公开(公告)号：US20240066113A1

公开(公告)日：2024-02-29

申请号：US18029758

申请日：2022-04-12

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Chung-Yi WU ,  Che MA ,  Chen-Yu FAN

IPC: A61K39/215 ,  A61K9/127 ,  A61P31/14 ,  C07K14/165

CPC classification number: A61K39/215 ,  A61K9/127 ,  A61P31/14 ,  C07K14/165 ,  A61K2039/545

Abstract: The present invention relates to the mRNA vaccine of coronavirus spike protein with deletion of glycosites in the receptor binding domain (RBD), the subunit 1 (S1) domain, or the subunit 2 (S2) domain, or a combination thereof. The vaccine elicits broadly protective immune responses coronavirus and variants thereof.

公开(公告)号：US11866485B2

公开(公告)日：2024-01-09

申请号：US17937744

申请日：2022-10-03

Applicant: ACADEMIA SINICA

Inventor： Kuo-I Lin ,  Che Ma ,  Chi-Huey Wong ,  Szu-Wen Wang ,  Yi-Hsuan Chang ,  Xiaorui Chen ,  Han-Yi Huang

IPC: C07K16/10 ,  A61K39/42 ,  A61K39/00

CPC classification number: C07K16/10 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

公开(公告)号：US20230418041A1

公开(公告)日：2023-12-28

申请号：US18464125

申请日：2023-09-08

Applicant: Academia Sinica

Inventor： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC: G02B21/36 ,  G02B21/26 ,  G02B21/06 ,  G06V10/25 ,  G06V10/141 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

CPC classification number: G02B21/365 ,  G02B21/26 ,  G02B21/06 ,  G06V10/25 ,  G06V10/141 ,  G06V20/693 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US11813317B2

公开(公告)日：2023-11-14

申请号：US17540289

申请日：2021-12-02

Applicant: Academia Sinica ,  National Yang Ming Chiao Tung University

Inventor： Ruey-Hwa Chen ,  Yu-Hsuan Chen ,  Tzu-Yu Huang ,  Wen-Hsin Li ,  Ting-Fen Tsai ,  Zhao-Qing Shen

IPC: A61P3/00 ,  C12N15/86 ,  A61K38/48 ,  A61P3/04 ,  A61K45/06 ,  C12N9/48

CPC classification number: A61K38/4813 ,  A61K45/06 ,  A61P3/04 ,  C12N9/485 ,  C12N15/86 ,  C12Y304/19012 ,  C12N2750/14111

Abstract: Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.

公开(公告)号：US11753432B2

公开(公告)日：2023-09-12

申请号：US16481042

申请日：2018-01-26

Applicant: Academia Sinica

Inventor： Chih-Cheng Chen ,  Jim-Min Fang ,  Cheng-Han Lee ,  Jen-Yao Chang

IPC: C07H19/16 ,  A61K47/55 ,  A61P29/00 ,  A61K31/7076 ,  A61K38/04

CPC classification number: C07H19/16 ,  A61K31/7076 ,  A61K38/046 ,  A61K47/55 ,  A61P29/00

Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-O-(glycine-N-carbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5-deoxy-5′-(glycine-N-amido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

公开(公告)号：US20230160892A1

公开(公告)日：2023-05-25

申请号：US17913986

申请日：2021-03-22

Applicant: Ming-Che SHIH ,  Academia Sinica

Inventor： Yu-Chan CHAO ,  Sung-Chan WEI ,  Huei-Ru LO ,  Chih-Hsuan TSAI ,  Yu-Wen LO ,  Wei-Ting HSU ,  Chuan-Yu LIAO

IPC: G01N33/569 ,  C12N15/86 ,  C07K14/435 ,  C07K14/005

CPC classification number: G01N33/56983 ,  C12N15/86 ,  C07K14/43572 ,  C07K14/005 ,  C12N2710/14022 ,  C12N2710/14042 ,  C12N2710/14052 ,  C12N2770/20034 ,  G01N2469/20 ,  A61K39/00

Abstract: Disclosed herein are recombinant viruses and/or insect cells suitable for detecting the infection of a pathogen in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the pathogen or not, so that proper course of treatment may be assigned to the subject. Also disclosed herein is a vaccine for the prophylaxis and/or treatment of infection caused by said pathogen.

公开(公告)号：US11630102B2

公开(公告)日：2023-04-18

申请号：US16484948

申请日：2018-02-08

Applicant: ACADEMIA SINICA

Inventor： Yuan-Tsong Chen ,  Yi-Ching Lee ,  Jer-Yuam Wu ,  Hsiao-Jung Kao

IPC: A01K67/027 ,  G01N33/50 ,  A61P19/00 ,  A61P35/00 ,  A61K31/409 ,  A61K36/21

Abstract: A method of inhibiting an overactive fibroblast growth factor receptor 3 (FGFR3) in a cell by contacting the cell with a composition that contains an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Also disclosed is a method for treating a disorder associated with an overactive FGFR3 with a composition containing an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Further, a composition for treating a disorder associated with an overactive FGFR3 is described. The composition contains an ethanol extract of Amaranthus viridis.

公开(公告)号：US20230097801A1

公开(公告)日：2023-03-30

申请号：US17829917

申请日：2022-06-01

Applicant: National Health Research Institutes ,  Academia Sinica

Inventor： Chih-Hao Chen ,  Wan-Ching Yen ,  Teng-Kuang Yeh ,  Chiung-Tong Chen ,  Hwei-Jiung Wang ,  Kai-Fa Huang

IPC: A61K31/41 ,  A61K31/427 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/381 ,  A61P35/00 ,  A61K45/06

Abstract: Disclosed are methods for treatments of conditions involving CD47 upregulation using a compound of formula (I): Variables R1-R9, X, and Het are defined therein. Also disclosed are methods for increasing phagocytosis of a cell using such a compound and pharmaceutical compositions each containing the compound and an anti-cancer agent.

公开(公告)号：US11511271B2

公开(公告)日：2022-11-29

申请号：US16454893

申请日：2019-06-27

Applicant: Academia Sinica

Inventor： Po-Wen Chung ,  Meng-Xun Wu

IPC: B01J37/03 ,  B01J23/02 ,  B01J21/08 ,  B01J35/10 ,  B01J37/02 ,  B01J37/10

Abstract: Metal oxides-silica composite materials are synthesized by a co-precipitation method to serve as modified catalysts for converting ethanol into four-carbon hydrocarbons. The method includes mixing a liquid-phase silicon source and a metal precursor at different ratios so as to change the acid-base composition of the composite materials and thereby increase selectivity with respect to the four-carbon products.

公开(公告)号：US11506664B1

公开(公告)日：2022-11-22

申请号：US17238431

申请日：2021-04-23

Applicant: Academia Sinica ,  National Tsing Hua University

Inventor： Shang-Cheng Hung ,  Gwo-Bin Lee ,  Priya Gopinathan

IPC: G01N33/574 ,  C08B37/00 ,  A61K33/243 ,  A61K31/53 ,  A61K31/7072 ,  A61K31/505 ,  A61K31/7068

Abstract: Disclosed herein is a novel compound of formula (I) for detecting circulating cancerous cells, particularly, cholangio-cancerous cells, from a biological sample, wherein, R1 and R2 are independently H, or —SO3M; and M is a monovalent cation selected from the group consisting of sodium ion, potassium ion, lithium ion or ammonium ion. Also disclosed herein is a method of treating and detecting cholangio-cancerous cells from a biological sample of a subject suspected of having cholangiocarcinoma (CCA). The method includes steps of, contacting the biological sample with a magnetic bead pre-coated with the compound of formula (I); detecting a complex formed between the magnetic bead and the biological sample in an immunoassay; and administering to the subject an effective amount of a chemotherapeutic agent to ameliorate symptoms associated with the CCA.