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公开(公告)号:US20090104152A1
公开(公告)日:2009-04-23
申请号:US12217352
申请日:2008-07-03
CPC分类号: A61K38/193
摘要: The invention relates to interferon-α molecules having certain O-linked oligosaccharide structures.
摘要翻译: 本发明涉及具有某些O-连接寡糖结构的干扰素-α分子。
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公开(公告)号:US07507873B2
公开(公告)日:2009-03-24
申请号:US11649543
申请日:2007-01-04
IPC分类号: A01K67/027 , A01K67/00 , A01K67/033
CPC分类号: C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要: Transgenic avians having a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
摘要翻译: 具有与一个或多个有用的氨基酸编码序列可操作地连接的重组卵巢粘蛋白基因表达控制区的转基因鸟类。
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公开(公告)号:US08846603B2
公开(公告)日:2014-09-30
申请号:US13583973
申请日:2011-03-11
申请人: Anthony Quinn , Alex J. Harvey , Zhinan Xia
发明人: Anthony Quinn , Alex J. Harvey , Zhinan Xia
CPC分类号: C12N9/16 , A61K38/00 , C07K7/06 , C07K2319/00 , C07K2319/01 , C07K2319/02 , C07K2319/30 , C07K2319/33 , C12N9/00 , C12N9/22 , C12N9/96 , C12N15/625 , C12N15/8509 , C12N15/86 , C12N2840/007 , C12Y301/04001 , Y10S530/827
摘要: The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.
摘要翻译: 本发明提供了一种新颖的融合多肽,其含有与靶向部分融合的NPP1的催化部分,编码融合多肽的核酸,含有整合在其中的核酸的载体,用载体转化的宿主细胞和包含融合多肽的药物组合物 。
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公开(公告)号:US08431770B2
公开(公告)日:2013-04-30
申请号:US12319396
申请日:2009-01-07
申请人: Alex J. Harvey
发明人: Alex J. Harvey
IPC分类号: C12P21/00 , A01K67/027
CPC分类号: A01K67/0275 , A01K2217/052 , A01K2227/30 , A01K2267/01 , C12N9/1048 , C12N9/1051 , C12N15/8509 , C12N2799/027 , C12N2830/008
摘要: Transgenic avians which produce proteins in their oviduct tissue having modified oligosaccharide structures and methods of making such avians are disclosed herein. The invention also includes the modified proteins produced in the transgenic birds.
摘要翻译: 在本文中公开了在其具有修饰的寡糖结构的输卵管组织中产生蛋白质的转基因鸟类和制备这种鸟类的方法。 本发明还包括在转基因鸟类中产生的修饰的蛋白质。
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公开(公告)号:US07803362B2
公开(公告)日:2010-09-28
申请号:US12217352
申请日:2008-07-03
CPC分类号: A61K38/193
摘要: The invention relates to interferon-α molecules having certain O-linked oligosaccharide structures.
摘要翻译: 本发明涉及具有某些O-连接的寡糖结构的干扰素-α分子。
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公开(公告)号:US20100083389A1
公开(公告)日:2010-04-01
申请号:US12387434
申请日:2009-05-01
IPC分类号: A01K67/027 , C12N15/09 , C12N15/13
CPC分类号: C07K16/00 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2227/30 , A01K2267/01 , C07K2317/20 , C07K2317/23 , C12N15/8509 , C12N2799/027 , C12N2800/30 , C12N2830/008 , C12N2830/15 , C12N2830/46 , C12N2830/90 , C12N2840/203
摘要: The invention includes methods of making transgenic avians by introducing a nucleic acid sequence into the genome of an avian embryo wherein the nucleic acid sequence comprises a nucleotide sequence encoding a heterologous protein, developing the avian embryo to hatch, developing the hatched chick to sexual maturity and obtaining offspring from the sexually mature hatched chick which produce egg white containing the heterologous protein.
摘要翻译: 本发明包括通过将核酸序列引入禽胚胎的基因组中来制备转基因鸟类的方法,其中所述核酸序列包含编码异源蛋白质的核苷酸序列,开发禽类胚胎孵化,将孵出的雏鸡发育成性成熟, 从产生含有异源蛋白质的蛋白的性成熟孵出的小鸡获得后代。
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公开(公告)号:US20090182130A1
公开(公告)日:2009-07-16
申请号:US12313064
申请日:2008-11-17
IPC分类号: C07K1/14
CPC分类号: C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要: Methods of producing protein using a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
摘要翻译: 使用与一个或多个有用的氨基酸编码序列有效连接的重组卵巢粘蛋白基因表达控制区产生蛋白质的方法。
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公开(公告)号:US20090178147A1
公开(公告)日:2009-07-09
申请号:US12319396
申请日:2009-01-07
申请人: Alex J. Harvey
发明人: Alex J. Harvey
IPC分类号: C12P21/00 , A01K67/027
CPC分类号: A01K67/0275 , A01K2217/052 , A01K2227/30 , A01K2267/01 , C12N9/1048 , C12N9/1051 , C12N15/8509 , C12N2799/027 , C12N2830/008
摘要: Transgenic avians which produce proteins in their oviduct tissue having modified oligosaccharide structures and methods of making such avians are disclosed herein. The invention also includes the modified proteins produced in the transgenic birds.
摘要翻译: 在本文中公开了在其具有修饰的寡糖结构的输卵管组织中产生蛋白质的转基因鸟类和制备这种鸟类的方法。 本发明还包括在转基因鸟类中产生的修饰的蛋白质。
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公开(公告)号:US07524626B2
公开(公告)日:2009-04-28
申请号:US11542093
申请日:2006-10-03
申请人: Alex J. Harvey
发明人: Alex J. Harvey
CPC分类号: C12N15/86 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K14/505 , C07K14/56 , C12N15/8509 , C12N2740/13043 , C12N2740/13052 , C12N2799/027
摘要: The invention includes methods of producing viral particles which include introducing into avian cells a nucleotide sequence encoding a replication deficient retroviral vector and introducing into the avian cells nucleotide sequences encoding products required for replication of the replication deficient retroviral vector under the control of a promoter that is functional in the avian cell line, and harvesting the viral particles.
摘要翻译: 本发明包括产生病毒颗粒的方法,其包括将编码复制缺陷型逆转录病毒载体的核苷酸序列引入禽类细胞,并将编码在复制缺陷型逆转录病毒载体复制的产物所需的核苷酸序列引入到启动子的控制下, 在禽类细胞系中起作用,并收获病毒颗粒。
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公开(公告)号:US07521591B2
公开(公告)日:2009-04-21
申请号:US10696671
申请日:2003-10-28
申请人: Robert D. Ivarie , Alex J. Harvey , Julie A. Morris , Guodong Liu
发明人: Robert D. Ivarie , Alex J. Harvey , Julie A. Morris , Guodong Liu
CPC分类号: C12N9/00 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A01K2267/025 , C07K14/77 , C07K16/00 , C12N15/8509 , C12N15/86 , C12N15/902 , C12N2740/11043 , C12N2799/027 , C12N2800/30 , C12N2800/90 , C12N2830/00 , C12N2830/008 , C12N2830/40 , C12N2830/42 , C12N2830/90 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要: This invention provides eggs which contain exogenous proteins. The invention further provides transgenic chickens which express exogenous sequences in their oviducts, and vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins.
摘要翻译: 本发明提供含有外源蛋白质的卵。 本发明还提供了在其输卵管中表达外源序列的转基因鸡,以及用于将外源核酸序列稳定引入鸟类基因组的载体和方法,用于表达所述外源序列以改变鸟的表型或产生所需蛋白 。
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