: A multiple laser optical assembly comprises two laser subassemblies with two lasers bonded on two bases respectively, a polarization beam combiner (PBC), a lens, a mechanical housing and an optical fiber. The two subassemblies are configured to have orthogonal polarization directions from the two lasers and are assembled coaxially. The PBC combines the orthogonal polarized beams from the two lasers. The lens focuses the combined beam and couples into the optical fiber. With such a two laser optical assembly as a building block and a wavelength division multiplexing (WDM) filter to combine the beams from two of such type of two laser optical assembly, one can further build a four laser optical assembly and extend to even more channel multiple laser optical assembly by adding more WDM filters and more similar two laser optical assemblies.

Abstract translation: 多激光光学组件包括两个激光子组件，其中两个激光器分别结合在两个基座上，偏振光束组合器（PBC），透镜，机械壳体和光纤。 这两个子组件被构造成具有来自两个激光器的正交偏振方向并被同轴地组装。 PBC组合了来自两个激光器的正交偏振光束。 镜头将组合的光束和光束聚焦到光纤中。 利用这样的两个激光光学组件作为构建块和波分复用（WDM）滤波器来组合来自两个这种类型的两个激光光学组件的光束，可以进一步构建四个激光光学组件并扩展到甚至更多的通道 多个激光光学组件通过添加更多的WDM滤光片和更多类似的两个激光光学组件。

公开(公告)号：US20150369812A1

公开(公告)日：2015-12-24

申请号：US14740914

申请日：2015-06-16

Applicant: Yi Pang ,  Bin Liu

Inventor： Yi Pang ,  Bin Liu

IPC: G01N33/58 ,  A61B5/02 ,  G01N33/50 ,  A61B5/00 ,  C07D311/30 ,  G01N33/68

CPC classification number: A61B5/0071 ,  A61B5/02007 ,  A61B2503/02 ,  A61B2503/40 ,  A61K49/0021 ,  C07D311/30 ,  G01N33/5088 ,  G01N33/582 ,  G01N2333/4603

Abstract: Flavonoid compounds that are selective for a protein, a portion or a living cell, or a portion of an organism may be used as biological imaging agents. The flavonoid compounds are useful for methods of imaging organisms such as zebrafish embryos and zebra fish. Flavonoid compounds may also be used to detect protein. Advantageously, flavonoids that selectively bind protein, a portion of a living cell, or a portion of an organism may exhibit a florescence “turn-on” mechanism, where the flavonoids that are selectively bound exhibit a florescence response when excited.

Abstract translation: 对蛋白质，部分或活细胞或生物体的一部分有选择性的类黄酮化合物可以用作生物显影剂。 类黄酮化合物可用于成像生物体如斑马鱼胚胎和斑马鱼的方法。 黄酮类化合物也可用于检测蛋白质。 有利地，选择性结合蛋白质，活细胞的一部分或生物体的一部分的类黄酮可以表现出荧光“开启”机制，其中选择性结合的类黄酮在被激发时表现出荧光反应。

公开(公告)号：US08969509B2

公开(公告)日：2015-03-03

申请号：US13378989

申请日：2010-06-25

Applicant: Bin Liu ,  Chun Wang ,  Ruoyu Zhan ,  Glenn P. Bartholomew ,  Janice W. Hong ,  Jean M. Wheeler ,  Brent S. Gaylord

Inventor： Bin Liu ,  Chun Wang ,  Ruoyu Zhan ,  Glenn P. Bartholomew ,  Janice W. Hong ,  Jean M. Wheeler ,  Brent S. Gaylord

IPC: C08G67/02 ,  C08G67/00

CPC classification number: C08G61/02 ,  C08G2261/3142 ,  C08G2261/3422 ,  C08G2261/5222

Abstract: The devices and method are provided for detecting labeled and label-free analytes, such as nucleic acids and proteins, employing conjugated cationic, anionic and neutral polymers. The analytes can be immobilized on a solid support material. The solid support material can be disposed in the pre-fabricated patterns on a substrate. The chemical structures of the polymers employed by the various embodiments of the present invention are described herein.

Abstract translation: 提供的装置和方法用于检测标记和无标记分析物，如核酸和蛋白质，使用共轭阳离子，阴离子和中性聚合物。 分析物可以固定在固体支持材料上。 固体支撑材料可以以衬底上的预制图案设置。 本文描述了由本发明的各种实施方案采用的聚合物的化学结构。

公开(公告)号：US20140338070A1

公开(公告)日：2014-11-13

申请号：US14236597

申请日：2012-07-18

Applicant: Andrew Mark Cigan ,  Saverio Carl Falco ,  Huirong Gao ,  Michael W. Lassner ,  Zhongsen Li ,  Zhan-Bin Liu ,  Leszek A. Lyznik ,  David J. Peterson ,  Christopher Jay Scelonge

Inventor： Andrew Mark Cigan ,  Saverio Carl Falco ,  Huirong Gao ,  Michael W. Lassner ,  Zhongsen Li ,  Zhan-Bin Liu ,  Leszek A. Lyznik ,  David J. Peterson ,  Christopher Jay Scelonge

IPC: C12N15/82

CPC classification number: C12N15/8213

Abstract: Compositions and methods are provided for the targeted integration of a polynucleotide sequence of interest into the genome of a plant or plant cell. The methods and compositions employ recognition sites for endonucleases and endonucleases in combination with site-specific recombination sites/recombinases to provide an effective system for establishing target sites within the genome of a plant, plant cell or seed. Once such target sites are established, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest.

Abstract translation: 提供组合物和方法用于将目的多核苷酸序列靶向整合到植物或植物细胞的基因组中。 方法和组合物使用核酸内切酶和内切核酸酶的识别位点与位点特异性重组位点/重组酶组合，以提供用于在植物，植物细胞或种子的基因组内建立靶位点的有效系统。 一旦建立了这样的靶位点，就可以采用多种方法来进一步修饰靶位点，使得它们含有多种感兴趣的多核苷酸。