公开(公告)号：US20190201518A1

公开(公告)日：2019-07-04

申请号：US16237325

申请日：2018-12-31

申请人： University of Maryland Baltimore County ,  Allotropic Tech, LLC

发明人： Vikram N. Vakharia ,  Robert Balcerzak

IPC分类号： A61K39/12 ,  A61K39/39 ,  A61K9/00 ,  A61K9/70 ,  A61K9/113 ,  A61K9/14 ,  A61P31/12

摘要： An oral vaccine composition for fish, and related oral vaccine delivery system and methods for making and using such oral vaccine composition and delivery system are described. The oral vaccine composition includes virus-like particles effective to mediate an immunoprotective response in a target fish species, wherein the virus-like particles are contained in biomass of an organism or cell culture in which the virus-like particles have been expressed, optionally further including (i) adjuvant effective to enhance the immunoprotective response of the virus-like particles in the target fish species; (ii) encapsulant protectively associated with the virus-like particles for selective locus bioavailability in the target fish species; and/or (iii) binding agent aggregating the ingredients of the composition with one another.

公开(公告)号：US20190185898A1

公开(公告)日：2019-06-20

申请号：US16323355

申请日：2017-08-10

申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK

发明人： LAI-XI WANG ,  CHAO LI ,  SHILEI ZHU

IPC分类号： C12P21/00

CPC分类号： C12P21/005 ,  C07K2319/21 ,  C07K2319/50 ,  C12N9/2402 ,  C12Y302/01127

摘要： The present invention provides for novel fucosidase mutants that server as fuco-ligases for core fucosylation of a range of biological glycopeptides and glycoproteins including intact therapeutic antibodies. Several mutants with mutation at the general acid/base residue E274 of the Lactobacillus casei α1,6-fucosidase, including E274A, E274S, and E274G, were able to efficiently fucosylate a wide variety of complex N-glycopeptides and intact glycoproteins. The site specific mutants enable the transfer of fucose to a core GlcNAc-Asn residue and useful for drug delivery and vaccine development.

公开(公告)号：US10228801B2

公开(公告)日：2019-03-12

申请号：US14523347

申请日：2014-10-24

申请人： University of Maryland, Baltimore County

发明人： Ryan Robucci ,  Nilanjan Banerjee

IPC分类号： G06F3/045 ,  G06F3/044 ,  G06F3/0488 ,  H03K17/96 ,  G06F3/0346

摘要： Systems and methods for proximity-based position, movement and gesture detection are provided that utilize capacitive sensor arrays. In one embodiment, the system utilizes textile-based capacitive sensor arrays that can be integrated into other textiles, such as clothing, bed linens, etc., or that can be integrated into the environment (e.g., furniture, wheelchairs, car seats, etc.). The system recognizes gestures from detected movement by utilizing hierarchical signal processing techniques.

公开(公告)号：US10078013B2

公开(公告)日：2018-09-18

申请号：US15723103

申请日：2017-10-02

申请人： UNIVERSITY OF MARYLAND BALTIMORE COUNTY

发明人： Bradley Arnold ,  Christopher Cooper ,  John Cataldi

IPC分类号： G01J3/28 ,  G01J3/44 ,  G01J3/18 ,  G02B6/32 ,  G01J3/06 ,  G02B5/18

CPC分类号： G01J3/44 ,  G01J3/0221 ,  G01J3/06 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/36 ,  G02B5/1814 ,  G02B5/1861 ,  G02B6/32

摘要： The invention provides methods and apparatus comprising a multi-wavelength laser source that uses a single unfocused pulse of a low intensity but high power laser over a large sample area to collect Raman scattered collimated light, which is then Rayleigh filtered and focused using a singlet lens into a stacked fiber bundle connected to a customized spectrograph, which separates the individual spectra from the scattered wavelengths using a hybrid diffraction grating for collection onto spectra-specific sections of an array photodetector to measure spectral intensity and thereby identify one or more compounds in the sample.

公开(公告)号：US09310303B2

公开(公告)日：2016-04-12

申请号：US14223254

申请日：2014-03-24

申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

发明人： Chris D. Geddes

IPC分类号： G01N21/64 ,  G01N33/543

CPC分类号： G01N21/648 ,  G01N33/54373

摘要： In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied current, surface plasmons in “just-continuous” low resistance films are sparsely available for fluorophore dipole coupling and hence the enhanced fluorescence is gated as a function of the applied current.

摘要翻译： 在本发明中，首次证明了电流对表面等离子体激元扩增荧光特征的能力的影响。 穿过具有低电阻的银岛膜（SiF）的施加的直流电扰扰近亲近荧光团的荧光增强。 对于给定的施加电流，“刚性连续”低电阻膜中的表面等离子体激元稀疏地可用于荧光团偶极耦合，因此增强的荧光作为施加电流的函数被门控。

公开(公告)号：US20150158064A1

公开(公告)日：2015-06-11

申请号：US14612887

申请日：2015-02-03

申请人： University of Maryland Baltimore County

发明人： Kevin R. Sowers ,  Birthe Kjellerup ,  Upal Ghosh

IPC分类号： B09C1/10 ,  B09C1/08 ,  C12N1/20

CPC分类号： B09C1/10 ,  A62D3/02 ,  A62D2101/22 ,  B09C1/08 ,  C12N1/20

摘要： A system and methods for removal of persistent organic pollutants (POPs) from an environment, where the system includes an inert and organic biofilm substrata as biofilm media for dual use: 1) inoculation of microorganisms to degrade POPs and 2) accumulation of POPs on the substrata, effective in maintaining bioavailable concentrations for sustaining microbial activity. Microorganisms capable of degrading or transforming POPs are actively associated with the substrata as a biofilm. Application of this delivery vehicle will enhance the microbial degradation of POPs, while simultaneously adsorbing hydrophobic POPs from the environment making them bioavailable for the microorganisms located in the formed biofilms and additionally lowering the aqueous concentration of POPs that have detrimental effects towards fish and mammals as they bioaccumulate through the food chain.

摘要翻译： 一种从环境中去除持久性有机污染物（POPs）的系统和方法，其中系统包括惰性和有机生物膜基质作为生物膜介质用于双重用途：1）接种微生物以降解POPs和2）POPs在 基质，有效维持生物可利用的浓度以维持微生物活性。 能够降解或转化持久性有机污染物的微生物与基质作为生物膜积极相关。 这种运输工具的应用将增强持久性有机污染物的微生物降解，同时从环境中吸收疏水性POPs，使其对于形成的生物膜中的微生物具有生物利用性，并且另外降低对鱼类和哺乳动物有害影响的持久性有机污染物的含水浓度，因为它们 通过食物链生物累积。

公开(公告)号：US08993972B2

公开(公告)日：2015-03-31

申请号：US12692752

申请日：2010-01-25

申请人： Govind Rao ,  Hung Lam ,  Yordan Kostov ,  Leah Tolosa ,  Xudong Ge

发明人： Govind Rao ,  Hung Lam ,  Yordan Kostov ,  Leah Tolosa ,  Xudong Ge

IPC分类号： G01T1/20 ,  G01N21/64

CPC分类号： G01N21/645

摘要： A fluorescence based sensor system that provides improved signal-to-noise over prior systems is provided. The system includes a fluorescence based sensing medium that is contained a recessed cavity with reflective sides that allow for more uniform excitation of the fluorescence based sensing medium by the excitation light.

摘要翻译： 提供了基于荧光的传感器系统，其提供了比现有系统更好的信噪比。 该系统包括基于荧光的感测介质，其包含具有反射侧的凹腔，其允许通过激发光更均匀地激发基于荧光的感测介质。

公开(公告)号：US08987004B2

公开(公告)日：2015-03-24

申请号：US11997778

申请日：2006-08-02

申请人： Chris D. Geddes

发明人： Chris D. Geddes

IPC分类号： G01N33/553 ,  G01N33/58 ,  G01N33/543

CPC分类号： G01N33/587 ,  G01N33/54346 ,  G01N33/54373 ,  Y10S436/805

摘要： The present invention relates to affinity biosensing using polarization of light scattering of aggregated noble metallic nanostructures to determine concentration of an analyte in a test sample. This new sensing system utilizes the changes in polarized plasmonic scattering from nanostructures as the nanostructures aggregate due to binding of the analyte to a binding partner attached to the surface of the metallic nanostructure.

摘要翻译： 本发明涉及使用聚集的贵金属纳米结构的光散射的偏振来确定测试样品中分析物的浓度的亲和生物传感。 由于分析物与附着于金属纳米结构表面的结合对象的结合，纳米结构聚集了纳米结构的极化等离子体飞散的这种新的感测系统。

公开(公告)号：US08759110B2

公开(公告)日：2014-06-24

申请号：US13104146

申请日：2011-05-10

申请人： Chris D. Geddes

发明人： Chris D. Geddes

IPC分类号： G01N21/64 ,  G01N33/52 ,  C07H21/02

CPC分类号： G01N21/6428 ,  G01N21/648 ,  G01N33/728 ,  G01N2021/6432 ,  Y10T436/14 ,  Y10T436/143333 ,  Y10T436/145555 ,  Y10T436/146666

摘要： The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background of bilirubin bound Human Serum Albumin (HSA) or sensing and isolating target nucleotide sequences wherein a fluorescence signal is enhanced by close proximity of the target substances near metallic surfaces.

摘要翻译： 本发明涉及金属表面检测系统，用于在存在主要高背景的胆红素结合人血清白蛋白（HSA）或检测和分离其中荧光信号增强的靶核苷酸序列的情况下测定新生儿血清中的游离胆红素的目标物质 靠近金属表面附近的目标物质。

公开(公告)号：US20140123787A1

公开(公告)日：2014-05-08

申请号：US14071989

申请日：2013-11-05

申请人： University of Maryland, Baltimore County

发明人： Weidong ZHU ,  Xuefeng Wang

IPC分类号： F16H21/14

CPC分类号： F16H29/20 ,  F16H19/043 ,  F16H21/14 ,  F16H21/20 ,  F16H29/04 ,  Y10T74/18408

摘要： An infinitely variable transmission (IVT) to provide a continuous output-to-input speed ratio from zero to a certain value is designed, and its working principle is illustrated. It is a geared IVT (GIVT), since its function to achieve the continuously varied speed ratio is implemented by gears. Crank-slider systems are used in the GIVT; the output-to-input speed ratio is changed with the crank length. Racks and pinions, whose motion is controlled by planetary gear sets, are used to change the crank length when the cranks are rotating. One-way bearings are used to rectify the output speeds from different crank-slider systems to obtain the output speed of the GIVT. Since the crank-slider systems can introduce variations of the instantaneous speed ratio, a pair of noncircular gears is designed to minimize the variations. A direction control system is also designed for the GIVT using planetary gear sets. Finally, a vehicle start-up simulation and a wind turbine simulation to maintain a constant generator speed are developed based on a GIVT module in the Matlab Simulink environment.

摘要翻译： 设计了一种无级变速器（IVT），从零到一定值提供连续的输出与输入速度比，并说明其工作原理。 它是一款齿轮传动系统（GIVT），由于实现变速比不断变化的功能是通过齿轮实现的。 GIVT中使用曲柄滑块系统; 输出转速比随曲柄长度变化。 齿轮和小齿轮，其运动由行星齿轮组控制，用于在曲柄旋转时改变曲柄长度。 单向轴承用于纠正不同曲柄滑块系统的输出速度，以获得GIVT的输出速度。 由于曲柄滑块系统可引入瞬时速比的变化，因此设计了一对非圆形齿轮以使变化最小化。 还使用行星齿轮组为GIVT设计了方向控制系统。 最后，基于Matlab Simulink环境中的GIVT模块开发车辆启动仿真和风力涡轮机模拟以保持恒定的发电机转速。