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    Tumor tissue-penetrating peptide specific to neuropilin and fusion protein having same peptide fused therein
    251.
    发明授权
    Tumor tissue-penetrating peptide specific to neuropilin and fusion protein having same peptide fused therein 有权

    公开(公告)号：US09975933B2

    公开(公告)日：2018-05-22

    申请号：US14893317

    申请日：2014-05-22

    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Yong Sung Kim ,  Tae Hwan Shin ,  Yae Jin Kim ,  Eun Sil Sung

    IPC: C07K14/47 ,  A61K38/00

    CPC classification number: C07K14/4703 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30

    Abstract: A tumor tissue-penetrating peptide specifically binding to neuropilin, or a fusion protein, a small molecule drug, a nanoparticle, or a liposome having the peptide fused therein is provided, as well as a method for preparing the same and a pharmaceutical composition comprising the same for treating, diagnosing, or preventing cancer or angiogenesis-related diseases. The tumor tissue-penetrating peptide is fused to the C-terminus of an anticancer antibody heavy-chain constant region (Fc) and the fused antibody specifically binds to neuropilin, and specifically accumulates in tumor tissue, widens intercellular gaps between tumor vascular endothelial cells, promotes extravasation, increases infiltration within tumor tissue, and shows a remarkably increased in vivo tumor-suppressing activity. Furthermore, the tumor tissue-penetrating peptide is fused into a fusion protein and inhibits the angiogenic function of neuropilin coreceptors resulting from targeting of neuropilin, and is expected to have an alleviating effect on angiogenesis-related diseases.

    METHOD AND APPARATUS FOR CALCULATING SIMILARITY OF LIFE LOG DATA
    255.
    发明申请
    METHOD AND APPARATUS FOR CALCULATING SIMILARITY OF LIFE LOG DATA 审中-公开

    公开(公告)号：US20180052892A1

    公开(公告)日：2018-02-22

    申请号：US15655430

    申请日：2017-07-20

    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： We Duke CHO ,  Kyu Pil LEE ,  Sun Taag CHOE ,  Jong Ik LEE

    IPC: G06F17/30

    CPC classification number: G06F16/24575 ,  G06F16/24578 ,  G06F16/2477 ,  G06F16/258 ,  G16H10/60 ,  G16H40/63 ,  G16H50/70

    Abstract: Disclosed are a method and an apparatus for calculating similarity of life log data, the method including: producing, by a life log data producing unit, a plurality of life log data on a daily basis, in which at least one estimated activity state is indicated for each predetermined time section, by matching a user's position information per time period and a user's motion state information per time period with an estimated activity table in which the user's estimated activity states are defined in advance; converting, by a modified life log data producing unit, the plurality of life logs data into a plurality of modified life log data which is indicated for each merged time section made by merging a preset number of continuous time sections; and calculating, by a similarity calculating unit, life log similarity among the plurality of modified life log data by comparing the plurality of modified life log data for each merged time section.

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