-
公开(公告)号：US08293714B2
公开(公告)日：2012-10-23
申请号：US12432528
申请日：2009-04-29
Applicant: Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
Inventor： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC: A61K38/16
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。
-
公开(公告)号：US20060025474A1
公开(公告)日：2006-02-02
申请号：US11076584
申请日：2005-03-08
Applicant: David Wallace , Thomas Arrhenius , Anna Russell , Dingguo Liu , Amy Xing , Sovouthy Tith , Zheng Hou , Tadakatsu Takahashi , Yoshiyuki Ono , Hirotaka Kashiwagi , Kazuki Shimizu , Hitoshi Ikura
Inventor： David Wallace , Thomas Arrhenius , Anna Russell , Dingguo Liu , Amy Xing , Sovouthy Tith , Zheng Hou , Tadakatsu Takahashi , Yoshiyuki Ono , Hirotaka Kashiwagi , Kazuki Shimizu , Hitoshi Ikura
IPC: A61K31/366 , A61K31/365 , A61K31/192
CPC classification number: C07D207/26 , C07C57/60 , C07C59/56 , C07C59/68 , C07C59/72 , C07C65/28 , C07C69/712 , C07C69/732 , C07C217/20 , C07C217/34 , C07C229/22 , C07C233/25 , C07C235/20 , C07C317/18 , C07C317/44 , C07C323/16 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/16 , C07D209/32 , C07D211/40 , C07D213/30 , C07D257/04 , C07D307/12 , C07D307/32 , C07D307/33 , C07D307/68 , C07D309/22 , C07D309/30 , C07D317/22 , C07D319/12
Abstract: The present invention discloses bisphenyl compounds of the formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W are defined herein after. These compounds are useful as pharmaceuticals.
Abstract translation: 本发明公开了下式的双苯化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，X，Y，W如下文所定义。 这些化合物可用作药物。
-
3.发明授权Methods of treating a disease or condition associated with abnormal angiogenesis 有权治疗与异常血管发生相关的疾病或病症的方法公开(公告)号：US08912148B2
公开(公告)日：2014-12-16
申请号：US13584721
申请日：2012-08-13
Applicant: Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
Inventor： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
IPC: A61K38/10 , C07K14/00 , C07K14/515 , A61K38/00
CPC classification number: C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
Abstract: The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.
Abstract translation: 本发明提供了治疗（包括预防）与受试者异常血管生成相关的疾病或病症的方法，包括向受试者施用治疗有效量的本发明的AA靶向化合物。 AA靶向化合物包含与抗体的结合位点连接的AA靶向剂 - 接头缀合物。
-
公开(公告)号：US20100003267A1
公开(公告)日：2010-01-07
申请号：US12432528
申请日：2009-04-29
Applicant: Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
Inventor： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC: A61K39/395 , C07K14/00 , C07K19/00
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。
-
公开(公告)号：US08937048B2
公开(公告)日：2015-01-20
申请号：US13595250
申请日：2012-08-27
Applicant: Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
Inventor： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC: A61K38/10 , C07K14/00 , C07K14/515 , A61K47/48 , C07K14/71
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules.
Abstract translation: 本发明提供VEGF结合肽的各种用途，包括治疗与异常血管发生相关的疾病的方法。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。
-
Patent Agency Ranking
公开(公告)号：US08288349B2
公开(公告)日：2012-10-16
申请号：US11938766
申请日：2007-11-12
Applicant: Curt William Bradshaw , Abhijit Suresh Bhat , Jing-Yu Lai , Venkata R. Doppalapudi , Dingguo Liu
Inventor： Curt William Bradshaw , Abhijit Suresh Bhat , Jing-Yu Lai , Venkata R. Doppalapudi , Dingguo Liu
IPC: A61K38/16 , A61K51/10 , C07K14/515
CPC classification number: C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。
-
公开(公告)号：US20190194655A1
公开(公告)日：2019-06-27
申请号：US16060171
申请日：2016-12-08
Applicant: Curt W. Bradshaw , Sukumar Sakamuri , Bryan R. Meade , Laxman Eltepu , Giuseppe Dello Iacono , Son Lam , Joseph Stock , Dingguo Liu , Bin Liu , Solstice Biologics, Ltd.
Inventor： Curt W. BRADSHAW , Sukumar SAKAMURI , Bryan R. MEADE , Laxman ELTEPU , Giuseppe Dello IACONO , Son LAM , Joseph STOCK , Dingguo LIU , Bin LIU
IPC: C12N15/113
CPC classification number: C12N15/113 , A61K31/7088 , A61K47/549 , C07F9/65515 , C07F9/65586 , C07F9/65616 , C12N2310/311 , C12N2310/312 , C12N2310/315 , C12N2310/351
Abstract: The invention features a hybridized polynucleotide construct including a passenger strand, a guide strand loadable into a RISC complex, and one or more auxiliary moieties. At least one of the auxiliary moieties is non-bioreversibly linked to an internucleoside phosphate or phosphorothioate in the passenger strand. The invention further features methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell. The methods typically involve contacting the cell with the hybridized polynucleotide construct.
-
公开(公告)号：US20170114341A1
公开(公告)日：2017-04-27
申请号：US15315608
申请日：2015-06-08
Applicant: Curt W. BRADSHAW , Sukumar SAKAMURI , Laxman ELTEPU , Son LAM , Dingguo LIU , Bryan MEADE , Giuseppe Dello IACONO , Joseph STOCK , Bin LIU , Solstice Biologics, Ltd.
Inventor： Curt W. BRADSHAW , Sukumar SAKAMURI , Laxman ELTEPU , Son LAM , Dingguo LIU , Bryan MEADE , Giuseppe Dello IACONO , Joseph STOCK , Bin LIU
CPC classification number: C12N15/113 , C07H19/10 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/85 , C12N2310/14 , C12N2310/31 , C12N2310/32 , C12N2310/346 , C12N2310/3513 , C12N2310/3515 , C12N2330/30
Abstract: The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3′-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5′-terminal, a 3′-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5′-terminal, a 3′-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.
-
公开(公告)号：US20120321591A1
公开(公告)日：2012-12-20
申请号：US13595250
申请日：2012-08-27
Applicant: Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
Inventor： Venkata Ramana Doppalapudi , Jing-Yu Lai , Bin Liu , Dingguo Liu , Joel Desharnais , Abhijit Suresh Bhat , Yanwen Fu , Bryan Douglas Oates , Gang Chen , Curt William Bradshaw
IPC: A61K38/18 , A61P35/00 , A61P19/02 , A61P9/12 , A61P13/12 , A61K38/21 , A61P27/06 , A61K39/395 , A61K33/36 , A61K38/50 , A61K33/24 , A61P27/02 , A61P17/06
CPC classification number: A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules
Abstract translation: 本发明提供VEGF结合肽的各种用途，包括治疗与异常血管生成相关的疾病的方法。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽
-
10.发明申请METHODS OF TREATING A DISEASE OR CONDITION ASSOCIATED WITH ABNORMAL ANGIOGENESIS 有权治疗与异常血管发生相关的疾病或病症的方法公开(公告)号：US20120301431A1
公开(公告)日：2012-11-29
申请号：US13584721
申请日：2012-08-13
Applicant: Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
Inventor： Curt Bradshaw , Abhijit Bhat , Jing Yu Lai , Venkata Doppalapudi , Dingguo Liu
IPC: A61K38/17 , A61K39/395 , A61K38/50 , A61K33/24 , A61P35/02 , A61P19/02 , A61P17/06 , A61P27/02 , A61P35/00 , A61K39/44 , A61K38/21
CPC classification number: C07K14/47 , A61K38/00 , C07K14/515 , C07K2319/30
Abstract: The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.
Abstract translation: 本发明提供了治疗（包括预防）与受试者异常血管生成相关的疾病或病症的方法，包括向受试者施用治疗有效量的本发明的AA靶向化合物。 AA靶向化合物包含与抗体的结合位点连接的AA靶向剂 - 接头缀合物。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.028 seconds)
