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28 条记录 (耗时 0.034 秒)

    Tip etching system and method for etching platinum-containing wire
    23.
    发明授权
    Tip etching system and method for etching platinum-containing wire 失效
    尖端蚀刻系统和蚀刻含铂线的方法

    公开(公告)号：US5630932A

    公开(公告)日：1997-05-20

    申请号：US524054

    申请日：1995-09-06

    申请人： Stuart M. Lindsay ,  Tianwei Jing ,  Yuri L. Lyubchenko ,  Alexander A. Gall

    发明人： Stuart M. Lindsay ,  Tianwei Jing ,  Yuri L. Lyubchenko ,  Alexander A. Gall

    IPC分类号： B05D1/00 ,  C25F3/14 ,  G01Q60/10 ,  G01Q70/16 ,  B23H9/08 ,  C25F7/00

    CPC分类号： G01Q70/16 ,  B82Y35/00 ,  Y10S977/875 ,  Y10S977/881 ,  Y10S977/891

    摘要： A tip and substrate preparation system for use with scanning probe microscopes (SPMs) includes a scanning tunneling microscope (STM) tip maker, STM tip coater, a substrate treatment method for producing clean, flat gold substrates for STM use and methods for preparing chemically activated substrates for use with an atomic force microscope (AFM). The tip maker includes a coater and an etcher which are preferably controlled by electronic controllers. The etcher provides fully automatic tip etching in a two-stage process in sodium hydroxide (NaOH) solution, permitting platinum alloys to be etched without the use of cyanide-containing chemicals. The coater is used to insulate the tips with soft polymer coatings so as to ensure very low tip leakage current (on the order of about 1 pA typical). The substrate treatment device comprises a quartz plate and a quartz torch for annealing substrates in a hydrogen flame. The chemically activated substrates for atomic force microscopy permit the surface of mica to be modified at will so as to be hydrophobic, hydrophilic, positively or negatively charged.

    摘要翻译： 用于扫描探针显微镜（SPM）的尖端和底物制备系统包括扫描隧道显微镜（STM）尖端制造器，STM尖端涂布机，用于制造用于STM的清洁的平坦金基底的基底处理方法和用于制备化学活化的方法 用于原子力显微镜（AFM）的底物。 尖端制造器包括优选由电子控制器控制的涂布机和蚀刻机。 蚀刻器在氢氧化钠（NaOH）溶液中在两步法中提供全自动尖端蚀刻，允许在不使用含氰化合物的情况下对铂合金进行蚀刻。 涂层机用于将尖端与柔性聚合物涂层绝缘，以确保极低的尖端泄漏电流（典型值约为1 pA）。 基板处理装置包括用于在氢火焰中退火基板的石英板和石英手电筒。 用于原子力显微镜的化学活化的底物允许云母的表面随意改性，以便是疏水性的，亲水的，带正电荷或带负电荷的。

    Fluorescent quenching detection reagents and methods
    27.
    发明授权
    Fluorescent quenching detection reagents and methods 有权
    荧光猝灭检测试剂及方法

    公开(公告)号：US06727356B1

    公开(公告)日：2004-04-27

    申请号：US09457616

    申请日：1999-12-08

    申请人： Michael W. Reed ,  Eugeny Alexander Lukhtanov ,  Alexander A. Gall ,  Robert O. Dempcy

    发明人： Michael W. Reed ,  Eugeny Alexander Lukhtanov ,  Alexander A. Gall ,  Robert O. Dempcy

    IPC分类号： C07H1900

    CPC分类号： C07D519/00 ,  C07B2200/11 ,  C07C245/08 ,  C07F9/2408 ,  C07F9/572 ,  C07F9/65522 ,  C07F9/6561 ,  C07H21/00 ,  C09B29/0813 ,  C12Q1/6818 ,  C40B40/00 ,  C12Q2565/1025 ,  C12Q2521/319

    摘要： Oligonucleotide-fluorophore-quencher conjugates wherein the fluorophore moiety has emission wavelengths in the range of about 300 to about 800 nm, and or where the quencher includes a substituted 4-(phenyldiazenyl)phenylamine structure provide improved signal to noise ratios and other advantageous characteristics in hybridization and related assays. The oligonucleotide-fluorophore-quencher conjugates can be synthesized by utilizing novel phosphoramidite reagents that incorporate the quencher moiety based on the substituted 4-(phenyldiazenyl)phenylamine structure, and or novel phosphoramidite reagents that incorporate a fluorophore moiety based on the substituted coumarin, substituted 7-hydroxy-3H-phenoxazin-3-one, or substituted 5,10-dihydro-10-[phenyl]pyrido[2,3-d;6,5-d′]dipyrimidine-2,4,6,8-(1H,3H,7H,9H,10H)-tetrone structure. Oligonucleotide-fluorophore-quencher-minor groove binder conjugates including a pyrrolo[4,5-e]indolin-7-yl}carbonyl)pyrrolo[4,5-e]indolin-7-yl]carbonyl}pyrrolo[4,5-e]indoline-7-carboxylate (DPI3) moiety as the minor groove binder and the substituted 4-(phenyldiazenyl)phenylamine moiety as the quencher, were synthesized and have substantially improved hybridization and signal to noise ratio properties.

    摘要翻译： 寡核苷酸 - 荧光团 - 猝灭剂缀合物，其中荧光团部分具有在约300至约800nm范围内的发射波长，或者猝灭剂包含取代的4-（苯基二氮烯基）苯胺结构的提供改善的信噪比和其它有利特征 杂交和相关测定。 寡核苷酸 - 荧光团 - 猝灭剂缀合物可以通过利用引入基于取代的4-（苯基二氮烯基）苯基胺结构的猝灭剂部分的新型亚磷酰胺试剂，和/或新型亚磷酰胺试剂合成，所述亚磷酰胺试剂掺入基于取代香豆素的荧光团部分，取代7 - 羟基-3H-吩恶嗪-3-酮或取代的5,10-二氢-10- [苯基]吡啶并[2,3-d; 6,5-d']二嘧啶-2,4,6,8-（ 1H，3H，7H，9H，10H） - 四酮结构。 吡咯并[4,5-e]二氢吲哚-7-基}羰基）吡咯并[4,5-e]二氢吲哚-7-基]羰基}吡咯并[4,5- e]二氢吲哚-7-羧酸酯（DPI 3）部分作为次槽粘合剂和取代的4-（苯基二氮烯基）苯胺部分作为猝灭剂，并且具有显着改善的杂交和信噪比性质。

    Tip coating system for scanning probe microscopy
    28.
    发明授权
    Tip coating system for scanning probe microscopy 失效
    尖端涂层系统用于扫描探针显微镜

    公开(公告)号：US6017590A

    公开(公告)日：2000-01-25

    申请号：US760757

    申请日：1996-12-05

    申请人： Stuart M. Lindsay ,  Tianwei Jing ,  Yuri L. Lyubchenko ,  Alexander A. Gall

    发明人： Stuart M. Lindsay ,  Tianwei Jing ,  Yuri L. Lyubchenko ,  Alexander A. Gall

    IPC分类号： B05D1/00 ,  C25F3/14 ,  G01Q60/10 ,  G01Q70/16

    CPC分类号： G01Q70/16 ,  B82Y35/00 ,  Y10S977/875 ,  Y10S977/881 ,  Y10S977/891

    摘要： A tip coating system for use with scanning tunneling microscope (STM) tips. The tip coating system includes a tip holder, a plate having a slot for receiving the tip and for holding a coating material, a heater for heating the coating material into a molten blob, a micropositioner for displacing the plate to and from the tip and for moving the tip within the slot so that selected portions of the tip contact the molten blob of coating material. The tip coating system is preferably controlled by electronic controllers, including a temperature controller for the heater. The tip coating system is used to insulate the tips with soft polymer coating material to ensure very low tip leakage current (on the order of about 1 pA typical).

    摘要翻译： 用于扫描隧道显微镜（STM）尖端的尖端涂层系统。 尖端涂覆系统包括：刀片保持器，具有用于接收尖端并用于保持涂层材料的槽的板，用于将涂层材料加热成熔融斑块的加热器，用于使板移动到尖端的微定位器， 将尖端移动到狭槽内，使得尖端的选定部分接触熔融的涂层材料块。 尖端涂覆系统优选地由电子控制器控制，包括用于加热器的温度控制器。 尖端涂层系统用于将尖端与软质聚合物涂层材料绝缘，以确保非常低的尖端泄漏电流（典型值约为1 pA）。