公开(公告)号：US20150178508A1

公开(公告)日：2015-06-25

申请号：US14632599

申请日：2015-02-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Lothar Gramelspacher ,  Andrzej Knafel

IPC: G06F21/60 ,  G06F21/36 ,  G06F19/00

CPC classification number: G06F21/602 ,  A61B5/7285 ,  G06F19/00 ,  G06F21/31 ,  G06F21/335 ,  G06F21/36 ,  G16H10/60

Abstract: A method for controlling an analysis system is presented. The method comprises receiving, by an encryption unit, authentication data of a user. In the case of a successful authentication, a user-specific security code is generated by the encryption unit. The security code is outputted by the encryption unit to the authenticated user. The security code and the user-ID are received by an authentication unit coupled to the analysis system via a user-interface coupled to the authentication unit. The security code is decrypted by the authentication unit. If the decrypted security code matches with the user-ID, the user is authenticated at the authentication unit and an authentication signal is generated by the authentication unit for permitting the user to initialize at least one function of the analysis system.

Abstract translation: 提出了一种控制分析系统的方法。 该方法包括由加密单元接收用户的认证数据。 在成功认证的情况下，加密单元生成用户特定的安全码。 安全码由加密单元输出给认证用户。 安全码和用户ID由耦合到分析系统的认证单元经由耦合到认证单元的用户界面接收。 认证单元对安全码进行解密。 如果解密的安全码与用户ID匹配，则认证单元认证用户，并由认证单元生成认证信号，以允许用户初始化分析系统的至少一个功能。

公开(公告)号：US09063038B2

公开(公告)日：2015-06-23

申请号：US13800795

申请日：2013-03-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Carlo Effenhauser ,  Patrick Griss ,  Stephan Korner ,  Emad Sarofim

IPC: G01N33/00 ,  G01N1/20 ,  B01L3/02 ,  B01L3/00

CPC classification number: G01N1/20 ,  B01L3/0244 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2400/025 ,  B01L2400/0406 ,  Y10T29/49826 ,  Y10T436/110833 ,  Y10T436/2575

Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

Abstract translation: 用于在nl和μl范围内采样，运输和/或处理流体介质的装置包括分别具有开放或封闭的毛细管状凹槽或通道的基底，分别具有开放或封闭的凹槽或毛细管的基底弯曲或 至少在一个位置弧形。 衬底包括至少一个端部，开放或封闭的毛细管状沟槽或沟槽分别延伸到其中，该端部根据其应用或用途被成形为例如形状。 针状，直线切割，尖端状，至少半圆形，圆形等

公开(公告)号：US20150160250A1

公开(公告)日：2015-06-11

申请号：US14561314

申请日：2014-12-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marco Bucher ,  Gottlieb Schacher

IPC: G01N35/04

CPC classification number: G01N35/0099 ,  G01N2035/0406 ,  G01N2035/0484 ,  Y10T436/114165

Abstract: A device for gripping vessels is presented. The device comprises a mount, a support having a longitudinal axis coupled to the mount so to be rotatable relative to the mount around the longitudinal axis, a rotating mechanism for rotating the support, a gripper coupled to the support so to be translatable relative to the support along the longitudinal axis. The gripper has jaws for gripping a vessel, a translating mechanism for translating the gripper, at least one actuator for driving the translating mechanism and/or rotating mechanism and at least two reference elements fixed to the mount in at least two different stop positions. The jaws are passively biasable towards each other for holding a vessel in positions other than the at least two stop positions. The jaws are actively biasable away from each other by pushing the gripper against a reference element in one of the stop positions.

Abstract translation: 提出了一种用于夹紧容器的装置。 该装置包括安装件，支撑件，其具有连接到安装件的纵向轴线，以相对于围绕纵向轴线的安装架可旋转;用于旋转支撑件的旋转机构，联接到支撑件的夹持器可相对于支承件平移 沿纵轴支撑。 夹持器具有用于夹持容器的夹爪，用于平移夹持器的平移机构，用于驱动平移机构和/或旋转机构的至少一个致动器以及在至少两个不同的停止位置固定到底座的至少两个参考元件。 钳口被动地偏向彼此，用于将船只保持在除了至少两个停止位置之外的位置。 通过将夹具推到停止位置之一处的参考元件上，钳口能够相互主动偏置。

公开(公告)号：US20150160249A1

公开(公告)日：2015-06-11

申请号：US14561283

申请日：2014-12-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marco Bucher ,  Gottlieb Schacher

IPC: G01N35/02 ,  B65G47/82 ,  B65G25/08

CPC classification number: G01N35/026 ,  B65G25/08 ,  B65G47/82 ,  B65G2201/0235 ,  G01N35/04 ,  G01N2035/0415 ,  G01N2035/0475

Abstract: A tube rack transfer device for transferring racks is presented. A first rail extends in a first horizontal direction and a second rail extends in a second horizontal direction orthogonal to the first direction. The second rail moves along the first rail and comprising a transfer head movable along the second rail. The transfer head comprises a control pin to be coupled with one of: an input pusher, translatable in the second direction, for transferring a rack from a carrier to a sampling area of an analyzer; an output pusher for transferring a rack from the sampling area to a carrier; a rack for transferring the rack between different carriers and/or between different positions of the same carrier. An in-vitro diagnostic instrument comprises an analyzer for carrying out tests on biological samples, a sample unit for inputting/outputting racks, a sampling area for withdrawing samples from tubes, and a transfer device.

Abstract translation: 介绍了一种用于传送机架的管架传送装置。 第一轨道沿第一水平方向延伸，第二轨道在与第一方向正交的第二水平方向上延伸。 第二轨道沿着第一轨道移动并且包括可沿着第二轨道移动的转移头。 所述传送头包括控制销，所述控制销与以下之一联接：输入推动器，可在第二方向上平移，用于将支架从载体传送到分析器的采样区域; 用于将架子从采样区域传送到载体的输出推动器; 用于在不同载体之间和/或在相同载体的不同位置之间传送机架的机架。 一种体外诊断仪器包括用于对生物样品进行测试的分析器，用于输入/输出机架的样品单元，用于从管中取出样品的采样区域和转移装置。

公开(公告)号：US20150151082A1

公开(公告)日：2015-06-04

申请号：US14518381

申请日：2014-10-20

Applicant: Roche Diagnostics Operations Inc.

Inventor： Illai J Gescheit

IPC: A61M25/02 ,  A61B5/00 ,  A61M5/142 ,  A61B5/145 ,  A61M5/172 ,  A61M5/50

Abstract: A cradle and methods of using embodiments of the cradle are described. The cradle has a proximal side and a distal side, where the proximal side has a skin attachment member for releasable attachment to a patient's skin. The distal side includes a device attachment member configured to attach an initially separate medical device. The cradle comprises an electronically controlled optical indication device, the electronically controlled optical indication device being configured to provide optical indications to the patient when the cradle is attached to the patient's skin.

Abstract translation: 描述了一种支架以及使用支架实施例的方法。 所述支架具有近侧和远侧，其中所述近侧具有用于可释放地附接到患者皮肤的皮肤附接构件。 远侧包括构造成附接最初分离的医疗装置的装置附接构件。 所述支架包括电子控制光学指示装置，所述电子控制光学指示装置被配置为当所述支架附接到所述患者皮肤时向所述患者提供光学指示。

公开(公告)号：US20150151035A1

公开(公告)日：2015-06-04

申请号：US14615743

申请日：2015-02-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herfried Huemer

IPC: A61M1/36

CPC classification number: A61M1/3616 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2200/0621 ,  B01L2300/0681 ,  B01L2400/0478 ,  G01N33/491

Abstract: A multi-part device for separating plasma from whole blood is provided, with a sample taking unit for receiving whole blood, a filter unit with a layered filter with multiple layers for extracting plasma, and a pumping unit, typically a plunger pump, for creating a partial vacuum in the filter unit. The filter unit and a plasma collector vessel with a conical tip extending towards the filter unit are contained in a filter cartridge, which may be taken apart after plasma extraction, thus exposing the conical tip of the plasma collector vessel for sample input into an analyser.

Abstract translation: 提供了用于从全血中分离血浆的多部分装置，具有用于接收全血的取样单元，具有用于提取等离子体的多层的分层过滤器的过滤单元，以及通常为柱塞泵的抽吸单元，用于产生 过滤器单元中的部分真空。 过滤器单元和具有朝向过滤器单元延伸的锥形末端的等离子体收集器容纳在过滤器滤芯中，其可以在等离子体提取之后被分离，从而将用于样品输入的等离子体收集器容器的锥形尖端暴露于分析器中。

公开(公告)号：US20150150496A1

公开(公告)日：2015-06-04

申请号：US14497991

申请日：2014-09-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Richard Forster ,  Susanne Gentsch ,  Andreas Gorshoefer ,  Michael Keil ,  Thomas Weiss ,  Robert Wessel

IPC: A61B5/151 ,  A61B5/15

CPC classification number: A61B5/15153 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150824 ,  A61B5/15115 ,  A61B5/15163 ,  A61B5/15176 ,  A61B5/1518

Abstract: A lancet magazine for use in a lancing aid is described comprising a plurality of lancets each having a lancet body at the proximal end of the lancet and a lancet tip at the distal end of the lancet, where the proximal end of the lancet points in the direction of the proximal end of the housing of the lancet magazine and the distal end of the lancet is aligned in the direction of the distal end of the housing and the lancets in the unused state are completely surrounded by the housing. Furthermore, an extension unit is movably connected to the housing in such a manner that the housing can be extended by movement of the extension unit in the direction of the distal end of the housing such that the lancet is prevented from emerging from the lancet magazine.

Abstract translation: 一种用于穿刺辅助装置的柳叶刀盒，其特征在于，包括多个在柳叶刀的近端具有刺血针主体的柳叶刀和位于柳叶刀前端的刺血针头，其中， 柳叶刀盒的壳体的近端的方向和柳叶刀的前端在壳体的远端的方向上对准，未使用状态的刺血针被壳体完全包围。 此外，延伸单元以这样的方式可移动地连接到壳体，使得可以通过延伸单元在壳体的远端的方向上的移动来延伸壳体，使得防止柳叶刀从刺血针盒中出来。

公开(公告)号：US20150148536A1

公开(公告)日：2015-05-28

申请号：US14610110

申请日：2015-01-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Robert Cysewski ,  Luisa de Cola ,  Jesus Miguel Fernandez Hernandez ,  Hans-Peter Josel ,  Elena Longhi ,  Gaston Hubertus Maria Vondenhoff

IPC: C07F15/00 ,  H01L51/00 ,  G01N33/58

CPC classification number: C07F15/0033 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/185 ,  G01N33/533 ,  G01N33/582 ,  G01N2458/30 ,  H01L51/0085 ,  H01L51/009 ,  H01L51/5012

Abstract: The present invention relates to novel bis-iridium-based Ir(III) complexes, labels manufactured using these complexes and a method for producing such complexes.

Abstract translation: 本发明涉及新的基于二铱的Ir（III）络合物，使用这些络合物制备的标记物和这种络合物的制备方法。

公开(公告)号：US20150140561A1

公开(公告)日：2015-05-21

申请号：US14542980

申请日：2014-11-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Dieter Heindl ,  Jessica Steger-Domandl

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C07H19/10 ,  C07H19/20 ,  C12Q2525/186

Abstract: The present invention provides deoxynucleoside tri- or tetraphosphate comprising a 3′ nitrate and a detectable label covalently bound to the oxygen atom of an oxymethyl or oxyallyl or oxypropargyl substitution of a nucleobase. Such compounds provide new possibilities for future Sequencing by Synthesis technologies.

Abstract translation: 本发明提供了脱氧核苷三磷酸酯或四磷酸酯，其包含3'硝酸盐和可与氧原子共价结合的可检测标记，其中氧基甲氧基或氧杂环烷基或氧代炔基取代为核碱基。 这些化合物为将来通过Synthesis技术测序提供了新的可能性。

公开(公告)号：US20150132859A1

公开(公告)日：2015-05-14

申请号：US14334773

申请日：2014-07-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Elke Faatz ,  Peter Schaarschmidt ,  Urban Schmitt ,  Christian Scholz

IPC: G01N33/68 ,  C07K14/245 ,  C07K14/28

CPC classification number: G01N33/6854 ,  C07K14/245 ,  C07K14/28 ,  C07K2319/35 ,  G01N33/5306 ,  G01N33/571 ,  G01N2333/20 ,  G01N2333/28 ,  G01N2469/20 ,  G01N2800/26

Abstract: The invention relates to a method for detecting antibodies against the TpN17 antigen of Treponema pallidum in an isolated sample wherein a peptide sequence of Vibrio cholerae lipoprotein 15 (VcLp15) or a partial sequence thereof is used as a reagent for reduction of interference, i.e. for minimizing false positive results. In addition the invention relates to fusion polypeptides comprising a VcLp15 peptide sequence and a chaperone, to their use as an additive in an immunoassay for said reduction of interferences and for minimizing false positive results and to a reagent kit for detecting antibodies against Treponema pallidum antigens in an isolated sample comprising a TpN17 antigen and said VcLp15-chaperone fusion polypeptide.

Abstract translation: 本发明涉及在分离的样品中检测针对梅毒螺旋体的TpN17抗原的抗体的方法，其中使用霍乱弧菌脂蛋白15（VcLp15）或其部分序列的肽序列作为减少干扰的试剂，即最小化 假阳性结果。 此外，本发明涉及包含VcLp15肽序列和伴侣的融合多肽，用于在用于所述减少干扰和最小化假阳性结果的免疫测定中作为添加剂，以及用于检测针对梅毒螺旋体抗原的抗体的试剂盒 包含TpN17抗原和所述VcLp15伴侣融合多肽的分离样品。