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公开(公告)号：US08815242B2
公开(公告)日：2014-08-26
申请号：US12800989
申请日：2010-05-27
申请人： Alex J. Harvey
发明人： Alex J. Harvey
IPC分类号： C07K16/02 , C07K16/28 , C07K16/30 , A61K39/395 , A01K67/027 , C12N15/85
CPC分类号： C07K16/2887 , A01K67/0275 , A01K2217/052 , A01K2227/30 , A01K2267/01 , A01K2267/02 , C07K2317/23 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C12N15/8509 , Y10S424/80 , Y10S424/801 , Y10S530/867
摘要： The invention is drawn to a composition comprising an isolated mixture of cytotoxic anti-CD20 antibody molecules produced in a transgenic avian. The antibody molecules have a heavy chain and a light chain whose amino acid sequences set forth in SEQ ID NOs: 4 and 5 and exhibit an increased level of cytotoxicity as compared to anti-CD20 antibody molecules produced in CHO cells.
摘要翻译： 本发明涉及包含在转基因禽类中产生的细胞毒抗CD20抗体分子的分离混合物的组合物。 与CHO细胞中产生的抗CD20抗体分子相比，抗体分子具有SEQ ID NO：4和5所示的氨基酸序列的重链和轻链，并表现出增加的细胞毒性水平。
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公开(公告)号：US08507749B2
公开(公告)日：2013-08-13
申请号：US11274674
申请日：2005-11-15
IPC分类号： A01K67/027 , C12P21/00
CPC分类号： C12N9/00 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , A01K2267/025 , C07K14/77 , C07K16/00 , C12N15/8509 , C12N15/86 , C12N15/902 , C12N2740/11043 , C12N2799/027 , C12N2800/30 , C12N2800/90 , C12N2830/00 , C12N2830/008 , C12N2830/40 , C12N2830/42 , C12N2830/90 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
摘要翻译： 本发明提供用于将外源核酸序列稳定引入鸟类基因组并用于表达所述外源序列以改变鸟的表型或产生所需蛋白质的载体和方法。 特别地，产生在其输卵管中表达外源序列的转基因鸡。 也产生含有外源蛋白质的蛋。
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公开(公告)号：US08420607B2
公开(公告)日：2013-04-16
申请号：US12317693
申请日：2008-12-24
申请人： Russell W. Carlson , Geert-Jan Boons , Conrad Quinn , Mahalakshmi Vasan , Margreet A. Wolfert , Biswa Choudhury , Elmar Kannenberg , Christine Leoff , Alok Mehta , Elke Saile , Jana Rauvolfova , Patricia Wilkins , Alex J. Harvey
发明人： Russell W. Carlson , Geert-Jan Boons , Conrad Quinn , Mahalakshmi Vasan , Margreet A. Wolfert , Therese Buskas , Biswa Choudhury , Elmar Kannenberg , Christine Leoff , Alok Mehta , Elke Saile , Jana Rauvolfova , Patricia Wilkins
IPC分类号： A01N43/04 , A61K31/70 , A61K39/02 , A61K39/00 , A61K39/38 , C07G3/00 , C07G11/00 , C07H15/00 , C07H17/00
CPC分类号： G01N33/56911 , A61K39/07 , A61K2039/55583 , A61K2039/6068 , C07H3/04 , C07H3/06 , C07H5/04 , C07H9/04 , C07K16/1278 , G01N2333/32 , G01N2400/00 , G01N2469/00
摘要： The present invention presents the isolation, characterization and synthesis of oligosaccharides of Bacillus anthracis. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.
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公开(公告)号：US08372956B2
公开(公告)日：2013-02-12
申请号：US11974657
申请日：2007-10-15
IPC分类号： C07K16/02
CPC分类号： C12N15/86 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C12N15/8509 , C12N15/902 , C12N2740/11043 , C12N2799/027 , C12N2800/30 , C12N2800/90 , C12N2830/00 , C12N2830/008 , C12N2830/15 , C12N2830/40 , C12N2830/90 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： The invention provides for antibodies produced in transgenic birds as chickens.
摘要翻译： 本发明提供了在转基因鸟中产生的抗体作为鸡。
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公开(公告)号：US20120266265A1
公开(公告)日：2012-10-18
申请号：US13168645
申请日：2011-06-24
IPC分类号： A01K67/027
CPC分类号： C12N15/86 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C12N15/8509 , C12N15/902 , C12N2740/13043 , C12N2799/027 , C12N2830/008 , C12N2830/15 , C12N2830/40 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
摘要翻译： 本发明提供用于将外源核酸序列稳定引入鸟类基因组的载体和方法，以便表达外源序列以改变鸟类的表型或产生所需的蛋白质。 特别地，产生转基因鸟类，其在其输卵管中表达外源序列，并将外源蛋白质沉积到其卵中。 含有外源蛋白质的禽类卵包含在本发明中。 本发明还提供干扰素和促红细胞生成素的新型形式，其在转基因鸟类的输卵管中有效表达并沉积到禽卵中。
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公开(公告)号：US20120039984A1
公开(公告)日：2012-02-16
申请号：US13002180
申请日：2009-07-02
申请人： Geert-Jan Boons , Therese Buskas , Alex J. Harvey , Sampat Ingale , Margaretha Wolfert , Robert Lance Wells
发明人： Geert-Jan Boons , Therese Buskas , Alex J. Harvey , Sampat Ingale , Margaretha Wolfert , Robert Lance Wells
IPC分类号： A61K39/00 , A61K39/395 , A61K9/127 , A61K39/12 , A61K39/02 , A61K39/42 , A61K39/40 , A61K39/002 , C07K16/00 , C07K17/00 , A61P35/00 , A61P31/12 , A61P33/02 , A61P31/04 , A61P31/14 , A61P31/18 , C12N5/16 , G01N33/53 , C07K17/02
CPC分类号： C07K16/44 , A61K9/127 , A61K38/00 , A61K39/0008 , A61K39/0011 , A61K47/646 , A61K2039/545 , A61K2039/55511 , A61K2039/55555 , A61K2039/57 , A61K2039/6018 , A61K2039/6075 , C07K9/00 , C07K14/22 , C07K14/4727 , C07K16/3076 , C07K2317/34 , C12N2740/16011 , C12N2740/16134 , G01N33/92 , G01N2400/02 , G01N2800/042 , G01N2800/2821
摘要： A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.
摘要翻译： 包含用作治疗或预防性疫苗的碳水化合物组分，肽组分和脂质组分的糖脂肽。 还提供了识别本发明的糖脂肽的单克隆和多克隆抗体及其用途。
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公开(公告)号：US07812215B2
公开(公告)日：2010-10-12
申请号：US12313064
申请日：2008-11-17
IPC分类号： C12P21/00 , A01K67/027
CPC分类号： C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要： Methods of producing protein using a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
摘要翻译： 使用与一个或多个有用的氨基酸编码序列有效连接的重组卵巢粘蛋白基因表达控制区产生蛋白质的方法。
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公开(公告)号：US20090188002A1
公开(公告)日：2009-07-23
申请号：US12316591
申请日：2008-12-12
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： C12N9/22 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2227/40 , A01K2267/01 , C12N15/8509 , C12N15/873 , C12N2800/20 , C12N2800/204 , C12N2800/206 , C12N2830/00 , C12N2830/40 , C12N2830/90 , C12N2840/203
摘要： The invention includes avians containing an artificial chromosome in their genome and methods of making the avians.
摘要翻译： 本发明包括在其基因组中含有人造染色体的鸟类和制作鸟类的方法。
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9.发明授权Transgenic avians with an ovomucoid gene expression control region linked to a nucleotide sequence encoding a heterologous polypeptide 有权具有与编码异源多肽的核苷酸序列连接的卵巢粘蛋白基因表达控制区的转基因鸟类公开(公告)号：US07375258B2
公开(公告)日：2008-05-20
申请号：US10496731
申请日：2002-12-02
申请人： Alex J. Harvey , Youliang Wang
发明人： Alex J. Harvey , Youliang Wang
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： C07K14/8135 , A01K2227/30 , C07K14/56 , C12N2799/021
摘要： The present invention provides novel isolated nucleic acids that comprise an avian nucleic acid sequence comprising a ovomucoid gene expression control region. The ovomucoid promoter region of the present invention will allow expression of an operably linked heterologous nucleic acid insert in a transfected avian cell such as, for example, an oviduct cell. The isolated avian ovomucoid of the present invention may be operably linked with a selected nucleic acid insert, wherein the nucleic acid insert encodes a polypeptide desired to be expressed in a transfected cell. The recombinant DNA of the present invention may further comprise a polyadenylation signal sequence. The present invention further includes expression vectors comprising an isolated avian ovomucoid gene expression control region of the present invention, and transfected cells and transgenic avians comprising the expression vectors.
摘要翻译： 本发明提供新的分离的核酸，其包含包含卵巢粘蛋白基因表达控制区的禽类核酸序列。 本发明的卵巢粘蛋白启动子区域将允许在经转染的禽类细胞例如输卵管细胞中表达可操作地连接的异源核酸插入物。 本发明的分离的禽类卵类粘蛋白可以与所选择的核酸插入物可操作地连接，其中核酸插入物编码期望在转染细胞中表达的多肽。 本发明的重组DNA还可以包含聚腺苷酸化信号序列。 本发明还包括包含本发明的分离的禽类卵巢粘蛋白基因表达控制区的表达载体，以及包含表达载体的转染细胞和转基因鸟类。
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公开(公告)号：US07335761B2
公开(公告)日：2008-02-26
申请号：US11047184
申请日：2005-01-31
CPC分类号： C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要： The present invention includes avian ovomucoid gene expression controlling regions which may be operably linked to one or more useful amino acid coding sequences.
摘要翻译： 本发明包括可以与一个或多个有用的氨基酸编码序列可操作地连接的鸟类卵类粘蛋白基因表达控制区。
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