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    Tissue implants for implantation and methods of preparing the same
    21.
    发明授权
    Tissue implants for implantation and methods of preparing the same 有权
    用于植入的组织植入物及其制备方法

    公开(公告)号：US08883408B2

    公开(公告)日：2014-11-11

    申请号：US13754029

    申请日：2013-01-30

    申请人： CryoLife, Inc.

    发明人： Joseph Hamby ,  Steven Walsh

    IPC分类号： A61L27/36

    CPC分类号： A61L27/3687 ,  A61L27/3604 ,  A61L2430/40

    摘要： A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.

    摘要翻译： 提供了一种用于制备用于植入的组织植入物的方法。 该方法包括从人或动物供体收集组织材料，在含有核酸酶的溶液中处理组织材料，然后用碱性醇溶液处理组织材料。 含有核酸酶的溶液包括抗微生物剂。 碱性醇溶液包含氢氧化钠和乙醇。

    IMPLANTABLE AND REMOVABLE CUSTOMIZABLE BODY CONDUIT
    22.
    发明申请
    IMPLANTABLE AND REMOVABLE CUSTOMIZABLE BODY CONDUIT 审中-公开
    可拆卸和可拆卸的可自定义身体导线

    公开(公告)号：US20140180190A1

    公开(公告)日：2014-06-26

    申请号：US14192567

    申请日：2014-02-27

    申请人： CryoLife, Inc.

    发明人： Mitchell Dann ,  Judson A. Herrig ,  Stephen Hohmann

    IPC分类号： A61M1/36

    CPC分类号： A61M1/3655 ,  A61F2/064 ,  A61F2250/0059 ,  A61M25/005 ,  A61M2025/0024

    摘要： An apparatus and method are provided to treat a stenosis. A delivery device is provided that has an elongate tubular member coupled therewith. The elongate tubular member has an outside surface that is configured to prevent adherence of in vivo matter. The tubular member has a proximal end and a distal end and is reinforced along its length to maintain open lumen under a transverse load. The tubular member is placed in the vasculature such that the distal end of the elongate tubular member is disposed distal of a stenosis. The proximal end of the elongate tubular member is disposed inside the vessel, preferably at a location proximal of the stenosis. Thereafter, after a therapeutic period, the elongate tubular member is removed intact.

    摘要翻译： 提供了一种治疗狭窄的装置和方法。 提供了一种具有与其连接的细长管状构件的输送装置。 细长管状构件具有被构造成防止体内物质粘附的外表面。 管状构件具有近端和远端，并且沿其长度被加强以在横向负载下保持开口腔。 管状构件放置在脉管系统中，使得细长管状构件的远端设置在狭窄远端。 细长管状构件的近端设置在容器内，优选地位于狭窄近端的位置。 此后，在治疗期后，细长管状构件被完整地去除。

    In situ bioprosthetic filler and method, particularly for the in situ formation of vertebral disc bioprosthetics
    23.
    发明授权
    In situ bioprosthetic filler and method, particularly for the in situ formation of vertebral disc bioprosthetics 有权
    原位生物假体填充剂和方法，特别是用于原位形成椎间盘生物假体

    公开(公告)号：US07896920B2

    公开(公告)日：2011-03-01

    申请号：US11932066

    申请日：2007-10-31

    申请人： K. Umit Yuksel ,  Steven P. Walsh ,  Kirby S. Black

    发明人： K. Umit Yuksel ,  Steven P. Walsh ,  Kirby S. Black

    IPC分类号： A61F2/44 ,  A61B17/68

    CPC分类号： A61L27/3691 ,  A61F2002/4445 ,  A61F2002/445 ,  A61L27/18 ,  A61L27/22 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/3658 ,  A61L27/40 ,  C08L71/02

    摘要： Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.

    摘要翻译： 生物假体装置包括至少部分地限定空腔的外部生物组织构件和填充空腔并插入并化学结合（固定）到周围生物组织构件的组织的蛋白质生物聚合物。 在优选形式中，生物假体装置是具有纤维外环的生物假体椎间盘，其围绕并限定内腔，并且通过从其中去除至少大部分天然胶状核而形成。 然后可以用可流动的蛋白质生物聚合物填充由纤维状外环形成的空腔。 优选地，蛋白质生物聚合物是由人或动物衍生的蛋白质材料和二醛或多醛组成的液体混合物，其允许在原位反应以在腔内形成交联的生物聚合物。 液体混合物可以在引入空腔之前形成，或者可以在引入空腔期间同时形成。

    Methods of making expandable foam-like biomaterials
    27.
    发明申请
    Methods of making expandable foam-like biomaterials 有权
    制造可膨胀泡沫状生物材料的方法

    公开(公告)号：US20050158364A1

    公开(公告)日：2005-07-21

    申请号：US11042181

    申请日：2005-01-26

    申请人： K. Yuksel ,  Ana Bird ,  Kirby Black

    发明人： K. Yuksel ,  Ana Bird ,  Kirby Black

    IPC分类号： G06Q30/00 ,  A61L27/22 ,  A61L27/56 ,  G06F21/00 ,  G10K15/02 ,  G10L11/00 ,  G11B20/10 ,  A61K38/17 ,  A61F2/00

    CPC分类号： A61L27/56 ,  A61L27/22

    摘要： Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.

    摘要翻译： 将液体，可注射的水溶液原位转化为可膨胀的泡沫样，空间填充和粘附的生物材料。 优选地，泡沫状生物材料是两部分液体体系实现其原位形成的反应产物。 液体系统通常由蛋白质溶液和交联剂溶液组成，其可以预混合，然后施用于需要生物材料的部位，或者同时混合并通过直接混合/分配尖端直接递送到该部位 。 在特别优选的实施方案中，可膨胀泡沫状生物材料包括人或动物衍生的蛋白质材料与二醛或多醛在碳酸氢盐存在下的反应产物和足以赋予材料泡沫结构的酸性滴定剂量 。