公开(公告)号：US20060183790A1

公开(公告)日：2006-08-17

申请号：US11352820

申请日：2006-02-13

Applicant: Derek Cole ,  Eric Manas ,  Lee Jennings ,  Frank Lovering ,  Joseph Stock ,  William Moore ,  John Ellingboe ,  Jeffrey Condon ,  Mohani Sukhdeo ,  Ping Zhou ,  JunJun Wu ,  Koi Morris

Inventor： Derek Cole ,  Eric Manas ,  Lee Jennings ,  Frank Lovering ,  Joseph Stock ,  William Moore ,  John Ellingboe ,  Jeffrey Condon ,  Mohani Sukhdeo ,  Ping Zhou ,  JunJun Wu ,  Koi Morris

IPC: A61K31/40 ,  C07D207/22

CPC classification number: C07D207/327 ,  C07D207/33 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D207/36 ,  C07D401/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12

Abstract: The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

公开(公告)号：US07017879B2

公开(公告)日：2006-03-28

申请号：US10704857

申请日：2003-11-10

Applicant: Brandon Robert Wetterberg ,  Michael Joseph Stock

Inventor： Brandon Robert Wetterberg ,  Michael Joseph Stock

IPC: A47B91/00

CPC classification number: A47B47/02 ,  A47B96/06 ,  Y10T16/19 ,  Y10T16/191

Abstract: A bracket is disclosed for use in open bottom type cabinets, such as file cabinets, which enables caster assemblies and the like to be secured thereto. The bracket is configured to be secured in the corners of an open bottom cabinet. In accordance with the present invention, the bracket provides stiffening of the cabinet as well as a secure surface for securing caster assemblies thereto. The brackets are simply mounted to the corners of the cabinet utilizing, for example, a pair of fasteners.

Abstract translation: 公开了用于开放式底柜（例如文件柜）中的支架，其能够将脚轮组件等固定在其上。 支架被配置为固定在敞开的底柜的角落。 根据本发明，支架提供机柜的加强以及用于将脚轮组件固定到其上的安全表面。 通过例如一对紧固件将支架简单地安装到机柜的角部。

公开(公告)号：US20050196813A1

公开(公告)日：2005-09-08

申请号：US11081784

申请日：2005-03-16

Applicant: Anthony Kreft ,  Derek Cole ,  Kevin Woller ,  Joseph Stock ,  George Diamantidis ,  Dennis Kubrak ,  Kristina Kutterer ,  William Moore ,  David Casebier

Inventor： Anthony Kreft ,  Derek Cole ,  Kevin Woller ,  Joseph Stock ,  George Diamantidis ,  Dennis Kubrak ,  Kristina Kutterer ,  William Moore ,  David Casebier

IPC: A61K31/341 ,  A61K31/381 ,  A61K31/382 ,  A61K31/4436 ,  A61K31/4535 ,  A61P25/28 ,  A61P43/00 ,  C07D233/66 ,  C07D277/32 ,  C07D307/64 ,  C07D333/34 ,  C07D333/48 ,  C07D409/12 ,  G01N33/53

CPC classification number: C07D409/12 ,  C07D307/64 ,  C07D333/34

Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described

Abstract translation: 式（I）化合物，其中R 1，R 2，R 3，R 4，R 3， 提供了本文所定义的R 5，R 6，T，W，X，Y和Z以及其药学上可接受的盐，水合物和/或前药。 描述了使用这些化合物抑制β淀粉样蛋白生成和治疗阿尔茨海默病和唐氏综合征的方法

公开(公告)号：US20190194655A1

公开(公告)日：2019-06-27

申请号：US16060171

申请日：2016-12-08

Applicant: Curt W. Bradshaw ,  Sukumar Sakamuri ,  Bryan R. Meade ,  Laxman Eltepu ,  Giuseppe Dello Iacono ,  Son Lam ,  Joseph Stock ,  Dingguo Liu ,  Bin Liu ,  Solstice Biologics, Ltd.

Inventor： Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Bryan R. MEADE ,  Laxman ELTEPU ,  Giuseppe Dello IACONO ,  Son LAM ,  Joseph STOCK ,  Dingguo LIU ,  Bin LIU

IPC: C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K47/549 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/65616 ,  C12N2310/311 ,  C12N2310/312 ,  C12N2310/315 ,  C12N2310/351

Abstract: The invention features a hybridized polynucleotide construct including a passenger strand, a guide strand loadable into a RISC complex, and one or more auxiliary moieties. At least one of the auxiliary moieties is non-bioreversibly linked to an internucleoside phosphate or phosphorothioate in the passenger strand. The invention further features methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell. The methods typically involve contacting the cell with the hybridized polynucleotide construct.

公开(公告)号：US20170114341A1

公开(公告)日：2017-04-27

申请号：US15315608

申请日：2015-06-08

Applicant: Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Laxman ELTEPU ,  Son LAM ,  Dingguo LIU ,  Bryan MEADE ,  Giuseppe Dello IACONO ,  Joseph STOCK ,  Bin LIU ,  Solstice Biologics, Ltd.

Inventor： Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Laxman ELTEPU ,  Son LAM ,  Dingguo LIU ,  Bryan MEADE ,  Giuseppe Dello IACONO ,  Joseph STOCK ,  Bin LIU

IPC: C12N15/113 ,  C07H19/20 ,  C07H21/02 ,  C07H19/10 ,  C12N15/85 ,  C07H21/04

CPC classification number: C12N15/113 ,  C07H19/10 ,  C07H19/20 ,  C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/32 ,  C12N2310/346 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2330/30

Abstract: The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3′-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5′-terminal, a 3′-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5′-terminal, a 3′-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.

公开(公告)号：US20070037778A1

公开(公告)日：2007-02-15

申请号：US11528001

申请日：2006-09-27

Applicant: Anthony Kreft ,  Derek Cole ,  Kevin Woller ,  Joseph Stock ,  Kristina Kutterer ,  Dennis Kubrak ,  Charles Mann ,  William Moore ,  David Casebier

Inventor： Anthony Kreft ,  Derek Cole ,  Kevin Woller ,  Joseph Stock ,  Kristina Kutterer ,  Dennis Kubrak ,  Charles Mann ,  William Moore ,  David Casebier

IPC: A61K31/655 ,  A61K31/36 ,  A61K31/34 ,  A61K31/18

CPC classification number: C07C311/40 ,  A61K31/18 ,  A61K31/335 ,  A61K31/34 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/655 ,  C07C311/17 ,  C07C311/18 ,  C07C311/20 ,  C07C311/29 ,  C07C323/49 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/42 ,  C07D209/16 ,  C07D307/52 ,  C07D319/06

Abstract: Compounds of Formula I, wherein R1—R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer's Disease and Down's syndrome are also described.

Abstract translation: 提供了其中R 1 -R 8 - 8的式I化合物及其药学上可接受的盐，水合物，代谢物和/或前药。 还描述了这些化合物用于抑制β淀粉样蛋白生成和预防和治疗阿尔茨海默病和唐氏综合征的用途。

公开(公告)号：US6014049A

公开(公告)日：2000-01-11

申请号：US431001

申请日：1995-04-28

Applicant: James Carter Bach ,  John J. Baker ,  Robert Joseph Stock ,  Richard J. Szep ,  Gerlad A. Kilgour

Inventor： James Carter Bach ,  John J. Baker ,  Robert Joseph Stock ,  Richard J. Szep ,  Gerlad A. Kilgour

IPC: H03K17/16 ,  H03K5/12

CPC classification number: H03K17/163

Abstract: A modulator has an FET output driver for applying repetitive pulses to an inductive load. A predriver comprises a resistor and capacitor in parallel across the FET source and gate for shaping the control voltage. A constant current source, turned on and off by an input signal, couples the shaping circuit to ground. The resistor and capacitor values determine the rate of control voltage change which is the same for turn-on and turn-off, to control the driver current slew rate for minimizing RFI emissions.

Abstract translation: 调制器具有用于向感性负载施加重复脉冲的FET输出驱动器。 预驱动器包括在FET源极和栅极上并联的电阻器和电容器，用于对控制电压进行整形。 通过输入信号导通和关断的恒流源将整形电路耦合到地。 电阻和电容值决定了接通和关断相同的控制电压变化率，以控制驱动器电流转换速率，以最大限度地减少RFI排放。

公开(公告)号：US20070027199A1

公开(公告)日：2007-02-01

申请号：US11495261

申请日：2006-07-28

Applicant: Michael Malamas ,  Iwan Gunawan ,  James Erdei ,  Pawel Nowak ,  Joseph Stock ,  Yinfa Yan

Inventor： Michael Malamas ,  Iwan Gunawan ,  James Erdei ,  Pawel Nowak ,  Joseph Stock ,  Yinfa Yan

IPC: A61K31/4178 ,  A61K31/4166 ,  C07D403/02

CPC classification number: C07D233/88 ,  C07D233/54 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D409/06

Abstract: The present invention provides a 2-amino-5-cycloalkyl-hydantoin compound of formula I The present invention also provides methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.

Abstract translation: 本发明提供了式I的2-氨基-5-环烷基 - 乙内酰脲化合物。本发明还提供了用于抑制β-分泌酶（BACE）和β-淀粉样沉积物和神经原纤维缠结的治疗的方法和组合物。