公开(公告)号：US20200373018A1

公开(公告)日：2020-11-26

申请号：US16895449

申请日：2020-06-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL

IPC: G16H50/80 ,  G16H10/20 ,  G16H50/70 ,  G16H50/30

Abstract: There is provided a method of diagnosing pathogenesis of viral infections for epidemic prevention, comprising: receiving a geographic location and responses to a questionnaire provided to undiagnosed persons, in each of iteration: inputting a first subset of answers and the geographical location of one of the undiagnosed persons into a geographic-level ML model component trained on a first training dataset including, for each subject: the first subset of answers, an indication of a certain geographic zone, and a label indicative of whether the respective subject is diagnosed or undiagnosed with the viral disease, inputting a second subset of the answers to a human-level ML model component trained on a second training dataset including, for each subject, the second subset of answers, and the label, and combining the outcome from the ML model components to calculate a combined likelihood of the respective undiagnosed person to be diagnosed with the viral disease.

公开(公告)号：US20200339635A1

公开(公告)日：2020-10-29

申请号：US16922039

申请日：2020-07-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ada YONATH ,  Zohar EYAL ,  Donna MATZOV ,  Haim ROZENBERG ,  Ella ZIMMERMAN ,  Anat BASHAN

IPC: C07K14/31 ,  G16B15/00 ,  G16C20/50 ,  G16B30/00 ,  C07D211/54 ,  C07D263/20 ,  C07H17/08

Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

公开(公告)号：US10799619B2

公开(公告)日：2020-10-13

申请号：US16387591

申请日：2019-04-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Noa Iuster ,  Raya Sorkin

IPC: A61L27/52 ,  A61L27/34 ,  A61K9/00 ,  C09D133/06 ,  A61L27/44 ,  C08F2/10 ,  C08F2/44

Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

公开(公告)号：US20200306343A1

公开(公告)日：2020-10-01

申请号：US16891165

申请日：2020-06-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eldad TZAHOR ,  Kfir Baruch UMANSKY ,  Rabea HINKEL ,  Christian KUPATT

IPC: A61K38/17 ,  A61P9/10

Abstract: A method of treating an ischemic heart disease in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of Agrin in an anterograde intracoronary manner, thereby treating the ischemic heart disease in the subject.

公开(公告)号：US10767201B2

公开(公告)日：2020-09-08

申请号：US15758372

申请日：2016-09-11

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph Aharoni ,  Guy Polturak

IPC: C12P23/00 ,  C12P13/22 ,  C12P13/04 ,  A23L3/3463 ,  A23L3/3526 ,  A23L5/46 ,  A23L3/3544 ,  C07K14/415 ,  C12N9/02 ,  C12N9/12 ,  C12P17/12 ,  C12P19/02

Abstract: The invention provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD6 or related gene and their use for producing L-DOPA from tyrosine and treating dopamine-responsive disorders, such as Parkinson's Disease. The invention also provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD1 and/or CYP76AD6, a nucleic acid encoding a DOPA 4.5-dioxygenase (DOD) enzyme, such as Beta vulgaris DODA1, and, in some cases, a nucleic acid encoding betalain related glucosyltransferase, such as M. jalapa gene cyclo-DOPA 5-O-glucosyltransferase (cDOPA5GT), and their use for producing betalains. Finally, the invention provides chimeric polypeptides, expression vectors, cells, compositions, and organisms, including plants, and their uses in various methods of the invention.

公开(公告)号：US20200268707A1

公开(公告)日：2020-08-27

申请号：US16833859

申请日：2020-03-30

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yifat MERBL ,  Ron BENYAIR

IPC: A61K31/35 ,  A61K31/575 ,  G01N33/50 ,  A61P37/06 ,  A61P35/00 ,  A61K31/365 ,  A61K31/472 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: A method of modulating protein exocytosis is provided. The method comprising contacting a cell with an agent that modulates the ubiquitin pathway in the Golgi, thereby modulating protein secretion.

公开(公告)号：US20200263135A1

公开(公告)日：2020-08-20

申请号：US16762164

申请日：2018-11-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Idit SHACHAR ,  Shirly HERMAN

IPC: C12N5/0789 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K35/28

Abstract: A method of generating hematopoietic stem cells for transplantation is disclosed. The method comprising: (a) collecting hematopoietic stem cells; and (b) contacting the hematopoietic stem cells with an agent capable of decreasing an activity or expression of CD74 and/or of macrophage migration inhibitory factor (MIF), to thereby generate hematopoietic stem cells for transplantation, and wherein the hematopoietic stem cells are not transduced with a lentivirus. Methods of increasing mobilization of hematopoietic stem cells and methods of treatment are also provided.

公开(公告)号：US10668109B2

公开(公告)日：2020-06-02

申请号：US15737290

申请日：2016-06-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Chava Rosen ,  Elias Shezen ,  Irit Milman Krentsis

IPC: A61K35/42 ,  A61K45/06 ,  A61K31/015 ,  A61K35/12 ,  A61K35/28 ,  C12N5/071 ,  A61K9/00 ,  A61K31/255 ,  A61K31/675 ,  A61N5/10

Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.

公开(公告)号：US10665324B2

公开(公告)日：2020-05-26

申请号：US15323994

申请日：2015-07-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Sarel Fleishman ,  Gideon Lapidoth ,  Maria Gabriele Pszolla ,  Christoffer Norn

IPC: G16B15/00 ,  G16B20/00 ,  G16B35/00 ,  G16C20/60

Abstract: A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are based on a stochastic sampling of backbone conformations and amino acid conservation patterns observed in experimentally available protein structures having the common structural fold.

公开(公告)号：US20200071669A1

公开(公告)日：2020-03-05

申请号：US16490568

申请日：2018-03-02

Applicant: Yeda Research and Development Co. Ltd. ,  The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

Inventor： Benjamin GEIGER ,  Nir FRIEDMAN ,  Shimrit LIEBER ,  Zelig ESHHAR ,  Tova WAKS ,  An at GLOBERSON LEVIN

IPC: C12N5/0783 ,  A61K35/17

Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising culturing T cells in the presence of a T cell stimulator, an exogenous CCL21 and an exogenous ICAM1, thereby culturing the T cells. Also provided are cell cultures, isolated T cells and uses of same.